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Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo en Ning chang Liu Yu-Chi Liu Tissue engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

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基于半导体桥芯片的钝感高瞬发底火设计

火工品 2025年第1期 7-12页

作者：牛惠媛任炜褚恩义李慧常英珂金豪杰陕西应用物理化学研究所瞬态化学效应与控制全国重点实验室陕西西安710061 杭州电子科技大学微电子研究院浙江杭州310018

针对超高速射武器弹药对高频高安全及高一致性点火的发展需求,基于半导体桥芯片点火技术,设计了一种新型钝感高瞬发底火。通过对比研究4种半导体桥芯片及其2种封装结构,选用斯蒂芬酸铅和亚铁氢化铅/高氯酸钾作为两级复合装药,优化形成... 详细信息

针对超高速射武器弹药对高频高安全及高一致性点火的发展需求,基于半导体桥芯片点火技术,设计了一种新型钝感高瞬发底火。通过对比研究4种半导体桥芯片及其2种封装结构,选用斯蒂芬酸铅和亚铁氢化铅/高氯酸钾作为两级复合装药,优化形成了模块化结构的半导体桥底火样机。该底火满足了与弹药接口的匹配要求,并达到1 A 1 W 5 min不发火的安全性要求。发火性能试验表明,所研制的半导体桥底火作用时间不大于200μs,散布不大于30μs,与传统桥丝电底火相比瞬发度和作用时间一致性显著提高,综合性能更好。

关键词：底火半导体桥模块化设计高瞬发高安全

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MAO Ze-dong's View on Traditional Chinese Medicine and Its Modern Significance

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Chinese Journal of Integrative Medicine 2020年第6期26卷 469-472页

作者： LI en-chang Wenzhou Medical University WenzhouZhejiang Province(325035)China

MAO Ze-dong's view on traditional Chinese medicine(TCM)can be divided into the scientific view on TCM,the development view on TCM and the future view on *** core of MAO Ze-dong's view on TCM lies in its scientific *** basic content of MAO Ze-dong's development view on TCM includes unity of TCM and Western medicine(WM),advocating the multi-angle development of TCM from the height of Chinese national dignity,independence and *** Ze-dong's future view on TCM is targeted at WM learning from TCM,integrating TCM and WM and establishing new Chinese *** contemporary enlightenment of MAO Ze-dong's view on TCM is to start from reforming the medical education system before establishing new Chinese medicine.

关键词： MAO Ze-dong view on traditional Chinese medicine(TCM) scientific view on TCM development view on TCM future view on TCM Western medicine learning from TCM

Acute transient hepatocellular injury in cholelithiasis and cholecystitis without evidence of choledocholithiasis

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World Journal of Gastroenterology 2009年第30期15卷 3788-3792页

作者： Chen-Wang chang Wen-Hsiung chang Ching-chung Lin Cheng-Hsin chu Tsang-en Wang Shou-chuan Shih Wen-Hsiung chang Ching-Chung Lin Cheng-Hsin Chu Tsang-En Wang Division of Gastroenterology Department of Intemal Medicine Mackay Memorial Hospital Mackay Medicine Nursing and Management College Taipei 10449 Taiwan China Division of Gastroenterology Department of Internal Medicine Health Evaluation Center Mackay Memorial Hospital Mackay Medicine Nursing and Management College Taipei 10449 Taiwan China

AIM： To investigate acute transient hepatocellular injury in patients with cholelithiasis and cholecystitis but no evidence of choledocholithiasis.METHODS： The medical records of patients with cholelithiasis who underwent cholecystectomy between July 2003 and June 2007 were retrospectively reviewed. Imaging studies to detect common bile duct （CBD） stones were performed in 186 patients, who constituted the study population. Biochemical liver tests before and after surgery, and with the presence or absence of CBD stones were analyzed.RESULTS： In 96 patients with cholelithiasis and cholecystitis without evidence of CBD stones, 49 （51.0%） had an alanine aminotransferase level elevated to 2-3 times the upper limit of normal, and 40 （41.2%） had an elevated aspartate aminotransferase level. Similar manifestations of hepatocellular injury were, as would be expected, even more obvious in the 90 patients with CBD stones. These markers of hepatocellular injury resolved almost completely within 2 wk to 1 mo after cholecystectomy. Compared to 59 patients with histologically less severe cholecystitisin the group undergoing urgent surgery （total 74 patients）, the 15 patients with a gangrenous gallbladder had a higher mean level of total bilirubin （2.14 ± 1.27 mg/dL vs 2.66 ± 2.97 mg/dL, P 〈 0.001） and white cell count （9480 ± 4681/μL vs 12840 ± 5273/μL, P = 0.018）.CONCLUSION： Acute hepatocellular injury in cholelithiasis and cholecystitis without choledocholithiasis is mild and transient. Hyperbilirubinemia and leukocytosis may predict severe inflammatory changes in the gallbladder.

关键词： Acute transient hepatitis Cholelithiasis Cholecystitis Hyperbilirubinemia Leukocytosis

The Analysis of a Griffith Crack Embedded in a Thermo-poro-elastic Medium

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Acta Mechanica Solida Sinica 2023年第5期36卷 734-744页

作者： Yu Tan Yi-en Wang chang Liu College of environment and Civil engineering Chengdu University of TechnologyChengdu 610059China School of Architecture and Civil engineering Xihua UniversityChengdu 610039China School of Mechanics and Aerospace engineering Southwest Jiaotong UniversityChengdu 610031China

The analytical solution of a thermo-poro-elastic medium in static state weakened by a Griffith crack with finite width is *** virtue of the Fourier cosine and sine integral transform techniques,the mixed boundary-value problem is formulated as three pairs of dual integral equations,which are solved with the help of the Abel *** addition,the stress intensity factor of mode Ⅰ and the crack surface displacement are presented *** examples are performed to show the distribution of displacement and stress over the thermo-poro-elastic *** results indicate that the thermal load will increase or decrease the crack surface displacement,but has a weak influence on the stress intensity *** present work may benefit future engineering applications.

关键词： Thermo-poro-elastic medium Analytical solution Grifﬁth crack Stress intensity factor

Outcome of simple use of mechanical lithotripsy of difficult common bile duct stones

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World Journal of Gastroenterology 2005年第4期11卷 593-596页

作者： Wen-Hsiung chang Cheng-Hsin chu Tsang-en Wang Ming-Jen Chen Ching-chung Lin Division of Gastroenterology Department of Internal Medicine Mackay Memorial HospitalMackay MedicineNursing and Management college TaipeiTaiwan

AIM: The usual bile duct stone may be removed by means of Dormia basket or balloon catheter, and results are quite good. However, the degree of difficulty is increased when stones are larger. Studies on the subject reported many cases where mechanical lithotripsy is combined with a second technique, e.g. electrohydraulic lithotripsy (EHL), where stones are crushed using baby-mother scope electric shock. The extracorporeal shock-wave lithotripsy (ESWL) or laser lithotripsy also yields an excellent success rate of greater than 90%. However, the equipment for these techniques are very expensive; hence we opted for the simple mechanical lithotripsy and evaluated its performance. METHODS: During the period from August 1996 to December 2002, Mackay Memorial Hospital treated 304 patients suffering from difficult bile duct stones (stone>1.5 cm or stones that could not be removed by the ordinary Dormia basket or balloon catheter). These patients underwent endoscopic papillotomy (EPT) procedure, and stones were removed by means of the Olympus BML-4Q lithotripsy. A follow-up was conducted on the post-treatment conditions and complications of the patients. RESULTS: Out of the 304 patients, bile duct stones were successfully removed from 272 patients, a success rate of about 90%. The procedure failed in 32 patients, for whom surgery was needed. Out of the 272 successfully treated patients, 8 developed cholangitis, 21 developed pancreatitis, and 10 patients had delayed bleeding, and no patient died. Among these 272 successful removal cases, successful bile duct stone removal was achieved after the first lithotripsy in 211 patients, whereas 61 patients underwent multiple sessions of lithotripsy. As for the 61 patients that underwent multiple sessions of mechanical lithotripsy, 6 (9.8%) had post-procedure cholangitis, 12 (19.6%) had pancreatitis, and 9 patients (14.7%) had delayed bleeding. Compared with the 211 patients undergoing a single session of mechanical lithotripsy, 3 (1.4

关键词： Common bile duct stones Mechanical lithotripsy

Efficient and simple synthesis of B_(2)O_(3)-Al_(2)O_(3)nanocomposites assisted by deep eutectic solvent for production of 5-hydroxymethylfurfural from glucose

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Nano Research 2025年第1期18卷 236-248页

作者： Yuchen Wang Kai Rong Shanlei chang Youxing Fang Shaojun Dong State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and engineering University of Science and Technology of ChinaHefei 230026China College of Chemistry Jilin UniversityChangchun 130012China

The catalytic conversion of glucose to high valueadded platform chemical 5-hydroxymethylfurfural(HMF)is a promising biorefinery process,and alumina-boria catalysts are considered to be green and mild solid acid catalysts for this catalytic ***,compared to the common synthesis methods with complicated steps,we reported a simple and efficient strategy to prepare B_(2)O_(3)-Al_(2)O_(3)nanocomposites by calcining cost-effective glucose-urea deep eutectic solvent(DES)solution containing the *** prepared B_(2)O_(3)-Al_(2)O_(3)nanocomposites exhibited an open three-dimensional skeleton and two-dimensional porous lamellar substructure,endowing them with a high specific surface area(228.27 m2/g).The introduction of boron changed the ratios of different aluminum species(AlⅣ,AlⅤ,and AlⅥ)and borate species(BO3 and BO4),thus further affecting the acidity and the types of acid sites of the *** prepared B_(2)O_(3)-Al_(2)O_(3)bifunctional acid catalysts possessing abundant Lewis acid sites and adjustable Brønsted acid sites showed complete glucose conversion and 55.38%of HMF yield under the optimum *** study proposed a concise method to synthesize alumina-boria solid acid catalysts assisted by glucose-urea *** hope to extend the application and prospect of this efficient and simple synthesis strategy.

关键词： 5-hydroxymethylfurfural(HMF) deep eutectic solvent glucose alumina-boria acid catalyst

Anisotropic Combustion of Aluminum Nanoparticles in Carbon Dioxide and Water Flows

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Journal of Thermal Science 2022年第3期31卷 867-881页

作者： chang Xiaoya CHen Dongping chu Qingzhao State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Explosion Protection and Emergency Disposal Technology engineering Research Center of the Ministry of Education Beijing100081China

Shock-induced combustion of aluminum nanoparticles was examined in the CO_(2)and H_(2)O flows up to 8 km/s using reactive molecular *** morphological evolutions and heat/mass transfer of ANPs were discussed to reveal the nature of anisotropic *** breakage of triatomic gas molecule and the formation of key intermediates were identified to illustrate the reaction mechanisms at the atomic *** was found that surface reactions prevail for cases in lower flow velocity(≤6 km/s),and gas-phase reactions govern the oxidation process under the intense impact(8 km/s).In particular,we converted the flow velocity to the initial kinetic energy of flow molecules to highlight the impact of oxidizing ability on the shock-induced *** the regime of low initial kinetic energy(energy(ens and the heat transfer becomes *** the extreme scenarios(>458.1 k J/mol),the overall oxidation is governed by the microexplosion mechanism,and different oxidizers share almost the same ignition delay.

关键词： anisotropic reaction surface reaction ignition combustion mode molecular dynamics simulation

Analysis of clinical manifestations of symptomatic acquired jejunoileal d i verticil la r disease

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World Journal of Gastroenterology 2005年第35期11卷 5557-5560页

作者： Chia-Yuan Liu Wen-Hsiung chang Shee-Chan Lin Cheng-Hsin chu Tsang-en Wang Shou-chuan Shih Division of Gastroenterology Department of Internal Medicine Mackay Memorial Hospital Taipei Taiwan China Department of Medical Research Mackay Memorial Hospital Taipei Taiwan China Division of Gastroenterology Department of Internal Medicine Mackay Memorial Hospital Taipei Taiwan China Division of Gastroenterology Department of Internal Medicine Mackay Memorial Hospital Taipei Taiwan China Mackay Medicine Nursing and Management College Taipei Taiwan China

AIM: To analyze systematically our experience over 22 years with symptomatic acquired diverticular disease of the jejunum and ileum, exploring the clinical manifestations and diagnosis of this rare but life-threatening ***: The medical records of patients with surgically confirmed symptomatic jejunoileal diverticular disease were retrospectively reviewed. Data collected included demographic data, laboratory results, clinical course (acute or chronic), preoperative diagnosis, and operative findings. Inclusion criteria were as follows: (1) surgical confirmation of jejunoileal diverticular disease and (2)exclusion of congenital diverticula (e.g. Meckel's diverticulum).RESULTS: From January 1982 to July 2004, 28 patients with a total of 29 operations met the study criteria. The male:female ratio was 14:14, and the mean age was 62.6±3.5 years. The most common manifestation was abdominal pain. In nearly half of the patients, the symptoms were chronic. Two patients died after surgery. Only four cases were correctly diagnosed prior to surgery, three by small bowel ***: Symptomatic acquired small bowel diverticular disease is difficult to diagnose. It should be considered in older patients with unexplained chronic abdominal symptoms. A small bowel series may be helpful in diagnosing this potentially life-threatening disease.

关键词： Acquired Symptomatic Jejunoileal Diverticulardisease