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Using Linear and Non-Linear Techniques to Characterize Gait Coordination Patterns of Two Individuals with NGLY1 Deficiency

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Case Reports in Clinical Medicine 2024年第9期13卷 391-409页

作者： Charles S. Layne Dacia Martinez Diaz christopher A. Malaya Brock Futrell Christian Alfaro Hannah E. Gustafson Bernhard Suter Department of Health and Human Performance University of Houston Houston TX USA Center for Neuromotor and Biomechanics Research University of Houston Houston TX USA Center for Neuro Engineering and Cognitive Science University of Houston Houston TX USA Research Center Parker University Dallas TX USA Blue Bird Circle Rett Center Texas Childrens Hospital Houston TX USA Baylor College of Medicine Houston TX USA

Individuals with NGLY1 Deficiency, an inherited autosomal recessive disorder, exhibit hyperkinetic movements including athetoid, myoclonic, dysmetric, and dystonic movements impacting both upper and lower limb motion. This report provides the first set of laboratory-based measures characterizing the gait patterns of two individuals with NGLY1 Deficiency, using both linear and non-linear measures, during treadmill walking, and compares them to neurotypical controls. Lower limb kinematics were obtained with a camera-based motion analysis system and bilateral time normalized lower limb joint time series waveforms were developed. Linear measures of joint range of motion, stride times and peak angular velocity were obtained, and confidence intervals were used to determine if there were differences between the patients and control. Correlations between participant and control mean joint waveforms were calculated and used to evaluate the similarities between patients and controls. Non-linear measures included: joint angle-angle diagrams, phase-portrait areas, and continuous relative phase (CRP) measures. These measures were used to assess joint coordination and control features of the lower limb motion. Participants displayed high correlations with their control counterparts for the hip and knee joint waveforms, but joint motion was restricted. Peak angular velocities were also significantly less than those of the controls. Both angle-angle and phase-portrait areas were less than the controls although the general shapes of those diagrams were similar to those of the controls. The NGLY1 Deficient participants’ CRP measures displayed disrupted coordination patterns with the knee-ankle patterns displaying more disruption than the hip-knee measures. Overall, the participants displayed a functional walking pattern that differed in many quantitative ways from those of the neurotypical controls. Using both linear and non-linear measures to characterize gait provides a more compre

关键词： NGLY1 Gait Disability Kinematics Angle-Angle Diagrams Phase Portraits

Multi-Elemental Analysis and 2D Image Mapping within Roots, Leaves and Seeds from O. glaberrima Rice Plants Using Micro-PIXE Technique

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World Journal of Nuclear Science and Technology 2024年第2期14卷 97-106页

作者： Alassane Traore Anna Ndiaye christopher Bongani Mtshali Manneh Baboucarr Jean Paul Latyr Faye Daouda Mbodj Kandiaba Traore Tapha Gueye Ababacar Sadikhe Ndao Département de Physique Faculté des Sciences et Techniques Université Cheikh Anta Diop Dakar Senegal Département de Chimie Faculté des Sciences et Techniques Université Cheikh Anta Diop Dakar Senegal Tandetron Laboratory IBA Group iThemba LABS Cape Town South Africa Africa Rice Center St. Louis Senegal

Understanding metal accumulation at organ level in roots, leaves and seeds in O. glaberrima (OG) is crucial for improving physiological and metabolic aspects in growing Asian and African rice in salted areas. The micro-analytical imaging techniques are required to reveal its accumulation and distribution within plant tissues. PIXE studies have been performed to determine different elements in rice plants. The existing microbeam analytical technique at the iThemba LABS will be applied for the 2D image mapping of fresh rice tissues to perform a concentration of low atomic mass elements (such as Al, Si, P, S, Cl, Ca, Ti, Mn, Fe, Cu, Br, Zn and K) with detection limits of typically 1-10 μg/g. Comparison of the distribution of the elements between leaves, root and seed samples using uptake and distribution of elements in particular environmental conditions with potential amount of salt in water have been performed. We are also expecting to indicate metal exclusion as salt tolerance strategies from leaves, root, and seed compartments using matrix correlation between samples and between elements on rice species.

关键词： PIXE 2D Mapping Rice Concentration Elemental Analysis

Assessing the Efficacy of Wheat-Soybean Based Intercropping System at Different Plant Densities in Bambili, Cameroon

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American Journal of Plant Sciences 2024年第4期15卷 235-251页

作者： Lendzemo E. Tatah Jeazet K. Teitiogo Oben Tom Tabi Tange D. Achiri Njualem D. Khumbah Chi christopher Tamu Department of Crop Production Technology College of Technology University of Bamenda Bambili Cameroon Department of Agronomic and Applied Molecular Sciences Faculty of Agriculture and Veterinary Medicine University of Buea Buea Cameroon School of Tropical Agriculture and Natural Resource Catholic University of Cameroon Bamenda Cameroon Department of Agricultural and Environmental Engineering College of Technology University of Bamenda Bambili Cameroon

Wheat is one of the most important cereals in the world, serving as a staple for millions globally. In the wake of the geopolitical crisis between Russia and Ukraine, it has become incumbent for many countries to invest in wheat production. Improving cropping systems for wheat production is paramount. Intercropping cereals with legumes has tremendous advantages. Therefore, this study was designed to optimize wheat production by intercropping it with soybean at different densities. Between March and August 2023, a randomized complete block design trial was conducted in Bambili, North West of Cameroon with treatments T1 (wheat monocrop at 200,000 plants ha−1), T2 (soybean monocrop at 250,000 plants ha−1), T3 (200,000 wheat and 125,000 soybean ha−1), T4 (100,000 wheat and 250,000 soybean ha−1), T5 (200,000 wheat and 250,000 soybean ha−1) and T6 (100,000 wheat and 125,000 soybean ha−1). Results revealed that growth parameters of wheat were not significantly influenced by monocrop or intercrop. The yield of wheat was significantly higher in the monocrop than the intercrop treatments, with slight variation amongst the intercrop treatments. Soybean yield was higher in the monocrop than in the intercrop, with no variations amongst the intercrop treatments. Only the land equivalence ratio (LER) for T5 was greater than 1.0. The competitive ratio for T5 was 0.54 for wheat and 1.90 for soybean, comparatively lower than the other monocrop treatments. Intercropping wheat and soybean at 200,000:250,000 ratio is recommended.

关键词： Competitive Ration Land Equivalence Ration Intercrop Soybean Wheat

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克里斯多夫·勒·布伦:真相即感知

青年视觉 2024年第3期 148-159页

作者： dawenwen christopher Le Brun(图) 里森画廊(图) 不详

日前,英国艺术家克里斯多夫,勒:布伦(christopher Le Brun)在里森画廊北京空间举办了全新个展「月相」。作为英国当代著名的画家、版画家和雕塑家,克里斯多夫,勒:布伦以其独特的艺术风格和深刻的哲学思考,赢得了国际艺术界的认可。VISIO... 详细信息

日前,英国艺术家克里斯多夫,勒:布伦(christopher Le Brun)在里森画廊北京空间举办了全新个展「月相」。作为英国当代著名的画家、版画家和雕塑家,克里斯多夫,勒:布伦以其独特的艺术风格和深刻的哲学思考,赢得了国际艺术界的认可。VISION也借助此次展览的机会,对克里斯多夫·勒·布伦进行了专访。

关键词：布伦雕塑家艺术风格哲学思考

Protecting miners from coal bursts during development above historic mine workings in Harlan County,KY

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International Journal of Mining Science and Technology 2021年第1期31卷 111-116页

作者： christopher Mark Mine Safety and Health Administration PittsburghPA 15236USA

In order to reach a large,untapped reserve of high-quality coal,D8 Cloverlick Mine proposed to mine a corridor nearly 600 m deep beneath the Benham Spur of Black Mountain,Kentucky’s highest peak.D8 Cloverlick Mine was extracting the Owl seam,but the corridor’s route lay approximately 20 m above century-old mine workings in the C–(Darby)*** to the concern,three serious coal bursts had recently occurred in nearby Owl seam *** of the old workings seemed to indicate that the underlying C–seam had been fully ***,two of the coal bursts had occurred above areas where the C–Seam was also shown as mined *** Safety and Health Administration(MSHA)Technical Support therefore investigated the records of past mining to better understand the old mine *** conditions observed in current Owl seam workings were also compared with the maps of the old C–seam *** study concluded that the presence of hazardous underlying remnants could not be ruled *** mitigate the burst risk,D8 Cloverlick Mine adopted a strategy of stress probe drilling.A self-propelled coal drill was used to auger 11.5-m-long,small diameter holes in advance of *** each hole was drilled,the cuttings were measured to detect the presence of highly stressed *** the crossing was successfully completed without incident.

关键词： Coal bursts Underground mining Room-and-pillar Destressing

Acquisition of epithelial plasticity in human chronic liver disease

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四川生理科学杂志 2024年第5期46卷 1143-1143页

作者： christopher Gribben 不详

For many adult human organs,tissue regeneration during chronic disease remains a controversial *** processes are easily observed in animal models,and their underlying mechanisms are becoming well characterized1-4,but technical challenges and ethical aspects are limiting the validation of these results in *** decided to address this difficulty with respect to the *** organ displays the remarkable ability to regenerate after acute injury,although liver regeneration in the context of recurring injury remains to be fully *** we performed single-nucleus RNA sequencing(snRNA-seq)on 47 liver biopsies from patients with different stages of metabolic dysfunction-associated steatotic liver disease to establish a cellular map of the liver during disease *** then combined these single-cell-level data with advanced 3D imaging to reveal profound changes in the liver architecture.

关键词： organs becoming limiting

An updated empirical model for ground control in *** coal mines

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International Journal of Mining Science and Technology 2021年第2期31卷 163-174页

作者： christopher Mark Mine Safety and Health Administration PittsburghPA 15217USA

Multiple seam interactions are a major source of ground instability in several *** methods are well suited for this problem,because while the mechanics multiple seam interactions are very complex and poorly understood,many mining case histories are available for *** study makes use of an updated database that includes 356 multiseam case histories,including 67 unsuccessful *** paper describes in detail the process used to design the study,collect the data,conduct the statistical analysis,and develop the quantitative *** model can be used for mine planning in multiple seam situations,and has been made available as a module within the Analysis of Coal Pillar Stability(ACPS)computer program.

关键词： Underground Coal Multiseam Ground control Pillar design Empirical

Quantifying Kinematic Tremor in an NGLY1-Deficient Individual: A Case Study

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Case Reports in Clinical Medicine 2024年第1期13卷 25-36页

作者： Brock Futrell christopher Alexander Malaya Dacia Martinez Diaz Christian Alfaro Hannah Elizabeth Gustafson Subhalakshmi Chandrasekaran Rhea Mohan Phatak Bernhard Suter Charles Shannon Layne Department of Health and Human Performance University of Houston Houston USA Center for Neuromotor and Biomechanics Research University of Houston Houston USA Department of Computer Science and Engineering Texas A&M University College Station USA Blue Bird Circle Rett Center Texas Children’s Hospital Houston USA Baylor College of Medicine Houston USA Center for NeuroEngineering and Cognitive Science University of Houston Houston USA

NGLY1 Deficiency is an autosomal recessive congenital disorder that has been identified in less than 100 individuals. Most individuals with NGLY1 Deficiency display hyperkinetic movement disorders, including choreiform, athetoid, dystonic myoclonic, dyskinetic, and dysmetric movements. Developing a consistent and concise consensus on the classification and evaluation of tremors is essential to forward the research and treatment of tremors. It has also been reported that some individuals with NGLY1 Deficiency demonstrate tremor, but such tremor has never been formally investigated. The primary objective of this study is to determine if an individual with NGLY1 Deficiency demonstrates an identifiable tremor during a series of arm movements and, if so, describe the frequency and power characteristics of that tremor. Arm movement kinematics were obtained using a 16-camera Vicon system, and time series trajectory waveforms for three planes of a marker placed on the hand were developed. Custom MATLAB scripts were utilized to compute Fast Fourier Transformations of the data within the identified waveform segments. A mean frequency of 2.30 Hz (SD = 1.05) with a mean power of 5.02 |P1(f)| (SD = 4.63) suggests that our participant’s kinematic data did display a persistent tremor in both hands across all tasks and movement planes. Analyses of the reaching hand and the non-reaching hand suggest the participant displayed an action tremor in both postural and intention (kinetic) tremors. Future directions should include assessing additional individuals with NGLY1 Deficiency to determine if the tremor is a distinguishable disorder behavior. Additionally, evaluating other anatomical sites, such as the elbow, head, and lower limbs, would provide further insights into the characteristics of this tremor.

关键词： Tremor NGLY Fast Fourier Transformation Reaching Hyperkinetic Movement

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地表-地下过程耦合的数值水文模型综述

中国科学：地球科学 2024年第5期54卷 1484-1505页

作者：舒乐乐陈昊孟宪红常燕胡立堂王文科束龙仓俞烜 christopher DUFFY 姚莹莹郑东海中国科学院西北生态环境资源研究院冰冻圈科学与冻土工程重点实验室兰州730000 北京师范大学水科学研究院北京100875 长安大学水利与环境学院西安710054 河海大学水文水资源学院南京210098 中国科学院南京土壤研究所土壤与农业可持续发展国家重点实验室南京210008 Pennsylvania State University State CollegePA 16801USA 西安交通大学地球环境科学系西安710054 中国科学院青藏高原研究所北京100101

水文模型是利用数学公式对水文循环过程的描述,是理解自然界水的时空运动和分布规律的重要工具;它不仅可以利用观测数据来验证理论的可靠性与适宜性,还能预测水文变量未来趋势,实现理解自然与预测自然的目的.随着计算方法的快速发展、... 详细信息

水文模型是利用数学公式对水文循环过程的描述,是理解自然界水的时空运动和分布规律的重要工具;它不仅可以利用观测数据来验证理论的可靠性与适宜性,还能预测水文变量未来趋势,实现理解自然与预测自然的目的.随着计算方法的快速发展、观测与试验手段的持续更新,目前基于物理过程的地表-地下过程耦合的数值水文模型快速发展.这种模型以微观尺度的守恒原理和物理公式为基础,利用数值方法将地表和地下水流进行耦合计算,从而模拟流域尺度水文响应过程.由于其物理过程明确、时空分辨率高且利于学科耦合,数值水文模型已成为水文模型发展的前沿和主流方向之一.本文阐述了地表-地下过程耦合数值水文模型的理论基础,从模型框架、数值求解方法、空间表达和耦合算法等方面对比和分析了当前主流数值水文模型,同时与传统水文模型比较,厘清了数值水文模型的优劣势,探讨了未来数值水文模型发展的方向.

关键词：数值水文模型地表-地下过程耦合数值方法水文模型