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Unifying concepts in methanogenic,aerobic,and anammox sludge granulation

Environmental Science and Ecotechnology 2024年第1期17卷 17-30页

作者： Simon Mills Anna christine Trego Marco Prevedello Jo De Vrieze Vincent O’Flaherty Piet N.l.lens Gavin Collins Microbial Communities laboratory School of Biological and Chemical SciencesNational University of Ireland GalwayUniversity RoadGalwayH91 TK33Ireland Microbial Ecology laboratory School of Biological and Chemical Sciences University of GalwayUniversity RoadGalwayH91 TK33Ireland Center for Microbial Ecology and Technology(CMET) Ghent UniversityCoupure Links 653B-9000GentBelgium University of Galway University RoadGalwayH91 TK33Ireland

The retention of dense and well-functioning microbial biomass is crucial for effective pollutant removal in several biological wastewater treatment *** solids retention is often achieved through aggregation of microbial communities into dense,spherical aggregates known as granules,which were initially discovered in the *** granules have since been widely applied in upflow anaerobic digesters for waste-to-energy ***,granular biomass has been applied in aerobic wastewater treatment and anaerobic ammonium oxidation(anammox)*** mechanisms underpinning the formation of methanogenic,aerobic,and anammox granules are the subject of ongoing *** each granule type has been extensively studied in isolation,there has been a lack of comparative studies among these granulation *** is likely that there are some unifying concepts that are shared by all three sludge *** these unifying concepts could allow a unified theory of granulation to be ***,we review the granulation mechanisms of methanogenic,aerobic,and anammox granular sludge,highlighting several common concepts,such as the role of extracellular polymeric substances,cations,and operational parameters like upflow velocity and shear *** have then identified some unique features of each granule type,such as different internal structures,microbial compositions,and quorum sensing ***,we propose that future research should prioritize aspects of microbial ecology,such as community assembly or interspecies interactions in individual granules during their formation and growth.

关键词： Granule Granulation Anaerobic digestion Anammox Aerobic granule

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Amyloid-beta and tau protein beyond Alzheimer's disease

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Neural Regeneration Research 2024年第6期19卷 1262-1276页

作者： Morteza Abyadeh Vivek Gupta Joao A.Paulo Arezoo Gohari Mahmoudabad Sina Shadfar Shahab Mirshahvaladi Veer Gupta christine T.O.Nguyen David I.Finkelstein Yuyi You Paul A.Haynes Ghasem H.Salekdeh Stuart l.Graham Mehdi Mirzaei ProGene Technologies Pty ltd. SydneyNSWAustralia Department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia Department of Cell Biology Harvard Medical SchoolBostonMAUSA School of Medicine Deakin UniversityGeelongVICAustralia Department of Optometry and Vision Sciences School of Health SciencesFaculty of Medicine Dentistry and Health SciencesUniversity of MelbourneParkvilleVICAustralia The Florey Institute of Neuroscience and Mental Health The University of MelbourneParkvilleVICAustralia School of Natural Sciences Macquarie UniversityMacquarie ParkNSWAustralia

The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer's disease pathogenesis and are considered the main pathological hallmarks of this devastating ***,these two proteins are produced and expressed within the normal human ***,under pathological conditions,abnormal expression,posttranslational modifications,conformational changes,and truncation can make these proteins prone to aggregation,triggering specific disease-related *** studies have indicated associations between aberrant behavior of amyloid-beta and tau proteins and various neurological diseases,such as Alzheimer's disease,Parkinson's disease,and amyotrophic lateral sclerosis,as well as retinal neurodegenerative diseases like Glaucoma and age-related macular ***,these proteins have been linked to cardiovascular disease,cancer,traumatic brain injury,and diabetes,which are all leading causes of morbidity and *** this comprehensive review,we provide an overview of the connections between amyloid-beta and tau proteins and a spectrum of disorders.

关键词： amyloid-beta cancer cardiovascular diseases diabetes neurodegeneration Tau traumatic brain injury

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Two adjacent NlR genes conferring quantitative resistance to clubroot disease in Arabidopsis are regulated by a stably inherited epiallelic variation

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Plant Communications 2024年第5期5卷 148-162页

作者： Antoine Gravot Benjamin lie gard leandro Quadrana Florian Veillet Yoann Aigu Tristan Bargain Juliette Benejam christine lariagon Jocelyne lemoine Vincent Colot Maria J.Manzanares-Dauleux Melanie Jubault IGEPP Institut Agro INRAEUniversitede Rennes35650 Le RheuFrance Institut de Biologie de l’Ecole Normale Superieure(IBENS) Ecole Normale SuperieureCentre National de la Recherche Scientifique(CNRS)Institut National de la Santeet de la Recherche Medicale(INSERM)75005 ParisFrance IGEPP INRAE Institut AgroUniversitede Rennes29260 PloudanielFrance Present address:Aix-Marseille University CEACNRSInstitute of Biosciences and BiotechnologiesBIAM Cadarache13108 Saint-Paul-lez-DuranceFrance.

Clubroot caused by the protist Plasmodiophora brassicae is a major disease affecting cultivated *** a combination of quantitative trait locus(QTl)fine mapping,CRISPR-Cas9 validation,and extensive analyses of DNA sequence and methylation patterns,we revealed that the two adjacent neigh-boring NlR(nucleotide-binding and leucine-rich repeat)genes AT5G47260 and AT5G47280 cooperate in controlling broad-spectrum quantitative partial resistance to the root pathogen *** in Arabidopsis and that they are epigenetically *** variation in DNA methylation is not associated with any nucleotide variation or any transposable element presence/absence variants and is stably ***-ations in DNA methylation at the Pb-At5.2 QTl are widespread across Arabidopsis accessions and corre-late negatively with variations in expression of the two *** study demonstrates that natural,stable,and transgenerationally inherited epigenetic variations can play an important role in shaping resistance to plant pathogens by modulating the expression of immune receptors.

关键词： methylation clubroot Plasmodiophora brassicae AT5G47260 AT5G47280 ADR1-l3 ddm1

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Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton lisa J Woodhouse Craig S Anderson Sandeep Ankolekar lesley Cala Mark Dixon Timothy J England Kailash Krishnan Grant Mair Keith W Muir John Potter Christopher I Price Marc Randall Thompson G Robinson christine Roffe Else C Sandset Jeffrey l Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and NIHR leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS AlREADY KNOWN ON THIS TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

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Randomized intervention to assess the effectiveness of an educational video on organ donation intent among Hispanics in the New York metropolitan area

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World Journal of Transplantation 2023年第4期13卷 190-200页

作者： Renee Pekmezaris Edgardo Cigaran Vidhi Patel Damian Clement christine l.sardo mol.enti Ernesto mol.enti Feinstein Institutes for Medical Research Northwell HealthManhassetNY 11030United States Department of Nephrology Northwell Health/Zucker School of Medicine at HosftraManhassetNY 11030United States

BACKGROUND The Hispanic community has a high demand for organ donation but a shortage of *** investigating factors that could promote or hinder organ donation have examined emotional video *** acting as barriers to organ donation registration have been classified as:(1)Bodily integrity;(2)medical mistrust;(3)“ick”-feelings of disgust towards organ donation;and(4)“jinx”-fear that registration may result in one dying due to premeditated *** predict that by providing necessary information and education about the donation process via a short video,individuals will be more willing to register as organ *** To determine perceptions and attitudes regarding barriers and facilitators to organ donation intention among Hispanic residents in the New York metropolitan *** This study was approved by the Institutional Review Board at Northwell *** approval reference number is No.19-0009(as presented in Supplementary material).Eligible participants included Hispanic New York City(NYC)residents,18 years of age and above,who were recruited voluntarily through Cloud Research and participated in a larger randomized survey study of NYC *** survey an 85-item Redcap survey measured participant demographics,attitudes,and knowledge of organ donation as well as the intention to register as an organ *** checks were implemented throughout the survey,and responses were excluded for those who did *** were randomly assigned two-between subject conditions:To view a short video on organ donation and then proceed to complete the survey(i.e.,video first)and view the same video at the end of the survey(video last).No intra-group activities were *** study utilized an evidenced-based emotive educational intervention(video)which was previously utilized and was shown to increase organ donation registration rates at the Ohio Department of Motor *** were analyzed using Jamovi statistical softw

关键词： Community engagement and health Health equity Diversity and inclusion Health policy Kidney donation Minority health and disparities Organ transplant

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Stereoselective Functionalization at C-2 and C-3 of the Gibberellin via an Intramolecular Free Radical Cyclization Approach

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Chinese Chemical letters 2001年第5期12卷 397-398页

作者： An Qi CHEN christine l.WIllIS Department of Chemistry Xiamen UniversityXiamen3610052School of ChemistryUniversity of BristolBristolUK BS81TS

Stereoselective functionalization at C-2 and C-3 of the gibberellin skeleton was achieved via an intramolecular free radical cyclization approach using a tethered C-19 halomethyl ester as the radical precursor.

关键词： Gibberellin lactonization free radical cyclization.

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Unexpected Stereospecific Rearrangement-Addition Reaction of Trisubstituted Gibberellin Epoxides with Trimethylaluminium

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Chinese Chemical letters 2001年第10期12卷 855-858页

作者： An Qi CHEN christine l.WIllIS Department of Chemistry Xiamen UniversityXiamen 361005 School of Chemistry University of BristolBristolUK BS8 1TS

A novel rearrangement-addition reaction of trisubstituted gibberellin epoxides with trimethylaluminium is reported. The reaction proceeds stereospecifically to give tertiary methyl alcohols. The possible mechanism for... 详细信息

关键词： gibberellin epoxide trimethylaluminium rearrangement-addition reaction

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Is convenience really king? Comparative evaluation of catastrophic costs due to tuberculosis in the public and private healthcare sectors of Viet Nam: a longitudinal patient cost study

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贫困所致传染病(英文) 2024年第2期13卷 1-12页

作者： Nguyen Hoa Binh Quang Vo luan Nguyen Forse Rachel Jeanette Wiemers Anja Maria christine Huynh Huy Ba Dong Thuy Thi Thu Phan Yen Thi Hoang Creswell Jacob Dang Thi Minh Ha Nguyen lan Huu Shedrawy Jad l?nnroth Knut Nguyen Tuan Dinh Van Dinh luong Annerstedt Kristi Sidney Codlin Andrew James National lung Hospital Ha Noi Viet Nam Friends for International TB Relief Ha Noi Viet Nam Department of Global Public Health WHO Collaboration Centre On Tuberculosis and Social Medicine Karolinska Institute Stockholm Sweden Stop TB Partnership Geneva Switzerland Pham Ngoc Thach Hospital Ho Chi Minh City Viet Nam

Background In Viet Nam, tuberculosis (TB) represents a devastating life-event with an exorbitant price tag, partly due to lost income from daily directly observed therapy in public sector care. Thus, persons with TB may seek care in the private sector for its flexibility, convenience, and privacy. Our study aimed to measure income changes, costs and catastrophic cost incurrence among TB-affected households in the public and private *** Between October 2020 and March 2022, we conducted 110 longitudinal patient cost interviews, among 50 patients privately treated for TB and 60 TB patients treated by the National TB Program (NTP) in Ha Noi, Hai Phong and Ho Chi Minh City, Viet Nam. Using a local adaptation of the WHO TB patient cost survey tool, participants were interviewed during the intensive phase, continuation phase and post-treatment. We compared income levels, direct and indirect treatment costs, catastrophic costs using Wilcoxon rank-sum and chi-squared tests and associated risk factors between the two cohorts using multivariate *** The pre-treatment median monthly household income was significantly higher in the private sector versus NTP cohort (USD 868 vs USD 578;P=0.010). However, private sector treatment was also significantly costlier (USD 2075 vs USD 1313;P=0.005), driven by direct medical costs which were 4.6 times higher than costs reported by NTP participants (USD 754 vs USD 164;Plted in no significant difference in catastrophic costs between the two cohorts (Private: 55% vs NTP: 52%;P=0.675). Factors associated with catastrophic cost included being a single-person household [adjusted odds ratio [(aOR=13.71; 95% confidence interval (CI): 1.36–138.14;P=0.026], unemployment during treatment (aOR=10.86; 95%CI: 2.64–44.60;Plated stigma (aOR=37.90; 95%CI: 1.72–831.73;P=0.021).Conclusions Persons with TB in Viet Nam face similarly high risk of catastrophic costs whether treated in the

关键词： Tuberculosis Patient cost Catastrophic cost Private sector Comparative analysis Viet Nam

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Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients

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Journal of Sport and Health Science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthuso Myriam Filion Spencer J.Allen Stephanie M.Ntoukas Gordon J.Bell Jessica McNeil Qinggang Wang Margaret l.McNeely Jeff K.Vallance lin Yang S.Nicole Culos-Reed leanne Dickau John R.Mackey christine M.Friedenreich Kerry S.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiology and Prevention Research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation Medicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Disciplines Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kinesiology University of CalgaryCalgary T2N 1N4Canada Faculty of Medicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life,treatment outcomes,and *** and managing breast cancer-related symptoms soon after diagnosis is *** purpose of this study was to investigate the associations between health-related fitness(HRF)and patient-reported symptoms in newly diagnosed breast cancer ***:This study utilized baseline data from the Alberta Moving Beyond Breast Cancer Cohort Study that were collected within 90 days of *** measures included peak cardiopulmonary fitness(peak volume of oxygen consumption(VO_(2peak))),maximal muscular strength and endurance,flexibility,and body *** measures included depression,sleep quality,and *** multivariable logistic regression was performed for ***:Of 1458 participants,51.5%reported poor sleep quality,26.5%reported significant fatigue,and 10.4%reported moderate *** multivariable-adjusted models,lower relative VO_(2peak)was independently associated with a greater likelihood of all symptom measures,including moderate depression(pleep quality(p=0.009),significant fatigue(p=0.008),any symptom(pltiple symptoms(pld associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest *** strength of the threshold associations varied by the symptom measure with odds ratios ranging from-1.5 for poor sleep quality to-3.0 for moderate depression and multiple ***,lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner(p=0.001),and higher body weight was independently associated with poor sleep quality in an inverted U pattern(p=0.021).Conclusion:Relative VO_(2peak)appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diag

关键词： Breast cancer Fatigue Depression Sleep quality Cardiorespiratory fitness

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The role of retinoic acid in the commitment to meiosis

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Asian Journal of Andrology 2021年第6期23卷 549-554页

作者： Rachel l Gewiss M christine Schleif Michael D Griswold School of molecular Biosciences and Center for Reproductive Biology Washington State UniversityPullmanWA 99164USA

Male meiosis is a complex process whereby spermatocytes undergo cell division to form haploid *** review focuses on the role of retinoic acid(RA)in meiosis,as well as several processes regulated by RA before cell entry into meiosis that are critical for proper meiotic entry and ***,we discuss RA metabolism in the testis as well as the roles of stimulated by retinoic acid gene 8(STRA8)and MEIOSIN,which are responsive to RA and are critical for *** assert that transcriptional regulation in the spermatogonia is critical for successful meiosis.

关键词： meiosis retinoic acid spermatogenesis testis

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