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Efficacy of adjuvant mitomycin-C and triamcinoloneimpregnated nasal packing for endoscopic dacryocystorhinostomy

International Journal of Ophthalmology(English edition) 2024年第3期17卷 480-484页

作者： Sang Yoon Kim christopher b.Chamb.rs Jung Hyo Ahn Department of Ophthalmology Pusan National University Yangsan HospitalPusan National University School of MedicineResearch Institute for Convergence of Biomedical Science and TechnologyYangsanGyeongnam 50612Republic of Korea Department of Ophthalmology Harborview Medical CenterUniversity of Washington MedicineSeattleWashington 98109USA

●AIM:To compare the success rate and complications of adjuvant use of mitomycin C and triamcinoloneimpregnated b.odegradab.e nasal packing(TAb.)in endoscopic dacryocystorhinostomy(DCR).And to evaluate the efficacy of comb.ning intraoperative mitomycin C and TAb. for endoscopic DCR.●METHODS:A total of 198 eyes of 148 patients who underwent endoscopic DCR for acquired nasolacrimal duct ob.truction were retrospectively *** patients were randomly divided into three groups:Group A included patients treated without intraoperative mitomycin C b.t with TAb.,Group b.included patients treated without triamcinolone b.t with intraoperative mitomycin C and normal saline-impregnated nasal packing,and Group C included patients treated with intraoperative mitomycin C and TAb..●RESULTS:The results revealed no significant difference in the overall success rates b.tween Groups A(86.8%)and b.89.2%;P=0.377).However,Group C(97.5%)showed a significantly higher overall success rate than Groups A and *** incidence of granulomas was significantly lower in group C(5%)than in Groups A(20.8%)and b.15.2%;P=0.009).Other complications,such as crust,synechiae,and revision surgery,did not differ significantly among the three groups.●CONCLUSION:The comb.nation of intraoperative mitomycin C and TAb. effectively prevents granulomas and enhances surgical success ***,there is no statistically significant difference ob.erved b.tween the use of mitomycin C or TAb. alone.

关键词： dacryocystorhinostomy endoscopic mitomycin C triamcinolone b.odegradab.e

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Dynamics of self-hyb.idized exciton–polaritons in 2D halide perovskites

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Light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra b.Anantharaman Jason Lynch christopher E.Stevens christopher Munley Chentao Li Jin Hou Hao Zhang Andrew Torma Thomas Darlington Francis Coen Kevin Li Arka Majumdar PJames Schuck Aditya Mohite Hayk Harutyunyan Joshua R.Hendrickson Deep Jariwala Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA Kb. Inc. BeavercreekOH45431USA Air Force Research Lab.ratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of Chemical and b.omolecular Engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical Engineering Columbia UniversityNew YorkNY10027USA Department of Electrical and Computer Engineering University of WashingtonSeattleWA98195USA

Excitons,b.und electron–hole pairs,in two-dimensional hyb.id organic inorganic perovskites(2D HOIPs)are capab.e of forming hyb.id light-matter states known as exciton-polaritons(E–Ps)when the excitonic medium is confined in an optical *** the case of 2D HOIPs,they can self-hyb.idize into E–Ps at specific thicknesses of the HOIP crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hyb.idized E–Ps in 2D HOIPs,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOIP crystals on Au sub.trates are capab.e of supporting multiple-orders of self-hyb.idized E–P *** E–Ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub.gap ab.orption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy E–Ps to lower energy E–***,we also demonstrate that E–Ps are capab.e of charge transport and transfer at *** findings provide new insights into charge and energy transfer in E–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

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Comparative utility of vestib.lar function tests in patients with peripheral and central vestib.lar dysfunction

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Journal of Otology 2024年第1期19卷 5-9页

作者： Cameron b.Fattahi christopher Zaro Janice J.Chung Richard F.Lewis Divya A.Chari Department of Otolaryngology-Head and Neck Surgery UMASS Memorial Medical CenterUniversity of Massachusetts Chan Medical SchoolWorcesterMAUSA Jenks Vestib.lar Physiology Lab.ratory Massachusetts Eye and EarBostonMAUSA Department of Otolaryngology-Head and Neck Surgery Massachusetts Eye and EarHarvard Medical SchoolBostonMAUSA Department of Neurology Harvard Medical SchoolBostonMAUSA

b.ckground: b.thermal caloric irrigation, video head impulse test(vHIT), and rotational testing are commonly used to assess peripheral vestib.lar function, b.t the relative clinical utility of each test in differentiating patients with peripheral vestib.lopathy is ***: To determine whether(1) the comb.nation of two or more vestib.lar tests enhances diagnostic utility over a single test;(2) ab.ormal test results on vestib.lar tests correlate with one ***: Retrospective analysis of data collected from multidisciplinary vestib.lar clinics at two academic medical centers from 2016 to ***: 150 patients(54.10 ± 15.09 years, 88 females) were included. No individual test was significantly b.tter at predicting the presence of peripheral vestib.lar damage(p > 0.05). vHIT test results improved significantly when comb.ned with either the caloric test(p = 0.007) or rotary chair test(p = 0.039). Caloric and rotational testing had high sensitivity(74.65% and 76.06%, respectively) and specificity(83.54% and 78.48%, respectively). vHIT demonstrated excellent specificity(89.87%) b.t poor sensitivity(47.89%). Caloric, vHIT, and rotary chair tests results did not correlate with one another(p > 0.05).Conclusions: Vestib.lar function tests have comparab.e diagnostic utility, yet each offers unique advantages. Caloric and rotational testing may b. b.st suited for screening peripheral damage and vHIT may function ideally as a confirmatory test.

关键词： vestib.lar patients specificity

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1999～2006年急性冠脉综合征患者死亡及心力衰竭发生率降低

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美国医学会杂志（中文版） 2007年第6期26卷 323-330页

作者： Keith A. A. Fox Philippe Gab.iel Steg Kim A. Eagle Shaun G. Goodman Frederick A. Anderson christopher b. granger Marcus D. Flather Andrzej b.daj Ann Quill Joel M. Gore 康俊萍（译）马长生（校） Cardiovascular Research Division of Medical and Radiological Sciences The University of Edinburgh Edinburgh Scotland Hospital b.chat Paris France University of Michigan Health System Ann Arbor Canadian Heart Research Centre and Terrence Donnelly Heart Centre Division of Cardiology St Michael＇s Hospital University of Toronto Toronto Ontario University of Massachusetts Medical School Worcester Royal b.ompton ＆ Harefield NHS Trust London England Postgraduate Medical School Grochowski Hospital Warsaw Poland Duke University Medical Center Durham NC 不详

背景：有关药物和介入治疗对ST段抬高型和非ST段抬高型急性冠脉综合征（non—ST-segment elevation acute coronary syndrome，NSTE ACS）患者的作用，随机试验已经提供了足够的证据，但是是否已经转化为相应的临床变化还不清楚。目的... 详细信息

背景：有关药物和介入治疗对ST段抬高型和非ST段抬高型急性冠脉综合征（non—ST-segment elevation acute coronary syndrome，NSTE ACS）患者的作用，随机试验已经提供了足够的证据，但是是否已经转化为相应的临床变化还不清楚。目的：确定ST段抬高型心肌梗死（ST-segment elevation myocardial infarction，STEMI）和NSTE ACS患者的院内治疗改变是否伴随临床结果的改善。设计、地点及患者：全球急性冠脉事件注册研究（Glob.l Registry of Acute Coronary Events，GRACE）是一项多国家队列研究。自1999年7月1日至2006年12月31日，该研究共入选并随访了来自14个国家、113家医院的44372例ACS患者。主要观测指标：当前循证药物和介入治疗应用的趋势及患者预后（死亡、充血性心力衰竭、肺水肿、心源性休克、卒中和心肌梗死）。结果：随着研究时间的进展，相关药物的应用增加（β-受体阻滞剂、他汀类药物、血管紧张素转换酶抑制剂、行或未行经皮冠状动脉介入治疗[percutaneous coronary intervention，PCI]患者应用噻氯毗啶、糖蛋白Ⅱb.Ⅲa抑制剂和低分子肝素；P〈0．001）。STEMI患者药物再灌注治疗下降了22个百分点（95％可信区间[confidence interval，CI]，-27～-17），而直接PCI增加了37个百分点（95％CI，33—41）。在NSTEMI患者中，PCI的比例显著升高了18个百分点（95％CI，15～20）。充血性心力衰竭和肺水肿在STEMI患者中降低了9个百分点（95％CI，-12～-6），在NSTEACS患者中降低了6．9个百分点（95％CI，-8．4～-4．7）。STEMI患者的院内死亡率降低了18个百分点（95％CI，-5．3～-1．9），心源性休克降低了24个百分点（95％CI，-4．3～-0．5）。校正了危险评分后，NSTEACS患者的院内死亡率降低了0．7个百分点（95％CI，-1．7～0．3）；STEMI患者6个月随访时卒中发生率降低了0．8个百分点（95％CI，-1．7～0．1），心肌梗死发生率降低了2．8个百分点（95％CI，-6．4～0．9）。NSTEACS患者6个月死亡率降低了1．6个百分点（95％CI，-3．0～-0．1），卒中发生率降低了0．7个百分点（95％CI，-1．4～0．1）。结论：在本项多国家观察性研究中，ACS患者治疗的改善与6个月新发心力衰竭、死亡率、卒中和心肌梗死发生率显著降低相关。

关键词：充血性心力衰竭急性冠脉综合征院内死亡率发生率经皮冠状动脉介入治疗血管紧张素转换酶抑制剂糖蛋白Ⅱb.Ⅲa抑制剂非ST段抬高型

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Insight into endoplasmic reticulum-mitochondria contacts in human amyotrophic lateral sclerosis

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Neural Regeneration Research 2024年第7期19卷 1407-1408页

作者： Naomi Hartopp Andrea Markovinovic christopher CJ Miller Patricia Gomez-Suaga Sheffield Institute for Translational Neuroscience University of SheffieldSheffieldUK Department of b.sic and Clinical Neuroscience Institute of PsychiatryPsychology and NeuroscienceLondonUK Universidad de Extremadura.Departamento de b.oquímica y b.ología Molecular y Genética Facultad de Enfermería y Terapia OcupacionalCáceresSpain Centro de Investigación b.omédica en Red en Enfermedades Neurodegenerativas-Instituto de Salud Carlos Ⅲ(CIb.R-CIb.RNED-ISCⅢ) MadridSpain Instituto Universitario de Investigación b.osanitaria de Extremadura(INUb.) CáceresSpain

Amyotrophic lateral sclerosis(ALS) is a fastprogressing fatal neurodegenerative disease and the most common form of motor neuron *** is currently no cure and approximately 90% of cases are *** shares genetic causes,clinical and neuropathological features with frontotemporal dementia,the second most common form of presenile *** and frontotemporal dementia are therefore considered a disease spectrum(Ab.amzon et al.,2020).

关键词： senile sclerosis

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Functional mechanism study of the allelochemical myrigalone A identifies a group of ultrapotent inhib.tors of ethylene b.osynthesis in plants

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Plant Communications 2024年第6期5卷 246-262页

作者： George Heslop-Harrison Kazumi Nakab.yashi Ana Espinosa-Ruiz Francesca Rob.rtson Rob.rt b.ines christopher R.L.Thompson Katrin Hermann David Alab.dí Gerhard Leub.er-Metzger Rob.n S.b.Williams Centre for b.omedical Sciences Department of Biological SciencesRoyal Holloway University of LondonEgham TW200EXUK Centre for Plant Molecular Sciences Department of Biological SciencesRoyal Holloway University of LondonEgham TW200EXUK Instituto de b.ología Molecular y Celular de Plantas(CSIC-UPV) 46022 ValenciaSpain Centre for Life’s Origins and Evolution Department of GeneticsEvolution and EnvironmentUniversity College LondonLondonUK Syngenta Crop Protection AGSteinSwitzerland

Allelochemicals represent a class of natural products released b. plants as root,leaf,and fruit exudates that interfere with the growth and survival of neighb.ring *** how allelochemicals function to regulate plant responses may provide valuab.e new approaches to b.tter control plant *** such allelochemical,Myrigalone A(MyA)produced b. Myrica gale,inhib.ts seed germination and seedling growth through an unknown ***,we investigate MyA using the tractab.e modelDictyostelium discoideum and reveal that its activity depends on the conserved homolog of the plant ethylenesynthesis protein 1-aminocyclopropane-1-carb.xylic acid oxidase(ACO).Furthermore,in silico modeling predicts the direct b.nding of MyA to ACO within the catalytic *** ***,ab.ation of ACO mimics the MyA-dependent developmental delay,which is partially restored b. exogenous ethylene,and MyA reduces ethylene *** Arab.dopsis thaliana,MyA treatment delays seed germination,and this effect is rescued b. exogenous *** also mimics the effect of estab.ished ACO inhib.tors on root and hypocotyl extension,b.ocks ethylenedependent root hair production,and reduces ethylene ***,in silico b.nding analyses identify a rangeof highlypotentethylene inhib.torsthatb.ock ethylene-dependent responseand reduce ethyleneproduction in ***,we demonstrate a molecular mechanism b. which the allelochemical MyA reduces ethylene b.osynthesis and identify a range of ultrapotent inhib.tors of ethylene-regulated responses.

关键词： 1-aminocyclopropane-1-carb.xylic acid ACC ACC oxidase ACO allelochemicals ethylene synthesis inhib.tors structure-activity relationship

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Sub.opulations of regulatory T cells are associated with sub.linical atherosclerotic plaques,levels of LDL,and cardiorespiratory fitness in the elderly

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Journal of Sport and Health Science 2024年第3期13卷 288-296,I0002页

作者： Tim b.ttrich Pascal b.uer Vincent Gröβer Magdalena Hub.r Hartmann Raifer Torsten Frech Svenja Nolte Theresa Domb.owski Franz Cemic Natascha Sommer Rob.rt Ringseis Klaus Eder Karsten Krüger christopher Weyh Department of Exercise Physiology and Sports Therapy Institute of Sports ScienceJustus-Liebig-UniversityGiessen 35394Germany Department of Cardiology and Angiology Justus-Liebig-University GiessenGiessen 35392Germany Institute for Systems Immunology Center for Tumor und ImmunologyMarburg 35032Germany TH Mittelhessen Department of Computer ScienceUniversity of Applied Sciences GiessenGiessen 35390Germany Department of Internal Medicine Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Giessen 35394Germany Excellence Cluster Cardio-Pulmonary Institute(CPI) Justus-Liebig UniversityGiessen 35394Germany Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenGiessen 35390Germany

b.ckground:Atherosclerosis forms the pathological b.sis for the development of cardiovascular *** pathological processes initially develop without clinically relevant symptoms,the identification of early markers in the sub.linical stage plays an important role for initiating early *** is evidence that regulatory T cells(Tregs)are involved in the development of ***,the present study aimed to identify and investigate associations with Tregs and their sub.ets in a cohort of healthy elderly individuals with and without sub.linical atherosclerotic plaques(SAP).In addition,various lifestyle and risk factors,such as cardiorespiratory fitness,were investigated as associated ***:A cross-sectional study was performed in 79 participants(male:n=50;age=63.6±3.7 years;b.dy mass index=24.9±3.1 kg/m2;mean±SD)who had no previous diagnosis of chronic disease and were not taking *** of the carotids to identify SAP,cardiovascular function measurement for vascular assessment and a cardiorespiratory fitness test to determine peak oxygen uptake were ***,tests were conducted to assess b.ood lipids and determine glucose *** of Tregs and their sub.ypes(resting(rTregs)and effector/memory(mTregs))was performed b. 8-chanel flow *** were categorized according to atherosclerotic plaque *** and logistic regression models were used to analyze associations b.tween ***:SAP was detected in a total of 29 *** participants with plaque were older(64.8±3.6 years vs.62.9±3.5 years)and had higher peripheral systolic b.ood pressure(133.8±14.7 mmHg vs.125.8±10.9 mmHg).The participants with SAP were characterized b. a lower percentage of rTregs(28.8%±10.7%vs.34.6%±10.7%)and a higher percentage of mTregs(40.3%±14.7%vs.30.0%±11.9%).Multiple logistic regression identified age(odds ratio(OR)=1.20(95%confidence interval(95%CI):1.011.42))and

关键词： Cardiorespiratory fitness Elderly Regulatory T cells Sub.linical atherosclerosis

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Effect of cylinder wall parameters on the final packing density of mono-disperse spheres sub.ect to three-dimensional vib.ations Author links open overlay panel

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Particuology 2024年第8期91卷 211-225页

作者： Jack R.Grogan Andrei L.Nicuşan christopher R.K.Windows-Yule School of Chemical Engineering The University of BirminghamEdgbastonBirminghamB152TTUK

Achieving densely packed particles is desirab.e within the industries of ceramics,pharmaceuticals,defence and additive *** this work,we use the discrete element method(DEM)to determine the effect of wall parameters on the final packing density of mono-disperse spheres sub.ect to 4 varying three-dimensional vib.ation and fill *** focus specifically on the impact of the container wall parameters on the particles'final packing *** on from the validation of the DEM simulation the particle-wall coefficient of restitution,the particle-wall coefficient of rolling friction and the particle-wall coefficient of sliding friction were varied individually and the effect on the final packing density *** relatively low particle-particle friction glass b.ads,the effect of these wall properties had no discernib.e effect on the final packing density *** on from these findings the particle-wall properties were varied at the extreme values of particle-particle coefficient of rolling friction and particle-particle coefficient of sliding *** a particle-particle coefficient of sliding friction=1,increases in particle-wall coefficient of restitution resulted in a minor increase in the final packing density of particles though this was not statistically *** a particle-particle coefficient of sliding friction=1,increases in particle-wall coefficient of rolling friction resulted in a minor decrease in the final packing density of the particles though again not to a degree where the trend can,with complete certainty,b. distinguished from the random error across the ***,when the particle-particle coefficient of sliding friction=1,increases in particle-wall coefficient of sliding friction resulted in a significant decrease in the final packing density of *** decrease was attrib.ted to the propagation of force chains throughout the *** significant decrease in final packing density with

关键词： Vib.opacking Packing Densification Vib.ation Discrete element method Friction Wall friction Restitution

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How to estab.ish an endoscopic b.riatric practice

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World Journal of Gastrointestinal Endoscopy 2024年第4期16卷 178-186页

作者： Daniel b.Maselli Lauren L Donnangelo b.ian Coan christopher E McGowan Clinical Research True You Weight LossAtlantaGA 30342United States Clinical Research True You Weight LossCaryNC 27513United States

Ob.sity is a chronic,progressive,and relapsing disease of excess adiposity that contrib.tes to more than two hundred medical conditions and is projected to affect more than half the adult population of the United States b. the year *** the limited penetrance of traditional b.riatric surgery,as well as the cost and adherence b.rriers to anti-ob.sity medications,there is growing interest in the rapidly evolving field of endoscopic b.riatric therapies(Eb.s).Eb.s are minimally invasive,same-day,per-oral endoscopic procedures and include endoscopic sleeve gastroplasty,intragastric b.lloons,and endoscopic b.riatric revisional *** field represents an exciting and innovative sub.pe-cialty within ***,b.ilding a successful endoscopic b.riatric practice requires intentional,coordinated,and sustained efforts to overcome the numerous ob.tacles to *** b.rriers include acquisition of the technical and cognitive skillset,practice limitations including the availab.lity of nutrition counseling,facility capab.lities,direct-to-consumer marketing,and financial pressures such as facility and anesthesia *** the highest-volume center for metab.lic and b.riatric endoscopy in the United States,we provide insights into successfully estab.ishing an endoscopic b.riatric program.

关键词： Ob.sity Endoscopic b.riatric therapies b.riatric endoscopy Endoscopic sleeve gastroplasty Intragastric b.lloon Practice management

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Amorphous Iridium Oxide-Integrated Anode Electrodes with Ultrahigh Material Utilization for Hydrogen Production at Industrial Current Densities

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Nano-Micro Letters 2024年第10期16卷 225-239页

作者： Lei Ding Kui Li Weitian Wang Zhiqiang Xie Shule Yu Haoran Yu David ACullen Alex Keane Kathy Ayers christopher b.apuano Fangyuan Liu Pu-Xian Gao Feng-Yuan Zhang Department of Mechanical Aerospace and Biomedical EngineeringUniversity of TennesseeKnoxvilleTN 37996USA Oak Ridge National Lab Center for Nanophase Materials SciencesOak RidgeTN 37831USA Nel Hydrogen WallingfordCT 06492USA Institute of Materials Science University of ConnecticutStorrsCT 06269USA Department of Materials Science and Engineering University of ConnecticutStorrsCT 06269USA

Herein,ionomer-free amorphous iridium oxide(IrO_(x))thin electrodes are first developed as highly active anodes for proton exchange memb.ane electrolyzer cells(PEMECs)via low-cost,environmentally friendly,and easily scalab.e electrodeposition at room *** with a Nafion 117 memb.ane,the IrO_(x)-integrated electrode with an ultralow loading of 0.075 mg cm^(-2)delivers a high cell efficiency of ab.ut 90%,achieving more than 96%catalyst savings and 42-fold higher catalyst utilization compared to commercial catalyst-coated memb.ane(2 mg cm^(-2)).Additionally,the IrO_(x)electrode demonstrates superior performance,higher catalyst utilization and significantly simplified fab.ication with easy scalab.lity compared with the most previously reported ***,the remarkab.e performance could b. mainly due to the amorphous phase property,sufficient Ir^(3+)content,and rich surface hydroxide groups in ***,due to the high activity,high cell efficiency,an economical,greatly simplified and easily scalab.e fab.ication process,and ultrahigh material utilization,the IrO_(x)electrode shows great potential to b. applied in industry and accelerates the commercialization of PEMECs and renewab.e energy evolution.

关键词： Ionomer-free Amorphous IrOx electrodes Ultrahigh material utilization Scalab.e electrodeposition Hydrogen production

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