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Geoscience Frontiers 2024年第1期15卷 29-38页

作者： chuan Yang yue Yin Jiantong Zhang Penghui Ding Jian Liu China Transport Telecommunications and Information Center Beijing 100011PR China China Nuclear Power Engineering Co. LtdBeijing 100011PR China

The accurate prediction of displacement is crucial for landslide deformation monitoring and early *** study focuses on a landslide in Wenzhou Belt Highway and proposes a novel multivariate landslide displacement prediction method that relies on graph deep learning and Global Navigation Satellite System(GNSS)*** model the graph structure of the monitoring system based on the engineering positions of the GNSS monitoring points and build the adjacent matrix of graph *** construct the historical and predicted time series feature matrixes using the processed temporal data including GNSS displacement,rainfall,groundwater table and soil moisture content and the graph *** introduce the state-of-the-art graph deep learning GTS(Graph for Time Series)model to improve the accuracy and reliability of landslide displacement prediction which utilizes the temporal-spatial dependency of the monitoring *** approach outperforms previous studies that only learned temporal features from a single monitoring point and maximally weighs the prediction performance and the priori graph of the monitoring *** proposed method performs better than SVM,XGBoost,LSTM and DCRNN models in terms of RMSE(1.35 mm),MAE(1.14 mm)and MAPE(0.2.)evaluation metrics,which is provided to be effective in future landslide failure early warning.

关键词： Landslide displacement prediction GNSS positioning Graph deep learning

Delivery room resuscitation intensity and associated neonatal outcomes of 2.^(+0)-31^(+6) weeks'preterm infants in China:a retrospective cross-sectional study

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World Journal of Pediatrics 2024年第1期20卷 64-72页

作者： Si-Lu Wang Chun Chen Xin-yue Gu Zhao-Qing Yin Le Su Si-Yuan Jiang Yun Cao Li-Zhong Du Jian-Hua Sun Jiang-Qin Liu chuan-Zhong Yang Department of Neonatology Shanghai Key Laboratory of Maternal Fetal MedicineShanghai Institute of Maternal-Fetal Medicine and Gynecologic OncologyShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityNo.2699Gaoke Western RoadPudong DistrictShanghai 201204China Department of Neonatology Affiliated Shenzhen Maternity and Child Healthcare HospitalSouthern Medical UniversityNo.2004Hongli RoadFutian DistrictShenzhen 518028China NHC Key Laboratory of Neonatal Diseases Fudan UniversityChildren's Hospital of Fudan UniversityShanghaiChina Department of Neonatology People's Hospital of DehongKunming Medical UniversityDehongChina Department of Neonatology Children's Hospital of Fudan UniversityShanghaiChina Department of Neonatology Children's HospitalZhejiang University School of MedicineHangzhouChina Department of Neonatology Shanghai Children's Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background The aim of this study was to review current delivery room(DR)resuscitation intensity in Chinese tertiary neonatal intensive care units and to investigate the association between DR resuscitation intensity and short-term outcomes in preterm infants born at 2.+0_31+6 weeks gestation age(GA).Methods This was a retrospective cross-sectional *** source population was infants born at 2.+0_31+6 weeks'GA who were enrolled in the Chinese Neonatal Network 2.19 *** infants were categorized into five groups:(1)regular care;(2.oxygen supplementation and/or continuous positive airway pressure(O2.CPAP);(3)mask ventilation;(4)endotracheal intubation;and(5)cardiopulmonary resuscitation(CPR).The association between DR resuscitation and shortterm outcomes was evaluated by inverse propensity score-weighted logistic *** Of 7939 infants included in this cohort,2.19(30.5%)received regular care,1994(2..1%)received O,/CPAP,1436(18.1%)received mask ventilation,1769(2..3%)received endotracheal intubation,and 32.(4.0%)received CPR in the *** maternal age and maternal hypertension correlated with a higher need for resuscitation,and antenatal steroid use tended to be associated with a lower need for resuscitation(P<0.001).Severe brain impairment increased significantly with increasing amounts of resuscitation in DR after adjusting for perinatal *** strategies vary widely between centers,with over 50%of preterm infants in eight centers requiring higher intensity *** Increased intensity of DR interventions was associated with increased mortality and morbidities in very preterm infants in *** is wide variation in resuscitative approaches across delivery centers,and ongoing quality improvement to standardize resuscitation practices is needed.

关键词： Cardiopulmonary resuscitation Delivery room Endotracheal intubation Neonatal resuscitation Preterm

Interaction between catechol-O-methyltransferase Val/Met polymorphism and cognitive reserve for negative symptoms in schizophrenia

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World Journal of Psychiatry 2024年第5期14卷 695-703页

作者： Wen-Peng Hou Xiang-Qin Qin Wei-Wei Hou Yun-Yi Han Qi-Jing Bo Fang Dong Fu-Chun Zhou Xian-Bin Li chuan-yue Wang Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders&National Center for Mental DisordersBeijing Anding HospitalCapital Medical UniversityBeijing 100088China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100069China

BACKGROUND Cognitive reserve(CR)and the catechol-O-methyltransferase(COMT)Val/Met polymorphism are reportedly linked to negative symptoms in ***,the regulatory effect of the COMT genotype on the relationship between CR and negative symptoms is still *** To investigate whether the relationship between CR and negative symptoms could be regulated by the COMT Val/Met *** In a cross-sectional study,54 clinically stable patients with schizophrenia underwent assessments for the COMT genotype,CR,and negative *** was estimated using scores in the information and similarities subtests of a short form of the Chinese version of the Wechsler Adult Intelligence *** COMT Met-carriers exhibited fewer negative symptoms than Val *** the total sample,significant negative correlations were found between negative symptoms and information,*** between information,similarities and negative symptoms were observed in Val homozygotes only,with information and similarities showing interaction effects with the COMT genotype in relation to negative symptoms(information,β=-0.2.2.95%CI:-0.552.to-0.011,P=0.042.similarities,β=-0.2.0,95%CI:-0.495 to-0.004,P=0.046).CONCLUSION This study provides initial evidence that the association between negative symptoms and CR is under the regulation of the COMT genotype in schizophrenia.

关键词： Catechol-O-methyltransferase Val/Met polymorphism Cognitive reserve Crystallized intelligence Negative symptoms Schizophrenia

Clinical and molecular characterization of 10 Chinese children with congenital adrenal hyperplasia due to 11beta‑hydroxylase deficiency

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World Journal of Pediatrics 2024年第4期20卷 422-433页

作者： Wen‑Li Lu Xiao‑Yu Ma Jiao Zhang Jun‑Qi Wang Ting‑Ting Zhang Lei Ye Yuan Xiao Zhi‑Ya Dong Wei Wang Shou‑yue Sun chuan‑Yin Li Rong‑Gui Hu Guang Ning Li‑Dan Zhang Department of Pediatrics Ruijin HospitalShanghai Jiao Tong University School of MedicineNo.197Ruijin 2nd RdHuangpu DistrictShanghai 200025China Department of Pediatric Genetic and Metabolic Endocrinology West China Second University HospitalSichuan UniversityNo.20Section 3Renmin South RoadSichuan 610041China Department of Endocrine and Metabolic Diseases Shanghai Clinical Center for Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Cancer Center School of MedicineShanghai Tenth People’s HospitalTongji UniversityYanchang Zhong Lu 301St RdJing’an DistrictShanghai 200031China

Background The clinical manifestations of nonclassical 11beta-hydroxylase deficiency are very similar to those of nonclassical 2.-hydroxylase *** this study,we investigated the relationship between the clinical and molecular features of congenital adrenal hyperplasia caused by 11beta-hydroxylase deficiency and reviewed the related literature,which are expected to provide assistance for the clinical diagnosis and analysis of congenital adrenal *** Clinical data for 10 Chinese patients diagnosed with congenital adrenal hyperplasia in our hospital from 2.18 to 2.2. were retrospectively *** examined the effects of gene mutations on protease activity and constructed threedimensional structure prediction models of *** We describe 10 patients with 11beta-hydroxylase gene mutations(n=5,46,XY;n=5,46,XX),with 10 novel mutations were *** patients received treatment at an early stage,with an average age of 2.08±1.66 years,whereas male patients received treatment significantly later,at an average age of 9.77±3.62.*** most common CYP11B1 pathogenic variant in the Chinese population was found to be c.1360C>*** mutations lead to spatial conformational changes that affect protein *** Our study found that there was no significant correlation between each specific mutation and the severity of clinical *** patients with the same gene pathogenic variant may have mild or severe clinical *** correlation between genotype and phenotype needs further ***-dimensional protein simulations may provide additional support for the physiopathological mechanism of genetic mutations.

关键词： 11β-hydroxylase deficiency CYP11B1 Enzymatic activity Phenotype-genotype correlation Threedimensional protein simulations

Serum LDL Promotes Microglial Activation and Exacerbates Demyelinating Injury in Neuromyelitis Optica Spectrum Disorder

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Neuroscience Bulletin 2024年第8期40卷 1104-1114页

作者： Man Chen Yun‑Hui Chu Wen‑Xiang Yu Yun‑Fan You yue Tang Xiao‑Wei Pang Hang Zhang Ke Shang Gang Deng Luo‑Qi Zhou Sheng Yang Wei Wang Jun Xiao Dai‑Shi Tian chuan Qin Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Hubei Key Laboratory of Neural Injury and Functional Reconstruction Huazhong University of Science and TechnologyWuhan 430030China Department of Neurology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311China

Neuromyelitis optica spectrum disorder(NMOSD)is an autoimmune inflammatory demyelinating disease of the central nervous system(CNS)accompanied by blood-brain barrier(BBB)*** in microglial lipid metabolism is believed to be closely associated with the neuropathology of ***,there is limited evidence on the functional relevance of circulating lipids in CNS demyelination,cellular metabolism,and microglial ***,we found that serum low-density lipoprotein(LDL)was positively correlated with markers of neurological damage in NMOSD *** addition,we demonstrated in a mouse model of NMOSD that LDL penetrates the CNS through the leaky BBB,directly activating *** activation leads to excessive phagocytosis of myelin debris,inhibition of lipid metabolism,and increased glycolysis,ultimately exacerbating myelin *** also found that therapeutic interventions aimed at reducing circulating LDL effectively reversed the lipid metabolic dysfunction in microglia and mitigated the demyelinating injury in *** findings shed light on the molecular and cellular mechanisms underlying the positive correlation between serum LDL and neurological damage,highlighting the potential therapeutic target for lowering circulating lipids to alleviate the acute demyelinating injury in NMOSD.

关键词： Neuromyelitis optica spectrum disorder Low-density lipoprotein Microglia

Coupling and characterization of a Si/SiGe triple quantum dot array with a microwave resonator

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Chinese Physics B 2024年第9期33卷 139-143页

作者： Shun-Li Jiang Tian-Yi Jiang Yong-Qiang Xu Rui Wu Tian-yue Hao Shu-Kun Ye Ran-Ran Cai Bao-chuan Wang Hai-Ou Li Gang Cao Guo-Ping Guo CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Origin Quantum Computing Company Limited Hefei 230088China

Scaling up spin qubits in silicon-based quantum dots is one of the pivotal challenges in achieving large-scale semiconductor quantum *** satisfy the connectivity requirements and reduce the lithographic complexity,utilizing the qubit array structure and the circuit quantum electrodynamics(cQED)architecture together is expected to be a feasible scaling scheme.A triple-quantum dot(TQD)coupled with a superconducting resonator is regarded as a basic cell to demonstrate this extension *** this article,we investigate a system consisting of a silicon TQD and a high-impedance TiN coplanar waveguide(CPW)*** TQD can couple to the resonator via the right double-quantum dot(RDQD),which reaches the strong coupling regime with a charge–photon coupling strength of g0/(2.)=175 ***,we illustrate the high tunability of the TQD through the characterization of stability diagrams,quadruple points(QPs),and the quantum cellular automata(QCA)*** results contribute to fostering the exploration of silicon-based qubit integration.

关键词： triple-quantum dot strong coupling circuit quantum electrodynamics (cQED) scalable siliconbased cQED architectures

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“悟空”号——空间宇宙线探测的中国利器

大学科普 2024年第1期18卷 76-78页

作者：岳川中国科学院紫金山天文台江苏南京

浩瀚宇宙中,除了恒星、行星等各种天体之外,还充斥着无数快速飞行的高能粒子,我们的地球无时无刻不在经受这些高能粒子流的轰击,它们被统称为宇宙线。宇宙线中最主要的粒子是质子,约占87%,其次是α粒子(氦核),约占12.,余下约1%是各种重... 详细信息

浩瀚宇宙中,除了恒星、行星等各种天体之外,还充斥着无数快速飞行的高能粒子,我们的地球无时无刻不在经受这些高能粒子流的轰击,它们被统称为宇宙线。宇宙线中最主要的粒子是质子,约占87%,其次是α粒子(氦核),约占12.,余下约1%是各种重原子核、少量电子、伽马光子以及微量反物质粒子(主要有正电子和反质子)。宇宙线能量范围横跨超过十一个量级,最高可达102.电子伏特(电子伏特为能量单位,记作eV,太阳发出的光子能量约为1eV)以上,远高于人类制造的大型粒子加速器加速粒子所获得的能量上限,是人类研究极端条件下天体环境和物理规律的重要信使,蕴藏着宇宙起源、天体演化等丰富信息。

关键词：物理规律高能粒子宇宙线反物质 α粒子天体演化能量单位宇宙起源

振型分解反应谱法计算加层后结构的几个问题研究

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工程抗震与加固改造 2024年第4期46卷 164-171页

作者：肖川史跃波张欣中国建筑科学研究院有限公司北京构力科技有限公司北京100013

在既有钢筋混凝土结构或砖混结构上加建钢结构层后,应采用整体模型进行抗震计算。由于加层部分与既有结构的阻尼特性不同,不能采用统一的振型阻尼比,本文研究了估计混合结构振型阻尼比的实用计算方法。为确保反映出加层结构部分的高阶... 详细信息

在既有钢筋混凝土结构或砖混结构上加建钢结构层后,应采用整体模型进行抗震计算。由于加层部分与既有结构的阻尼特性不同,不能采用统一的振型阻尼比,本文研究了估计混合结构振型阻尼比的实用计算方法。为确保反映出加层结构部分的高阶振型响应,本文引入了部分结构的有效质量系数的计算方法。最后,探讨了加层结构与既有结构的动力相互作用问题,分析了加层后结构层剪力相对于原结构降低的原因。本文研究的计算方法均已在PKPM程序中实现,选用这些方法可以更准确地进行既有结构的加层改造计算。

关键词：既有结构加层阻尼比有效质量系数

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人工智能辅助含能分子设计的应用与展望

含能材料 2024年第4期32卷 408-421页

作者：刘锐刘建唐岳川张朝阳黄静黄鑫中国工程物理研究院化工材料研究所四川绵阳621999 西南石油大学化学化工学院四川成都610500

含能分子研发面临多重挑战,传统“试错法”效率低下,计算机辅助分子设计的出现改变了研发模式。本综述回顾了含能分子设计的发展历程,介绍了计算机辅助含能分子设计的研究现状,并概述了人工智能技术(AI)在性质预测、分子生成、合成路线... 详细信息

含能分子研发面临多重挑战,传统“试错法”效率低下,计算机辅助分子设计的出现改变了研发模式。本综述回顾了含能分子设计的发展历程,介绍了计算机辅助含能分子设计的研究现状,并概述了人工智能技术(AI)在性质预测、分子生成、合成路线和反应条件预测等多个设计环节的最新进展,讨论了当前含能分子设计模式与其他材料设计方法的差距,思考差距产生的原因,并对未来AI辅助含能分子设计的发展方向提出展望。研究发现,AI在含能分子性能预测和分子生成等方面已经有了应用,但在合成路径规划和反应条件优化等环节的应用仍有待进一步探索,应用前景巨大。通过数据增强、迁移学习或高通量计算有望能够解决含能分子数据薄弱的问题;加强AI辅助含能分子合成路线与反应条件探索有望贯通“设计→评估→制备→验证”全流程自动化分子设计模式。AI辅助含能分子设计为提升含能分子设计水平提供新的可能性,有助提升含能分子研发效率。

关键词：含能分子分子设计人工智能机器学习定量构效关系

Adenylate kinase phosphate energy shuttle underlies energetic communication in flagellar axonemes

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Science China(Life Sciences) 2024年第8期67卷 1697-1714页

作者： Huan Wu Yanman Zhang Yuqian Li Shuya Sun Jintao Zhang Qingsong Xie yue Dong Shushu Zhou Xuan Sha Kuokuo Li Jinyi Chen Xin Zhang Yang Gao Qunshan Shen Guanxiong Wang Xiaomin Zha Zongliu Duan Dongdong Tang chuan Xu Hao Geng Mingrong Lv Yuping Xu Ping Zhou Zhaolian Wei Rong Hua Yunxia Cao Mingxi Liu Xiaojin He Reproductive Medicine Center Department of Obstetrics and GynecologyThe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China State Key Laboratory of Reproductive Medicine and Offspring Health Department of Histology and EmbryologySchool of Basic Medical SciencesNanjing Medical UniversityNanjing 210029China State Key Laboratory of Reproductive Medicine and Offspring Health The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou School of Clinical MedicineNanjing Medical UniversityNanjing 211166China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China State Key Laboratory of Reproductive Medicine and Offspring Health Clinical Center of Reproductive MedicineThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University) Hefei 230032China Key Laboratory of Population Health Across Life Cycle(Anhui Medical University) Ministry of Education of the People’s Republic of ChinaHefei 230032China Anhui Province Key Laboratory of Reproductive Health and Genetics Hefei 230032China Biopreservation and Artificial Organs Anhui Provincial Engineering Research CenterAnhui Medical UniversityHefei 230032China

The complexities of energy transfer mechanisms in the flagella of mammalian sperm flagella have been intensively investigated and demonstrate significant diversity across *** shuttles,particularly adenylate kinase(AK)and creatine kinase(CK),are pivotal in the efficient transfer of intracellular ATP,showing distinct tissue-and ***,the expression profiles of AK and CK were investigated in mice and found to fall into four subgroups,of which Subgroup III AKs were observed to be unique to the male reproductive system and conserved across *** AK8 and AK9 were found to be indispensable to male reproduction after analysis of an infertile male *** mouse models showed that AK8 and AK9 were central to promoting sperm *** combined with mass spectrometry revealed that AK8 and AK9 interact with the radial spoke(RS)of the *** of various human and mouse sperm samples with substructural damage,including the presence of multiple RS subunits,showed that the head of radial spoke 3 acts as an adapter for AK9 in the flagellar *** an ATP probe together with metabolomic analysis,it was found that AK8 and AK9 cooperatively regulated ATP transfer in the axoneme,and were concentrated at sites associated with energy consumption in the *** findings indicate a novel function for RS beyond its structural role,namely,the regulation of ATP *** conclusion,the results expand the functional spectrum of AK proteins and suggest a fresh model regarding ATP transfer within mammalian flagella.

关键词： adenylate kinase Subgroup III AKs AK8 AK9 male infertility ATP transfer radial spoke