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Deprescribing antihypertensive treatment in nursing home patients and the effect on blood pressure

Journal of Geriatric Cardiology 2018年第4期15卷 275-283页

作者： christine Gulla Elisabeth Flo Reidun LS Kjome Bettina S Husebo Centre for Elderly and Nursing Home Medicine Department of Global Public Health and Primary Care University of Bergen Norway Department of Clinical Psychology University of Bergen Norway Centre for Pharmacy/Department of Global Public Health and Primary Care University of Bergen Norway Municipality of Bergen Bergen Norway

Background It is debatable whether treating multimorbid nursing home patients with antihypertensive drugs produces beneficial effects. Most cardiovascular guidelines promote treatment; few have advice on how to deprescribe when treatment may no longer be necessary. We investigated the effect of medication review on antihypertensive drug use and the association between cognition, blood pressure, and prescribing. Methods From August 2014 to December 2015, 765 patients from 72 units （clusters） in 32 Norwegian nursing homes were included in a 4-month, multicentre, cluster-randomized, controlled trial, with 9-month follow-up. Patients ≥ 65 years old with antihypertensive treatment （n = 295, 39%） were randomized to systematic medication review where the physician received support from peers （collegial mentoring） or were given care as usual （control condition）. Outcome measures were the number of antihypertensive drugs, systolic blood pressure, and pulse. We used hospitalizations and deaths as criteria to assess harm. Results At baseline, each patient used 9.2 ± 3.5 regular drugs, and 1.6 ± 0.7 antihypertensives. Mean blood pressure was 128/71 mmHg and 9% had a systolic pressure ≥ 160 mmHg. Between baseline and month four, antihypertensives were deprescribed to a significantly higher extent in the intervention group （n = 43, 32%） compared to control （n = 11, 10%）; Incidence Rate Ratio = 0.8, 95% CI = 0.7？0.9. In the intervention group, there was an immediate increase in systolic blood pressure when antihypertensives were reduced, from baseline 128 ± 19.5 mmHg to 143 ± 25.5 mmHg at month four. However, at month nine, the blood pressure had reverted to baseline values （mean 134 mmHg）. Deprescription did not affect pulse and systolic pressure. The number of hospitalizations was higher in control patients at month four （P = 0.031） and nine （P = 0.041）. Conclusion A systematic medication review supported by collegial mentoring significantly decreased the use of antihypertensive

关键词： Antihypertensive drugs Deprescribing Hypertension Long-term care Medication review

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Cytosolic HSP90 Cochaperones HOP and FKBP Interact with Freshly Synthesized Chloroplast Preproteins of Arabidopsis

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Molecular Plant 2011年第6期4卷 1133-1145页

作者： christine Fellerer Regina Schweiger Katharina Schongruber Jurgen Soil Serena Schwenker Department of Biology 1 Botany Ludwig-Maximilians-Universitat Munchen Grobhaderner Strasse 2-4 D-82152 Planegg-Martinsried Germany Munich Center for Integrated Protein Science CiPSM Ludwig-Maximilians-Universitut Munchen Feodor-Lynen-Strasse 25 D-81377 Munich Germany

Most chloroplast and mitochondrial proteins are synthesized in the cytosol of the plant cell and have to be imported into the organelles post-translationally. Molecular chaperones play an important role in preventing protein aggregation of freshly translated preproteins and assist in maintaining the preproteins in an import competent state. Pre- proteins can associate with HSP70, HSP90, and 14-3-3 proteins in the cytosol. In this study, we analyzed a large set of wheat germ-translated chloroplast preproteins with respect to their chaperone binding. Our results demonstrate that the formation of distinct 14-3-3 or HSP90 containing preprotein complexes is a common feature in post-translational protein transport in addition to preproteins that seem to interact solely with HSP70. We were able to identify a diverse and extensive class of preproteins as HSP90 substrates, thus providing a tool for the investigation of HSP90 client protein association. The analyses of chimeric HSP90 and 14-3-3 binding preproteins with exchanged transit peptides indicate an involvement of both the transit peptide and the mature part of the proteins, in HSP90 binding. We identified two partner components of the HSP90 cycle, which were present in the preprotein containing high-molecular-weight complexes, the HSP70/HSP90 organizing protein HOP, as well as the immunophilin FKBP73. The results establish chloroplast preproteins as a general class of HSP90 client proteins in plants using HOP and FKBP as novel cochaperones.

关键词： Wheat germ in vitro translation chloroplast import chaperone.

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Iterative Factors Favoring Collaboration for Interorganizational Resilience:The Case of the Greater Montréal Transportation Infrastructure

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International Journal of Disaster Risk Science 2015年第1期6卷 75-86页

作者： Marie-christine Therrien Stéphane Beauregard Anais Valiquette-L'Heureux National School of Public Administration(ENAP) University of Montréal

Between members of a network, interorganizational resilience is favored by effective collaboration and coordination during a crisis. The quality of that collaboration depends on various iterative factors present between these organizations before the occurrence of a *** find that these factors are iterative since collaboration factors follow a mutually reinforcing cycle: collaboration within a crisis management network is conditioned by a general agreement, which is in turn conditioned by the extent to which the institutions coordinate themselves prior to crisis. We evaluated the factors that promote collaboration between public and private organizations that manage the Greater Montréal transportation *** factors are based on adaptive management processes such as mutual agreements, common organizational culture, knowledge and financial resources, levers of power,regulations, and pressure. Crisis management coordination represents the ability to build and assess the effectiveness of common response plans to risks to which they are exposed. We show how these processes vary depending on the links between private and public organizations.

关键词： Adaptive management Collaborative management Interorganizational resilience Montréal Transportation infrastructure

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Selective deletion of the soluble Colony-Stimulating Factor 1 isoform in vivo prevents estrogen-deficiency bone loss in mice

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Bone Research 2017年第4期5卷 367-374页

作者： Gang-Qing Yao Nancy Troiano christine A Simpson Karl L Insogna Department of Internal Medicine Yale University School of MedicineNew HavenUSA Department of Orthopaedics Yale University School of MedicineNew HavenUSA

Neutralizing CSF1 in vivo completely prevents ovariectomy （OVX）-induced bone loss in mice. There are two isoforms of CSF1, soluble （sCSF1）, and membrane-bound （mCSF1）, but their individual biological functions are unclear. It had been previously reported that mCSF1 knockout （K/O） and wild type （Wt） female mice experience the same degree of bone loss following OVX. In Wt mice the expression of sCSF1 was elevated fourfold in skeletal tissue following OVX while expression of mCSF1 was unchanged. To examine the role of sCSF1 in OVX-induced bone loss, mice were engineered in which sCSF1 was not expressed but expression of mCSF1 was unaffected （sCSF1 K/O）. Isoform-specific reverse transcription PCR confirmed the absence of transcripts for sCSF1 in bone tissue isolated from these animals and no circulating CSF1 was detected by ELISA. Surprisingly, there were no significant differences in bone mineral density （BMD） between sCSF1 K/O mice and Wt controls as assessed by dual-energy X-ray absorptiometry and micro-CT. However, one month after OVX, femoral, spinal and total BMD had declined by 11.2%, 8.9%, and 8.7% respectively in OVX-Wt animals as compared to Sham-OVX. In contrast OVX sCSF1 K/O mice showed changes of ＋0.1%, - 2.4%, and ＋2.3% at the same 3 sites compared to Sham-OVX sCSF1 K/O mice. These data indicate important non-redundant functions for the two isoforms of CSF1 and suggest that sCSF1, but not mCSF1, plays a key role in estrogen-deficiency bone loss.

关键词： CSF Selective deletion of the soluble Colony-Stimulating Factor 1 isoform in vivo prevents estrogen-deficiency bone loss in mice

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Host cell protein quantification workflow using optimized standards combined with data-independent acquisition mass spectrometry

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Journal of Pharmaceutical Analysis 2023年第5期13卷 494-502页

作者： Steve Hessmann Cyrille Chery Anne-Sophie Sikora Annick Gervais christine Carapito BioOrganic Mass Spectrometry Laboratory(LSMBO) IPHC UMR 7178University of StrasbourgCNRSProFI-FR2048Strasbourg67000France Department of Analytical Development Sciences for Biologicals UCB Pharma S.A.Braine l'Alleud1420Belgium

Monitoring of host cell proteins(HCPs)during the manufacturing of monoclonal antibodies(mAb)has become a critical requirement to provide effective and safe drug ***-linked immunosorbent assays are still the gold standard methods for the quantification of protein ***,this technique has several limitations and does,among others,not enable the precise identification of *** this context,mass spectrometry(MS)became an alternative and orthogonal method that delivers qualitative and quantitative information on all identified ***,in order to be routinely implemented in biopharmaceutical companies,liquid chromatography-MS based methods still need to be standardized to provide highest sensitivity and robust and accurate ***,we present a promising MS-based analytical workflow coupling the use of an innovative quantification standard,the HCP Profiler solution,with a spectral library-based data-independent acquisition(DIA)method and strict data validation *** performances of the HCP Profiler solution were compared to more conventional standard protein spikes and the DIA approach was benchmarked against a classical datadependent acquisition on a series of samples produced at various stages of the manufacturing *** we also explored spectral library-free DIA interpretation,the spectral library-based approach still showed highest accuracy and reproducibility(coefficients of variation<10%)with a sensitivity down to the sub-ng/mg mAb ***,this workflow is today mature to be used as a robust and straightforward method to support mAb manufacturing process developments and drug products quality control.

关键词： Host cell proteins Absolute quantification standards Data-independent acquisition

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Single CD271 marker isolates mesenchymal stem cells from human dental pulp

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International Journal of Oral Science 2015年第4期7卷 205-212页

作者： Ruth Alvarez Hye-Lim Lee christine Hong Cun-Yu Wang Division of Oral Biology and Medicine School of DentistryUniversity of California at Los Angeles Section of Orthodontics School of DentistryUniversity of California at Los Angeles Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California at Los Angeles

Mesenchymal stem cells （MSCs） are a promising tool in regenerative medicine due to their capacity to differentiate into multiple lineages. In addition to MSCs isolated from bone marrow （BMSCs）, adult MSCs are isolated from craniofacial tissues including dental pulp tissues （DPs） using various stem cell surface markers. However, there has been a lack of consensus on a set of surface makers that are reproducibly effective at isolating putative multipotent dental mesenchymal stem cel^s （~M^Cs）. II1 ~his stucly, we used clif^et（~nt combinations of surface markers （CD51/CD140a, CD271, and STRO-1/CD146） to isolate homogeneous populations of DMSCs from heterogeneous dental pulp cells （DPCs） obtained from DP and compared their capacity to undergo multilineage differentiation. Fluorescence-activated cell sorting revealed that 27.3% of DPCs were CD51＋/CD140a＋, 10.6% were CD271＋, and 0.3% were STRO-1＋/CD146＋. Under odontogenic conditions, all three subsets of isolated DMSCs exhibited differentiation capacity into odontogenic lineages. Among these isolated subsets of DMSCs, CD271＋ DMSCs demonstrated the greatest odontogenic potential. While all three combinations of surface markers in this study successfully isolated DMSCs from DPCs, the single CD271 marker presents the most effective stem cell surface marker for identification of DMSCs with high odontogenic potential. Isolated CD271＋ DMSCs could potentially be utilized for future clinical applications in dentistry and regenerative medicine.

关键词： dental mesenchymal stem cells odontogenic differentiation cell surface markers dental pulp fluorescence-activated cellsorting

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Feedback of inter-hospital transfer of patients under high-flow nasal cannula oxygen therapy

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World Journal of Emergency Medicine 2022年第3期13卷 219-221页

作者： Emilien Arnaud Sylvain Leclere Martin Petitprez Gilles Vincent christine Ammirati Department of Emergency Medicine Amiens-Picardy University HospitalAmiens 80000France

Severe forms of coronavirus disease 2019 (COVID-19)can lead to hypoxemic pneumonia and the need for treatment with high-flow nasal cannula (HFNC) oxygen *** treatment decreases the need for subsequent invasive ventilation in patients with hypoxemic *** oxygen flow in the nasal cannula is driven pneumatically or using a *** and air are mixed (giving the fraction of inspired oxygen[FiO;]) and propelled at up to 80L·min;.The propelled gases must be heated and *** system is not intended for use outside a hospital environment.

关键词： nasal patients flow

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Iron-catalyzed reductive cyclization of nitroarenes: Synthesis of aza-heterocycles and DFT calculations

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Chinese Chemical Letters 2023年第3期34卷 337-341页

作者： christine Tran Aicha Abdallah Valentin Duchemann Guillaume Lefevre Abdallah Hamze CNRS BioCISUniversitéParis-SaclayChatenay-Malabry 92290France Chimie ParisTech CNRSInstitute of Chemistry for Life and Health SciencesPSL UniversityCSB2DParis 75005France

Research into environmentally friendly strategies for hydrogen transfer reduction is increasing, along with the need for more elaborate heterocyclic platforms. Within this context, we develop a new approach for substituted dihydrobenzo[c]carbazoles and indoles. These compounds were synthesized through an iron-catalyzed hydrogen transfer reduction of nitroarenes, followed by intramolecular cyclization. This transformation involves using a Kn?lker-type catalyst, Cs_(2)CO_(3) as the base, and benzyl alcohol as the nonexpensive and low volatile hydrogen donor. We synthesize 30 examples of aza-heterocycles with moderate to excellent yields by applying this strategy. Additionally, DFT calculations demonstrated that the pathway reaction could follow an anionic mechanism.

关键词： Iron Cyclization Nitroarenes Dihydrobenzo[c]carbazoles Indoles

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语言如何塑造认知

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环球科学 2024年第1期 52-63页

作者：克里斯蒂娜·肯尼利黄子璇(翻译) 不详

一种澳大利亚原住民的语言为我们了解人类的认知,提供了意外的见解。20世纪初,美国语言学家本杰明·李·沃夫(BenjaminLeeWhorf)指出,美国亚利桑那州原住民所讲的霍皮语(HopiLanguage)中没有表示时间的词汇或语法要素(例如动词、形容词... 详细信息

一种澳大利亚原住民的语言为我们了解人类的认知,提供了意外的见解。20世纪初,美国语言学家本杰明·李·沃夫(BenjaminLeeWhorf)指出,美国亚利桑那州原住民所讲的霍皮语(HopiLanguage)中没有表示时间的词汇或语法要素(例如动词、形容词等),这一观点震惊了同时代的其他学者。

关键词：本杰明原住民认知

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Decreased plasma urotensin Ⅱ levels inversely correlate with extent and severity of coronary artery disease

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Journal of Geriatric Cardiology 2007年第2期4卷 105-110页

作者： V. Borlongan christine E. Stahl Department of Neurology Medical College of Georgia Augusta GA 30912 USA Department of Internal Medicine Dwight D. Eisenhower Army Medical Center Fort Gordon GA 30909 USA

Objective To determine the plasma urolensin Ⅱ(UII) levels in various types of coronary heart disease and to clarify how the plasma UII levels correlate with the clinical presentation, extent and severity of coronary artery atherosclerosis (CAD). Methods: One hundred and three aged patients undergoing elective diagnostic coronary angiography for proven or clinical suspected coronary heart disease were enrolled in this study. The extent and severity of coronary artery disease were evaluated by vessel score and Gensini score, respectively. Plasma UII levels were measured by radioimmunoassay. Results: The plasma UII levels in the patients with modest to severe coronary stenosis (3.03±0.34 pg/ml, 1.83±0.67 pg/ml) were significantly lower than that in subjects with normal coronary artery (4.80±1.11 pg/ml, P<0.001). The plasma UII levels in patients with coronary heart disease were also significantly lower than that in patients with insignificant coronary stenosis (P < 0. 001). Compared to patients with stable angina pectoris, plasma UII levels in patients with acute coronary syndrome were significantly decreased (1.89±0.51 pg/ml vs 2.42±0.77 pg/ml, P < 0.001). Plasma UII levels were found to be negatively correlated with the severity of coronary artery stenosis (r = -0.488, P<0.001), as well as the vessel score (r = -0.408, P<0.05) in the patients with CAD. Conclusion: Significant inverse correlations exist between the plasma UII levels, and the extent and severity of coronary artery stenosis. These findings suggest that plasma UII contribute to the development and progression of coronary artery stenosis, and may be a novel marker to predict clinical types, as well as the extent and severity of coronary artery disease in the patients.

关键词： Urotensin Ⅱ Coronary artery atherosclerosis Coronary heart disease

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