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LTE无线通信技术与物联网技术的结合应用

通信电源技术 2024年第2期41卷 151-153页

作者：欧阳川马鸣李卉刘洪赫中船凌久高科(武汉)有限公司湖北武汉430074

随着科技的不断发展,人们对信息服务的需求越来越高。在无线通信技术方面,长期演进(Long Term Evolution,LTE)被广泛应用于移动通信领域,因其高速、高质量的数据传输能力而备受青睐。物联网技术的出现和发展为各行各业带来了巨大的机遇... 详细信息

随着科技的不断发展,人们对信息服务的需求越来越高。在无线通信技术方面,长期演进(Long Term Evolution,LTE)被广泛应用于移动通信领域,因其高速、高质量的数据传输能力而备受青睐。物联网技术的出现和发展为各行各业带来了巨大的机遇和挑战。将LTE无线通信技术与物联网技术相结合,可以进一步提高用户的信息服务体验,为后续发展提供坚实的基础。

关键词：长期演进(LTE)无线通信技术物联网技术结合应用

Development of small molecule drugs targeting immune checkpoints

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Cancer Biology & Medicine 2024年第5期21卷 382-399页

作者： Luoyi Chen Xinchen Zhao Xiaowei Liu Yujie ouyang chuan Xu Ying Shi Department of Oncology Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610054China Institute for Breast Health Medicine State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Acupuncture and Massage College Chengdu University of Traditional Chinese MedicineChengdu 611137China

Immune checkpoint inhibitors(ICIs)are used to relieve and refuel anti-tumor immunity by blocking the interaction,transcription,and translation of co-inhibitory immune checkpoints or degrading co-inhibitory immune *** of small molecule drugs or biological materials,especially antibody-based ICIs,are actively being studied and antibodies are currently widely ***,such as anti-tumor efficacy,poor membrane permeability,and unneglected tolerance issues of antibody-based ICIs,remain evident but are thought to be overcome by small molecule *** structural studies have broadened the scope of candidate immune checkpoint molecules,as well as innovative chemical *** way of comparison,small molecule drug-based ICIs represent superior oral bioavailability and favorable pharmacokinetic *** ongoing clinical trials are exploring the synergetic effect of ICIs and other therapeutic strategies based on multiple ICI functions,including immune regulation,anti-angiogenesis,and cell cycle *** this review we summarized the current progression of small molecule ICIs and the mechanism underlying immune checkpoint proteins,which will lay the foundation for further exploration.

关键词： Immune checkpoints small molecule drugs programmed death protein 1 CD47 signal-regulatory proteinα

Simulation study on cuttings transport of the backreaming operation for long horizontal section wells

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Petroleum Science 2024年第2期21卷 1149-1170页

作者： Yu-Fei Chen Hui Zhang Wen-Xin Wu Jun Li Yong ouyang Zong-Yu Lu De-Xin Ma Yong-chuan Wu Jun-Bo Liu Ke-Rou Liu Zhuo-Xin Dong China University of Petroleum(Beijing) Beijing102249China Beijing Normal University at Zhuhai Experimental and Practical Education Innovation CenterZhuhai519087GuangdongChina Oil&Gas Technology Research Institute of PetroChina Changqing Oilfield Company Xi'an710016ShaanxiChina PetroChina Xinjiang Oilfield Company Karamay834002XinjiangChina China Oilfield Services Ltd. Tianjin300459China

The backreaming operation plays a significant role in safe drilling for horizontal wellbores, while it may cause severe stuck pipe accidents. To lower the risk of the stuck pipe in backreaming operations, the mechanism of cuttings transport needs to be carefully investigated. In this research, a transient cuttings transport with multiple flow patterns model is developed to predict the evolution of cuttings transported in the annulus while backreaming. The established model can provide predictions of the distribution of cuttings bed along the wellbore considering the bulldozer effect caused by large-size drilling tools(LSDTs). The sensitivity analyses of the size of LSDTs, and backreaming operating parameters are conducted in Section 4. And a new theory is proposed to explain the mechanism of cuttings transport in the backreaming operation, in which both the bit and LSDTs have the “cleaning effect” and “plugging effect”.The results demonstrate that the cuttings bed in annuli is in a state of dynamic equilibrium, but the overall trend and the distribution pattern are obvious. First, larger diameters and longer drilling tools could lead to a higher risk of the stuck pipe. Second, we find that it is not the case that the higher flow rate is always better for hole cleaning, so three flow-rate intervals are discussed separately under the given conditions. When the “dangerous flow rate”(35 L/s in Case 4),the higher the flow rate, the better the cleaning effect of cuttings beds. Third, an interval of tripping velocity called “dangerous velocity” is proposed, in which the cuttings bed accumulation near the LSDTs is more serious than

关键词： Backreaming Stuck pipe Hole cleaning Transient solid transport Multiple flow patterns

Induction of Lung Injury by Cooking Oil Fumes in Mice and the Protective Effects of Vitamin C

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Biomedical and Environmental Sciences 2021年第11期34卷 916-919页

作者： LI Xiao Hong YU Xiao Li ZHOU Jian SHAN Hui ouyang chuan KE Hong Yang WU Tao Jin LI Wan Wei School of Public Health Weifang Medical UniversityWeifang 261053ShandongChina Public Health Testing Center School of Public Health and ManagementWeifang Medical UniversityWeifang 261053ShandongChina Weifang Key Laboratory of Health Inspetion and Quarantine Weifang 261053ShandongChina

Cooking oil fumes(COF)are one of the most common air pollutants in indoor living environments in *** oil is heated above 250°C,at least220 types of products are produced in the lampblack,including carcinogenic hetero... 详细信息

关键词： Cook heated heterocyclic

“木有意思”——利用家长资源实施木工坊活动课程的探索

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玩具世界 2023年第2期 179-181页

作者：欧阳川湖南省人民政府直属机关第三幼儿院

为满足幼儿园儿童成长的多样化需求，文章探讨了利用家长资源实施木工坊活动课程的方式和方法，包括活动准备、活动设计与课程实施。通过对活动课程效果进行分析和总结，揭示出如何最大程度地发挥家长资源的优势来构建完整而有效的教育... 详细信息

为满足幼儿园儿童成长的多样化需求，文章探讨了利用家长资源实施木工坊活动课程的方式和方法，包括活动准备、活动设计与课程实施。通过对活动课程效果进行分析和总结，揭示出如何最大程度地发挥家长资源的优势来构建完整而有效的教育教学平台。

关键词：木工坊家长资源幼儿园活动课程课程设计

Promotion of TLR-mediated production of type I interferon by Clec16a

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Promotion of TLR-mediated production of type I interferon by...

西北地区典型城市PM_(2.5)中重金属污染特征及健康风险评价

第八届全国免疫学学术大会

作者： chuan ouyang Jun Lou Linrong Lu Institute of Immunology Program in Molecular and Cellular Biology Zhejiang University School of Medicine

Clec16a is a C-type lectin and encodes a protein of unknown *** independent genomewide as-sociation studies(GWAS) have implicated the CLEC16 A gene in several autoimmune diseases, including multiple sclerosis and type 1 ***, how CLEC16 A SNPs confer susceptibility to autoimmune diseases remains *** we report that Clec16 a is considerably expressed in innate immune cells including dendritic cells(DCs), macrophages and microglias and it locates to endosome and *** also found that Clec16 a regulated the activation of type I interferon mediated by LPS or double-stranded RNA in DCs and *** of Clec16 a promoted T RIF-dependent type I interferon signaling pathway and knockdown of Clec16 a inhibited the secretion of type I interferon and the activation of TBK1 and I *** biochemical analysis revealed that Clec16 a interacted with TBK1-IKKi complex and overexpression of Clec16 A enhanced phosphroylation and K63-linked polyubiquitination of TBK1 suggesting a regulatory role of Clec16 A in this signaling *** study identified a previously unrecognized role for Clec16 a in the regulation of type I interferon production and provided molecular insight into the underling mechanisms for the involvement of Clec16 a in autoimmune diseases.

关键词： Clec16a TLR type I interferon TBK1

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中国公共卫生 2022年第4期38卷 476-480页

作者：单慧欧阳钏柯鸿阳刘玉梅王飞李晓红李万伟潍坊医学院公共卫生学院山东潍坊261053 潍坊市卫生检验与检疫重点实验室 “健康山东”重大社会风险预测与治理协同创新中心潍坊医学院公共卫生与管理实验示范中心

目的了解西北地区4个典型城市PM_(2.5)中7种重金属元素的污染特征,评价PM_(2.5)中重金属对人群的健康风险。方法选取乌鲁木齐、西安、兰州和银川市作为西北地区的典型城市,收集PM_(2.5)中重金属浓度的文献作为数据来源,分析重金属的污... 详细信息

目的了解西北地区4个典型城市PM_(2.5)中7种重金属元素的污染特征,评价PM_(2.5)中重金属对人群的健康风险。方法选取乌鲁木齐、西安、兰州和银川市作为西北地区的典型城市,收集PM_(2.5)中重金属浓度的文献作为数据来源,分析重金属的污染特征,采用健康风险评价模型对4个城市不同人群的健康风险进行评价。结果重金属元素的浓度水平存在地区差异,7种元素中Zn在4个城市中的浓度均为最高,As和Cr(VI)在4个城市中的年均值均高于参考限值,且As和Cr(VI)在西安市的浓度最高;Cd元素仅在乌鲁木齐市的年均值高于参考限值;4个城市的非致癌风险以Pb为主,但危险指数HI(hazard index)值均小于1,西安市的HI值最高;4个城市致癌风险以As为主,乌鲁木齐市As和Cr(VI)的终生致癌风险LCR(lifetime cancer risk)值均接近10^(-4),西安市As和Cr(VI)的LCR值均大于10^(-4),2个城市的终生总致癌风险ILCR(integrated lifetime cancer risk)值均超过阈值水平,其中西安市的ILCR值最高,而兰州和银川市的ILCR值均低于阈值水平。结论在纳入研究的4个城市中,西安市的致癌和非致癌风险均为最高,重金属污染最严重;乌鲁木齐市重金属污染也应受到重视,而兰州和银川市重金属的健康风险在人群可接受的范围内。

关键词：西北地区 PM_(2.5)重金属污染特征健康风险评价

聚醚侧链非离子型水性聚氨酯改性油田固井水泥石性能评价

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塑料工业 2020年第2期48卷 170-174页

作者：郭源欧阳传湘长江大学石油工程学院湖北武汉430100

通过采用含聚醚侧链的非离子型水性聚氨酯实现对油井水泥石的韧性化改造,用以解决常规聚氨酯(PU)同水泥浆配伍性差的问题,并探究了不同水性聚氨酯加量下对水泥石各项工程性能的影响因素,优化出了适用于酸性地层封固的水泥浆配方体系。... 详细信息

通过采用含聚醚侧链的非离子型水性聚氨酯实现对油井水泥石的韧性化改造,用以解决常规聚氨酯(PU)同水泥浆配伍性差的问题,并探究了不同水性聚氨酯加量下对水泥石各项工程性能的影响因素,优化出了适用于酸性地层封固的水泥浆配方体系。结果表明,5%非离子型水性聚氨酯的增韧效果最佳,配浆流动性高,压缩强度稳定在20 MPa以上,稠化时间4 h可控,弹性模量控制在5 GPa以内,表现出了较高的强度和较好的增韧效果。

关键词：固井增韧非离子型水性聚氨酯

Raf kinase inhibitor protein and TANK-binding kinase 1 form a positive feedback loop to promote type I interferon production in innate immune

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Raf kinase inhibitor protein and TANK-binding kinase 1 form ...