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Phenotypic research on senile osteoporosis caused by SIRT6 deficiency

International Journal of Oral Science 2016年第2期8卷 84-92页

作者： De-Mao Zhang Di-Xin Cui Ruo-Shi Xu Ya-chuan zhou Li-Wei Zheng Peng Liu Xue-Dong zhou State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University

Osteoporosis is a serious public bone metabolic disease. However, the mechanisms underlying bone loss combined with ageing, which is known as senile osteoporosis, remains unknown. Here we show the detailed phenotype of this disease caused by SIRT6 knock out （KO） in mice. To the best of our knowledge, this is the first study to reveal that SIRT6 is expressed in both bone marrow stroma cells and bone-related cells in both mouse and human models, which suggests that SIRT6 is an important regulator in bone metabolism. SIRT6-KO mice exhibit a significant decrease in body weight and remarkable dwarfism. The skeleton of the SIRT6-KO mouse is deficient in cartilage and mineralized bone tissue. Moreover, the osteocalcin concentration in blood is lower, which suggests that bone mass is markedly lost. Besides, the tartrate-resistant acid phosphatase 5b （TRAP5b） concentration is much higher, which suggests that bone resorption is overactive. Both trabecular and cortical bones exhibit severe osteopenia, and the bone mineral density is decreased. Moreover, double-labelling analysis shows that bone formation is much slower. To determine whether SIRT6 directly regulates bone metabolism, we cultured primary bone marrow stromal cells for osteogenesis and osteoclastogenesis separately to avoid indirect interference in vivo responses such as inflammation. Taken together, these results show that SIRT6 can directly regulate osteoblast proliferation and differentiation, resulting in attenuation in mineralization. Furthermore, SIRT6 can directly regulate osteoclast differentiation and results in a higher number of small osteoclasts, which may be related to overactive bone resorption.

关键词： ageing osteoclastogenesis osteogenesis osteoporosis

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Active Cu and Fe Nanoparticles Codecorated Ruddlesden-Popper-Type Perovskite as Solid Oxide Electrolysis Cells Cathode for CO_(2)Splitting

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Energy & Environmental Materials 2024年第5期7卷 215-223页

作者： Dongliang Liu Hang Shang chuan zhou Jie Miao Daxiang Xue Zeping Chen Meijuan Fei Fengli Liang Qiang Niu Ran Ran Wei zhou Zongping Shao State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 210009China Suzhou Laboratory Suzhou 215000China School of Environmental Science and Engineering Nanjing Tech UniversityNanjing 210009China Inner Mongolia Erdos Electric Power and Metallurgy Group Co. Ltd.Ordos 016064China Jiangsu Province Key Laboratory of Aerospace Power System College of Energy and Power EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China WA School of Mines:Minerals Energy and Chemical Engineering(WASM-MECE)Curtin UniversityPerthWA 6102Australia

Solid oxide electrolysis cells(SOECs),displaying high current density and energy efficiency,have been proven to be an effective technique to electrochemically reduce CO_(2)into ***,the insufficiency of cathode activity and stability is a tricky problem to be addressed for ***,it is urgent to develop suitable cathode materials with excellent catalytic activity and stability for further practical application of ***,a reduced perovskite oxide,Pr_(0.35)Sr_(0.6)Fe_(0.7)Cu_(0.2)Mo_(0.1)O_(3-δ)(PSFCM0.35),is developed as SOECs cathode to electrolyze CO_(2).After reduction in 10%H_(2)/Ar,Cu and Fe nanoparticles are exsolved from the PSFCM0.35 lattice,resulting in a phase transformation from cubic perovskite to Ruddlesden-Popper(RP)perovskite with more oxygen *** exsolved metal nanoparticles are tightly attached to the perovskite substrate and afford more active sites to accelerate CO_(2)adsorption and dissociation on the cathode *** significantly strengthened CO_(2)adsorption capacity obtained after reduction is demonstrated by in situ Fourier transform-infrared(FT-IR)*** cells with the reduced PSFCM0.35(R-PSFCM0.35)electrode exhibit a low polarization resistance of 0.43Ωcm^(2)at 850℃.Single electrolysis cells with the R-PSFCM0.35 cathode display an outstanding current density of 2947 mA cm^(-2)at 850℃and 1.6 *** addition,the catalytic stability of the R-PSFCM0.35 cathode is also proved by operating at 800℃with an applied constant current density of 600 mA cm^(-2)for 100 h.

关键词： cathode CO_(2)reduction nanoparticles decoration solid oxide electrolysis cells

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Enhanced mechanical properties and formability of 316L stainless steel materials 3D-printed using selective laser melting

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International Journal of Minerals,Metallurgy and Materials 2019年第11期26卷 1396-1404页

作者： Xiao-qin Yang Ying Liu Jin-wen Ye Ren-quan Wang Ting-chuan zhou Bin-yang Mao College of Materials Science and Engineering Sichuan University

This study is conducted to develop an innovative and attractive selective laser melting(SLM)method to produce 316 L stainless steel materials with excellent mechanical performance and complex part *** this work,the subregional manufacturing strategy,which separates the special parts from the components using an optimized process,was *** results showed that produced 316 L materials exhibited superior strength of^755 MPa and good *** the as-built parts,austenite with preferred orientation of the(220)plane,δ-ferrite,and a small amount of CrO phases were *** addition,the crystal size was fine,which contributed to the enhancement of the parts’mechanical *** structural anisotropy mechanism of the materials was also investigated for a group of half-sized samples with variable inclination *** technique was used to fabricate a set of impellers with helical bevels and high-precision planetary gears,demonstrating its strong potential for use in practical applications.

关键词： 316L stainless steel selective laser melting formability mechanical properties microstructure

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Synthesis and characterization of β-cyclodextrin modified hyperbranched carbosilane as stationary phase for GC

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Chinese Chemical Letters 2012年第11期23卷 1259-1262页

作者： Guo Wen Chen Chen Zhang Wen Jie Li chuan Jian zhou Sheng Yu Feng School of Materials Science and Engineering Shandong UniversityJinan 250061China Key Laboratory of Special Functional Aggregated Materials Ministry of Education of ChinaJinan 250100China

A new β-cyclodextrin modified hyperbranched carbosilane stationary phase for gas chromatography was synthesized by substituting the -OH groups of β-cyclodextrin with hyperbranched carbosilane and was coated on the inner wall of fused silica capillary column for gas chromatography. The chromatographic behaviors of the stationary phase were studied. The initial testing results showed that it possessed good separation abilities for several kinds of mixtures, such as benzenes, acrylates, ketones and alkylchlorides.

关键词： Hyperbranched carbosilane Cyclodextrin Stationary phase Gas chromatography

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Phonon engineering significantly reducing thermal conductivity of thermoelectric materials: a review

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Rare Metals 2023年第9期42卷 2825-2839页

作者： chuan-Dong zhou Bo Liang Wen-Jie Huang Jacques-Guillaume Noudem Xiao-Jian Tan Jun Jiang State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004China ENSICAEN UNICEFCNRSCRISMATNormandie UniversityNormandie14000CaenFrance Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo315201China

Lattice thermal conductivity, κL, is a fundamental parameter for evaluating the performance of thermoelectric materials. However, the predicted value of κL based on the Debye dispersion model is often overestimated compared with the experimentally determined *** researchers have attempted to modify the theoretical model and have sought more reliable results. In this review,the recent progress in the study of phonon dispersion models is summarized and we propose that the lattice thermal conductivity can be most accurately determined by using the modified sinusoidal phonon dispersion ***, experimental methods that have the potential to reduce a thermoelectric material's κLare reviewed, for example, methods that generate standing waves or anharmonic lattice vibrations. A high concentration of standing waves and anharmonic lattice vibrations can effectively suppress excessive κL. Finally, this review presents the challenges of sinusoidal phonon dispersion when applied to real materials, which are often complicated and therefore time-consuming, especially when dealing with material defects.

关键词： Thermoelectric Lattice thermal conductivity Sinusoidal phonon dispersion model Standing wave Anharmonicity

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Mechanistic target of rapamycin kinase(Mtor)is required for spermatogonial proliferation and differentiation in mice

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Asian Journal of Andrology 2020年第2期22卷 169-176页

作者： Jun Cao Zuo-Bao Lin Ming-Han Tong Yong-Lian Zhang Yi-Ping Li Yu-chuan zhou State Key Laboratory of Molecular Biology Shanghai Key Laboratory of Molecular AndrologyCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular AndrologyCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China

Spermatogonial development is a vital prerequisite for spermatogenesis and male ***,the exact mechanisms underlying the behavior of spermatogonia,including spermatogonial stem cell(SSC)self-renewal and spermatogonial proliferation and differentiation,are not fully *** studies demonstrated that the mTOR complex 1(mTORC1)signaling pathway plays a crucial role in spermatogonial development,but whether MTOR itself was also involved in any specific process of spermatogonial development remained *** this study,we specifically deleted Mtor in male germ cells of mice using Stra8-Cre and assessed its effect on the function of *** Mtor knockout(KO)mice exhibited an age-dependent perturbation of testicular development and progressively lost germ cells and fertility with *** age-related phenotypes were likely caused by a delayed initiation of Mtor deletion driven by *** examination revealed a reduction of differentiating spermatogonia in Mtor KO mice,suggesting that spermatogonial differentiation was *** proliferation was also impaired in Mtor KO mice,leading to a diminished spermatogonial pool and total germ cell *** results show that MTOR plays a pivotal role in male fertility and is required for spermatogonial proliferation and differentiation.

关键词： male fertility mice Mtor spermatogenesis spermatogonia testis

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Synthesis of unnatural N-glycosyl α-amino acids via Petasis reaction

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Chinese Chemical Letters 2014年第4期25卷 532-534页

作者： chuan-zhou Tao Zhong-Tang Zhang Jian-Wei Wu Rong-Hua Li Zhi-Ling Cao School of Chemical Engineering Huaihai Institute of Technology Jiangsu Marine Resources Development Research Institute

A convenient and efficient protocol for the synthesis of unnatural N-glycosyl cz-amino acids was developed. Condensation of 1,3,4,6-tetra-O-actyl-/%D-glucosamine hydrochloride, alkenyl boronic acid, and glyoxylic acid was achieved in CH2C12 to give the derivatives of 2-（N-glycosyl）aminobut-3-enoic acid which may find applications in glycobiology research and medicinal chemistry.

关键词： N-'Glycosyl s-amino acid Petasis reaction D-Glucosamine Alkenyl boronic acid

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An epididymis-specific carboxyl esterase CES5A is required for sperm capacitation and male fertility in the rat

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Asian Journal of Andrology 2015年第2期17卷 292-297,I0010,I0011页

作者： Yan-Fei Ru Hai-Min Xue Zi-Mei Ni Dong Xia Yu-chuan zhou Yong-Lian Zhang Shanghai Key Laboratory of Molecular Andrology State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institute for Biological Sciences Chinese Academy of Sciences Shanghai China University of Chinese Academy of Sciences Beijing China Institute of Animal Husbandry and Veterinary Sciences Shanghai Academy of Agricultural Sciences Shanghai China Shanghai Institute of Planned Parenthood Research Shanghai China.

Despite the fact that the phenomenon of capacitation was discovered over half century ago and much progress has been made in identifying sperm events involved in capacitation, few specific molecules of epididymal origin have been identified as being directly involved in this process in vivo. Previously, our group cloned and characterized a carboxyl esterase gene CesSa in the rat epididymis. The CES5A protein is mainly expressed in the corpus and cauda epididymidis and secreted into the corresponding lumens. Here, we report the function of CESSA in sperm maturation. By local injection of Lentivirus-mediated siRNA in the *** region of the rat epididymis, CesSa-knockdown animal models were created. These animals exhibited an inhibited sperm capacitation and a reduction in male fertility. These results suggest that CESSA plays an important role in sperm maturation and male fertility.

关键词： carboxylesterase CES5A epididymis male fertility sperm capacitation

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Red-Light-Dependent Interaction of phyB with SPA1 Promotes COP1-SPA1 Dissociation and Photomorphogenic Development in Arabidopsis

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Molecular Plant 2015年第3期8卷 467-478页

作者： Xue-Dan Lu chuan-Miao zhou Peng-Bo Xu Qian Luo Hong-Li Lian Hong-Quan Yang Key Laboratory of Urban Agriculture (South) Ministry of Agriculture and School of Agriculture and Biology Shanghai Jiaotong University Shanghai 200240 China National Key Laboratory of Plant Molecular Genetics (NKLPMG) Institute of Plant Physiology and Ecology (SIPPE) Shanghai Institutes for Biological Sciences(SIBS) Shanghai 200032 China School of Life Sciences and Biotechnology Shanghai Jiaotong University Shanghai 200240 China

Arabidopsis phytochromes （phyA-phyE） are photoreceptors dedicated to sensing red/far-red light. Phyto- chromes promote photomorphogenic developments upon light irradiation via a signaling pathway that involves rapid degradation of PIFs （PHYTOCHROME INTERACTING FACTORS） and suppression of COP1 （CONSTITUTIVE PHOTOMORPHOGENIC 1） nuclear accumulation, through physical interactions with PIFs and COP1, respectively. Both phyA and phyB, the two best characterized phytochromes, regulate plant photomorphogenesis predominantly under far-red light and red light, respectively. It has been demonstrated that SPA1 （SUPPRESSOR OF PHYTOCHROME A 1） associates with COP1 to promote COP1 activity and suppress photomorphogenesis. Here, we report that the mechanism underlying phyB- promoted photomorphogenesis in red light involves direct physical and functional interactions between red-light-activated phyB and SPA1. We found that SPA1 acts genetically downstream of PHYB to repress photomorphogenesis in red light. Protein interaction studies in both yeast and Arabidopsis demonstrated that the photoactivated phyB represses the association of SPA1 with COP1, which is mediated, at least in part, through red-light-dependent interaction of phyB with SPA1. Moreover, we show that phyA physically interacts with SPA1 in a Pfr-form-dependent manner, and that SPA1 acts downstream of PHYA to regulate photomorphogenesis in far-red light. This study provides a genetic and biochemical model of how photo- activated phyB represses the activity of COP1-SPA1 complex through direct interaction with SPA1 to promote photomorphogenesis in red light.

关键词： phyB photoactivation SPA1 COP1 photomorphogenesis phyA

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Enhanced H_(2) permeation and CO_(2) tolerance of self-assembled ceramic-metal-ceramic BZCYYb-Ni-CeO_(2) hybrid membrane for hydrogen separation

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Journal of Energy Chemistry 2023年第7期82卷 47-55,I0002页

作者： Jianqiu Zhu Jingzeng Cui Yuxuan Zhang Ze Liu chuan zhou Susu Bi Jingyuan Ma Jing zhou Zhiwei Hu Tao Liu Zhi Li Xiangyong Zhao Jian-Qiang Wang Linjuan Zhang Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China Key Laboratory of Optoelectronic Material and Device Department of PhysicsShanghai Normal UniversityShanghai 200234China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816JiangsuChina Shanghai Synchrotron Radiation Facility Zhangjiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Max Planck Institute for Chemical Physics of Solids Nöthnitzer Strasse 40Dresden 01187Germany Shandong Energy Group Co. Ltd.Jinan 250014ShandongChina University of Chinese Academy of Sciences Beijing 100049China

Perovskite-type mixed protonic-electronic conducting membranes have attracted attention because of their ability to separate and purify hydrogen from a mixture of gases generated by industrial-scale steam reforming based on an ion diffusion *** cost-effective membrane materials that can achieve both high H_(2) permeability and strong CO_(2)-tolerant chemical stability has been a major challenge for industrial ***,we constructed a triple phase(ceramic-metal-ceramic)membrane composed of a perovskite ceramic phase BaZr_(0.1)Ce_(0.7)Y_(0.1)Yb_(0.1)O_(3-δ)(BZCYYb),Ni metal phase and a fluorite ceramic phase CeO_(2).Under H_(2) atmosphere,Ni metal in-situ exsolved from the oxide grains,and decorated the grain surface and boundary,thus the electronic conductivity and hydrogen separation performance can be *** BZCYYbNi-CeO_(2)hybrid membrane achieved an exceptional hydrogen separation performance of 0.53 mL min^(-1)cm^(-2) at 800℃ under a 10 vol% H_(2) atmosphere,surpassing all other perovskite membranes reported to ***,the CeO_(2) phase incorporated into the BZCYYb-Ni effectively improved the CO_(2)-tolerant chemical *** BZCYYbNi-CeO_(2) membrane exhibited outstanding long-term stability for at least 80 h at 700℃ under 10 vol%CO_(2)-10 vol%H_(2).The success of hybrid membrane construction creates a new direction for simultaneously improving their hydrogen separation performance and CO_(2) resistance stability.

关键词： Hydrogen separation Triple phase hybrid membrane Mixed proton-electron conductor Chemical stability X-ray absorption spectra

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