检索结果-南通市图书馆

Establishing proof of concept:Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus

引用

World Journal of Orthopedics 2012年第7期3卷 101-108页

作者： Niall A Smyth christopher d murawski Amgad M Haleem Charles P Hannon Ian Savage-Elliott John G Kennedy department of Orthopaedic Surgery Hospital for Special SurgeryNew YorkNY 10021United States

Osteochondral lesions of the talus are common injuries in the athletic patient. They present a challenging clinical problem as cartilage has a poor potential for healing. Current surgical treatments consist of reparative(microfracture) or replacement(autologous osteochondral graft) strategies and demonstrate good clinical outcomes at the short and medium term follow-up. Radiological findings and second-look arthroscopy however, indicate possible poor cartilage repair with evidence of fibrous infill and fissuring of the regenerative tissue following microfracture. Longer-term follow-up echoes these findings as it demonstrates a decline in clinical outcome. The nature of the cartilage repair that occurs for an osteochondral graft to become integrated with the native surround tissue is also of concern. Studies have shown evidence of poor cartilage integration,with chondrocyte death at the periphery of the graft, possibly causing cyst formation due to synovial fluid ingress. Biological adjuncts, in the form of platelet-rich plasma(PRP) and bone marrow aspirate concentrate(BMAC), have been investigated with regard to their potential in improving cartilage repair in both in vitro and in vitro settings. The in vitro literature indicates that these biological adjuncts may increase chondrocyte proliferation as well as synthetic capability, while limiting the catabolic effects of an inflammatory joint environment. These findings have been extrapolated to in vitro animal models, with results showing that both PRP and BMAC improve cartilage repair. The basic science literature therefore establishes the proof of concept that biological adjuncts may improve cartilage repair when used in conjunction with reparative and replacement treatment strategies for osteochondral lesions of the talus.

关键词： Osteochondral lesion Cartilage repair Platelet-rich plasma Bone marrow aspirate concentrate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

引用

Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： christopher J.O’Connell Matthew J.Robson department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Jet flows from bubbles during subcooled pool boiling on micro wires

引用

Science China(Technological Sciences) 2005年第4期48卷 385-402页

作者： d. M. christopher Laboratory of Phase Change and Interfacial Transport Phenomena Department of Thermal Engineering Tsinghua University Beijing 100084 China

An experimental investigation was conducted on subcooled nucleate boiling on ultra-small wires having diameters of 25―100 μm. High-speed photography and laser PIV (Particle Image Velocimetry) technology were used to visually observe the bubble dynamics. For highly subcooled boiling at moderate heat fluxes, the bubbles generally remained attached to the micro heating wires and bubble-top jet flows were clearly observed. Smaller bubbles usually had stronger bubble-top jet flows, while larger bubbles seemed to produce multi-jet flows. The structures of the bubble-top jet flows, as well as multi-jet flows, were proposed from the experimental observation. A model was developed to describe jet flow phenomena from bubbles on micro wires. Numerical simulations for bubbles having diameter of 0.03 and 0.06 mm showed that both the bubble-top and multi-jet flows were induced by a strong Marangoni effect due to high temperature gradients near the wire. The predicted velocity magnitudes and flow structures agreed very well with experimental measurements. The bubble size relative to the wire is an important factor affecting the jet flow structure. For a 0.03 mm bubble on a 0.1 mm wire, only a bubble-top jet flow forms, while a complex multi-jet flow pattern forms around the bubble with a weak bubble-top jet and two side jet flows for a 0.06 mm bubble.

关键词： subcooled boiling, bubble, multi-jet, jet flow, PIV, Marangoni, CFd.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Matrix metalloproteinases in neural development:a phylogenetically diverse perspective

引用

Neural Regeneration Research 2016年第3期11卷 357-362页

作者： christopher d.Small Bryan d.Crawford department of Biology University of New Brunswick

The matrix metalloproteinases（MMPs） are a family of zinc-dependent endopeptidases originally characterized as secreted proteases responsible for degrading extracellular matrix *** canonical role in matrix remodelling is of significant importance in neural development and regeneration,but emerging roles for MMPs,especially in signal transduction pathways,are also of obvious importance in a neural *** of MMP activity is a hallmark of many neuropathologies,and members of every branch of the MMP family have been implicated in aspects of neural development and ***,while extraordinary research efforts have been made to elucidate the molecular mechanisms involving MMPs,methodological constraints and complexities of the research models have impeded *** we discuss the current state of our understanding of the roles of MMPs in neural development using recent examples and advocate a phylogenetically diverse approach to MMP research as a means to both circumvent the challenges associated with specific model organisms,and to provide a broader evolutionary context from which to synthesize an understanding of the underlying biology.

关键词： matrix metalloproteinases extracellular matrix xenopus drosophila zabrafish neural development evolution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

On a connectedness principle of Shokurov-Kollr type

引用

Science China Mathematics 2019年第3期62卷 411-416页

作者： christopher d.Hacon Jingjun Han department of Mathematics University of Utah Beijing International Center for Mathematical Research Peking University

Let(X, ?) be a log pair over S, such that-(KX+ ?) is nef over S. It is conjectured that the intersection of the non-klt(non Kawamata log terminal) locus of(X, ?) with any fiber Xs has at most two connected components. We prove this conjecture in dimension no greater than 4 and in arbitrary dimension assuming the termination of klt flips.

关键词： minimal model program non-klt locus connectedness

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Obstructive sleep apnea syndrome and fatty liver: Association or causal link?

引用

World Journal of Gastroenterology 2010年第34期16卷 4243-4252页

作者： Mohamed H Ahmed christopher d Byrne Chemical Pathology department Southampton University Hospital NHS Trust Southampton SO16 6YD United Kingdom Endocrinology and Metabolism DOHaD Division University of Southampton and Southampton University Hospitals Trust Southampton SO16 6YD United Kingdom

Obstructive sleep apnea (OSA) is a complex disorder that consists of upper airway obstruction, chronic intermittent hypoxia and sleep fragmentation. OSA is well known to be associated with hypoxia, insulin resistance and glucose intolerance, and these factors can occur in the presence or absence of obesity and metabolic syndrome. Although it is well established that insulin resistance, glucose intolerance and obesity occur frequently with non-alcoholic fatty liver disease (NAFLd), it is now becoming apparent that hypoxia might also be important in the development of NAFLd, and it is recognized that there is increased risk of NAFLd with OSA. This review discusses the association between OSA, NAFLd and cardiovascular disease, and describes the potential role of hypoxia in the development of NAFLd with OSA.

关键词： Sleep apnea syndrome Hyperlipidemia Non-alcoholic fatty liver disease Insulin resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Experimental Study of High Moisture Content Gas Flow Across a Cylinder at Moderate Reynolds Numbers

引用

Tsinghua Science and Technology 2003年第5期8卷 598-604页

作者： d.M.christopher 郭亮 department of Thermal Engineering

The Nusselt number for cross flow of a mixture of air and vapor over a cylinder was measured at moderate Reynolds numbers (30007000) for temperatures from 300℃ to 700℃ and for vapor mass fractions of 0.180.35. Results are also presented for a set of three cylinders aligned perpendicular to the flow for the same range of conditions. The effect of the vapor concentration and temperature on the convection coefficients was investigated to develop a modified Zhukauskas correlation. The results show that the Nusselt number increases as the moisture content increases and that the increase is more than could be accounted for by typical models for the property variations of mixtures. The exponent of the vapor concentration term in the modified correlation is 0.145 for the entire data set indicating the importance of the property variation due to the moisture content.

关键词： high moisture content cross flow convection coefficients heat exchangers

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tuning periodicity of polymer-decorated carbon nanotubes

引用

Science China Chemistry 2012年第5期55卷 802-807页

作者： LAIRd Eric d. LI christopher Y. A. J. drexel Nanotechnology Institute and department of Materials Science and Engineering Drexel University Philadelphia Pennsylvania 19104 USA

Carbon nanotube (CNT) is one of the most extensively investigated nanomaterials. Patterning soft matter such as liquid crystals and polymers on CNTs could potentially enable various applications for CNTs. We have demonstrated that controlled polymer crystallization using CNTs as the 1d nucleation sites can lead to periodically functionalized CNTs. Here we show that selected crystalline block copolymers can be periodically decorated along CNTs. This facile technique opens a gateway to periodic patterning on 1-d nanomaterials.

关键词： polymer crystallization carbon nanotube block copolymers

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neurological and neuropsychological consequences of electrical and lightning shock： review and theories of causation

引用

Neural Regeneration Research 2017年第5期12卷 677-686页

作者： christopher J.Andrews Andrew d.Reisner Faculty of Medicine-The University of Queensland HerstonAustraliaLightning and Electrical InjuriesMt Ommaney Family PracticeMt OmmaneyBrisbaneAustralia Forensic diagnostic Center of district Nine CambridgeOHUSA

Injuries from lightning and electrical injuries involve multiple systems of the body, however neurological symptoms are very widely reported. A disabling neuropsychological syndrome is also noted. This paper presents a comprehensive review of neurological and neuropsychological symptoms. Partial theories of causation for these injuries have been advanced, however, there is no convincing explanation for both delay in onset of symptoms and also the genesis of the neuropsychological syndrome. A theory of causation is proposed which satisfies both these constraints. This theory suggests circulating hormones such as cortisol, together with nitric oxide and oxidant free radicals from glutamatergic hyper-stimulation, act on tissues remote from the injury path including the hippocampus. This theory opens a research path to explore treatment options.

关键词： electrical injury lightning injury neurology neuropsychology neuropsychiatry injury trauma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Repair of traumatic plasmalemmal damage to neurons and other eukaryotic cells

引用

Neural Regeneration Research 2016年第7期11卷 1033-1042页

作者： George d.Bittner christopher S.Spaeth Andrew d.Poon Zachary S.Burgess christopher H.Mc Gill department of Neuroscience The University of Texas at Austin

The repair（sealing） of plasmalemmal damage,consisting of small holes to complete transections,is critical for cell survival,especially for neurons that rarely regenerate cell *** first describe and evaluate different measures of cell *** measures,including morphological/ultra-structural observations,membrane potential,and input resistance,provide very ambiguous assessments of plasmalemmal *** contrast,measures of ionic current flow and dye barriers can,if appropriately used,provide more accurate *** describe the effects of various substances（calcium,calpains,cytoskeletal proteins,ESCRT proteins,m UNC-13,NSF,PEG） and biochemical pathways（PKA,PKC,PLC,Epac,cytosolic oxidation） on plasmalemmal sealing probability,and suggest that substances,pathways,and cellular events associated with plasmalemmal sealing have undergone a very conservative *** sealing,calcium ion influx mobilizes vesicles and other membranous structures（lysosomes,mitochondria,etc.） in a continuous fashion to form a vesicular plug that gradually restricts diffusion of increasingly smaller molecules and ions over a period of seconds to ***,we find no direct evidence that sealing occurs through the collapse and fusion of severed plasmalemmal leaflets,or in a single step involving the fusion of one large wound vesicle with the nearby,undamaged *** describe how increases in perikaryal calcium levels following axonal transection account for observations that cell body survival decreases the closer an axon is transected to the ***,we speculate on relationships between plasmalemmal sealing,Wallerian degeneration,and the ability of polyethylene glycol（PEG） to seal cell membranes and rejoin severed axonal ends – an important consideration for the future treatment of trauma to peripheral nerves.A better knowledge of biochemical pathways and cytoplasmic structures involved in plasmalemmal sealing might provide insights to develo

关键词： sealing traumatic eukaryotic vesicles axonal membranous closer biochemical vesicular muscular

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：