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World Journal of Diabetes 2024年第7期15卷 1551-1561页

作者： Ke-Ke Tong Yun-Feng Yu Xin-Yu Yang Jing-Yi Wu Rong Yu chuan-chuan tan The First Hospital of Hunan University of Chinese Medicine Changsha 410007Hunan ProvinceChina School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The Third Hospital Zhejiang Chinese Medical UniversityHangzhou 310005Zhejiang ProvinceChina

BACKGROUND The impact of type 1 diabetes(T1D)on inflammatory bowel disease(IBD)remains *** To analyze the causal relationship between T1D and IBD using Mendelian randomization(MR).METHODS Single nucleotide polymorphisms were sourced from FinnGen for T1D,IBD,ulcerative colitis(UC)and Crohn’s disease(CD).Inverse variance-weighted,MREgger,and weighted median tests were used to assess exposure-outcome *** MR-Egger intercept was used to assess horizontal ***’s Q and leave-one-out method were used to analyze heterogeneity and sensitivity,*** Our MR analysis indicated that T1D was associated with a reduced risk of IBD[odds ratio(OR):0.959;95%confidence interval(CI):0.938-0.980;P0.05).Cochran’s Q and leave-one-out sensitivity analyses showed that the results were not heterogeneous(P>0.05)and were *** This MR analysis suggests that T1D serves as a potential protective factor against IBD and UC but is independent of CD.

关键词： Type 1 diabetes Inflammatory bowel disease Ulcerative colitis Crohn’s disease Mendelian randomization

Research status and hotspots of autoimmune gastritis:A bibliometric analysis

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World Journal of Gastroenterology 2023年第42期29卷 5781-5799页

作者： Yun-Feng Yu Ke-Ke Tong Xue-Li Shangguan Xin-Yu Yang Jing-Yi Wu Gang Hu Rong Yu chuan-chuan tan The First Hospital Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina The Hospital of Hunan University of Traditional Chinese Medicine Hunan University of Traditional Chinese MedicineChangde 415213Hunan ProvinceChina College of Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The Third Hospital Zhejiang Chinese Medical UniversityHangzhou 310005Zhejiang ProvinceChina

BACKGROUND As an emerging potential risk factor for gastric cancer,autoimmune gastritis(AIG)has garnered increasing attention from *** To analyze the research overview and popular topics in the field of AIG using *** Relevant publications on AIG in the Web of Science Core Collection were collated,and data visualization and analysis of the number of publications,countries,institutions,journals,authors,keywords,and citations were performed using software such as VOSviewer,CiteSpace,and Scimago *** In total,316 relevant articles were included in the *** 2015 to 2022,the number of publications increased *** countries,institutions,authors,and journals with the highest number of publications in this field were Italy,Monash University,Toh BH,and Internal *** main keywords used in this field of research were pathogenesis,Helicobacter pylori,autoantibody,parietal cell antibody,atrophic gastritis,classification,diagnosis,autoimmune disease,risk,cancer,gastric cancer,vitamin B12 deficiency,and pernicious *** following directions may be popular for future research:(1)The role of Helicobacter pylori in the pathogenesis of AIG;(2)diagnostic criteria for AIG and reference values for serum antibodies;(3)comorbidity mechanisms between AIG and other autoimmune diseases;(4)specific risks of AIG complicating gastric and other cancers;and(5)the role of vitamin B12 supplementation in patients with early-stage *** This bibliometric analysis reported on popular topics and emerging trends in AIG,with diagnosis and prognosis being research hotspots in this field.

关键词： Autoimmune gastritis Autoimmune diseases Bibliometric CiteSpace VOSviewer Helicobacter pylori

Optimization of resource allocation in FDD massive MIMO systems

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Digital Communications and Networks 2024年第1期10卷 117-125页

作者： Jun Cai chuan Yin Youwei Ding School of Artificial Intelligence and Information Technology Nanjing University of Chinese MedicineNanjing 210046China School of Electronic and Information Hangzhou Dianzi UniversityHangzhou 310018ZhejiangChina

The performance of massive MIMO systems relies heavily on the availability of Channel State Information at the Transmitter(CSIT).A large amount of work has been devoted to reducing the CSIT acquisition overhead at the pilot training and/or CsI feedback *** fact,the downlink communication generally includes three stages,i.e.,pilot training,CsI feedback,and data *** three stages are mutually related and jointly determine the overall system ***,there exist few studies on the reduction of csIT acquisition overhead from the global point of *** this paper,we integrate the Minimum Mean Square Error(MMSE)channel estimation,Random Vector Quantization(RVQ)based limited feedback and Maximal Ratio Combining(MRC)precoding into a unified framework for investigating the resource allocation *** particular,we first approximate the covariance matrix of the quantization error with a simple expression and derive an analytical expression of the received Signal-to-Noise Ratio(SNR)based on the deterministic equivalence *** the three performance metrics(the spectral efficiency,energy efficiency,and total energy consumption)oriented problems are formulated *** practical system requirements,these three metrics can be collaboratively ***,we propose an optimization solver to derive the optimal partition of channel coherence *** results verify the benefits of the proposed resource allocation schemes under three different scenarios and illustrate the tradeoff of resource allocation between three stages.

关键词： Massive MIMO FDD CSIT Resource allocation

Trace formula of the integro-differential operator on a quantum graph

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 311-318页

作者： WEI Li-xiao YANG chuan-fu School of Mathematics and Statistics Nanjing University of Science and TechnologyNanjing 210094China.

In this paper we study the eigenvalue problem for integro-differential operators on a lasso *** trace formula of the operator is established by applying the residual technique in complex analysis.

关键词： integro-differential operators eigenvalue trace formula

Physiological and pathological functions of circular RNAs in the nervous system

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Neural Regeneration Research 2024年第2期19卷 342-349页

作者： Min Zhou Shi Li chuan Huang School of Life Sciences Chongqing UniversityChongqingChina

Circular RNAs(circRNAs)are a class of covalently closed single-stranded RNAs that are expressed during the development of specific cells and *** play crucial roles in physiological and pathological processes by sponging microRNAs,modulating gene transcription,controlling the activity of certain RNA-binding proteins,and producing functional peptides.A key focus of research at present is the functionality of circRNAs in the nervous system and several advances have emerged over the last 2 ***,the precise role of circRNAs in the nervous system has yet to be comprehensively *** this review,we first summarize the recently described roles of circRNAs in brain development,maturity,and ***,we focus on the involvement of circRNAs in various diseases of the central nervous system,such as brain cancer,chronic neurodegenerative diseases,acute injuries of the nervous system,and neuropathic pain.A better understanding of the functionality of circRNAs will help us to develop potential diagnostic,prognostic,and therapeutic strategies to treat diseases of the nervous system.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis brain development circRNAs neuropathic pain Parkinson’s disease

Hot Compression Behavior and Tensile Property of a Novel Ni-Co-Based Superalloy Prepared by Electron Beam Smelting Layered Solidification Technology

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 283-292页

作者： Yong-Chao Gai Rui Zhang chuan-Yong Cui Zi-Jian Zhou Yi tan Yi-Zhou Zhou Xiao-Feng Sun Key Laboratory of Materials Modification by Laser Ionand Electron Beams(Ministry of Education)School of Materials Science and EngineeringDalian University of TechnologyDalian116024China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

The hot compression behavior and tensile strength after compression of a new Ni-Co-based superalloy produced using electron beam smelting layered(EBSL)solidification technology were *** compression tests were performed at temperatures of 1120℃and 1150℃,with strain rates of 1 s^(-1) and 0.01 s^(-1),reaching a true strain of *** strength was evaluated at room *** results revealed that this EBSL technology accelerates dynamic recrystallization(DRX),without compromising the strength of alloy.A significant correlation between the volume fraction of DRX and the strain rate was observed,with higher fractions at lower strain rates,leading to higher tensile ***,at the same strain rate,the specimens compressed at 1120℃exhibited higher tensile strength due to undissolvedγ′*** solution and aging heat treatment,the alloy maintained high tensile *** results suggested that the EBSL Ni-Co-based superalloy offers excellent prospects for practical applications.

关键词： Ni-Co-based superalloy Hot deformation Electron beam smelting Tensile strength

Review on laser directed energy deposited aluminum alloys

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International Journal of Extreme Manufacturing 2024年第2期6卷 84-131页

作者： Tian-Shu Liu Peng Chen Feng Qiu Hong-Yu Yang Nicholas tan Yew Jin Youxiang Chew Di Wang Ruidi Li Qi-chuan Jiang Chaolin tan Singapore Institute of Manufacturing Technology(SIMTech) Agency for ScienceTechnology and Research(A∗STAR)5 Cleantech LoopSingapore 636732Singapore State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130025People’s Republic of China Key Laboratory of Automobile Materials Ministry of Education and Department of Materials Science and EngineeringJilin UniversityChangchun 130025People’s Republic of China School of Mechanical&Automotive Engineering South China University of TechnologyGuangzhou 510640People’s Republic of China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083People’s Republic of China

Lightweight aluminum(Al)alloys have been widely used in frontier fields like aerospace and automotive industries,which attracts great interest in additive manufacturing(AM)to process high-value Al *** a mainstream AM technique,laser-directed energy deposition(LDED)shows good scalability to meet the requirements for large-format component manufacturing and ***,LDED Al alloys are highly challenging due to their inherent poor printability(*** laser absorption,high oxidation sensitivity and cracking tendency).To further promote the development of LDED high-performance Al alloys,this review offers a deep understanding of the challenges and strategies to improve printability in LDED Al *** porosity,cracking,distortion,inclusions,element evaporation and resultant inferior mechanical properties(worse than laser powder bed fusion)are the key challenges in LDED Al *** parameter optimizations,in-situ alloy design,reinforcing particle addition and field assistance are the efficient approaches to improving the printability and performance of LDED Al *** underlying correlations between processes,alloy innovation,characteristic microstructures,and achievable performances in LDED Al alloys are *** benchmark mechanical properties and primary strengthening mechanism of LDED Al alloys are *** review aims to provide a critical and in-depth evaluation of current progress in LDED Al *** opportunities and perspectives in LDED high-performance Al alloys are also outlined.

关键词： additive manufacturing laser directed energy deposition(LDED) aluminum alloys printability aluminum matrix composite auxiliary fields mechanical properties

C-CORE:Clustering by Code Representation to Prioritize Test Cases in Compiler Testing

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2069-2093页

作者： Wei Zhou Xincong Jiang chuan Qin School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai200240China Hikvision Research Institute Hangzhou Hikvision Digital Technology Co.Ltd.Hangzhou310051China

Edge devices,due to their limited computational and storage resources,often require the use of compilers for program ***,ensuring the security and reliability of these compilers is of paramount importance in the emerging field of edge *** widely used testing method for this purpose is fuzz testing,which detects bugs by inputting random test cases into the target ***,this process consumes significant time and *** improve the efficiency of compiler fuzz testing,it is common practice to utilize test case prioritization *** researchers use machine learning to predict the code coverage of test cases,aiming to maximize the test capability for the target compiler by increasing the overall predicted coverage of the test ***,these methods can only forecast the code coverage of the compiler at a specific optimization level,potentially missing many optimization-related *** this paper,we introduce C-CORE(short for Clustering by Code Representation),the first framework to prioritize test cases according to their code representations,which are derived directly from the source *** approach avoids being limited to specific compiler states and extends to a broader range of compiler ***,we first train a scaled pre-trained programming language model to capture as many common features as possible from the test cases generated by a *** this pre-trained model,we then train two downstream models:one for predicting the likelihood of triggering a bug and another for identifying code representations associated with ***,we cluster the test cases according to their code representations and select the highest-scoring test case from each cluster as the high-quality test *** reduction in redundant testing cases leads to time *** evaluation results reveal that code representations are better at distinguishing test capabilities,and C-CORE significantly enhanc

关键词： Compiler testing test case prioritization code representation

Catalytic enantioselective N-silylation of sulfoximine

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Chinese Chemical Letters 2024年第4期35卷 352-356页

作者： Xingfen Huang Jiefeng Zhu chuan He Shenzhen Grubbs Institute and Department of Chemistry Guangdong Provincial Key Laboratory of CatalysisSouthern University of Science and TechnologyShenzhen 518055China Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education Hangzhou Normal UniversityHangzhou 311121China

A rhodium/diphosphine-catalyzed asymmetric cross-dehydrogenative coupling between sulfoximines and dihydrosilanes has been achieved. This is the first report on the enantioselective N-silylation of sulfoximines. The protocol gives access to a variety of Si-stereogenic N-silylated sulfoximines in decent yield(up to 99%) with excellent stereoselectivity(up to 99%), featuring high atom economy, and a cleaner manner with H2as the sole byproduct. The obtained bis-Si-stereogenic monohydrosilane product can be further converted into the corresponding chiral polymer with pendant sulfoximine groups.

关键词： N-Silylation of sulfoximine Chiral silylamine Si-stereogenic silanes Si-CADC Asymmetric catalysis

Axial enantiomers with donor-regulated TADF feature for multicolor circularly polarized electroluminescence

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Science China Chemistry 2024年第6期67卷 2039-2045页

作者： Chen-Hao Guo Wen-Long Zhao Ke-Ke tan Wei-Chen Guo Liheng Feng chuan-Feng Chen Meng Li School of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan030006China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

This study optimized the TADF feature of axial chiral enantiomers through precise donor engineering,and multicolor CP-TADFwas achieved in the axial chiral *** pairs of axial enantiomers with donor-regulated TADF feature,namely(R/S)-TPCBD,(R/S)-DPCBD,and(R/S)-DPACBD,were synthesized by introducing carbazole donors with different substituents onto biphenyl cyanide *** the electron-donating ability of donors increases,the emission of these axial enantiomers ranges from 455,476 to 552 nm,their singlet-triplet energy gaps(ΔE_(ST))gradually decrease from 0.30,0.22 to 0.02 e V,accompanied by an increasement in the transition rate(k_(RISC))of RISC process,and the k_(RISC)of DPACBD could reach up to 7.16×10^(5)s^(-1).These axial enantiomers also exhibit mirror-image CD and circularly polarized luminescence(CPL)***,OLEDs based on TPCBD,DPCBD,and DPACBD as emitter were then fabricated,which displayed blue,green,and orange electroluminescence with EQE_(max)of 13.0%,16.4%,and 25.0%,*** results also exhibited a phenomenon of device efficiency increasing with the enhancement of donor ***,the CP-OLEDs using(R/S)-TPCBD,(R/S)-DPCBD and(R/S)-DPACBD as emitters displayed intense CPEL signals with g_(EL)values of 3.4×10^(-3)/-4.1×10^(-3),3.2×10^(-3)/-3.1×10^(-3)and2.3×10^(-3)/-2.1×10^(-3),*** convenient molecular engineering of donor regulation in the same molecular skeleton,CP-TADF materials with multicolor CPEL and improved device performance could be conveniently achieved.

关键词： axial chirality thermally activated delayed fluorescence circularly polarized luminescence electroluminescence organic light-emitting diodes