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Small P values may not yield robust findings:an example using REST-meta-PD

Science Bulletin 2021年第21期66卷 2148-2152,M0003页

作者： Xi-Ze Jia Na Zhao Hao-Ming Dong Jia-Wei Sun Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa Bo-Yu Chen Jun Chen Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito Guo-Guang Fan Federica Di Nardo Yi-Xuan Feng Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay BHorak Xiao Hu Xiao-Fei Hu Biao Huang Pei-Yu Huang Ze-Juan Jia christina jones Jan Kassubek Lenka Krajcovicova Ajay Kurani Jing Li Qing Li Ai-Ping Liu Bo Liu Hu Liu Wei-Guo Liu Renaud Lopes Yu-Ting Lou Wei Luo Tara Madhyastha Ni-Ni Mao Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica Hui-Fang Shang James M.Shine Priyank Shukla Tomas Slavicek Xiao-Peng Song Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt Jian Wang Jue Wang Z.Jane Wang Lu-Qing Wei Xia Wu Xiao-Jun Xu Lei Yan Jing Yang Wan-Qun Yang Nai-Lin Yao De-Long Zhang Jiu-Quan Zhang Min-Ming Zhang Yan-Ling Zhang Cai-Hong Zhou Chao-Gan Yan Xi-Nian Zuo Mark Hallett Tao Wu Yu-Feng Zang Center for Cognition and Brain Disorders the Affiliated HospitalHangzhou Normal UniversityHangzhou 310015China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments Hangzhou 311121China National Basic Science Data Center Beijing 100190China State Key Laboratory of Cognitive Neuroscience and Learning&McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China School of Information and Electronics Technology Jiamusi UniversityJiamusi 154007China Neuroscience Program Central European Institute of TechnologyCEITECMasaryk UniversityBrno 62500Czech Republic Department of Applied Physiology and Kinesiology University of FloridaGainesville FL 32611USA Univ.Lille InsermCHU LilleU1172-LilNCog-Lille Neuroscience&CognitionLille F-59000France The Institute for Biomedical Research and Innovation National Research CouncilMangone CS 87050Italy Department of Radiology The First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Radiology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Medicine Surgery and DentistryScuola Medica SalernitanaUniversity of SalernoFiscianoSA 132-84084Italy Department of Advanced Medical and Surgery Sciences University of Campania“Luigi Vanvitelli”Caserta 81100Italy Eye Center of the 2nd Affiliated Hospital Medical College of Zhejiang UniversityHangzhou 310020China Zhejiang Provincial Key Lab of Ophthalmology Hangzhou 310020China Department of Health and Exercise Science Colorado State UniversityFort Collins CO 80523USA Pacific Parkinson’s Research Centre University of British ColumbiaVancouver BC V6E 2M6Canada Department of Medicine(Neurology)University of British Columbia Vancouver BC V6T 1B7Canada Brain and Mind Center The University of SydneySydney NSW 2006Australia Department of Neurology Ulm UniversityUlm 89081Germany Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong Kong 999077China Department of

Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain *** precise localization of abnormal brain activity,a voxel-level comparison is *** of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1].

关键词：帕金森病 precise correction

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Auxin Binding Protein 1 Reinforces Resistance to Sugarcane Mosaic Virus in Maize

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Molecular Plant 2017年第10期10卷 1357-1360页

作者： Pengfei Leng Qing Ji Torben Asp Ursula K. Frei christina R. Ingvardsen Yongzhong Xing Bruno Studer Margaret Redinbaugh Mark jones Priyanka Gajjar Sisi Liu Fei Li Guangtang Pan Mingliang Xu Thomas Lǖbberstedt National Maize Improvement Center China Agricultural University Beijing 100193 China Department of Agronomy Iowa State University Ames IA 50011 USA Department of Molecular Biology and Genetics Aarhus University Forsegsvej 14200 Slagelse Denmark National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan 430070 China Institute of Agricultural Sciences Molecular Plant Breeding ETH Zurich Universitaetstrasse 2 8092 Zurich Switzerland USDA Agricultural Research Service Corn Soybean and Wheat Quality Research Unit and Department of Plant Pathology Ohio State University Wooster OH 44691 USA Maize Research Institute Sichuan Agricultural University Chengdu 611130 China School of Life Sciences Guizhou Normal University Laboratory of Plant Physiology and Developmental Regulation Guiyang 550000 China

Dear Editor,Sugarcane mosaic virus （SCMV） causes severe viral diseases in maize worldwide （Fuchs and Gruntzig, 1995）, resulting in significant losses in grain and forage yield in susceptible cultivars of maize and related crops. The most promising solution is to cultivate resistant varieties, which contribute to sustainable crop production. Two epistatically interacting major SCMV resistance loci （Scmvl and Scmv2） are required to confer complete resistance against SCMV in the resistant nearisogenic line F7RPJRR （the letters left of the slash refer to the genotype at Scmv2 on chromosome 3 and those on the right refer to the genotype at Scmvl on chromosome 6, with R indicating a resistance allele and S a susceptibility allele）（Xing et al., 2006）.

关键词： Auxin Binding Protein 1 Reinforces Resistance Sugarcane Mosaic Virus Maize

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Influence of biological sex and exercise on murine cardiac metabolism

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Journal of Sport and Health Science 2022年第4期11卷 479-494页

作者： Kyle Fulghum Helen E.Collins Steven P.jones Bradford G.Hill Diabetes and Obesity Center Department of MedicineDivision of Environmental MedicineChristina Lee Brown Envirome InstituteUniversity of LouisvilleLouisvilleKY 40202USA Department of Physiology University of LouisvilleLouisvilleKY 40202USA

Although the structural and functional effects of exercise on the heart are well established,the metabolic changes that occur in the heart during and after exercise remain *** this study,we used metabolomics to assess time-dependent changes in the murine cardiac metabolome following 1 session of treadmill *** the exercise bout,we also recorded blood lactate,glucose,and ketone body levels and measured cardiac mitochondrial *** both male and female mice,moderate-and high-intensity exercise acutely increased blood lactate *** both sexes,low-and moderate-intensity exercise augmented circulating 3-hydroxybutryrate levels immediately after the exercise bout;however,only in female mice did high-intensity exercise increase 3-hydroxybutyrate levels,with significant increases occurring 1 h after the exercise *** metabolomics analyses of sedentary female and male hearts suggest considerable sex-dependent differences in basal cardiac metabolite levels,with female hearts characterized by higher levels of pantothenate,pyridoxamine,homoarginine,tryptophan,and several glycerophospholipid and sphingomyelin species and lower levels of numerous metabolites,including acetyl coenzyme A,glucuronate,gulonate,hydroxyproline,prolyl-hydroxyproline,carnosine,anserine,and carnitinylated and glycinated species,as compared with male *** after a bout of treadmill exercise,both male and female hearts had higher levels of corticosterone;however,female mice showed more extensive exercise-induced changes in the cardiac metabolome,characterized by significant,time-dependent changes in amino acids(e.g.,serine,alanine,tyrosine,tryptophan,branched-chain amino acids)and the ketone body *** from experiments using isolated cardiac mitochondria suggest that high-intensity treadmill exercise does not acutely affect respiration or mitochondrial coupling;however,female cardiac mitochondria demonstrate generally higher adenosi

关键词： Ketone bodies Metabolomics Mitochondria Physical activity Sex difference

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Targeting KRAS in pancreatic adenocarcinoma:Progress in demystifying the holy grail

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World Journal of Clinical Oncology 2023年第8期14卷 285-296页

作者： Ahmed Elhariri Ahmed Alhaj Daniel Ahn Mohamad Bassam Sonbol Tanios Bekaii-Saab christina Wu Michael Scott Rutenberg John Stauffer Jason Starr Umair Majeed Jeremy jones Mitesh Borad Hani Babiker Division of Hematology-Oncology Department of MedicineMayo Clinic FloridaMayo Clinic Cancer CenterJacksonvilleFL 32224United States Division of Hematology-Oncology Department of MedicineMayo Clinic ArizonaMayo Clinic Cancer CenterPhoenixAZ 85054United States Department of Radiation-Oncology Mayo Clinic FloridaMayo Clinic Cancer CenterJacksonvilleFL 32224United States Department of Surgical Oncology Hepatopancreatobiliary SurgeryMayo Clinic FloridaJacksonvilleFL 32224United States

Pancreatic cancer(PC)remains one of the most challenging diseases,with a very poor 5-year overall survival of around 11.5%.Kirsten rat sarcoma virus(KRAS)mutation is seen in 90%-95%of PC patients and plays an important role in cancer cell proliferation,differentiation,metabolism,and survival,making it an essential mutation for targeted *** extensive efforts in studying this oncogene,there has been little success in finding a drug to target this pathway,labelling it for decades as“undruggable”.In this article we summarize some of the efforts made to target the KRAS pathway in PC,discuss the challenges,and shed light on promising clinical trials.

关键词： Kirsten rat sarcoma virus Targeted therapy Pancreatic cancer Drug resistance Next generation sequencing Clustered regularly interspaced short palindromic repeats

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致约翰·亨特的感谢信

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英国医学杂志中文版 2018年第10期21卷 612-614页

作者： christina Messiou Daniel Vanel Rob Pollock Martyn Cooke Eleanor Moskovic Care Savidge Laurence King Anisha Patel Robin L jones 陈雪扬(译) 张大庆(校) Sarcoma Unit The Royal Marsden NHS Foundation Trust London Istituto Ortopedico Rizzoli Bologna Italy Royal National Orthopaedic Hospital Stanmore Middlesex Hunterian Museum Royal College of Surgeons London Sarcoma Unit The Royal Marsden NHS Foundation Trust 北京大学医学院人文研究院

皇家马斯登医院的临床医生写给18世纪外科医生的感谢信，感谢他在骨肉瘤领域中开创性的、记录详尽的研究。非常感谢您对您的患者的详细病史记录，他的大腿上有一肿块。我们有幸在皇家马斯登医院的肉瘤科回顾这些病例记录和标本。我们很... 详细信息

皇家马斯登医院的临床医生写给18世纪外科医生的感谢信，感谢他在骨肉瘤领域中开创性的、记录详尽的研究。非常感谢您对您的患者的详细病史记录，他的大腿上有一肿块。我们有幸在皇家马斯登医院的肉瘤科回顾这些病例记录和标本。我们很抱歉超过了癌症治疗等待时间的要求，尽管您的患者在1786年留下记录时，皇家马斯登医院还未建立（1851年创立）。

关键词：约翰·亨特医疗卫生行业医院骨肉瘤

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身高、体质指数和社会经济地位之关系：对英国生物样本库的孟德尔随机化研究

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英国医学杂志中文版 2016年第7期19卷 363-363页

作者： Jessica Tyrrell Samuel E jones Robin Beaumont christina M Astley Rebecca Lovell Hanieh Yaghootkar Marcus Tuke Katherine S Ruth Rachel M Freathy Joel N Hirschhorn Andrew R Wood Anna Murray Michael N Weedon Timothy M Frayling 莫云凌邓晓春不详解放军空军航空医学研究所附属医院内四科

目的确定身高、体质指数（BMI）与社会经济状况的5个方面是否存在因果关系。方法孟德尔随机化研究测试身高、BMI与社会经济状况之间的因果关系有何不同。孟德尔随机化方法运用基因型随机分配理论，这样不会受到非基因混杂因素的干扰。

关键词：体质指数社会经济地位英国生物样本库

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