Association of homocysteine and smoking with cerebral microemboli in patients with mechanical heart valves:a transcranial Doppler study
作者机构:Stroke Prevention and Atherosclerosis Research CentreRobarts Research InstituteWestern UniversityLondonOntarioCanada Department of NeurologyMcMaster UniversityHamiltonOntarioCanada Division of Epidemiology and BiostatisticsWestern UniversityLondonOntarioCanada Division of NeurologyWestern UniversityLondonOntarioCanada Division of Cardiac SurgeryWestern UniversityLondonOntarioCanada Division of Clinical PharmacologyWestern UniversityLondonOntarioCanada
出 版 物:《Stroke & Vascular Neurology》 (卒中与血管神经病学(英文))
年 卷 期:2017年第2卷第4期
页 面:199-204页
核心收录:
基 金:The study was funded by donations to the Stroke Prevention&Atherosclerosis Research Centre mainly from patients attending the stroke prevention clinics
主 题:patients assessed cerebral
摘 要:Objectives Microembolic signals(MES)on transcranial Doppler(TCD)predict stroke and cognitive *** levels of total homocysteine(tHcy),a prothrombotic factor,are higher in patients with microemboli in carotid stenosis and in patients with paradoxical *** this study we assessed the association between the level of tHcy and the number of MES in patients with mechanical heart valves(MHVs).Methods TCD monitoring was performed to detect MES before and after breathing 100% oxygen and repeated every 2-4 weeks up to six *** Twenty-five patients with MHVs(mean age:63.60±10.15 years)participated in this study;15 were men(66.47±7.25 years)and 10 were women(59.30±12.60 years).In total,there were 126 study *** multiple regression,higher tHcy was associated with more MES in both preoxygenation(OR 1.34(95%CI 1.07 to 1.68,P=0.009))and postoxygenation(OR 1.40(95% CI 1.07 to 1.83,P=0.01))*** smoking and the length of time between the operation and monitoring also correlated with a higher number of MES before and after breathing oxygen,particularly in *** Higher tHcy and smoking were associated with a higher MES count in both preoxygenation and postoxygenation *** smoking can be stopped and hyperhomocysteinaemia is treatable,these are clinically important findings.