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Matrix from urine stem cells boosts tissue-specific stem cell mediated functional cartilage reconstruction

Bioactive Materials 2023年第5期23卷 353-367页

作者： Ming Pei Yixuan Amy Pei Sheng Zhou Elmira Mikaeiliagah christopher erickson Benjamin Giertych Halima Akhter Lei Wang Amanda Stewart Joshua Parenti Bin Wang Sijin Wen Sotcheadt Sim Eric Quenneville Kirk C.Hansen Steven Frisch Gangqing Hu Stem Cell and Tissue Engineering Laboratory Department of OrthopaedicsWest Virginia UniversityMorgantownWVUSA WVU Cancer Institute Robert C.Byrd Health Sciences CenterWest Virginia UniversityMorgantownWVUSA Perelman School of Medicine University of PennsylvaniaPhiladelphiaPAUSA Department of Biology Ardabil BranchIslamic Azad UniversityArdabilIran Department of Biochemistry&Molecular Genetics University of Colorado DenverAuroraCOUSA Department of Microbiology Immunologyand Cell BiologyWest Virginia UniversityMorgantownWVUSA Department of Foot and Hand Surgery Clinical Medical College of Yangzhou UniversitySubei People’s Hospital of Jiangsu ProvinceYangzhouJiangsuChina Department of Biostatistics School of Public HealthWest Virginia UniversityMorgantownWVUSA Biomomentum Inc. LavalQuebecCanada Department of Biochemistry West Virginia UniversityMorgantownWVUSA Bioinformatics Core West Virginia UniversityMorgantownWVUSA

Articular cartilage has a limited capacity to self-heal once ***-specific stem cells are a solution for cartilage regeneration;however,ex vivo expansion resulting in cell senescence remains a challenge as a large quantity of high-quality tissue-specific stem cells are needed for cartilage *** previous report demonstrated that decellularized extracellular matrix(dECM)deposited by human synovium-derived stem cells(SDSCs),adipose-derived stem cells(ADSCs),urine-derived stem cells(UDSCs),or dermal fibroblasts(DFs)provided an ex vivo solution to rejuvenate human SDSCs in proliferation and chondrogenic potential,particularly for dECM deposited by *** make the cell-derived dECM(C-dECM)approach applicable clinically,in this study,we evaluated ex vivo rejuvenation of rabbit infrapatellar fat pad-derived stem cells(IPFSCs),an easily accessible alternative for SDSCs,by the abovementioned C-dECMs,in vivo application for functional cartilage repair in a rabbit osteochondral defect model,and potential cellular and molecular mechanisms underlying this *** found that C-dECM rejuvenation promoted rabbit IPFSCs’cartilage engineering and functional regeneration in both ex vivo and in vivo models,particularly for the dECM deposited by UDSCs,which was further confirmed by proteomics ***-Seq analysis indicated that both mesenchymal-epithelial transition(MET)and inflammation-mediated macrophage activation and polarization are potentially involved in the C-dECM-mediated promotion of IPFSCs’chondrogenic capacity,which needs further investigation.

关键词： Decellularized extracellular matrix Tissue-specific stem cell Urine-derived stem cell Rejuvenation Functional cartilage repair

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