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BIR repeat-containing ubiquitin conjugating enzyme (BRUCE) regulation of β-catenin signaling in the progression of drug-induced hepatic fibrosis and carcinogenesis

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World Journal of Hepatology 2021年第3期13卷 343-361页

作者： chrystelle l vilfranc li-Xiao Che Krushna C Patra liang Niu Olugbenga Olowokure Jiang Wang Shimul A Shah Chun-Ying Du Department of Cancer Biology University of CincinnatiCincinnatiOH 45267United States Department of Environmental and Public Health Sciences University of CincinnatiCincinnatiOH 45267United States Department of Internal Medicine University of CincinnatiCincinnatiOH 45267United States Department of Pathology and laboratory Medicine University of CincinnatiCincinnatiOH 45267United States Department of Surgery University of CincinnatiCincinnatiOH 45267United States

BACKGROUND BIR repeat-containing ubiquitin conjugating enzyme(BRUCE)is a liver tumor suppressor,which is downregulated in a large number of patients with liver *** facilitates DNA damage repair to protect the mouse liver against the hepatocarcinogen diethylnitrosamine(DEN)-dependent acute liver injury and *** there exists an established pathologic connection between fibrosis and hepatocellular carcinoma(HCC),DEN exposure alone does not induce robust hepatic *** studies are warranted to identify new suppressive mechanisms contributing to DEN-induced fibrosis and *** To investigate the suppressive mechanisms of BRUCE in hepatic fibrosis and HCC *** Male C57/Bl6/J control mice[loxp/loxp;albumin-cre(Alb-cre)-]and BRUCE Alb-Cre KO mice(loxp/loxp;Alb-Cre+)were injected with a single dose of DEN at postnatal day 15 and sacrificed at different time points to examine liver disease *** By using a liver-specific BRUCE knockout(lKO)mouse model,we found that BRUCE deficiency,in conjunction with DEN exposure,induced hepatic fibrosis in both premalignant as well as malignant stages,thus recapitulating the chronic fibrosis background often observed in HCC *** in fibrosis and HCC,β-catenin activity depends on its stabilization and subsequent translocation to the ***,we observed that livers from BRUCE KO mice demonstrated an increased nuclear accumulation and elevated activity ofβ-catenin in the three stages of carcinogenesis:Pre-malignancy,tumor initiation,and *** suggests that BRUCE negatively regulatesβ-catenin activity during liver disease progression.β-catenin can be activated by phosphorylation by protein kinases,such as protein kinase A(PKA),which phosphorylates it at Ser-675(pSer-675-β-catenin).Mechanistically,BRUCE and PKA were colocalized in the cytoplasm of hepatocytes where PKA activity is maintained at the basal ***,in BRUCE deficient mouse livers

关键词： BIR repeat-containing ubiquitin conjugating enzyme Diethylnitrosamine Mouse model liver fibrosis liver cancer Hepatocellular carcinoma

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Temporomandibular joint damage in K/BxN arthritic mice

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International Journal of Oral Science 2020年第1期12卷 59-67页

作者： Sabine Kuchler-Bopp Alexandre Mariotte Marion Strub chrystelle Po Aurore De Cauwer Georg Schulz Xavier Van Bellinghen Florence Fioretti Francois Clauss Philippe Georgel Nadia Benkirane-Jessel Fabien Bornert INSERM(French National Institute of Health and Medical Research) UMR 1260Regenerative NanoMedicine(RNM)FMTSStrasbourgFrance INSERM UMR 1109Immuno Rhumatologie Moléculaire(IRM)FMTSStrasbourgFrance Fédération Hospitalo-Universitaire(FHU)OMICARE Universitéde StrasbourgStrasbourgFrance Facultéde Chirurgie Dentaire Universitéde Strasbourg(UDS)8 rue Ste ElisabethStrasbourgFrance Pole de Médecine et Chirurgie Bucco-Dentaires Hopitaux Universitaires de Strasbourg(HUS)1 place de l’HopitalStrasbourgFrance ICube UMR 7357 Universitéde StrasbourgCNRSFMTS4 rue KirschlegerStrasbourgFrance Department of Biomedical Engineering Core Facility Micro-and NanotomographyBiomaterials Science Center(BMC)University of BaselGewerbestrasse 144123AllschwilSwitzerland

Rheumatoid arthritis(RA) is an autoimmune disease affecting 1% of the world population and is characterized by chronic inflammation of the joints sometimes accompanied by extra-articular manifestations. K/Bx N mice, originally described in 1996 as a model of polyarthritis, exhibit knee joint alterations. The aim of this study was to describe temporomandibular joint(TMJ)inflammation and damage in these mice. We used relevant imaging modalities, such as micro-magnetic resonance imaging(μMRI)and micro-computed tomography(μCT), as well as histology and immunofluorescence techniques to detect TMJ alterations in this mouse model. Histology and immunofluorescence for Col-I, Col-II, and aggrecan showed cartilage damage in the TMJ of K/Bx N animals, which was also evidenced by μCT but was less pronounced than that seen in the knee joints. μMRI observations suggested an increased volume of the upper articular cavity, an indicator of an inflammatory process. Fibroblast-like synoviocytes(FlSs)isolated from the TMJ of K/Bx N mice secreted inflammatory cytokines(Il-6 and Il-1β) and expressed degradative mediators such as matrix metalloproteinases(MMPs). K/Bx N mice represent an attractive model for describing and investigating spontaneous damage to the TMJ, a painful disorder in humans with an etiology that is still poorly understood.

关键词： damage alterations inflammation

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The Identification of the Character for “Blessing” in Ancient Chinese Writing

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甲骨文与殷商史 2016年第1期 69-81页

作者：麥里筱 CNRS EHESS-CRLAO

本文討論商代甲骨文裏一組異體字的隸定問題。這一組包括■、■、■、■、■、■、■等甲骨文異體字,于省吾認爲它們'於形則難徵,只能存疑'。其他學者的解釋可分兩派:一派以羅振玉爲代表,他將這一組異體字均隸定爲'福'字;另一派以島邦... 详细信息

本文討論商代甲骨文裏一組異體字的隸定問題。這一組包括■、■、■、■、■、■、■等甲骨文異體字,于省吾認爲它們'於形則難徵,只能存疑'。其他學者的解釋可分兩派:一派以羅振玉爲代表,他將這一組異體字均隸定爲'福'字;另一派以島邦男爲代表,將這一組異體字隸定爲'祼'字。目前學者多從島邦男之説,釋祼之説似佔上風。《説文》釋祼曰:'灌祭也。从示,果聲。'然而'祼'字的字源不明。本文考察這一組異體字在商代卜辭中的用法,並通過字形分析來探討釋祼與釋福兩派學者的主要論點。筆者認爲釋祼説的證據要遠比釋福説薄弱。所有這些甲骨文異體字最主要的特徵是酒器的象形部件,雖然取象不盡相同,但毫無疑議均象酒器,所以應該隸定爲'福'字。'福'最初當爲會意字,表示以酒敬祭與祖先享用。敬享祖先,自然是爲求取福報,所以'福'字由祭儀之'福'而引申爲福報之'福'。最後筆者根據公元前四世紀的竹簡資料,提出'祼'字的字源可能就是'福'字,從而坐實這一組甲骨文異體字應該隸定爲'福'而不可能是'祼'。

关键词：異體論點酒器字形資料字源學者筆者

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Management of Breast Cancer in Visceral Surgery of CNHU-HKM of Cotonou in Benin

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Surgical Science 2016年第3期7卷 170-176页

作者： Dansou Gaspard Gbessi Ismail lawani chrystelle Tawo-Nounagnon Francis Mo&iumlse Dossou Yacoubou Imorou Soua&iumlbou Delphin Kuassi Mehinto Jean-léon Olory-Togbe Kémoko Osséni Bagnan Nazaire Padonou Visceral Surgery A CNHU-HKM Cotonou Benin General Surgery CHDU-OP of Porto-Novo Porto-Novo Benin Visceral Surgery B CNHU-HKM of Cotonou Cotonou Benin

Breast cancer affects more females than males. It occurs earlier with the black females and is often diagnosed at a stage of complication. This study aims to describe its epidemiological characteristics, the changing stages, and to analyze the treatment and means of interdisciplinary and international cooperation in its care and treatment. Our study was retrospective, descriptive and analytic on breast cancer patients received at CNHU-HKM of Cotonou between January 1, 2001 and December 31, 2013. Breast cancer accounts for 24.24% of mammary pathologies and most affects the left breast. Females aged from 40 to 59 years old are the most affected. For males, the average age was 47.5 years old. Patients mostly consult at a later stage where the tumor is already palpable with nodal metastasis. Breast echography and mammography had been done only for 23.85% of the cases. In an anatomical pathology perspective, the invasive ductal carcinoma was the most common type with 87.2%. For the therapeutical aspect, a radical mastectomy according to Patey was realized in 81.65% of the cases;48.65% underwent a chemotherapy and 14.7% were able to do a radiotherapy. The chance at life for patients was decreasing while the life time is increasing. Also, the average life span of patients was increased by the combination of diverse types of treatments notably when radiotherapy is done. The incidence of breast cancers in Visceral Surgery A and B department of CNHU-HKM-Cotonou is increasing over years.

关键词： Cancer Breast Epidemiology Stage Diagnosis Chemotherapy Radiotherapy

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