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Cyclophilin D-induced mitochondrial impairment confers axonal injury after intracerebral hemorrhage in mice

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Neural Regeneration Research 2023年第4期18卷 849-855页

作者： yang yang Kai-Yuan Zhang Xue-Zhu Chen chuan-yan yang Ju Wang Xue-Jiao Lei Yu-Lian Quan Wei-Xiang Chen Heng-Li Zhao Li-Kun yang Yu-Hai Wang Yu-Jie Chen Hua Feng Department of Neurosurgery The 904th Hospital of PLAAnhui Medical UniversityWuxiJiangsu ProvinceChina Department of Neurosurgery and State Key Laboratory of Trauma Burn and Combined InjurySouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina Chongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration Third Military Medical University(Army Medical University)ChongqingChina Wuxi Translational Medicine Center WuxiJiangsu ProvinceChina Department of Neurosurgery General Hospital of Xinjiang Military Command of PLAUrumqiXinjiang Uygur Autonomous RegionChina Department of Neurology The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijingChina

The mitochondrial permeability transition pore is a nonspecific transmembrane *** of mitochondrial permeability transition pore opening has been shown to alleviate mitochondrial swelling,calcium overload,and axonal *** D is an important component of the mitochondrial permeability transition *** cyclophilin D participates in mitochondrial impairment and axonal injury after intracerebral hemorrhage is not *** this study,we established mouse models of intracerebral hemorrhage in vivo by injection of autologous blood and oxyhemoglobin into the striatum in Thy1-YFP mice,in which pyramidal neurons and axons express yellow fluorescent *** also simulated intracerebral hemorrhage in vitro in PC12 cells using *** found that axonal degeneration in the early stage of intracerebral hemorrhage depended on mitochondrial swelling induced by cyclophilin D activation and mitochondrial permeability transition pore *** further investigated the mechanism underlying the role of cyclophilin D in mouse models and PC12 cell models of intracerebral *** found that both cyclosporin A inhibition and short hairpin RNA interference of cyclophilin D reduced mitochondrial permeability transition pore opening and mitochondrial *** addition,inhibition of cyclophilin D and mitochondrial permeability transition pore opening protected corticospinal tract integrity and alleviated motor dysfunction caused by intracerebral *** findings suggest that cyclophilin D is used as a key mediator of axonal degeneration after intracerebral hemorrhage;inhibition of cyclophilin D expression can protect mitochondrial structure and function and further alleviate corticospinal tract injury and motor dysfunction after intracerebral *** findings provide a therapeutic target for preventing axonal degeneration of white matter injury and subsequent functional impairment in central nervous diseases.

关键词： axonal injury corticospinal tract cyclophilin D cyclosporin A intracerebral hemorrhage mitochondrial impairment mitochondrial permeability transition pore motor dysfunction retraction bulb white matter

Graphene oxide-composited chitosan scaffold contributes to functional recovery of injured spinal cord in rats

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Neural Regeneration Research 2021年第9期16卷 1829-1835页

作者： Bing yang Pang-Bo Wang Ning Mu Kang Ma Shi Wang chuan-yan yang Zhong-Bing Huang Ying Lai Hua Feng Guang-Fu Yin Tu-Nan Chen Chen-Shi Hu College of Biomedical Engineering Sichuan UniversityChengduSichuan ProvinceChina Department of Neurosurgery Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

The study illustrates that graphene oxide nanosheets can endow materials with continuous electrical conductivity for up to 4 weeks. Conductive nerve scaffolds can bridge a sciatic nerve injury and guide the growth of neurons;however, whether the scaffolds can be used for the repair of spinal cord nerve injuries remains to be explored. In this study, a conductive graphene oxide composited chitosan scaffold was fabricated by genipin crosslinking and lyophilization. The prepared chitosan-graphene oxide scaffold presented a porous structure with an inner diameter of 18–87 μm, and a conductivity that reached 2.83 mS/cm because of good distribution of the graphene oxide nanosheets, which could be degraded by peroxidase. The chitosan-graphene oxide scaffold was transplanted into a T9 total resected rat spinal cord. The results show that the chitosan-graphene oxide scaffold induces nerve cells to grow into the pores between chitosan molecular chains, inducing angiogenesis in regenerated tissue, and promote neuron migration and neural tissue regeneration in the pores of the scaffold, thereby promoting the repair of damaged nerve tissue. The behavioral and electrophysiological results suggest that the chitosan-graphene oxide scaffold could significantly restore the neurological function of rats. Moreover, the functional recovery of rats treated with chitosangraphene oxide scaffold was better than that treated with chitosan scaffold. The results show that graphene oxide could have a positive role in the recovery of neurological function after spinal cord injury by promoting the degradation of the scaffold, adhesion, and migration of nerve cells to the scaffold. This study was approved by the Ethics Committee of Animal Research at the First Affiliated Hospital of Third Military Medical University(Army Medical University)(approval No. AMUWEC20191327) on August 30, 2019.

关键词： angiogenesis chitosan electrical conduction graphene oxide regeneration repair scaffold spinal cord injury

A Search for High-velocity Gas Associated H_2O Masers and Ultracompact HII Regions

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Chinese Journal of Astronomy and Astrophysics 2001年第1期1卷 60-65页

作者： YeXu Dong－RongJiang 等 ShanghaiAstronomicalObservatory ChineseAcademyofSciencesShanghai200030 NationalAstronomicalObservato

With the objective of studying the relationships between high-velocity gas and water maser emissions the results of a search from 95 IRAS sources for high-velocity gas associated with star forming molecular clouds are... 详细信息

关键词： HII regions - ISM: jets and outflows - stars: formation - masers

Prevalence and molecular characterization of Cryptosporidium *** dairy cattle,northwest China

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Prevalence and molecular characterization of Cryptosporidium...

中国畜牧兽医学会兽医寄生虫学分会第十三次学术研讨会

作者： Xiao-Xuan Zhang Qi-Dong Tan Dong-Hui Zhou Xiao-Ting Ni Guang-Xue Liu yan-chuan yang Xing-Quan Zhu College of Animal Science and Technology Jilin Agricultural University State Key Laboratory of Veterinary Etiological Biology Key Laboratory of Veterinary Parasitology of Gansu Province Lanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences College of Animal Science and Technology Anhui Agricultural University

Cryptosporidium *** enteric diseases in a wide range of animals,including dairy ***,limited information is available regarding prevalence and molecular characterization of Cryptosporidium *** dairy cattle in Gansu Province and Ningxia Hui Autonomous Region(NXHAR),northwest China.A total of 2945 dairy feces samples(1224 from Gansu Province and 1614 from NXHAR)were collected between December 2012 and March 2014,and were tested by PCR amplification of the small subunit(SSU) rRNA gene.150(5.09%,58 from Gansu and 92 from NXHAR) samples were PCR-positive for Cryptosporidium,and the prevalence is associated with the region and age of dairy *** identification showed *** in 36 samples(24.00%,19 from NXHAR and 17 from Gansu),*** in 24 samples(16.00%,13 from NXHAR and 11 from Gansu),*** in 70 samples(46.67%,41 from NXHAR and 29 from Gansu),and *** in 20 samples(13.33%,19 from NXHAR and 1 from Gansu).A DNA sequence analysis of the gp60 gene suggested that all the 20 *** isolates represented subtype *** findings indicated the presence of zoonotic Cryptosporidium in Gansu and *** is the first report of four species of Cryptosporidium(***,***,*** and ***)infection in dairy cattle in Gansu *** is also the first report of *** infection in dairy cattle in *** control strategies should be implemented to prevent and control Cryptosporidium infection in dairy cattle and humans.

关键词： Prevalence Genotyping Cryptosporidium Dairy cattle Northwest China

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大学生身处设定生活事件下自杀危险性调查

社区医学杂志 2018年第7期16卷 4-6页

作者：巢传宣杨艳陈红南昌工程学院马克思主义学院江西330099

目的了解大学生在设定生活事件下的自杀危险性,为高校心理危机预防与干预提供理论参考。方法 2017年11月在江西省某本科院校随机发放1 036份问卷,对大学生在身处所设定的10种生活事件下的自杀危险性进行投射法调查。计数资料比较采用χ~... 详细信息

目的了解大学生在设定生活事件下的自杀危险性,为高校心理危机预防与干预提供理论参考。方法 2017年11月在江西省某本科院校随机发放1 036份问卷,对大学生在身处所设定的10种生活事件下的自杀危险性进行投射法调查。计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果大学生在身处所设定的10种生活事件下均不会考虑自杀的仅占15.3%;大学生在身处所设定的10种生活事件下的自杀危险性为23.6%~66.1%,由高到低依次为:就业压力大或求职失败(66.1%)、学习压力大或难以顺利完成学业(64.5%)、恋爱不顺或失恋(63.3%)、考试舞弊被发现(55.2%)、受严厉批评或处分(54.5%)、考试失败或成绩不理想(52.7%)、家庭内部有矛盾(52.1%)、家庭经济困难(50.7%)、与老师关系紧张(46.8%)、与同学或好友发生纠纷(23.6%);设定生活事件下不同性别大学生的自杀危险性比较差异有统计学意义(均P<0.05)。结论大学生经历生活事件时有必要给予及时的心理帮助,以防范自杀行为的发生。

关键词：生活事件自杀危险性投射法现况调查大学生

血管内皮源性舒张因子对血管平滑肌钙激活钾通道活性影响的对比研究

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中国实用内科杂志 2005年第2期25卷 134-136页

作者：罗兴林何川杨艳李秀琴泸州医学院附属医院心内科 646000

目的　探讨血管内皮源性舒张因子对高血压及非高血压患者血管平滑肌钙激活钾通道 (KCa)活性的影响。方法　选择 2 0 0 1～ 2 0 0 3年泸州医学院附属医院 2 1例高血压病患者及 18例非高血压者 ,切取肠系膜动脉小分支节段用酶消化法获取... 详细信息

目的　探讨血管内皮源性舒张因子对高血压及非高血压患者血管平滑肌钙激活钾通道 (KCa)活性的影响。方法　选择 2 0 0 1～ 2 0 0 3年泸州医学院附属医院 2 1例高血压病患者及 18例非高血压者 ,切取肠系膜动脉小分支节段用酶消化法获取血管平滑肌细胞 ,以膜片钳技术检测KCa通道的活性 ,通过Pclamp专用软件实时采样记录其平均开放时间 (To)、平均关闭时间 (Tc)、平均开放概率 (Po)等。采用硝酸还原法测定血浆一氧化氮(NO)含量 ,用比色法测定血浆一氧化氮合成酶 (NOS)含量。结果　 (1)两组对象KCa通道活性变化 :于细胞内面向外膜片下 ,高血压病组与非高血压组比较 ,前者KCa通道Po增加 ,Tc延长、To缩短。在浴液中分别加入Ca2 +后 ,两组KCa通道均被明显激活 ,与加Ca2 + 前比较 ,非高血压组Po的增加显著高于高血压病组 (P <0 0 1) ,说明高血压病组KCa通道对Ca2 + 的敏感性显著低于血压正常组。 (2 )高血压患者血浆NO、NOS较非高血压组显著降低。 (3)非高血压组血浆NO与KCa通道Po、To呈正相关 ,与Tc呈负相关。高血压病组NO与KCa通道Po、To、Tc的相关性明显弱于非高血压组。结论　高血压病患者肠系膜动脉平滑肌KCa通道活性明显增高 ,血管内皮源性舒张因子对非高血压及高血压病患者血管平滑肌KCa通道均有激活作?

关键词：高血压病血管平滑肌血管内皮患者钙激活钾通道肠系膜动脉血浆一氧化氮开放时间结论概率

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低浓度低伤害胍胶压裂液室内实验评价

当代化工 2018年第3期47卷 458-461页

作者：吴俣昊欧阳传湘闫梦长江大学石油工程学院湖北武汉430100

压裂工艺是低渗油藏的开发的必要手段,压裂液在压裂工艺中起着非常重要的作用,为进一步提高压裂效果,新型的压裂液也被不断的研发出来,对压裂液性能的分析评价,是实践应用的前提。介绍了低浓度胍胶压裂液,并通过室内实验分析该压裂的性... 详细信息

压裂工艺是低渗油藏的开发的必要手段,压裂液在压裂工艺中起着非常重要的作用,为进一步提高压裂效果,新型的压裂液也被不断的研发出来,对压裂液性能的分析评价,是实践应用的前提。介绍了低浓度胍胶压裂液,并通过室内实验分析该压裂的性能,研究表明:该压裂液耐温耐剪切能力强,高温下仍能保持120 mPa·s以上的黏度;悬砂能力强;破胶效果优于普通胍胶压裂液;具有较低的表面张力和界面张力。适用于低渗储层压裂工艺,能起到更加良好的压裂效果。

关键词：低渗储层胍胶压裂液压裂工艺实验分析

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Poisson仿射群的性质

新疆师范大学学报（自然科学版） 2011年第4期30卷 65-67页

作者：侯传燕杨祺何勇新疆师范大学数学科学学院新疆乌鲁木齐830054

Poisson流形在现代Hamilton系统中扮演了很重要的角色,基于以前的研究,文章在李群上赋予poisson结构,提出了poisson仿射群的概念,在此基础上定义了Poisson括号,并证明了此poisson括号满足双线性,反称性,Leibniz法则及Jacobi恒等式,同时... 详细信息

Poisson流形在现代Hamilton系统中扮演了很重要的角色,基于以前的研究,文章在李群上赋予poisson结构,提出了poisson仿射群的概念,在此基础上定义了Poisson括号,并证明了此poisson括号满足双线性,反称性,Leibniz法则及Jacobi恒等式,同时讨论了Poisson映射和Poisson作用的性质。

关键词：李群仿射群 poisson仿射群 Poisson结构 Poisson括号

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Poisson仿射群的性质

新疆师范大学学报（自然科学版） 2011年第3期30卷 72-74页

作者：侯传燕杨祺何勇新疆师范大学数学科学学院新疆乌鲁木齐830054

Poisson流形在现代Hamilton系统中扮演了很重要的角色,基于以前的研究,文章在李群上赋予poisson结构,提出了poisson仿射群的概念,在此基础上定义了Poisson括号,并证明了此poisson括号满足双线性,反称性,Leibniz法则及Jaco-bi恒等式,同... 详细信息

Poisson流形在现代Hamilton系统中扮演了很重要的角色,基于以前的研究,文章在李群上赋予poisson结构,提出了poisson仿射群的概念,在此基础上定义了Poisson括号,并证明了此poisson括号满足双线性,反称性,Leibniz法则及Jaco-bi恒等式,同时讨论了Poisson映射和Poisson作用的性质.

关键词：李群仿射群 poisson仿射群 Poisson结构 Poisson括号