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时尚育儿 2009年第12期 42-,44页

作者： christine cheng NUK中国区

宝宝的口腔发育和母乳喂养、奶瓶奶嘴的选择等都是息息相关的,本期我们邀请了NUK中国区市场经理christine cheng,除了本身的工作接触外,christine也是两个宝宝的妈妈,所以对于口腔发育与产品选购的关系,她一定能给《时尚育儿》的读者妈... 详细信息

宝宝的口腔发育和母乳喂养、奶瓶奶嘴的选择等都是息息相关的,本期我们邀请了NUK中国区市场经理christine cheng,除了本身的工作接触外,christine也是两个宝宝的妈妈,所以对于口腔发育与产品选购的关系,她一定能给《时尚育儿》的读者妈妈提供一些必要的知识和中肯的建议。

关键词：口腔发育母乳喂养奶瓶用品牙齿发音运动乳房产品

Mutation analysis of 13 driver genes of colorectalcancer-related pathways in Taiwan Residents patients

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World Journal of Gastroenterology 2016年第7期22卷 2314-2325页

作者： Yuli christine Chang Jan-Gowth Chang Ta-Chih Liu Chien-Yu Lin Shu-Fen Yang cheng-Mao Ho William Tzu-Liang Chen Ya-Sian Chang Graduate Institute of Medicine College of MedicineKaohsiung Medical UniversityKaohsiung 80708Taiwan Department of Laboratory Medicine Kaohsiung Medical University HospitalKaohsiung 80708Taiwan Department of Laboratory Medicine China Medical University HospitalTaichung 40447Taiwan Epigenome Research Center China Medical University HospitalTaichung 40447Taiwan School of Medicine China Medical UniversityTaichung 40402Taiwan Institute of Clinical Medicine College of MedicineKaohsiung Medical UniversityKaohsiung 80707Taiwan Division of Colorectal Surgery Department of SurgeryChina Medical University HospitalTaichung 40447Taiwan

AIM To investigate the driver gene mutations associatedwith colorectal cancer （CRC） in the Taiwan ***： In this study, 103 patients with CRCwere evaluated. The samples consisted of 66 menand 37 women with a median age of 59 years and anage range of 26-86 years. We used high-resolutionmelting analysis （HRM） and direct DNA sequencing tocharacterize the mutations in 13 driver genes of CRCrelatedpathways. The HRM assays were conductedusing the LightCycler？ 480 Instrument provided with the software LightCycler 480 Gene Scanning SoftwareVersion 1.5. We also compared the clinicopathologicaldata of CRC patients with the driver gene ***： Of the 103 patients evaluated, 73.79%had mutations in one of the 13 driver genes. Wediscovered 18 novel mutations in APC , MLH1 , MSH2 ,PMS2 , SMAD4 and TP53 that have not been previouslyreported. Additionally, we found 16 de novo mutationsin APC , BMPR1A , MLH1 , MSH2 , MSH6 , MUTYH andPMS2 in cancerous tissues previously reported in thedbSNP database; however, these mutations couldnot be detected in peripheral blood cells. The APCmutation correlates with lymph node metastasis（34.69% vs 12.96%, P = 0.009） and cancer stage（34.78% vs 14.04%, P = 0.013）. No association wasobserved between other driver gene mutations andclinicopathological features. Furthermore, having twoor more driver gene mutations correlates with thedegree of lymph node metastasis （42.86% vs 24.07%,P = 0.043）.CONCLUSION： Our findings confirm the importanceof 13 CRC-related pathway driver genes in the developmentof CRC in Taiwan Residents patients.

关键词： Colorectal cancer Driver gene Colorectalcancer-related pathway Mutation High-resolutionmelting analysis

Photodynamic therapy of cancer-Challenges of multidrug resistance

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Journal of Innovative Optical Health Sciences 2015年第1期8卷 14-26页

作者： Zheng Huang Yih-Chih Hsu Li-Bo Li Luo-Wei Wang Xiao-Dong Song christine M.N.Yow Xia Lei Ali I.Musani Rong-cheng Luo Brian J.Day MOE Key Laboratory of OptoElectronic Science and Technology for Medicine Fujian Normal University FuzhouP.R.China College of Engineering and Applied Science University of Colorado Denver COUSA Department of Medicine National Jewish Health COUSA Department of Bioscience Technology Center for Nanotechnology and Institute of Biomedical Technology Chung Yuan Christian University TaoyuanTaiwan TCM-Integrated Cancer Center Southern Medical University GuangzhouP.R.China Department of Gastroenterology&Endoscopy Changhai Hospital Second Military Medical University ShanghaiP.R.China Department of Urologic Surgery Tongji Medical College of Huazhong University of Science&TechnologyWuhanP.R.China Department of Health Technology Informatics Hong Kong Polytechnic University Hong Kong SARP.R.China Department of Dermatology Daping Hospital Third Military Medical UniversityChongqingP.R.China

Photodynamic therapy(PDT)of cancer is a two-step drug device combination modality,which involves the topical or systemie administration of a photosensitizer followed by light ilumnination of cancer *** the presence of oxygen molecules,the light illmnination of photosensitizer(PS)can lead to the generation of cytotoxic reactive oxygen species(ROS)and consequently destroy *** to many other anticancer therapies,PDT is also subject to intrinsic cancer resistance mediated by mutidrug resistance(MDR)*** paper will review the recent progress in understanding the interaction between MDR transporters and PS *** strategies that can be used in a clinical setting to owercome or bypass MDR will also be discussed.

关键词： Photodynamic therapy photosensitizer multidrug resistance cancer

Air quality monitoring using mobile microscopy and machine learning

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Light(Science & Applications) 2017年第1期6卷 555-566页

作者： Yi-Chen Wu Ashutosh Shiledar Yi-cheng Li Jeffrey Wong Steve Feng Xuan Chen christine Chen Kevin Jin Saba Janamian Zhe Yang Zachary Scott Ballard Zoltán Göröcs Alborz Feizi Aydogan Ozcan Electrical Engineering Department University of CaliforniaLos AngelesCA 90095USA Bioengineering Department University of CaliforniaLos AngelesCA 90095USA California NanoSystems Institute(CNSI) University of CaliforniaLos AngelesCA 90095USA Computer Science Department University of CaliforniaLos AngelesCA 90095USA David Geffen School of Medicine University of CaliforniaLos AngelesCA 90095USA

Rapid,accurate and high-throughput sizing and quantification of particulate matter(PM)in air is crucial for monitoring and improving air *** fact,particles in air with a diameter of≤2.5μm have been classified as carcinogenic by the World Health *** we present a field-portable cost-effective platform for high-throughput quantification of particulate matter using computational lens-free microscopy and *** platform,termed c-Air,is also integrated with a smartphone application for device control and display of *** mobile device rapidly screens 6.5 L of air in 30 s and generates microscopic images of the aerosols in *** provides statistics of the particle size and density distribution with a sizing accuracy of~93%.We tested this mobile platform by measuring the air quality at different indoor and outdoor environments and measurement times,and compared our results to those of an Environmental Protection Agency–approved device based on beta-attenuation monitoring,which showed strong correlation to c-Air ***,we used c-Air to map the air quality around Los Angeles International Airport(LAX)over 24 h to confirm that the impact of LAX on increased PM concentration was present even at 47 km away from the airport,especially along the direction of landing *** its machinelearning-based computational microscopy interface,c-Air can be adaptively tailored to detect specific particles in air,for example,various types of pollen and mold and provide a cost-effective mobile solution for highly accurate and distributed sensing of air quality.

关键词： air-quality monitoring holography machine learning particulate matter

Symmetrically dispersed spectroscopic singlemolecule localization microscopy

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Light(Science & Applications) 2020年第1期9卷 1154-1163页

作者： Ki-Hee Song Yang Zhang Benjamin Brenner cheng Sun Hao F.Zhang Department of Biomedical Engineering Northwestern University2145 Sheridan Rd.EvanstonIL 60208USA Department of Mechanical Engineering Northwestern University2145

Spectroscopic single-molecule localization microscopy(sSMLM)was used to achieve simultaneous imaging and spectral analysis of single molecules for the first *** sSMLM fundamentally suffers from a reduced photon budget because the photons from individual stochastic emissions are divided into spatial and spectral ***,both spatial localization and spectral analysis only use a portion of the total photons,leading to reduced precisions in both *** improve the spatial and spectral precisions,we present symmetrically dispersed sSMLM,or SDsSMLM,to fully utilize all photons from individual stochastic emissions in both spatial and spectral *** achieved 10-nm spatial and 0.8-nm spectral precisions at a total photon budget of *** with the existing sSMLM using a 1:3 splitting ratio between spatial and spectral channels,SDsSMLM improved the spatial and spectral precisions by 42% and 10%,respectively,under the same photon *** also demonstrated multicolour imaging of fixed cells and three-dimensional single-particle tracking using *** enables more precise spectroscopic single-molecule analysis in broader cell biology and material science applications.

关键词： dispersed spectroscopic stochastic

Absence of KHDC3L mutations in Chinese patients with recurrent and sporadic hydatidiform moles

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Absence of KHDC3L mutations in Chinese patients with recurre...

2013浙江省医学遗传学学术年会

作者： Wei Zhao ALa NuEr Muhetaer TengFei Luo Wei Zhou cheng Qi ZhiFen Zhang christine Dery Rima Slim JianHua Qian Women's Reproductive Health Laboratory Women's Hospital Zhejiang University School of Medicine Hangzhou First People's Hospital Hangzhou hospital of Nanjing Medical University Departments of Human Genetics and dObstetrics and Gynecology McGill University Health Centre

To date,two maternal-effect genes have been shown to play causal roles in recurrent hydatidiform moles (RHMs).NLRP7 ,Is a major gene for this condition,codes for a NOD-like receptor,and is mutated in 48

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臭氧氧化耦合陶瓷膜过滤处理煤制气废水研究

水处理技术 2019年第2期45卷 82-86页

作者：王卓袁骋程延峰宋军丽张潇源黄霞清华大学环境学院环境模拟与污染控制国家重点联合实验室北京100084 亚琛工业大学环境工程研究所北莱茵威斯特伐利亚亚琛52074 河南省煤气(集团)有限责任公司义马气化厂河南三门峡472300

构建了臭氧氧化耦合陶瓷膜过滤小试反应器,通过连续流实验进行深度处理煤制气废水研究。结果表明,臭氧投加量≥100 mg/L,COD和UV_(254)的去除率分别≥54.4%和71.1%,出水BOD_5/COD> 0.3,TMP增长缓慢,膜污染得到有效控制;反应器HRT的优选... 详细信息

构建了臭氧氧化耦合陶瓷膜过滤小试反应器,通过连续流实验进行深度处理煤制气废水研究。结果表明,臭氧投加量≥100 mg/L,COD和UV_(254)的去除率分别≥54.4%和71.1%,出水BOD_5/COD> 0.3,TMP增长缓慢,膜污染得到有效控制;反应器HRT的优选时间为40～60 min,延长HRT对COD去除率的提高不显著。曝空气后,COD去除率无明显变化,TMP稍降低但不显著。与pH分别为5和10相比,pH=8时系统COD的去除率分别提高27.1和20.1个百分点;UV_(254)去除率分别提高提高20.4和6.7个百分点。NaHCO3(羟基自由基清除剂)对照实验证明,系统对COD的去除,除膜过滤(23.5%)和臭氧分子氧化作用外,羟基自由基反应(17.8%～31.9%)也是主要贡献因素。

关键词：煤制气废水臭氧氧化耦合陶瓷膜过滤深度处理臭氧投加量膜污染

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护理专业课人文关怀教学现状调查问卷的编制

护理学杂志 2021年第4期36卷 11-15页

作者：熊晗刘义兰张可可张丰健 Marlaine Smith 耿力程利胡翠环何娇王双毛靖华中科技大学同济医学院附属协和医院护理部湖北武汉430022 华中科技大学同济医学院附属协和医院新生儿科湖北武汉430022 华中科技大学同济医学院护理学院 Florida Atlantic University Christine E.Lynn College of Nursing 湖北医药学院护理学院

目的编制护理专业课人文关怀教学现状调查问卷并检验其信效度,为评估关怀教学实施情况提供工具。方法依据Noddings关怀教育理论,结合文献分析、半结构式深入访谈结果,初步拟定问卷条目池并形成框架,再经过2轮专家咨询确定问卷初稿,对31... 详细信息

目的编制护理专业课人文关怀教学现状调查问卷并检验其信效度,为评估关怀教学实施情况提供工具。方法依据Noddings关怀教育理论,结合文献分析、半结构式深入访谈结果,初步拟定问卷条目池并形成框架,再经过2轮专家咨询确定问卷初稿,对315名护理专业学生进行问卷调查,测定问卷的信效度。结果护理专业课人文关怀教学现状调查问卷包括5个维度39个条目。探索性因子分析提取5个公因子,累积方差贡献率为66.276%,问卷内容效度指数为0.939,总问卷Cronbach′sα系数为0.972,折半信度为0.894,重测信度为0.950。结论护理专业课人文关怀教学现状调查问卷具有良好的信效度,可用于调查我国护理专业课人文关怀教学现状。

关键词：人文关怀护理专业课教学问卷信度效度