Acquisition of epithelial plasticity in human chronic liver disease
作者机构：不详
出 版 物：《四川生理科学杂志》 (Sichuan Journal of Physiological Sciences)
年 卷 期：2024年第46卷第5期
页 面：1143-1143页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
摘 要：For many adult human organs,tissue regeneration during chronic disease remains a controversial *** processes are easily observed in animal models,and their underlying mechanisms are becoming well characterized1-4,but technical challenges and ethical aspects are limiting the validation of these results in *** decided to address this difficulty with respect to the *** organ displays the remarkable ability to regenerate after acute injury,although liver regeneration in the context of recurring injury remains to be fully *** we performed single-nucleus RNA sequencing(snRNA-seq)on 47 liver biopsies from patients with different stages of metabolic dysfunction-associated steatotic liver disease to establish a cellular map of the liver during disease *** then combined these single-cell-level data with advanced 3D imaging to reveal profound changes in the liver architecture.
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