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Quantifying Kinematic Tremor in an NGLY1-Deficient Individual: A Case Study

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Case Reports in Clinical medicine 2024年第1期13卷 25-36页

作者： Brock Futrell christopher Alexander malaya Dacia martinez Diaz Christian Alfaro Hannah Elizabeth Gustafson Subhalakshmi Chandrasekaran Rhea mohan Phatak Bernhard Suter Charles Shannon Layne Department of Health and Human Performance University of Houston Houston USA Center for Neuromotor and Biomechanics Research University of Houston Houston USA Department of Computer Science and Engineering Texas A&M University College Station USA Blue Bird Circle Rett Center Texas Children’s Hospital Houston USA Baylor College of medicine Houston USA Center for NeuroEngineering and Cognitive Science University of Houston Houston USA

NGLY1 Deficiency is an autosomal recessive congenital disorder that has been identified in less than 100 individuals. most individuals with NGLY1 Deficiency display hyperkinetic movement disorders, including choreiform, athetoid, dystonic myoclonic, dyskinetic, and dysmetric movements. Developing a consistent and concise consensus on the classification and evaluation of tremors is essential to forward the research and treatment of tremors. It has also been reported that some individuals with NGLY1 Deficiency demonstrate tremor, but such tremor has never been formally investigated. The primary objective of this study is to determine if an individual with NGLY1 Deficiency demonstrates an identifiable tremor during a series of arm movements and, if so, describe the frequency and power characteristics of that tremor. Arm movement kinematics were obtained using a 16-camera Vicon system, and time series trajectory waveforms for three planes of a marker placed on the hand were developed. Custom mATLAB scripts were utilized to compute Fast Fourier Transformations of the data within the identified waveform segments. A mean frequency of 2.30 Hz (SD = 1.05) with a mean power of 5.02 |P1(f)| (SD = 4.63) suggests that our participant’s kinematic data did display a persistent tremor in both hands across all tasks and movement planes. Analyses of the reaching hand and the non-reaching hand suggest the participant displayed an action tremor in both postural and intention (kinetic) tremors. Future directions should include assessing additional individuals with NGLY1 Deficiency to determine if the tremor is a distinguishable disorder behavior. Additionally, evaluating other anatomical sites, such as the elbow, head, and lower limbs, would provide further insights into the characteristics of this tremor.

关键词： Tremor NGLY Fast Fourier Transformation Reaching Hyperkinetic movement

Effectiveness of psychological intervention following sport injury

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Journal of Sport and Health Science 2012年第2期1卷 71-79页

作者： Laura m.Schwab Reese ryan Pittsinger Jingzhen Yang Department of Community and Behavioral Health The University of IowaIowa CityIA 52242USA Department of Psychological and Quantitative Foundations The University of IowaIowa CityIA 52242USA

With increasing attention given to the development and implementation of psychological interventions during the sport injury rehabilitation process,there is a need to document the effectiveness of these *** purpose of this review was to summarize the empirical findings of the effects of psychological interventions in reducing post-injury psychological consequences and improving psychological coping during the injury rehabilitation process among competitive and recreational *** February 2012,utilizing a comprehensive search strategy,we conducted electronic searches of multiple electronic databases for randomized and nonrandomized control trials that evaluated interventions targeting populations of injured competitive and recreational athletes age 17 years and *** included interventions that directly intervene on injured athletes’ psychological outcomes(e.g.,psychological consequences,psychological coping and re-injury anxiety) and utilized psychological strategies including imagery,goal-setting,relaxation,and other common techniques during the post-injury rehabilitation *** studies,described in seven peer-reviewed published articles,met study inclusion criteria and were included in this *** those studies,two included randomized control trials,two used before and after study designs and two were case study *** interventions utilized guided imagery and relaxation,two interventions utilized goal-setting and one each utilized microcounseling,written disclosure,and acceptance and commitment *** imagery/relaxation was shown to be associated with improved psychological coping and reduced re-injury anxiety. Goal setting,however,was not directly associated with the reduction of negative psychological *** psychological techniques such as microcounseling skills,acceptance and commitment therapy,and written disclosure have demonstrated effectiveness in reducing negative psychological consequences,improving

关键词： Intervention Psychological consequence Psychological coping Sport injury

Protecting miners from coal bursts during development above historic mine workings in Harlan County,KY

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International Journal of mining Science and Technology 2021年第1期31卷 111-116页

作者： christopher mark mine Safety and Health Administration PittsburghPA 15236USA

In order to reach a large,untapped reserve of high-quality coal,D8 Cloverlick mine proposed to mine a corridor nearly 600 m deep beneath the Benham Spur of Black mountain,Kentucky’s highest peak.D8 Cloverlick mine was extracting the Owl seam,but the corridor’s route lay approximately 20 m above century-old mine workings in the C–(Darby)*** to the concern,three serious coal bursts had recently occurred in nearby Owl seam *** of the old workings seemed to indicate that the underlying C–seam had been fully ***,two of the coal bursts had occurred above areas where the C–Seam was also shown as mined *** Safety and Health Administration(mSHA)Technical Support therefore investigated the records of past mining to better understand the old mine *** conditions observed in current Owl seam workings were also compared with the maps of the old C–seam *** study concluded that the presence of hazardous underlying remnants could not be ruled *** mitigate the burst risk,D8 Cloverlick mine adopted a strategy of stress probe drilling.A self-propelled coal drill was used to auger 11.5-m-long,small diameter holes in advance of *** each hole was drilled,the cuttings were measured to detect the presence of highly stressed *** the crossing was successfully completed without incident.

关键词： Coal bursts Underground mining Room-and-pillar Destressing

Bubble Coalescence Heat Transfer During Subcooled Nucleate Pool Boiling

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工程热物理学报 2012年第12期33卷 2171-2175页

作者： Abdoulaye Coulibaly LIN Xipeng Bi Jingliang David m christopher Department of Thermal Engineering Tsinghua University

Bubble coalescence during subcooled nucleate pool boiling was investigated experimentally using constant wall temperature boundary conditions while the wall heat flux was measured at a various locations to understand the effects of coalescence on the heat *** observations showed that the coalesced bubble moved and oscillated on the heater surface with significant heat transfer variations prior to *** observations also showed coalescence with no increase in the heat transfer *** heat flux for boiling with coalescence fluctuated much more than for single bubble boiling due to the vaporization of the liquid layer trapped between the bubbles.

关键词： microheater pool boiling bubble coalescence bubble dynamics

matrix interactions modulate neurotrophin-mediated neurite outgrowth and pathfinding

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Neural Regeneration Research 2015年第4期10卷 514-517页

作者： christopher m.madl Sarah C.Heilshorn Department of Bioengineering Stanford University Department of materials Science and Engineering Stanford University

Both matrix biochemistry and neurotrophic factors are known to modulate neurite outgrowth and pathifnding; however, the interplay between these two factors is less studied. While previous work has shown that the biochemical identity of the matrix can alter the outgrowth of neurites in response to neurotrophins, the importance of the concentration of cell-adhesive ligands is unknown. Using engineered elastin-like protein matrices, we recently demonstrated a synergistic effect between matrix-bound cell-adhesive ligand density and soluble nerve growth factor treat-ment on neurite outgrowth from dorsal root ganglia. This synergism was mediated by Schwann cell-neurite contact through L1CAm. Cell-adhesive ligand density was also shown to alter the pathifnding behavior of dorsal root ganglion neurites in response to a gradient of nerve growth factor. While more cell-adhesive matrices promoted neurite outgrowth, less cell-adhesive ma-trices promoted more faithful neurite pathifnding. These studies emphasize the importance of considering both matrix biochemistry and neurotrophic factors when designing biomaterials for peripheral nerve regeneration.

关键词： neurotrophic factors cell-adhesive ligands dorsal root ganglia L1CAm nerve growth factor biomaterials elastin-like proteins

Bidirectional relationships of physical activity and gross motor skills before and after summer break:Application of a cross-lagged panel model

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Journal of Sport and Health Science 2022年第2期11卷 244-251页

作者： ryan D.Burns Yang Bai Wonwoo Byun Taylor E.Colotti christopher D.Pfledderer Sunku Kwon Timothy A.Brusseau Department of Health Kinesiologyand RecreationUniversity of UtahSalt Lake CityUT 84112USA

Background:Gross motor skills are postulated to have a bidirectional relationship with physical activity(PA);however,no study has tested this relationship before and after a summer *** purpose of this study was to examine the bidirectional relationships between school PA and gross motor skills in children before and after a summer ***:Participants were a sample of 440 children recruited from 3 low-income schools(age=8.9±1.2 years,mean±SD).PA was assessed as average school-day step counts using Yamax DigiWalker pedometers(Yamasa Tokei Keiki,Tokyo,Japan)worn for 5 consecutive school *** motor skills were assessed using the Test for Gross motor Development,3 rd *** were collected at 2 timepoints:at the end of spring semester(T1)and at the beginning of the subsequent fall semester(T2).An age-and body mass index-adjusted cross-lagged model was employed to relate T1 school step counts with T2 gross motor skills and T1 gross motor skills with T2 school step ***:T1 gross motor skills significantly predicted T2 school step counts(β=0.24,95%confidence interval(95%CI):0.08-0.40,p=0.003);however,Tl school step counts did not predict T2 gross motor skills(β=0.04,95%CI:-0.06 to 0.14,p=0.445).The model explained 35.4%and 15.9%of the variances of T2 gross motor skills and T2 school step counts,*** analyses indicated that these relationships were driven primarily by ball ***:The relationship between gross motor skills and school PA was not bidirectional;however,higher gross motor skills,specifically ball skills,predicted higher school PA after a 3-month summer break.

关键词： Children motor competence Physical activity Schools

Vascular disease in the older adult

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Journal of Geriatric Cardiology 2016年第9期13卷 727-732页

作者： Andrew P miller christopher m Huff Gary S Roubin Cardio Vascular Associates Birmingham Alabama USA

1 Introduction Among older adults, incidence and prevalence of aortic disease, peripheral arterial disease （PAD）, and venous thromboembolism （VTE） increase as age-related alterations in vascular structure and function are compounded by longer exposure to cardiovascular disease （CVD） risk factors. This review highlights the unique presentations and treatment strategies for aortic dissection, abdominal aortic aneurysm （AAA）, PAD, and VTE in older adults.

关键词： Aortic diseases Cardiovascular disease Peripheral arterial disease The elderly

melanization in living organisms: a perspective of species evolution

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Protein & Cell 2010年第9期1卷 830-841页

作者： christopher J Vavricka Bruce m.Christensen Jianyong Li CAS Key Laboratory of Pathogenic microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CASPMI)Beijing 100101China Department of Pathobiology University of Wisconsin-MadisonMadisonWI 53706USA Department of Biochemistry Virginia TechBlacksburgVA 24061USA

Eumelanin is a heteropolymer that is generally composed of hydroxylated indole residues and plays diverse protective functions in various *** is derived from the amino acid tyrosine and production of melanin is a highly complex oxidative process with a number of steps that can either proceed enzymatically or *** melanin plays important protective roles in many species,during melanization,particularly in steps that can proceed non-enzymatically,many toxic intermediates are produced,including semiquinones,dopaquinone,indole-quinones and moreover,the production of many reactive oxygen *** mitigate the production of reactive species,a number of proteins that regulate the biochemical process of melanization have evolved in various living species,which is closely related to adaptation and physiological *** this communication,we discuss differences between non-enzymatic and enzymatic processes of melanization and the enzymatic regulation of melanization in difference species with an emphasis on differences between mammals and *** between melanization and insect sclerotization is also emphasized which raises some interesting questions about the current models of these pathways.

关键词： melanization melanogenesis sclerotization tanning dopa tyrosinase dopachrome tautomerase

Erratum to “A gyroscope-based system for intraoperative measurement of tibia coronal plane alignment in total knee arthroplasty” [med Nov Technol Dev, 13, 2022, 100112]

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medicine in Novel Technology and Devices 2024年第1期21卷 120-120页

作者： michael A.Kokko ryan m.Chapman martin W.Roche Douglas W.Van Citters Thayer School of Engineering at Dartmouth College 14 Engineering DriveHanoverNH03755USA Department of Kinesiology College of Health SciencesUniversity of Rhode Island25 W.Independence WayKingstonRI02881USA Orthopedic Research Institute Holy Cross Hospital 4725 N Federal Hwy.FtLauderdaleFL33308USA

The publisher would like to include the Ethical approval and informed consent statement for this *** study did not involve human subjects or animal research,and was therefore not subject to institutional ethics approval and did not require informed *** single cadaveric specimen used in ex vivo evaluation was obtained from Science Care(https://***/)and was handled in accordance with applicable Science Care policy.

关键词： approval statement alignment