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Evaluation of a culturally adapted cognitive behavior therapy-based,third-wave therapy manual

World Journal of Psychiatry 2023年第1期13卷 15-35页

作者： peter Phiri Isabel clarke Lydia Baxter Yu-Tian Zeng Jian-Qing Shi Xin-Yuan Tang Shanaya Rathod Mustafa G Soomro Gayathri Delanerolle Farooq Naeem Research&Innovation Southern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom School of Psychology Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUnited Kingdom Department of Italk Southern Health NHS Foundation TrustSouthampton SO509FHUnited Kingdom Department of Italk Step 3 Southern Health NHS Foundation TrustSouthampton SO519FHUnited Kingdom Department of Statistics and Data Science Southern University of Science and TechnologyShenzhen 518055Guangdong ProvinceChina National Center for Applied Mathematics Shenzhen Shenzhen 518055Guangdong ProvinceChina Nuffield Department of Primary Health Care Science University of OxfordOxford OX37JXUnited Kingdom Centre for Addition and Mental Health University of TorontoToronto ON M5SCanada

BACKGROUND Recommendations for psychotherapy have evolved over the years,with cognitive behavioral therapy(CBT)taking precedence since its inception within clinical guidelines in the United Kingdom and United *** use of CBT for severe mental illness is now more common *** To investigate the feasibility and acceptability of a culturally adapted,CBT-based,third-wave therapy manual using the Comprehend,Cope,and Connect approach with individuals from a diverse population presenting to primary and secondary healthcare *** A pilot study was used to assess the feasibility and acceptability of the manualised *** measures were evaluated at baseline,post-intervention and 12 wk-follow up.32 participants with mental health conditions aged 20-53 years were *** were completed at three time points,using Clinical Outcomes in Routine Evaluation(CORE),Hospital Anxiety and Depression Scale(HADS),Bradford Somatic Inventory and World Health Organization Disability Assessment Schedule 2.0(WHODAS).The Patient Experience Questionnaire was completed *** Repeated measures of analysis of variance associated with HADS depression,F(2,36)=12.81,P<0.001,partialη^(2)=0.42 and HADS anxiety scores,F(2,26)=9.93,P<0.001,partialη^(2)=0.36;CORE total score and WHODAS both showed significant effect F(1.25,18.72)=14.98,P<0.001,partialη^(2)=*** F(1.29,14.18)=6.73,P<0.001,partialη^(2)=0.38 *** These results indicate the effectiveness and acceptability of the culturally adapted,CBT-based,third-wave therapy manual intervention among minoritized groups with moderate effect *** levels and acceptability were highly *** viability and cost-effectiveness of this approach should be explored further to support universal implementation across healthcare systems.

关键词： Cognitive behavioral therapy Comprehend Cope Connect Ethnicity Culture

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Small bowel MRI enteroclysis or follow through:Which is optimal?

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World Journal of Gastroenterology 2009年第42期15卷 5300-5306页

作者： Ian C Lawrance christopher J Welman peter Shipman Kevin Murray School of Medicine and Pharmacology University of Western AustraliaFremantle HospitalWA 6160Australia Centre for Inflammatory Bowel Disease Fremantle HospitalWA 6160Australia Department of Radiology Fremantle HospitalWA 6160Australia Statistical Consulting Group School of Mathe-matics and StatisticsUniversity of Western AustraliaWA 6009Australia

AIM： TO determine if a nasojejunal tube （NJT） is required for optimal examination of enteroclysis and if patients can be examined only in the supine position. METHODS： Data were collected from all patients undergoing small bowel （SB） magnetic resonance imaging （MRI） examination over a 32-mo period. Patients either underwent a magnetic resonance （MR） follow-through （MRFT） or a MR enteroclysis （MRE） in the supine position. The quality of proximal and distal SB distension as well as the presence of motion artefact and image quality were assessed by 2 radiologists. RESULTS： One hundred and fourteen MR studies were undertaken （MRFT-49, MRE-65） in 108 patients in the supine position only. Image artefact was more frequent in MRE than in MRFT （29.2% vs 18.4%）, but was not statistically significant （P = 0.30）. Adequate distension of the distal SB was obtained in 97.8% of MRFT examinations and in 95.4% of MRE examinations, respectively. Proximal SB distension was, however, less frequently optimal in MRFT than in MRE （P = 0.0036）, particularly in patients over the age of 50 years （P = 0.0099）. Image quality was good in all examinations. CONCLUSION： All patients could be successfully iraaged in the supine position. MRE and MRFT are equivalent for distal SB distension and artefact effects. Proximal SB distension is frequently less optimal in MRFT than in MRE. MRE is, therefore, the preferred MR examination method of the SB.

关键词： Magnetic resonance enteroclysis Magnetic resonance enterography Magnetic resonance follow through Artefact

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Correlation of MRI-determined small bowel Crohn’s disease categories with medical response and surgical pathology

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World Journal of Gastroenterology 2009年第27期15卷 3367-3375页

作者： Ian Craig Lawrance christopher J Welman peter Shipman Kevin Murray School of Medicine and Pharmacology University of Western AustraliaFremantle Hospital WA 6160 Australia Department of Gastroenterology Fremantle Hospital WA 6160 Australia Department of Radiology Fremantle Hospital WA 6160 Australia Statistical Consulting Group School of Mathematics and Statistics University of Western AustraliaWA 6160 Australia

AIM: To determine whether magnetic resonance imaging (MRI) can be used to categorize small bowel Crohn's disease (SB CD) into groups that correlate with response to medical therapy and surgical ***: Data was collected from all patients with MRI evidence of SB CD without significant colonic disease over a 32-mo period. Two radiologists, blinded to clinical findings, evaluated each MRI and grouped them based on bowel wall thickness and wall enhancement. These categories were: (1) "fibrosis", (2) "mild segmental hyper-enhancement and mild wall thickening", (3) "mild segmental hyper-enhancement and marked wall thickening", (4) "marked segmental transmural hyper-enhancement". Patient response to additional medical therapy post-MRI was prospectively determined at 8-wk. Non-responders underwent endoscopy and were offered therapeutic endoscopy or surgery. Surgical pathology was assessed against the MRI category. RESULTS: Fifty-five patients were included. Females and category "2" patients were more likely, and patients with luminal narrowing and hold-up less likely, to respond to medical therapy (P < 0.05). Seventeen patients underwent surgery. The surgical pathologicalfindings of fibrosis and the severity of inflammation correlated with the MRI category in all ***: Our fi ndings suggest that SB CD can be grouped by the MRI f indings and that these groups are associated with patients more likely to respond to continued medical therapy. The MRI categories also correlated with the presence and level of intestinal inflammation and fibrosis on surgical pathology, and may be of prognostic use in the management of CD patients.

关键词： Magnetic resonance imaging Crohn's disease Fibrosis Prognosis Pathology

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Rising incidence,progression and changing patterns of liver disease in Wales 1999-2019

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World Journal of Hepatology 2023年第1期15卷 89-106页

作者： Thomas peter Ignatius Pembroke Gareth John Berry Puyk Keith Howkins Ruth clarke Fidan Yousuf Marek Czajkowski Andrew Godkin Jane Salmon Andrew Yeoman Department of Gastroenterology and Hepatology University Hospital of WalesCardiff CF144XNUnited Kingdom Division of Infection and Immunity Cardiff UniversityCardiff CF144XWUnited Kingdom Digital Health and Care Wales NHS WalesCardiff CF119ADUnited Kingdom Gwent Liver Unit Royal Gwent HospitalNewport NP202UBUnited Kingdom Public Health Wales NHS WalesCardiff CF104BZUnited Kingdom

BACKGROUND Liver disease incidence and hence demand on hepatology services is *** To describe trends in incidence and natural history of liver diseases in Wales to inform effective provision of hepatology *** The registry is populated by International Classification of Diseases-10(ICD-10)code diagnoses for residents derived from mortality data and inpatient/day case activity between ***-anonymised linkage of:(1)Causative diagnoses;(2)Cirrhosis;(3)Portal hypertension;(4)Decompensation;and(5)Liver cancer diagnoses enabled tracking liver disease *** The population of Wales in 2019 was 3.1 *** 1999 and 201973054 individuals were diagnosed with a hepatic disorder,including 18633 diagnosed with cirrhosis,10965 with liver decompensation and 2316 with hepatocellular carcinoma(HCC).Over 21 years the incidence of liver diseases increased 3.6 fold,predominantly driven by a 10 fold increase in non-alcoholic fatty liver disease(NAFLD);the leading cause of liver disease from *** incidence of cirrhosis,decompensation,HCC,and allcause mortality ***-related mortality ***-related liver disease(ArLD),autoimmune liver disease and congestive hepatopathy were associated with the highest rates of decompensation and all-cause *** A 10 fold increase in NAFLD incidence is driving a 3.6 fold increase in liver disease in Wales over 21 ***-related morbidity and mortality rose more slowly reflecting the lower progression rate in *** of ArLD remained stable but was associated with the highest rates of liver-related and all-cause mortality.

关键词： Epidemiology Cirrhosis Liver failure Non-alcoholic fatty liver disease hepatitis Hepatocellular carcinoma

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Depression and the ending of depression： tradition, science and subjectivities

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Life Research 2018年第2期1卷 68-72页

作者： christopher Anthony David peter Gerard Coan California Southern University Costa MesaCalifornia.

What is depression？ What causes it？ How many people suffer from it？ Why does it affect some people and not others？ How can we test objectively whether a person is depressed or not？ How can we best help depressed people？ In this brief comment paper, we show that answers to these questions found in the current medical research literature are far from conclusive.

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Frozen shoulder:A systematic review of therapeutic options

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World Journal of Orthopedics 2015年第2期6卷 263-268页

作者： Harpal Singh Uppal Jonathan peter Evans christopher Smith Shoulder Unit Princess Elizabeth Orthopaedic CentreRoyal Devon and Exeter Hospital

Frozen shoulder is a common disease which causes significant morbidity. Despite over a hundred years of treating this condition the definition, diagnosis, pathology and most efficacious treatments are still largely unclear. This systematic review of current treatments for frozen shoulder reviews the evidence base behind physiotherapy, both oral and intra articular steroid, hydrodilatation, manipulation under anaesthesia and arthroscopic capsular release. Key areas in which future research could be directed are identified, in particular with regard to the increasing role of arthroscopic capsular release as a treatment.

关键词： Frozen shoulder Adhesive capsulitis Bursitis Shoulder Arthroscopic capsular release Arthrographic distension Physiotherapy Steroid Hydrodilatation

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南澳卫生医疗研究中心

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城市环境设计 2016年第5期 430-433页

作者： peter clarke 伍兹贝格建筑事务所

全新的南澳大利亚卫生医疗研究中心（SAHMRI）作为21世纪南澳最重要的卫生医疗研究开发项目,总建筑面积约25 000m;,可容纳来自南澳、澳大利亚和其他区域的675名研究人员。研究中心位于城市的西端,毗邻新建的阿德莱德皇家医院,打造出全... 详细信息

全新的南澳大利亚卫生医疗研究中心（SAHMRI）作为21世纪南澳最重要的卫生医疗研究开发项目,总建筑面积约25 000m;,可容纳来自南澳、澳大利亚和其他区域的675名研究人员。研究中心位于城市的西端,毗邻新建的阿德莱德皇家医院,打造出全新的卫生医疗和科研片区。SAHMRI雕塑般的外形不仅具有独特的吸引力和启发性,同时能够满足各项建筑功能。通透的外立面向外界展示了

关键词：卫生医疗建筑功能南澳大利亚中庭外立面

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Generation and preservation of continental crust in the Grenville Orogeny

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Geoscience Frontiers 2015年第3期6卷 357-372页

作者： christopher J.Spencer peter A.Cawood Chris J.Hawkesworth Anthony R.Prave Nick M.W.Roberts Matthew S.A.Horstwood Martin J.Whitehouse EIMF Department of Earth and Environmental Sciences University of St Andrews NERC Isotope Geosciences Laboratory British Geological Survey Swedish Museum of Natural History and Nordic Center for Earth Evolution(NordCEE) Edinburgh Ion Microprobe Facility University of Edinburgh

Detrital zircons from modern sediments display an episodic temporal distribution of U-Pb crystallization ages forming a series of ＇peaks＇ and ＇troughs＇. The peaks are interpreted to represent either periods of enhanced generation of granitic magma perhaps associated with mantle overturn and superplume events, or preferential preservation of continental crust during global collisional orogenesis. The close association of those peaks with the assembly of supercontinents implies a causal relationship between collisional orogenesis and the presence of zircon age peaks. Here these two end-member models （episodic periodicity of increased magmatism versus selective preservation during collisional orogenesis） are assessed using U-Pb, Hf, and 0 analysis of detrital zircons from sedimentary successions deposited during the - 1.3-1.1 Ga accretionary, -1.1-0.9 Ga collisional, and 〈 0.9 Ga extensional collapse phases of the Grenville orogenic cycle in Labrador and Scotland. The pre-collisional, accretionary stage provides a baseline of continental crust present prior to orogenesis and is dominated by Archean and Paleoproterozoic age peaks associated with pre-1300 Ma Laurentian geology. Strata deposited during the Grenville Orogeny display similar Archean and Paleoproterozoic detrital populations along with a series of broad muted peaks from - 1500 to 1100 Ma. However, post-collisional sedimentary successions display a dominant age peak between 1085 and 985 Ma, similar to that observed in modern North American river sediments. Zircons within the post-orogenic sedimentary successions have progressively lower EHf and higher -lSO values from - 1800 to - 1200 Ma whereupon they have higher EHf and -3180 within the dominant 1085-985 Ma age peak. Furthermore, the Lu-Hf isotopic profile of the Grenville-related age peak is consistent with significant assimilation and contamination by older crustal material, The timing of this dominant age peak coincides with the peak of metamorphism and

关键词： Zircon Continental crust Grenville Orogeny Crustal preservation

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三空间的构思——建筑师谈“三空间”

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缤纷 2003年第12期 101-107页

作者：姚京 peter clarke

《缤纷》:以建筑师的视角看,"三空间"究竟意味着什么?HLS:三空间就是被包含在都市生活群落中的自我领地,它的周围是形形色色、五彩光鲜的现代生活元素。要想成功地营造三空间项目及它所承载的生活方式,需要熔炼从现代工作环境中提取的元... 详细信息

《缤纷》:以建筑师的视角看,"三空间"究竟意味着什么?HLS:三空间就是被包含在都市生活群落中的自我领地,它的周围是形形色色、五彩光鲜的现代生活元素。要想成功地营造三空间项目及它所承载的生活方式,需要熔炼从现代工作环境中提取的元素,创造各式各样满足不同人群需求及喜好的户型和格局,以及康体娱乐设施,还有融零售服务于一体的商业中心等;同时,把相互结合的这些因素再融入风景优美的环境之中。有了这些,居住、工作、社交、休闲汇聚一堂,便可构筑起快乐生活的共同体。三空间就是生产快乐共同体的车间。

关键词：空间式生活方式室内设计建筑师空间项目墨尔本不同人群共同体康体娱乐零售服务

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Approaches to identifying drug resistance mechanisms to clinically relevant treatments in childhood rhabdomyosarcoma

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Cancer Drug Resistance 2022年第1期5卷 80-89页

作者： Samson Ghilu christopher L.Morton Angelina V.Vaseva Siyuan Zheng Raushan T.Kurmasheva peter J.Houghton Department of Molecular Medicine Greehey Children’s Cancer Research InstituteUT HealthSan AntonioTX 78229USA Department of Surgery St.Jude Children’s Research HospitalMemphisTN 38105USA Department of Epidemiology and Biostatistics Greehey Children’s Cancer Research InstituteUT HealthSan AntonioTX 78229USA

Aim:Despite aggressive multiagent protocols,patients with metastatic rhabdomyosarcoma(RMS)have poor *** a recent high-risk trial(ARST0431),25% of patients failed within the first year,while on therapy and 80% had tumor progression within 24 ***,the mechanisms for tumor resistance are essentially *** we explore the use of preclinical models to develop resistance to complex chemotherapy regimens used in ***:A Single Mouse Testing(SMT)protocol was used to evaluate the sensitivity of 34 RMS xenograft models to one cycle of vincristine,actinomycin D,cyclophosphamide(VAC)*** response was determined by caliper measurement,and tumor regression and event-free survival(EFS)were used as endpoints for *** tumors at regrowth were transplanted into recipient mice,and the treatment was repeated until tumors progressed during the treatment period(i.e.,became resistant).At transplant,tumor tissue was stored for biochemical and omics ***:The sensitivity to VAC of 34 RMS models was *** varied from 3 weeks to>20 *** models were classified as having intrinsic resistance,intermediate sensitivity,or high sensitivity to VAC *** to VAC was developed in multiple models after 2-5 cycles of therapy;however,there were examples where sensitivity remained unchanged after 3 cycles of ***:The SMT approach allows for in vivo assessment of drug sensitivity and development of drug resistance in a large number of RMS *** such,it provides a platform for assessing in vivo drug resistance mechanisms at a“population”level,simulating conditions in vivo that lead to clinical *** VAC-resistant models represent“high-risk”tumors that mimic a preclinical phase 2 population and will be valuable for identifying novel agents active against VAC-resistant disease.

关键词： Rhabdomyosarcoma patient-derived xenografts combination therapy intrinsic drug resistance acquired drug resistance

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