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Rapid metabolic fingerprinting with the aid of chemometric models to identify authenticity of natural medicines: turmeric, Ocimum, and Withania somnifera study

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Journal of Pharmaceutical Analysis 2023年第9期13卷 1041-1057页

作者： Samreen Khan Abhishek Kumar Rai Anjali Singh Saudan Singh Basant Kumar Dubey Raj Kishori Lal Arvind Singh Negi Nicholas Birse Prabodh Kumar trivedi christopher t.elliott Ratnasekhar Ch Metabolomics Lab Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Department of Crop Production&Protection Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Academy of Council of Scientific and Industrial Research(ACSIR) Ghaziabad201002India Department of Biotechnology Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Genetics and Plant Breeding Department Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Department of Phytochemistry Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India School of Biological Sciences Queen's UniversityBelfastBT95DLUK

Herbal medicines are popular natural medicines that have been used for *** use of alternative medicines continues to expand rapidly across the *** World Health Organization suggests that quality assessment of natural medicines is essential for any therapeutic or health care applications,as their therapeutic potential varies between different geographic origins,plant species,and *** of herbal medicines based on a limited number of secondary metabolites is not an ideal *** quality should be considered based on a complete metabolic profile,as their pharmacological activity is not due to a few specific secondary metabolites but rather a larger group of bioactive compounds.A holistic and integrative approach using rapid and nondestructive analytical strategies for the screening of herbal medicines is required for robust *** this study,a rapid and effective quality assessment system for geographical traceability,species,and variety-specific authenticity of the widely used natural medicines turmeric,Ocimum,and Withania somnifera was investigated using Fourier transform near-infrared(Ft-NIR)spectroscopy-based metabolic *** different geographical origins of turmeric,five different Ocimum species,and three different varieties of roots and leaves of Withania somnifera were studied with the aid of machine learning *** good discrimination(R^(2)>0.98,Q^(2)>0.97,and accuracy=1.0)with sensitivity and specificity of 100%was achieved using this metabolic fingerprinting *** study demonstrated that Ft-NIR-based rapid metabolic fingerprinting can be used as a robust analytical method to authenticate several important medicinal herbs.

关键词： Rapid metabolic fingerprinting Natural medicines Ft-NIR Chemometric models

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液相色谱质谱联用测定多种兽药残留方法中标准品稳定性的挑战

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粮油食品科技 2021年第6期29卷 93-99页

作者： Lidija Kenjeric Michael Sulyok Alexandra Malachova David Steiner Rudolf Krska Brian Quinn Brett Greer christopher t.elliott 奥地利饲料和食品质量、安全和创新能力中心奥地利图尔恩3430 奥利地维也纳自然资源与生命科学大学生物分析与农业代谢组学研究所农业生物技术系奥地利图尔恩3430 英国贝尔法斯特女王大学生物科学学院全球食品安全研究所英国北爱尔兰贝尔法斯特BT95DL 奥地利Romer实验室诊断有限公司分析服务部科技园5奥地利图尔恩3430

采用等时测量法对可用于食品和饲料链中兽药检测的标准品混合溶液和中间混合液进行了短期和长期稳定性研究。其中短期稳定性实验考察了混合标准曲线在–20(作为基线)、4和23℃(避光和不避光保存)条件下存储1、2、4和7 d的稳定性,而长期... 详细信息

采用等时测量法对可用于食品和饲料链中兽药检测的标准品混合溶液和中间混合液进行了短期和长期稳定性研究。其中短期稳定性实验考察了混合标准曲线在–20(作为基线)、4和23℃(避光和不避光保存)条件下存储1、2、4和7 d的稳定性,而长期稳定性实验考察了中间混合液在–20、4、23℃(避光和不避光保存)和–80℃储存条件下2、4、8和12周的稳定性。结果表明,使用不含酸溶剂配制的混合标准曲线在4℃下建议储存1~2 d,中性储存条件即使在室温也可短期储存1~2 d。对于含有ß-内酰胺和头孢菌素类标准品的中间混合液在4℃和室温下储存超过1个月会损失近90%。对于含有青霉素V和G的混和标准品中间储备液,在–20℃不含酸的条件下可储存2周。其他类别的兽药标准品对长期储存条件要求较少。整体而言,兽药标准品中间混合液长期储存的最佳储存条件为–20℃。

关键词：兽药长期稳定短期稳定性等时测量液相色谱质谱联用(LC-MS/MS)

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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： christopher J.O’Connell Matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

traumatic brain injury(tBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).tBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

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Amalgamated gold-nanoalloys with enhanced catalytic activity for the detection of mercury ions(Hg^2+)in seawater samples

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Nano Research 2020年第4期13卷 989-998页

作者： Natasha Logan Claire McVey christopher elliott Cuong Cao Institute for Global Food Security School of Biological SciencesQueens University Belfast19 Chlorine GardensBelfastBT95DLUK Material and Advanced technologies for Healthcare Queens University Belfast18-30 Malone RoadBelfastBT95BNUK

Mercury(Hg)is extremely toxic,and continues to cause major threats to aquatic life,human health and the ***^2+mainly derives from seawater as a product of atmospheric deposition,therefore there is great demand for sensing approaches that can detect Hg^2+in seawater ***,we demonstrate that the peroxidase-mimicking activity of gold nanoparticles(AuNPs)or so-called nanozymes,can be exploited for the detection of Hg^2+ions in various water *** a high electrolyte environment,the catalytic activity for the oxidation of 3,3’,5,5’-tetramethylbenzidine(tMB)was significantly diminished due to poor stability of the *** activity was reduced by-73.7%when the NaCl concentration was higher than 1.168%,which is much lower than that of seawater(-3.5%),thus presenting its unsuitability for detecting Hg^2+in harsh water *** overcome this limitation,AuNPs were first functionalized with oligo-ethylene glycol(OEG),of which their colloidal form presented high stability in NaCl concentrations up to 20%and across a wide range of pHs from ***,the catalytic activity of OEG-AuNPs for the oxidation of tMB was strongly suppressed by the coating,but enhanced upon formation of Au-Hg *** novel finding underlies a straightforward,sensitive,and highly selective detection platform for Hg^2+in water *** approach could detect the exposure limit level for Hg^2+in drinking water(i.e.,2 ppb for tap and bottled water)as set by the United States Environmental Protection Agency(EPA)and the World Health Organization(WHO).When Hg^2+was spiked into a 3.5%saline solution and a coastal seawater certified reference material(CRM),the detection limits were found to be 10 ancM 3 ppb,respectively,which exceed the Hg^2+concentrations commonly found within seawater(-60-80 ppb).the whole procedure takes less than 45 min to conduct,providing a highly innovative,rapid and low-cost approach for detecting Hg^2+in complex water matrices.

关键词： gold nanoparticles nanozyme peroxidase-like mercury detection w ater samples seawater

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Unusual switchable peroxidase-mimicking nanozyme for the determination of proteolytic biomarker

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Nano Research 2019年第3期12卷 509-516页

作者： Claire McVey Natasha Logan Nguyen t. K. thanh christopher elliott Cuong Cao Institute for Global Food Security School of Biological Sciences Queens University Belfast 18-30 Malone Road Belfast BT9 5BN UK Biophysics Group Department of Physics and Astronomy University College London London WC1E 6BT UK UCL Healthcare Biomagnetic and Nanomaterials Laboratories 21 Albemarle Street London W1S 4BS UK Material and Advanced technologies for Healthcare Queens University Belfast 18-30 Malone Road Belfast BT9 5BN UK

Detection of enzyme biomarkers originating from either bio-fluids or contaminating microorganisms is of utmost importance in clinical diagnostics and food safety. Herein, we present a simple, low-cost and easy-to-use sensing approach based on the switchable peroxidase-mimicking activity of plasmonic gold nanoparticles (AuNPs) that can catalyse for the oxidation of 3,3’,5’5-tetramethylbenzidine (tMB) for the determination of protease enzyme. the AuNP surface is modified with casein, showing dual functionalities. the first function of the coating molecule is to suppress the intrinsic peroxidase-mimicking activity of AuNPs by up to 77.1%, due to surface shielding effects. Secondly, casein also functions as recognition sites for the enzyme biomarker. In the presence of protease, the enzyme binds to and catalyses the degradation of the coating layer on the AuNP surface, resulting in the recovery of peroxidase-mimicking activity. this is shown visually in the development of a blue colored product (oxidised tMB) or spectroscopically as an increase in absorbance at 370 and 650 nm. this mechanism allows for the detection of protease at 44 ng·mL^-1 in 90 min. the nanosensor circumvents issues associated with current methods of detection in terms of ease of use, compatibility with point-of-care testing, low-cost production and short analysis time. the sensing approach has also been applied for the detection of protease spiked in ultra-heat treated (UHt) milk and synthetic human urine samples at a limit of detection of 490 and 176 ng·mL^-1, respectively, showing great potential in clinical diagnostics, food safety and quality control.

关键词： gold nano particles peroxidase-mimicking nanozyme enzyme detection biomarkers

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Gold Nanozymes:From Concept to Biomedical Applications

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Nano-Micro Letters 2021年第1期13卷 138-173页

作者： Javier Lou‑Franco Bhaskar Das christopher elliott Cuong Cao Institute for Global Food Security School of Biological SciencesQueen’s University of Belfast19 Chlorine GardensBelfast BT95DLUK Present Address:Department of Biotechnology and Medical Engineering National Institute of Technology RourkelaRourkelaIndia

In recent years,gold nanoparticles have demonstrated excellent enzyme-mimicking activities which resemble those of peroxidase,oxidase,catalase,superoxide dismutase or ***,merged with their ease of synthesis,tunability,biocompatibility and low cost,makes them excellent candidates when compared with biological enzymes for applications in biomedicine or biochemical ***,over 200 research papers have been systematically reviewed to present the recent progress on the fundamentals of gold nanozymes and their potential *** review reveals that the morphology and surface chemistry of the nanoparticles play an important role in their catalytic properties,as well as external parameters such as pH or ***,real applications often require specific biorecognition elements to be immobilized onto the nanozymes,leading to unexpected positive or negative effects on their ***,rational design of efficient nanozymes remains a challenge of paramount *** implementation paths have already been explored,including the application of peroxidase-like nanozymes for the development of clinical diagnostics or the regulation of oxidative stress within cells via their catalase and superoxide dismutase *** review also indicates that it is essential to understand how external parameters may boost or inhibit each of these activities,as more than one of them could ***,further toxicity studies are required to ensure the applicability of gold nanozymes in *** challenges and future prospects of gold nanozymes are discussed in this review,whose significance can be anticipated in a diverse range of fields beyond biomedicine,such as food safety,environmental analyses or the chemical industry.

关键词： Gold nanoparticles Catalysis Nanozymes Diagnosis Nanomedicine

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Sino-EU Intergovernmental Collaboration in the Campaign Against the COVID-19 Pandemic on Food via EU-China-Safe Framework

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China CDC weekly 2021年第2期3卷 39-40页

作者： Di Wu christopher elliott Institute for Global Food Security Queens University BelfastBelfastUnited Kingdom.

the coronavirus disease 2019(COVID-19)pandemic has swept across the planet with more than 81 million confirmed cases and deaths surpassing 1.8 million in over 222 countries(1).Since the first outbreak found in Wuhan in late December 2019,the capital city in Hubei Province of China,healthcare workers and scientists having been working relentlessly to fight against this invisible *** is very clear that starting from nowhere.

关键词： planet starting fir

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Food Safety Strategies:the One Health Approach to Global Challenges and China’s Actions

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China CDC weekly 2021年第24期3卷 507-513页

作者： Di Wu christopher elliott Yongning Wu Institute for Global Food Security Queen’s University BelfastBelfastthe United Kingdom National Health Commission Key Laboratory of Food Safety Risk Assessment Food Safety Research Unit(2019RU014)of Chinese Academy of Medical ScienceChina National Center for Food Safety Risk AssessmentBeijingChina.

WORLD FOOD SAFEtY DAY World Food Safety Day(WFSD)(1)celebrated on 7 June 2021 aims to draw attention and inspire action to help prevent,detect and manage foodborne risks,contributing to food security,human health,economic prosperity,agriculture,market access,tourism and sustainable *** theme of 2021,“Safe food today for a healthy tomorrow”,stresses that production and consumption of safe food has immediate and long-term benefits for people,the planet and the *** the systemic connections between the health of people,animals,plants,the environment and the economy will help us meet the needs of the future.

关键词： planet tourism benefits

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A systematic review of global occurrence of emerging mycotoxins in crops and animal feeds,and their toxicity in livestock

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Emerging Contaminants 2024年第3期10卷 32-39页

作者： Oluwatobi Kolawole Wipada Siri-Anusornsak Awanwee Petchkongkaew christopher elliott Plant Sciences Group Wageningen University&ResearchDroevendaalsesteeg 46708 PB WageningenNetherlands Microarray Laboratory National Centre for Genetic Engineering and Biotechnology113 Thailand Science ParkPhahonyothin RoadPathum Thani12120Thailand the International Joint Research Centre on Food Security 113 Thailand Science ParkPhahonyothin RoadPathum Thani12120Thailand Department of Food Science and technology Faculty of Agro-IndustryKasetsart UniversityBangkok10900Thailand Scientific Equipment and Research Division Kasetsart University Research and Development Institute(KURDI)Kasetsart UniversityBangkok10900Thailand School of Food Science and technology Faculty of Science and TechnologyThammasat UniversityPathum Thani12120Thailand

Mycotoxins are the most frequently occurring natural contaminant in food and *** occurrence in crops and animal feed represents an enormous challenge,particularly for livestock farmers in terms of increased production costs,reduced animal performance and *** study investigates the scale of emerging mycotoxins contamination of crops and animal feeds globally,and evaluates their impacts on the health and performance of livestock,especially when they co-occur alongside regulated *** mycotoxins including nivalenol,enniatins,beauvericin,diacetoxyscirpenol,fusaric acid,patulin,moniliformin and sterigmatocystin were found to be the most prevalent contaminants of cereals and other feed commodities *** pooled mean levels for beauvericin,nivalenol,enniatins,moniliformin,sterigmatocystin,diacetoxyscirpenol,fusaric acid,and patulin were 386,421,7,854,204,136,126,370 and 138 mg/kg,*** terms of toxicity,co-occurrence of emerging mycotoxins with each other and also with regulated mycotoxins profoundly impacts livestock performance,even at low ***,there is a need for cumulative risk assessments to evaluate the health risks associated with simultaneous exposure to emerging and regulated mycotoxins and also to develop effective mitigation strategies.

关键词： Emerging mycotoxins Animal feeds Contamination Livestock Systematic review toxicity Crops Cereals

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Complications of button battery ingestion or insertion in children:a systematic review and pooled analysis of individual patient-level data

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World Journal of Pediatrics 2024年第10期20卷 1017-1028页

作者： christopher tran Carlos Nunez Guy D.Eslick Ruth Barker Elizabeth J.elliott Sydney Medical School Faculty of Medicine and HealthThe University of SydneySydneyNSWAustralia the Australian Paediatric Surveillance Unit Level 2Kids ResearchThe Sydney Children’s Hospital Network(Westmead)Locked Bag 4001WestmeadNSW2145Australia Queensland Children’s Hospital BrisbaneQLDAustralia Queensland Injury Surveillance Unit Jamieson Trauma InstituteRoyal Brisbane and Women’s HospitalHerstonQLDAustralia

Background Button battery(BB)exposures are common in children and can have devastating *** reviewed current evidence on the complications associated with BB exposure and identified predictors of outcomes using individual patient-level *** sources We carried out a systematic review and pooled analysis by searching MEDLINE,Embase,and Scopus up to May 19,*** studies describe complications following BB exposures in children(agedtios(ORs)were calculated using binary logistic regression to measure associations between predictive factors and different *** two-hundred seventeen studies(439 children)were *** median age at presentation was 1.75[interquartile range(IQR)1.00–3.00]years and 399(90.9%)exposures were *** the 380 cases reporting sex,162(42.6%)were ***(192,48.1%)and respiratory difficulties(138,34.6%)were common presenting features for ingestions,while symptomatology was site-specific for *** complications included oesophageal mucosal damage alone(105,26.3%)and tracheooesophageal fistula(93,23.3%)for ingestions,and nasal septal perforation(22,55.0%)and mucosal damage alone(13,32.5%)for *** perforation occurred in 2.5%of ingestion cases,including perforation of Meckel's diverticulum,peritonitis,and jejunocolic *** complications were common among children who ***(≤2 years),battery exposure duration(>6 hours),and battery diameter(≥20 mm)were associated with common and severe complications of *** BB injuries are time-critical,with severe sequelae predominantly affecting young *** is *** work through regulation and safer battery design are required to eliminate this problem.

关键词： Child Electric power supplies Digestive systems Fatal outcome Foreign bodies

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