Raf kinase inhibitor protein and TANK-binding kinase 1 form a positive feedback loop to promote type I interferon production in innate immune
作者单位：浙江大学医学院免疫研究所 Life Sciences Institute and Innovation Center for Cell Signaling Network Zhejiang University
会议名称：《第十届全国免疫学学术大会》
会议日期：2015年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
关 键 词：TBK1 RKIP type I interferon antiviral immunity
摘 要：TANK-binding kinase 1(TBK1)activation is a central event in type I interferon production in anti-virus innate ***,the regulatory mechanism underlying TBK1 activation remains *** we report that raf kinase inhibitory protein(RKIP)is essential for TBK1 activation and type I interferon production triggered by virus *** virus infection,RKIP is phosphorylated at serine 109(S109)by *** of RKIP enhances its interaction