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Measuring Social Capital Linkage： The Role of the State-Based Voluntary Professional Association

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Sociology Study 2015年第6期5卷 429-443页

作者： christopher lowe Monash Sustainability Institute Australia

This paper discusses the nature of the Australian bus and coach representative environment and the role of the state-based voluntary professional association （SBVPA）. A literature review associated with memberships to which businesses subscribe for representation and linking social capital is presented, as well as a discussion on agency theory that possibly explains the member/association dynamic. The results of an Australia-wide survey of bus operators, which measures the extent of linking social capital between themselves and their SBVPA, are revealed. It is found that one state with consistently higher results may possess a competitive advantage in the form of a partnership agreement with the State Government Authority--an agreement that rests on co-operation and facilitates social capital. This evidence could contribute to the global narrative on how non-profit associations can be a mechanism for institutionalising social capital, sustain a firm＇s operation and encourage governments to increase their use of non-profit associations, as agents of government, to achieve public policy outcomes.

关键词： Voluntary professional association bus operators linking social capital

Addressing On-board Assaults and Driver Health and Well-Being： A Voluntary Professional Association＇s Approach

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Sociology Study 2016年第11期6卷 683-692页

作者： christopher lowe Julia Evans Bus Association Victoria Inc. Australia University of Melbourne Australia

This paper provides an account of how a voluntary professional association （or industry representative body） in Victoria, Australia, led a whole-of-industry response to an alarming increase in on-board assaults on bus drivers by passengers, and the resulting impact on drivers＇ health and well-being. Influenced by literature and guided by the results from two commissioned research pieces, the association developed and implemented a five pillar strategy to address these issues. A stakeholder perspective was adopted to develop the strategy in order to ensure high relevance and value by being as inclusive as possible across the entire industry, and agency theory underpinned the association＇s implementation of the strategy. It is hoped that this case study exemplar will assist increase the productivity and social capital of an industry. others in utflising theory for policy change with a view to

关键词： Voluntary professional association stakeholder perspective agency theory health wellness and safety

Harmony, Productivity, and Informed Decision Making： The Fundamental Competencies of the Chief Emotional Officer

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Sociology Study 2015年第1期5卷 60-73页

作者： christopher lowe Julia Evans Monash Sustainability Institute Australia Independent scholar Australia

Existing in most family firms, the chief emotional officer （CEmO） is the enigmatic heart of the organisation, linking family harmony with business performance and productivity. The literature is rich in acknowledging the existence and value of the CEmO in family firms, but little is said of the abilities mastered by CEmOs and how organisations can leverage the value of the CEmO through professional development. It is this nexus that this paper aims to fill. Commencing with an exploration of the literature on the purpose and value of the CEmO, key findings are advanced through interviews and a focus group. The specific site of research selected is one rich in family business in which to explore the CEmO phenomenon--the bus and coach industry in Victoria, Australia. Revealed is the fundamental competencies of the CEmO, being their adept ability to facilitate harmony, drive productive and focus values-based decision making in family firms. The outcomes that these competencies achieve and the obstacles and challenges of the CEmO role are also presented. Concluding remarks ask how the CEmO and these core competencies can be developed in a role that is often unstructured, intuitive, and unrecognised within the firm.

关键词： Chief emotional officer (CEmO) family business business sustainability competency professional development

Occult Hepatitis B Reactivation after Liver Transplant: The Role of a Novel Mutation in the Surface Antigen

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Journal of Clinical and Translational Hepatology 2021年第1期9卷 136-138页

作者： Harjot K.Bedi Daljeet Chahal christopher F.lowe Gordon Ritchie Trana Hussaini Vladimir Marquez Eric M.Yoshida Department of Medicine University of British ColumbiaVancouverBCCanada Division of Gastroenterology University of British ColumbiaVancouverBCCanada Department of Pathology&Laboratory Medicine University of British ColumbiaVancouverBCCanada Faculty of Pharmaceutical Sciences University of British ColumbiaVancouverBCCanada

Occult hepatitis B infection is characterized by loss of hepa-titis B surface antigen(HBsAg)and persistence of low levels of hepatitis B virus(HBV)replication that may or may not be detectable in plasma/*** present a case of HBV reactivation in a male patient who underwent orthotopic liver transplant for hepatocellular carcinoma secondary to active hepatitis C(HCV)***-transplant,he was HBsAg-negative and hepatitis B core antibody-positive,with an undetectable HBV viral load that was incidentally found to be positive at a very low HBV viral load on the day of ***-transplant,his HBsAg remained undetect-able,with an undetectable HBV viral load,until eradication of his HCV infection with direct acting antiviral ***-ter eradication of HCV,there was reactivation of HBV,with a high viral load and emergence of serum HBsAg.A deep sequencing genetic analysis of his HBV both pre-and post-transplant revealed the presence of a mutation in the"a"determinant of the HBV surface *** role of HBV genotype'a'determinant mutation in HBV reactivation post-transplant is unknown and needs further *** experience suggests a possible role for antiviral prophylaxis in these patients or monitoring of HBV viral loads post-transplant.

关键词： Antigen infection activation

Sense of CommuniW Responsibility as a Determinant of Corporate Responsibility

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Sociology Study 2016年第10期6卷 653-662页

作者： christopher lowe Janet Stanley John Stanley Bus Association Victoria Inc. Melbourne VictoriaAustralia University of Melbourne Melbourne Victoria Australia University of Sydney Sydney New South Wales Australia

Research on the social value of the bus industry in Australia revealed an inconsistency in findings between qualitative and quantitative results in relation to the nature of a bus operator＇s interaction with the community where they provide a transport service. As part of a larger research project that surveyed bus operators about their corporate social responsibility, bivariate analysis found that the responses to the embedded Sense of Community Index （SOCI） did not provide a predictor of the extent of a bus operator＇s community interaction or determinant of Corporate Responsibility （CR）. However, qualitative comments in the survey suggested that bus operators did display strong positive feelings about their community. Published after the data collection stage was completed, the Sense of Community Responsibility Index （SOCRI） appeared to be a better fit than SOCI to explain the nature of bus operator＇s interaction with their community. Rather than drawing on community resources, the interaction was shown to be one of leaderships on the part of the operator. Further examination of this relationship using the SOCR would test this finding.

关键词： Corporate responsibility sense of community sense of community responsibility leadership bus operators family business

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人工蛋白A的结构优化(英文)

人工蛋白A的结构优化(英文)

Urine exosome mRNA-based test for monitoring kidney allograft rejection:Effects of sample transportation and storage,and interference substances

“科技增强国力，青年开创未来——携手走向辉煌的新世纪”中国科协第三届青年学术年会

作者：李荣秀 christopher R.lowe 中国科学院上海生物工程研究中心 Institute of Biotechnology University of CambridgeUK

人工蛋白A是为大规模生产中分离纯化抗体类药物而设计合成的。它已经表现出了一些比天然蛋白A更优越的性质,如稳定性更高等。但是,在计算机辅助分子模拟中发现,当人工蛋白A放在其抗体的结合位点时,人工蛋白A显得太小;人工蛋白A的两边都... 详细信息

人工蛋白A是为大规模生产中分离纯化抗体类药物而设计合成的。它已经表现出了一些比天然蛋白A更优越的性质,如稳定性更高等。但是,在计算机辅助分子模拟中发现,当人工蛋白A放在其抗体的结合位点时,人工蛋白A显得太小;人工蛋白A的两边都有一定空间,可能有一定的改善余地。分子模拟及其他实验结果都表明:在一定范围内,增加亲和配基的体积能够增加配基和抗体之间的亲和力;当亲和配基的体积超过这个程度时,增加亲和配基的体积反而降低了配基和抗体之间的亲和力。但人工蛋白A与抗体之间的结合专一性并不随亲和力的改变而变化。考虑到亲和层析对亲和力大小与结合专一性的要求,人工蛋白A仍然是设计和合成的亲和配基中最适合用于纯化抗体的。

关键词：亲和层析亲和配基分子设计分子识别分离纯化

来源： cnki会议评论

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World Journal of Methodology 2023年第5期13卷 492-501页

作者： Matt McFaul Chris Ventura Sean Evans Halil Dundar Marc J Rumpler christopher McCloskey Dave lowe Alexandre V Vlassov Department of Research and Development Thermo Fisher ScientificWest HillsCA 91304United States

BACKGROUND Exosomes are 30-150 nm nanovesicles with sophisticated nucleic acids cargo,actively secreted by all cells within human body,and found in abundance in all body fluids,including *** extracellular vesicles have tremendous potential for next generation diagnostics,theoretically enabling noninvasive assessment of organ and tissue function via liquid biopsy *** Recently,feasibility of an exosomal molecular test was demonstrated for postorgan transplant monitoring:Analysis of urine-derived exosomal mRNA cargo allowed early detection of kidney allograft ***,we further studied urine-derived exosomes and their mRNA content as a highly promising diagnostic *** included stability studies of urine samples and exosomal mRNA upon transportation from the point of collection to a centralized testing facility,short-term storage of urine at different conditions upon receipt till the point molecular assay is performed,and effects of various potentially interfering substances on the downstream quantitative polymerase chain reaction(qPCR)*** The urine specimens were stored at various conditions and pre-processed in different ***,samples were passed through the columns to capture all extracellular vesicles,the vesicles were lysed to release their content and the exosomal RNA was purified on the mini-columns,reverse transcription was performed,next pre-amplification,followed by a qPCR analysis for a panel of RESULTS To ensure exosomal RNA integrity,the harvested urine specimens should be shipped refrigerated,by overnight *** can next be stored at the test site for up to 1 wk at 4°C,and long term should be frozen at-80°*** specimens must be centrifuge at low G-force to deplete cells and debris,to ensure consistent top results in downstream molecular *** commonly used medications(tacrolimus,cyclosporin A,mycophenolic acid,everolimus,sirolimus,ascomycin,teriflunomide)were tested and confirmed that they do n

关键词： Kidney allograft Post-transplant monitoring Liquid biopsy Exosome mRNA Quantitative polymerase chain reaction

Heparin resistance in severe thermal injury:a prospective cohort study

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Burns & Trauma 2021年第1期9卷 157-169页

作者： Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian lowe christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison Scar Free Foundation Birmingham Centre for Burns Research University Hospitals Birmingham Foundation TrustQueen Elizabeth Hospital BirminghamMindelsohn WayBirminghamB152WBUK Department of Haematology University Hospitals Birmingham Foundation TrustMindelsohnWayBirminghamB152WBUK Institute of Inflammation and Ageing University of BirminghamBirminghamB152TTUK NIHR Surgical Reconstruction and Microbiology Research Centre University Hospitals Birmingham Foundation TrustMindelsohn WayBirminghamB152WBUK

Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for *** studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically *** hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa ***:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and *** anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were *** effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and ***:A total of 30 patients with severe burns were *** TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin *** levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the *** final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of ***:Heparin resistance is a prevalent issue in severe *** levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they ma

关键词： Burn Heparin resistance Low molecular-weight heparin Nucleosomes Neutrophil extracellular traps Factor-Xa Thrombosis Enoxaparin NETosis

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脑膜瘤对AV-1451的摄取研究

中华核医学与分子影像杂志 2018年第6期38卷 455-455页

作者：唐军 Tyler J.Bruinsma Derek R.Johnson Ping Fang Matthew Senjem Keith A.Josephs Jennifer L.Whitwell Bradley F.Boeve Mukesh K Pandey Kejal Kantarci David T.Jones Prashanthi Vemuri Melissa Murray Jonathan Graff-Radford christopher G.Schwarz David S.Knopman Ronald C.Petersen Clifford R.Jack Val J.lowe 上海交通大学医学院附属苏州九龙医院核医学科 Department of Radiology Mayo Clinic

目的 AV-1451是;F标记的正电子核素显像剂,;F-AV-1451可与成对螺旋丝状的tau蛋白（PHF-tau）结合,而tau蛋白与阿尔茨海默病的病理机制有关。对650例认知正常的对象进行AV-1451显像的过程中,偶然发现1例脑膜瘤患者的病灶可显著摄取AV-145... 详细信息

目的 AV-1451是;F标记的正电子核素显像剂,;F-AV-1451可与成对螺旋丝状的tau蛋白（PHF-tau）结合,而tau蛋白与阿尔茨海默病的病理机制有关。对650例认知正常的对象进行AV-1451显像的过程中,偶然发现1例脑膜瘤患者的病灶可显著摄取AV-1451。因此,对该650例研究对象进行回顾性分析,以总结其中的脑膜瘤患者病灶对AV-1451的摄取特点。方法经回顾性分析确诊,650例研究对象中有脑膜瘤患者12例,对其PET/CT显像和MRI图像重新读片,并对PET图像进行半定量分析。本底和肿瘤组织的标准摄取值（SUV）采用配对t检验进行统计分析,AV-1451的摄取与CT图像上钙化灶的出现的关系采用确切概率法进行分析。结果 12例脑膜瘤患者中,7例（58%）经视觉分析及计算肿瘤与正常皮质比值（T/N=1.90±0.83）均发现病灶对AV-1451的摄取高于本底。t检验提示本底和肿瘤组织的SUV差异无统计学意义,但在T/N大于1的患者中,其病灶对AV-1451的摄取增高差异有统计学意义（P=0.01）。AV-1451摄取增高与钙化灶的出现明显相关。结论使用AV-1451行PET显像时,应对PET和解剖影像学图像同时读片,以避免将脑膜瘤对AV-1451的摄取误读为PHF-tau蛋白的聚集。

关键词：脑膜瘤 AV-1451显像