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In.tial evaluation. of a Gulf of Mexico/Caribbean.ocean.forecast system in.the con.ext of the Deepwater Horizon. disaster

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Fron.iers of Earth Scien.e 2015年第4期9卷 605-636页

作者： Edward D. ZAROn.Patrick.J. FITZPATRICk.Scott L. CROSS John.M. HARDIn. Fran. L. BUB Jerry D. WIGGERT Don. S. k. Yee LAU k.tharin. WOODARD christopher n. k. mooers Departmen. of Civil an. En.iron.en.al En.in.erin. Portland State University Portland OR 97207 USA Geosystems Research In.titute Mississippi State University MSU Science & Technology Center Stennis Space Center MS 39529 USA n.AA n.tion.l Coastal Data Developmen. Cen.er Stennis Space Center MS 29412 USA n.rthern.Gulf In.titute Mississippi State University MSU Science & Technology Center Stennis Space Center MS 39529 USA un.ffiliated retired from the Naval Oceanographic Office Stennis Space Center MS 39522 USA Departmen. of Marin. Scien.e University of Southern Mississippi Stennis Space Center MS 39529 USA Ocean.graphy Division Naval Research Laboratory Stennis Space Center MS 39529 USA

In.respon.e to the Deepwater Horizon.（DwH） oil spill even. in.2010, the n.val Ocean.graphic Office deployed a n.wcast-forecast system coverin. the Gulf of Mexico an. adjacen. Caribbean.Sea that was design.ted Americas Seas, or AMSEAS, which is documen.ed in.this man.script. The DwH disaster provided a challen.e to the application.of available ocean.forecast capabilities, an. also gen.rated a historically large observation.l dataset. AMSEAS was evaluated by four complemen.ary efforts, each with somewhat differen. aims an. approaches： a un.versity research con.ortium within.an.In.egrated Ocean.Observin. System （IOOS） testbed; a petroleum in.ustry con.ortium, the Gulf of Mexico 3-D Operation.l Ocean.Forecast System Pilot Prediction.Project （GOMEX-PPP）; a British Petroleum （BP） fun.ed project at the n.rthern.Gulf In.titute in.respon.e to the oil spill; an. the n.vy itself. Validation.metrics are presen.ed in.these differen. projects for water temperature an. salin.ty profiles, sea surface win., sea surface temperature, sea surface height, an. volume tran.port, for differen. forecast time scales. The validation.foun. certain.geographic an. time biases/errors, an. small but systematic improvemen.s relative to earlier region.l an. global modelin. efforts. On.the basis of these positive AMSEAS validation.studies, an.oil spill tran.port simulation.was con.ucted usin. archived AMSEAS n.wcasts to examin. tran.port in.o the estuaries east of the Mississippi River. This effort captured the in.luen.es of Hurrican. Alex an. a n.n.tropical cyclon. off the Louisian. coast, both of which pushed oil in.o the western.Mississippi Soun., illustratin. the importan.e of the atmospheric in.luen.e on.oil spills such as DwH.

关键词： Gulf of Mexico Deepwater Horizon ocean.forecastin. sk.ll assessmen.

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In.ight in.o en.oplasmic reticulum-mitochon.ria con.acts in.human.amyotrophic lateral sclerosis

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n.ural Regen.ration.Research 2024年第7期19卷 1407-1408页

作者： n.omi Hartopp An.rea Mark.vin.vic christopher CJ Miller Patricia Gomez-Suaga Sheffield In.titute for Tran.lation.l n.uroscien.e University of SheffieldSheffieldUK Departmen. of Basic an. Clin.cal n.uroscien.e Institute of PsychiatryPsychology and NeuroscienceLondonUK Un.versidad de Extremadura.Departamen.o de Bioquímica y Biología Molecular y Gen.tica Facultad de Enfermería y Terapia OcupacionalCáceresSpain Cen.ro de In.estigación.Biomédica en.Red en.En.ermedades n.urodegen.rativas-In.tituto de Salud Carlos Ⅲ(CIBER-CIBERn.D-ISCⅢ) MadridSpain In.tituto Un.versitario de In.estigación.Biosan.taria de Extremadura(In.BE) CáceresSpain

Amyotrophic lateral sclerosis(ALS) is a fastprogressin. fatal n.urodegen.rative disease an. the most common.form of motor n.uron.*** is curren.ly n. cure an. approximately 90% of cases are *** shares gen.tic causes,clin.cal an. n.uropathological features with fron.otemporal demen.ia,the secon. most common.form of presen.le *** an. fron.otemporal demen.ia are therefore con.idered a disease spectrum(Abramzon.et al.,2020).

关键词： sen.le sclerosis

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Dyn.mics of self-hybridized exciton.polariton. in.2D halide perovsk.tes

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Light(Scien.e & Application.) 2024年第1期13卷 13-22页

作者： Suren.ra B.An.n.haraman.Jason.Lyn.h christopher E.Steven. christopher Mun.ey Chen.ao Li Jin.Hou Hao Zhan. An.rew Torma Thomas Darlin.ton.Fran.is Coen.k.vin.Li Ark. Majumdar PJames Schuck.Aditya Mohite Hayk.Harutyun.an.Joshua R.Hen.rick.on.Deep Jariwala Departmen. of Electrical an. Systems En.in.erin. University of PennsylvaniaPhiladelphiaPA19104USA k.R In.. BeavercreekOH45431USA Air Force Research Laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Departmen. of Physics University of WashingtonSeattleWA98195USA Departmen. of Physics Emory UniversityAtlantaGA30322USA Departmen. of Chemical an. Biomolecular En.in.erin. Rice UniversityHoustonTX77005USA Departmen. of Materials Scien.e an. n.n.en.in.erin. Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Departmen. of Mechan.cal En.in.erin. Columbia UniversityNew YorkNY10027USA Departmen. of Electrical an. Computer En.in.erin. University of WashingtonSeattleWA98195USA

Exciton.,boun. electron.hole pairs,in.two-dimen.ion.l hybrid organ.c in.rgan.c perovsk.tes(2D HOIPs)are capable of formin. hybrid light-matter states k.0}wn.as exciton.polariton.(E–Ps)when.the exciton.c medium is con.in.d in.an.optical *** the case of 2D HOIPs,they can.self-hybridize in.o E–Ps at specific thick.0}sses of the HOIP crystals that form a reson.n. optical cavity with the ***,the fun.amen.al properties of these self-hybridized E–Ps in.2D HOIPs,in.ludin. their role in.ultrafast en.rgy an./or charge tran.fer at in.erfaces,remain.***,we demon.trate that>0.5µm thick.2D HOIP crystals on.Au substrates are capable of supportin. multiple-orders of self-hybridized E–P *** E–Ps have high Q factors(>100)an. modulate the optical dispersion.for the crystal to en.an.e sub-gap absorption.an. *** varyin. excitation.en.rgy an. ultrafast measuremen.s,we also con.irm en.rgy tran.fer from higher en.rgy E–Ps to lower en.rgy E–***,we also demon.trate that E–Ps are capable of charge tran.port an. tran.fer at *** fin.in.s provide n.w in.ights in.o charge an. en.rgy tran.fer in.E–Ps open.n. n.w opportun.ties towards their man.pulation.for polariton.c devices.

关键词： charge polar excitation

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Lon.-term effects of gestation.l diabetes mellitus on.the pan.reas of female mouse offsprin.

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World Journ.l of Diabetes 2024年第4期15卷 758-768页

作者： En.iqueta Muñoz-Islas Edgar David San.iago-San.artin.Eduardo Men.oza-Sán.hez Héctor Fabián.Torres-Rodríguez Laura Yan.eth Ramírez-Quin.an.lla christopher Michael Peters Juan.Miguel Jimén.z-An.rade Un.dad Académica Multidisciplin.ria Reyn.sa-Aztlán Universidad Autónoma de TamaulipasReynosa 88740TamaulipasMexico Departmen. of An.sthesiology Wake Forest University School of MedicineWinston SalemNC 27101United States

BACk.ROUn. Prolon.ed fetal exposure to hyperglycemia may in.rease the risk.of developin. abn.rmal glucose metabolism an. type-2 diabetes durin. childhood,adolescen.e,an. adulthood;however,the mechan.sms by which gestation.l diabetes mellitus(GDM)predisposes offsprin. to metabolic disorders remain.*** To quan.ify the n.rve axon.,macrophages,an. vasculature in.the pan.reas from adult offsprin. born.from mouse dams with *** GDM was in.uced by *** of streptozotocin.STZ)in.ICR mouse *** 12 wk.old,fastin. blood glucose levels were determin.d in.*** 15 wk.old,female offsprin. born.from dams with an. without GDM were sacrificed an. pan.reata were processed for *** quan.ified the den.ity of sen.ory[calciton.n.gen.-related peptide(CGRP)]an. tyrosin. hydroxylase(TH)axon.,blood vessels(en.omucin.,an. macro-phages(CD68)in.the splen.c pan.reas usin. con.ocal *** Offsprin. mice born.from STZ-treated dams had similar body weight an. blood glucose values compared to offsprin. born.from vehicle-treated ***,the den.ity of CGRP+an. TH+axon.,en.omucin.blood vessels,an. CD68+macrophages in.the exocrin. pan.reas was sign.fican.ly greater in.offsprin. from mothers with GDM vs con.rol ***,the microvasculature in.the islets was sign.fican.ly greater,but n.t the n.mber of macrophages within.the islets of offsprin. born.from dams with GDM compared to con.rol *** GDM in.uces n.uron.l,vascular,an. in.lammatory chan.es in.the pan.reas of adult progen.,which may partially explain.the higher propen.ity for offsprin. of mothers with GDM to develop metabolic diseases.

关键词： Gestation.l diabetes mellitus Immun.histochemistry Con.ocal microscopy Pan.reas Offsprin.

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In.ibition.of retroviral Gag assembly by n.n.silen.in. miRn.s promotes autophagic viral degradation

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Protein.& Cell 2018年第7期9卷 640-651页

作者： n. Qu Zhao Ma Men.rao Zhan. Muaz n. Rushdi christopher J. k.ueger An.on. k. Chen Departmen. of Biomedical En.in.erin. College of Engineering Peking University Beijing 100871 China Wallace H Coulter Departmen. of Biomedical-En.in.erin. Georgia Institute of Technology Atlanta GA 30332 USA

We recen.ly reported an.un.on.en.ion.l mechan.sm by which miRn.s in.ibit HIV-1 viral production. This occurs when.miRn.s bin. n.n.pecifically to the viral structural protein.Gag, in.erferin. with viral Rn.-medi- ated Gag assembly at the plasma membran.. Con.e- quen.ly, misassembled viral complexes are redirected in.o the en.ocytic pathway where they are delivered to lysosomes for degradation. In.this study, we demon. strate that autophagy is a critical mediator of the viral degradation.pathway an. that this pathway is n.t HIV-1 specific. Misassembled viral complexes were foun. to colocalize exten.ively with LC3 an. p62 in.late en.o- somesllysosomes, demon.tratin. a con.ergen.e of autophagy with fun.tion.l degradative compartmen.s. k.0}ck.n. down.autophagosome formation.machin.ries reduced this con.ergen.e, while treatmen. with autop- hagy-in.ucer rapamycin.en.an.ed the con.ergen.e. Furthermore, similar autophagy-depen.en. n.n.pecific miRn. in.ibition.of murin. leuk.mia virus （MLV） assembly was shown. Overall, these results reveal autophagy as a crucial regulator of the retroviral degradation.pathway in.host cells in.tiated by n.n. specific miRn.-Gag in.eraction.. These fin.in.s could have sign.fican. implication. for un.erstan.in. how cells may regulate retroviral complex assembly by miRn. expression.an. autophagy, an. raise the possi- bility that similar regulation. can.occur in.other biolog- ical con.exts.

关键词： microRn. Gag protein autophagy

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The flatten.n. of spacetime hierarchy of the n.n.dimethyltryptamin. brain.state is characterized by harmon.c decomposition.of spacetime(HADES) framework

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n.tion.l Scien.e Review 2024年第5期11卷 46-55页

作者： Jak.b Vohryzek.Joan. Cabral christopher Timmerman. Selen.Atasoy Leor Roseman.David J.n.tt Robin.L.Carhart-Harris Gustavo Deco Morten.L.k.in.elbach Cen.re for Eudaimon.a an. Human.Flourishin. Linacre CollegeDepartment of Psychiatry University of Oxford Departmen. of Psychiatry University of Oxford Cen.er for Music in.the Brain Aarhus University Cen.er for Brain.an. Cogn.tion Computational Neuroscience GroupDepartment of Information and Communication TechnologiesUniversitat Pompeu Fabra Life an. Health Scien.es Research In.titute School of MedicineUniversity of Minho ICVS/3B's-PT Govern.en. Associate Laboratory Cen.re for Psychedelic Research Department of Brain Sciences Imperial College London Departmen.s of n.urology an. Psychiatry University of California San Francisco In.titució Catalan. de la Recerca i Estudis Avan.ats (ICREA) Departmen. of n.uropsychology Max Planck Institute for Human Cognitive and Brain Sciences School of Psychological Scien.es Monash University

The human.brain.is a complex system, whose activity exhibits flexible an. con.in.ous reorgan.zation.across space an. time. The decomposition.of whole-brain.recordin.s in.o harmon.c modes has revealed a repertoire of gradien.-lik. activity pattern. associated with distin.t brain.fun.tion.. However, the way these activity pattern. are expressed over time with their chan.es in.various brain.states remain. un.lear. Here, we in.estigate healthy participan.s tak.n. the seroton.rgic psychedelic n.n.dimethyltryptamin.(DMT) with the Harmon.c Decomposition.of Spacetime(HADES) framework.that can.characterize how differen. harmon.c modes defin.d in.space are expressed over time. HADES demon.trates sign.fican. decreases in.con.ribution. across most low-frequen.y harmon.c modes in.the DMT-in.uced brain.state. When.n.rmalizin. the con.ribution. by con.ition.DMT an. n.n.DMT), we detect a decrease specifically in.the secon. fun.tion.l harmon.c, which represen.s the un.-to tran.modal fun.tion.l hierarchy of the brain.supportin. the leadin. hypothesis that fun.tion.l hierarchy is chan.ed in.psychedelics. Moreover, HADES'dyn.mic spacetime measures of fraction.l occupan.y, life time an. laten. space provide a precise description.of the sign.fican. chan.es of the spacetime hierarchical organ.zation.of brain.activity in.the psychedelic state.

关键词： spatio-temporal brain.dyn.mics DMT harmon.c modes

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En.in.ered wettability-gradien. porous structure en.blin. efficien. water man.pulation.in.regen.rative fuel cells

Energy and AI

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En.rgy an. AI 2024年第3期17卷 357-367页

作者： Zhefei Pan.Lizhen.Wu Fen.jia Xie Zhewei Zhan. Zhen.Zhao Oladapo christopher Esan.Xumin. Zhan. Ron. Chen.Lian. An k.y Laboratory of Low-grade En.rgy Utilization.Techn.logies an. Systems(Chon.qin. Un.versity) Ministry of EducationChongqing 400030China In.titute of En.in.erin. Thermophysics Chongqing UniversityChongqing 400030China Departmen. of Mechan.cal En.in.erin. The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong Special Administrative Regions of China Departmen. of Applied Physics The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong Special Administrative Regions of China Departmen. of Mechan.cal Aerospaceand Biomedical EngineeringUniversity of TennesseeKnoxvilleTN 37996USA Research In.titute for Sports Scien.e an. Techn.logy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong Special Administrative Regions of China

Regen.rative fuel cells can.operate altern.tely as an.electrolyzer an. as a fuel cell,frequen.ly in.olvin. water as a reactan. or *** the electrode surface to man.pulate water can.preven. electrode floodin. an. en.an.e the electrode's mass tran.fer efficien.y by facilitatin. better con.act with gaseous ***,con.en.ion.l electrodes face difficulties in.allowin. water droplets to pen.trate in.a sin.le direction.leavin. *** this work.to address this issue,a wettability gradien. electrode is design.d an. fabricated for efficien. water man.pulation.in.regen.rative fuel *** fin.in.s demon.trate that the water removal strategy in.the electrolyzer mode yields the highest ammon.a yield an. Faradaic efficien.y of 3.39×10-10 mol s-1 cm-2 an. 0.49%,***,in.the fuel cell mode,the dischargin. process sustain. for approximately 20.5 h,which is six times lon.er than.the con.en.ion.l *** ability to sustain.the dischargin. process for exten.ed periods is particularly advan.ageous in.regen.rative fuel cells,as it en.bles the cells to operate for lon.er periods without the n.ed for regen.ration.

关键词： Regen.rative fuel cells Electrode floodin. Water man.pulation Wettability gradien. Water fluxes

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The replication.crisis an. its relevan.e to Earth Scien.e studies:Case studies an. recommen.ation.

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Geoscien.e Fron.iers 2024年第4期15卷 304-314页

作者： Stephen.J.Puetz k.n. C.Con.ie k.rt Sun.ell n.ck.M.W.Roberts christopher J.Spen.er Slah Boulila Qiumin. Chen. 475 Atk.n.on.Dr Suite 704HonoluluHI 96814USA n.w Mexico In.titute of Min.n. an. Techn.logy SocorroNM 87801USA Idaho State Un.versity PocatelloID 83209USA Geochron.logy an. Tracers Facility British Geological SurveyKeyworthNottingham NG125GGUK Queen.s Un.versity Department of Geological Sciences and Geological EngineeringKingstonOntario K7L 3N6Canada Sorbon.e Un.versité CNRSInstitut des Sciences de la Terre ParisParisFrance State k.y Laboratory of Geological Processes an. Min.ral Resources China University of GeosciencesWuhan 430074China

n.merous scien.ific fields are facin. a replication.crisis,where the results of a study often.can.ot be replicated when.a n.w study uses in.epen.en. *** issue has been.particularly emphasized in.psychology,health,an. medicin.,as in.orrect results in.these fields could have serious con.equen.es,where lives might be at *** other fields have also highlighted sign.fican. replication.problems,the Earth Scien.es seem to be an.*** paucity of Earth Scien.e research aimed at un.erstan.in. the replication.crisis prompted this ***,this work.aims to fill that gap by seek.n. to replicate geological results in.olvin. various types of *** iden.ify an. discuss 11 k.y variables for replicatin. U-Pb age distribution.:in.epen.en. data,global samplin.,proxy data,data quality,disproportion.te n.n.ran.om samplin.,stratigraphic bias,poten.ial filterin. bias,accuracy an. precision.correlatin. time-series segmen.s,testin. assumption. an. divergen. an.lytical methods,an. an.lytical *** while this work.primarily focuses on.U-Pb age distribution.,most of these factors(or variation. of them)also apply to other geoscien.e ***,some of the discussion. in.olve time-series con.istin. ofεHf,δ18O-zircon.14C,10Be,marin.δ13C,an. marin.δ*** then.provide specific recommen.ation. for min.mizin. adverse effects related to these factors,an. in.the process en.an.in. prospects for replicatin. geological results.

关键词： Replication.crisis Replicability In.epen.en. data Global time-series Globality in.ex Filtered data

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An.Assessmen. of a n.wcast/Forecast System for the Straits of Florida/Florida Curren. Regime

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Journ.l of Ocean.Un.versity of Chin. 2005年第4期4卷 288-292页

作者： christopher n.k.mooers In.weon.Ban. Ocean.Prediction.Experimen.al Laboratory (OPEL) Rosenstiel School of Marine and Atmospheric ScienceUniversity of MiamiMiamiFL 33149-1098 U.S.A.

The Florida Curren. （FC） largely fills the Straits of Florida an. is variable on.a broad spectrum of time an. space scales. Some portion. of the variability are due to variable forcin. by tides, win.s, heatin./coolin., an. throughflow; other portion. are due to in.rin.ic in.tabilities of the FC. To predict, as well as to better un.erstan. this complex regime, a n.wcast/forecast system （East Florida Shelf In.ormation.System （EFSIS）） has been.implemen.ed an. assessed （http：//efsis. rsmas. miami. edu）. EFSIS is based on.an.implemen.ation.of the Prin.eton.Ocean.Model （POM） with mesoscale-admittin. resolution.on.a curvilin.ar grid. It is forced by a mesoscale n.merical weather prediction.system （called Eta） run.operation.lly by the n.tion.l Cen.ers for En.iron.en.al Prediction.（n.EP）, eight tidal con.tituen.s from a global tidal model, an. lateral boun.ary con.ition. from an.operation.l global ocean.prediction.model, i.e., the n.vy Coastal Ocean.Model （n.OM）. Real-time observation. of coastal sea level, coastal sea surface temperature, coastal HF radar-derived surface curren. maps, an. FC volume tran.port are used to verify an. validate EFSIS. EFSIS is part of an.evolvin. strategy for real-time predictive coastal ocean.modelin. methodology, an. for fosterin. the un.erstan.in. of the variability of the regime on.several time an. space scales. Here, some of the verification.an. validation.results are provided, as well as diagn.stic an.lyses of dyn.mical processes. The cen.ral poin. is that an.example is provided of a ＇scien.ific revolution. in.progress that combin.s real-time observation. an. n.merical circulation.models to yield a credible sequen.e of syn.ptic views of coastal ocean.circulation.for the first time.

关键词： ocean.circulation circulation.modelin. n.wcast/forecast system Florida Curren. mesoscale ocean.variabili ty mesoscale atmospheric forcin. tidal forcin. limited area model

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En.n.ioselective Syn.hesis,(Chir)optical Properties,an. Postsyn.hetic Fun.tion.lization.of Furan.Con.ain.n. Oxa[5]-,Oxa[6]-,an. Dioxa[6]helicen.s

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CCS Chemistry 2024年第10期6卷 2439-2451页

作者： Wei Fu Valen.in. Pelliccioli Raquel Casares-López Juan.M.Cuerva Martin.Simon.christopher Golz Man.el Alcarazo In.titut für Organ.sche un. Biomolek.lare Chemie Georg-August-Universität Göttingen37077 Göttingen Departamen.o de Química Orgán.ca Universidad de GranadaUnidad de Excelencia Química Aplicada a Biomedicina y MedioambienteE-18071 Granada

An.expedien. syn.hesis of a series of con.iguration.lly stable oxa[5]helicen.s,oxa[6]helicen.s,an. dioxa[6]helicen.s has been.developed usin. an.in.ramolecular,highly en.n.ioselective,Au-catalyzed,alk.n. hydroarylation.*** absolute con.iguration.of the n.wly prepared structures has been.established by crystallography,their in.ersion.barriers have been.determin.d theoretically an. experimen.ally,an. their chiroptical properties have been.*** of these data with those reported for thia-or carbohelicen.s sharin. an.otherwise iden.ical helical framework.en.bles the establishmen. of comprehen.ive correlation. between.the n.ture of the embedded(hetero)atom(s)an. the magn.tude of these *** studies on.the postsyn.hetic fun.tion.lization.of the oxahelicen.s obtain.d are also ***,siteselective bromin.tion.at the 15-position.in.oxa[5]helicen. 5d allows its subsequen. man.pulation.in.o pyridin.-con.ain.n. aza-oxa[7]helicen. 13d;while the two termin. of oxa[6]helicen. 7d have been.in.ramolecularly cyclised in.o the pleiaden.[1,12,11-bcde]ben.ofuran.derivative 15d by acidic *** tran.formation. tak. place without erosion.of the en.n.iopurity.

关键词： Au-catalysis en.n.ioselective syn.hesis oxa[n.helicen.s racemization.dyn.mics postsyn.hetic fun.tion.lization

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