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Glucocorticoid and mineralocorticoid receptor expression in critical illness:A narrative review

World Journal of Critical Care Medicine 2021年第4期10卷 102-111页

作者： Alice G Vassiliou Nikolaos Athanasiou Dimitra A Vassiliadi Edison Jahaj chrysi keskinidou Anastasia Kotanidou Ioanna Dimopoulou 1^(st)Department of Critical Care Medicine&Pulmonary Services School of MedicineNational&Kapodistrian University of Athens“Evangelismos”HospitalAthens 10676Greece Department of Endocrinology Diabetes and Metabolism“Evangelismos”HospitalAthens 10676Greece

The glucocorticoid receptor(GCR)and the mineralocorticoid receptor(MR)are members of the steroid receptor superfamily of hormone-dependent transcription *** receptors are structurally and functionally *** are localized in the cytosol and translocate into the nucleus after ligand *** and MRs can be co-expressed within the same cell,and it is believed that the balance in GCR and MR expression is crucial for homeostasis and plays a key role in normal *** critical illness,the hypothalamic-pituitary-adrenal axis is activated,and as a consequence,serum cortisol concentrations are ***,a number of patients exhibit relatively low cortisol levels for the degree of illness ***(GC)actions are facilitated by GCR,whose dysfunction leads to GC tissue *** MR is unique in this family in that it binds to both aldosterone and *** GCs play a critical role in controlling inflammatory responses in critical *** GC concentrations can differ greatly from blood levels due to the action of the two 11β-hydroxysteroid dehydrogenase isozymes,type 1 and type 2.11β-hydroxysteroid dehydrogenases interconvert endogenous active cortisol and intrinsically inert *** degree of expression of the two isozymes has the potential to dramatically influence local GC availability within cells and *** this review,we will explore the clinical studies that aimed to elucidate the role of MR and GCR expression in the inflammatory response seen in critical illness.

关键词： Mineralocorticoid receptor Glucocorticoid receptor,Critical illness 11betahydroxysteroid dehydrogenase Aldosterone Cortisol

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Association of homocysteine and smoking with cerebral microemboli in patients with mechanical heart valves:a transcranial Doppler study

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Stroke & Vascular Neurology 2017年第4期2卷 199-204页

作者： Alicia Mattia M Reza Azarpazhooh Claudio Munoz chrysi Bogiatzi Mackenzie A Quantz J David Spence Stroke Prevention and Atherosclerosis Research Centre Robarts Research InstituteWestern UniversityLondonOntarioCanada Department of Neurology McMaster UniversityHamiltonOntarioCanada Division of Epidemiology and Biostatistics Western UniversityLondonOntarioCanada Division of Neurology Western UniversityLondonOntarioCanada Division of Cardiac Surgery Western UniversityLondonOntarioCanada Division of Clinical Pharmacology Western UniversityLondonOntarioCanada

Objectives Microembolic signals(MES)on transcranial Doppler(TCD)predict stroke and cognitive *** levels of total homocysteine(tHcy),a prothrombotic factor,are higher in patients with microemboli in carotid stenosis and in patients with paradoxical *** this study we assessed the association between the level of tHcy and the number of MES in patients with mechanical heart valves(MHVs).Methods TCD monitoring was performed to detect MES before and after breathing 100% oxygen and repeated every 2-4 weeks up to six *** Twenty-five patients with MHVs(mean age:63.60±10.15 years)participated in this study;15 were men(66.47±7.25 years)and 10 were women(59.30±12.60 years).In total,there were 126 study *** multiple regression,higher tHcy was associated with more MES in both preoxygenation(OR 1.34(95%CI 1.07 to 1.68,P=0.009))and postoxygenation(OR 1.40(95% CI 1.07 to 1.83,P=0.01))*** smoking and the length of time between the operation and monitoring also correlated with a higher number of MES before and after breathing oxygen,particularly in *** Higher tHcy and smoking were associated with a higher MES count in both preoxygenation and postoxygenation *** smoking can be stopped and hyperhomocysteinaemia is treatable,these are clinically important findings.

关键词： patients assessed cerebral

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Regulation of Resource Partitioning Coordinates Nitrogen and Rhizobia Responses and Autoregulation of Modulation in Medicago tmncatula

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Molecular Plant 2019年第6期12卷 833-846页

作者： Beatriz Lagunas Mingkee Achom Roxanna Bonyadi-Pour Alonso J.Pardal Bethany L.Richmond chrysi Sergaki Saul Vazquez Patrick Schafer Sascha Ott John Hammond Miriam L.Gifford School of Life Sciences University of Warwick Coventry CV4 7AL UK Department of Computer Science University of Warwick Coventry CV4 7AL UK Gateway Building Sutton Bonington Campus University of Nottingham Sutton Bonington LE12 5RD UK School of Agriculture Policy and Development University of Reading Reading RG6 6AH UK Southern Cross Plant Science Southern Cross University Lismore NSW 2480 Australia

Understanding how plants respond to nitrogen in their environment is crucial for determining how they use it and how the nitrogen use affects other processes related to plant growth and development. Under nitrogen limitation the activity and affinity of uptake systems is increased in roots, and lateral root formation is regulated in order to adapt to low nitrogen levels and scavenge from the soil. Plants in the legume family can form associations with rhizobial nitrogen-fixing bacteria, and this association is tightly regulated by nitrogen levels. The effect of nitrogen on nodulation has been extensively investigated, but the effects of nodulation on plant nitrogen responses remain largely unclear. In this study, we integrated molecular and phenotypic data in the legume Medicago truncatula and determined that genes controlling nitrogen influx are differently expressed depending on whether plants are mock or rhizobia inoculated. We found that a functional autoregulation of nodulation pathway is required for roots to perceive, take up, and mobilize nitrogen as well as for normal root development. Our results together revealed that autoregulation of nodulation, root development, and the location of nitrogen are processes balanced by the whole plant system as part of a resource-partitioning mechanism.

关键词： Nitrogen transport Medicago root system architecture transcriptomics autoregulation of nodulation rhizobia

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Nutrient and Chlorophyll <i>α</i>Variability at a Micro-Scale Level in a Suspended Mussel Culture

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Journal of Water Resource and Protection 2017年第12期9卷 1491-1509页

作者： Amalia Moriki Dimitris Petridis chrysi Papadimitriou Irene Fantidou Nikos Kapageridis Department of Food Technology Alexander Technological Educational Institute of Thessaloniki (ATEITh) Sindos Thessalo-niki Greece

Mussel farming by the long-line system, in the shallow waters of the NW Thessaloniki Gulf, Greece, is a vital economic activity for the local communities. The management practices play an important role both in the environmental quality and the support of the healthy growth of mussels. Αn experimental line of mussels in suspension placed at different sock distances as a management practice was systematically monitored for nutrients, chlorophyll α and dissolved oxygen. The study at four different mussel densities (distances of the socks) lasted from July 2014 to April 2015, covering the growth, reproduction and harvest cycle of mussels. Additional sampling took place in two selected sock distances, 30 and 70 cm, in the second sampling period, May-August 2015. The variability of nutrients along with chlorophyll α and dissolved oxygen, seasonally, spatially and vertically, was examined with the application of multivariate statistical analysis. The results showed low variation of nitrates among the sites but statistically significant differences of dissolved oxygen, ammonium, phosphate and chlorophyll α. The application of environmental indicators (TRIX, EI) in the data set was a useful tool in the identification of different variation schemes of the measured parameters in the cultures of various mussel densities.

关键词： Nutrients Chlorophyll α Mussel Farming Thessaloniki Gulf Eutrophication Indicators

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逆向二头肌负荷试验--一个针对SLAP损伤的新试验

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中华骨与关节外科杂志 2017年第5期10卷 408-411,416页

作者：申剑 Daniel Mok chrysi Tsiouri 薛庆云王飞中国医学科学院北京协和医学院研究生院北京100730 卫生部北京医院骨科北京100730 Upper Limb Unit Epsom General HospitalEpsom and St.Helier University of UK

背景:肩关节上盂唇前后部(SLAP),是维持肩关节稳定的重要结构。SLAP的损伤常常造成肩关节的疼痛和功能障碍,但在临床上通过常规查体却很难确诊。目的:验证我们发现的一个新的临床试验用于诊断SLAP损伤。方法:选取因肩关节疼痛初次进行... 详细信息

背景:肩关节上盂唇前后部(SLAP),是维持肩关节稳定的重要结构。SLAP的损伤常常造成肩关节的疼痛和功能障碍,但在临床上通过常规查体却很难确诊。目的:验证我们发现的一个新的临床试验用于诊断SLAP损伤。方法:选取因肩关节疼痛初次进行关节镜手术治疗的患者。术前均进行4项常用的SLAP损伤的临床检查法Speed、Yergason、O'Brien、及我们的新试验(Reverse Biceps Load test)进行检查做初步诊断。之后所有患者进行肩关节镜检查,术中镜下对有SLAP损伤的患者进行记录并分型。结果:从2010年2月至2010年8月大约有137名肩关节疼痛的患者进行了肩关节镜手术治疗,其中52名患者存在有SLAP或二头肌长头腱的损伤。其中对于SLAP及二头肌腱的损伤,新试验敏感度76.92%,特异性为43.53%。当肩关节后伸,前部极度外旋时SLAP及二头肌长头腱处于高张力状态。此时轻微的外力就可诱发疼痛,因此新试验具有较高的敏感性,但此位置时前关节囊及部分肩袖亦处于高张力状态,所以特异性会受一定影响。结论:新试验对于SLAP及二头肌腱损伤有较高的敏感性,可以作为SLAP损伤的筛选试验运用于临床。

关键词： SLAP损伤肩关节试验关节镜

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访谈一:社交网络营销的关键五步

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成功营销 2007年第9期 60-60页

作者： chrysi Philalithes MIVA

V：在您眼中，社交网络是否具有营销功能？chrysi：首先我认为我比较了解社交网站的复杂现状，作为一个积极的Facebook用户，我对“整个游戏”感到很适应，我与一些一度失去联络的朋友重新联系上了。自这一个月以来，通过社交网络营销... 详细信息

V：在您眼中，社交网络是否具有营销功能？chrysi：首先我认为我比较了解社交网站的复杂现状，作为一个积极的Facebook用户，我对“整个游戏”感到很适应，我与一些一度失去联络的朋友重新联系上了。自这一个月以来，通过社交网络营销，我们的电影评论网站***，也确定看到了回报——用户注册量不断提升，网站流量也在增加。所以我想分离下进行社交网络营销首先需要采取的五个步骤。

关键词：网络营销社交营销功能电影评论网站注册量用户回报

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正确处理技术、教学法和新常态三者关系:后新冠疫情时代高等教育的挑战

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中国远程教育 2022年第3期 26-41,77页

作者：克莱西·拉潘塔卢卡·博图里彼得·古德伊尔卢尔德·古尔迪亚玛格丽特·库尔肖俊洪葡萄牙新里斯本大学西班牙加泰罗尼亚开放大学瑞士意大利语应用科学与艺术大学圣贝内代托基金会悉尼大学悉尼大学学习与创新研究中心英国兰卡斯特大学英国兰卡斯特大学先进学习技术研究中心加泰罗尼亚开放大学心理学与教育科学部加泰罗尼亚开放大学E-Learning研究、创新和培训中心欧洲远程教学大学协会加拿大萨斯喀彻温大学汕头开放大学

新冠肺炎大流行是一个对教育,尤其是高等教育的认识进行重新思考的机会。由于这场大流行病所造成的全面危机,尤其是所谓应急远距离教学的开展,各级各类教育工作者不得不重新思考他们的角色、支持学生完成学习任务的方法,以及如何把学生... 详细信息

新冠肺炎大流行是一个对教育,尤其是高等教育的认识进行重新思考的机会。由于这场大流行病所造成的全面危机,尤其是所谓应急远距离教学的开展,各级各类教育工作者不得不重新思考他们的角色、支持学生完成学习任务的方法,以及如何把学生看作是自我组织学习者、积极公民和自主社会能动者。我们发表在本刊的前一篇文章试图总结和分享一些专家的建议,帮助普通高校教师适应在线教与学。作为该文续篇,本文旨在回答以下问题:普通高校教师已经经历了突发、不得不为之的在线教与学,这种经验如何能有助于弥合今后在线与面授教学的距离?受访的四位专家(同时也是本文合作者)一致强调高等教育的教学法理论化而不是数字化,认为战略决策是后新冠大流行时代教育实践的核心。本文回顾过去一年发表的文章,并分析受访专家对研究问题的看法,结果表明,在应急远距离教学过程中“被迫”使用数字技术教学这种情况有可能渐渐变成数字和非数字工具和方法的和谐融合,以促成更加主动、灵活和有意义学习的发生。

关键词：应急远距离教学在线教与学高等教育后新冠疫情时代教学法数字技术

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