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neural plasticity in Parkinson's disease:a neuroimaging perspective

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neural Regeneration Research 2024年第6期19卷 1203-1205页

作者： christina Andica Koji Kamagata Department of Radiology Juntendo University Graduate School of MedicineTokyoJapan Faculty of Health Data Science Juntendo UniversityChibaJapan

Parkinson's disease(PD)is a progressive neurodegenerative disorder characterized primarily by classical motor signs of bradykinesia,rigidity,tremors,and postural instability usually manifesti ng unilate rally or at least *** disease involves a loss of dopaminergic neurons projecting from the substantia nigra pars compacta to the dorsal striatum.

关键词： rigidity tremor primarily

The Disintegration of a Floating Ferrofluid Layer into an Ordered Drop System in a Vertical Magnetic Field

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Fluid Dynamics & Materials Processing 2024年第10期20卷 2205-2218页

作者： christina Khokhryakova Konstantin Kostarev Irina Mizeva Laboratory of Dispersed System Dynamics Institute of Continuous Media Mechanics UrB RASPerm614018Russia Laboratory of Hydrodynamical Stability Institute of Continuous Media Mechanics UrB RASPerm614018Russia Laboratory of Turbulence Institute of Continuous Media Mechanics UrB RASPerm614018Russia

Magnetic fluids,also known as ferrofluids,are versatile functional materials with a wide range of *** applications span from industrial uses such as vacuum seals,actuators,and acoustic devices to medical uses,including serving as contrast agents for magnetic resonance imaging(MRI),delivering medications to specific locations within the body,and magnetic hyperthermia for cancer *** use of a non-wettable immiscible liquid substrate to support a layer of magnetic fluid opens up new possibilities for studying various fluid flows and related instabilities in multi-phase systems with both a free surface and an *** presence of two deformable boundaries within a ferrofluid layer significantly reduces the critical magnetic field strength required to transform the layer into an organized system of drops or polygonal figures evolving according to the intensity,frequency and direction of the considered magnetic *** paper experimentally investigates this problem by assuming a uniform magnetic field perpendicular to the *** specific subject has not been previously explored *** critical magnetic field intensity required to destabilize the ferrofluid layer is determined based on the layer’s thickness and the fluid’s initial magnetic *** is demonstrated that the critical magnetic field strength needed to disrupt the initially continuous ferrofluid layer increases with the layer’s ***,an increase in the ferrofluid’s magnetic susceptibility results in a decrease in the critical magnetic field *** emerging droplet structures are analyzed in terms of the number of drops,their size,and the periodicity of their *** number of droplets formed depends on the initial thickness of the layer,the presence or absence of a stable rupture in the upper layer,and the rate at which the magnetic field strength is increased to the critical value.A characteristic viscous time is proposed

关键词： Ferrofluid liquid substrate normal field instability ordered droplet structure

Microglial complex I activity: a crucial factor for smoldering inflammation in the central nervouss system

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3165-3166页

作者： Jana K.Sonner christina Mayer Manuel A.Friese Institute of neuroimmunology and Multiple Sclerosis University Medical Center Hamburg-EppendorfHamburgGermany

In their article published in nature,Peruzotti-Jametta et *** metabolic reprogramming of microglia as a defining characteristic of their persistent and harmful activation during inflammatory neurodegeneration,which is observable in conditions like multiple sclerosis(MS).Subsequently,the authors demonstrate how mitigating mitochondrial dysregulation in microglia alleviates disease progression in an animal model of MS,thereby unveiling a potential novel target for the treatment of MS(Fig.1).

关键词： inflammation al. thereby

Sol-gel derived B_(2)O_(3)-CaO borate bioactive glasses with hemostatic,antibacterial and pro-angiogenic activities

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Regenerative Biomaterials 2024年第1期3卷 108-118页

作者： Kai Zheng Faina Bider Mahshid Monavari Zhiyan Xu christina Janko Christoph Alexiou Ana M.Beltran Aldo R.Boccaccini Jiangsu Province Engineering Research Center of Stomatological Translational Medicine College of StomatologyNanjing Medical UniversityNanjing 210029China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjing 210029China Institute of Biomaterials University of Erlangen-Nuremberg91058 ErlangenGermany Department of Oto-Rhino-Laryngology Head and Neck SurgerySection of Experimental Oncology and Nanomedicine(SEON)Else Kroener-Fresenius-Stiftung ProfessorshipUniversitaetsklinikum Erlangen91058 ErlangenGermany Departamento de Ingenier�ıa y Ciencia de los Materiales y del Transporte Escuela Politecnica

Sol-gel borate bioactive glasses(BGs)are promising ion-releasing biomaterials for wound healing ***,we report the synthesis of a series of binary B_(2)O_(3)-CaO borate BGs(CaO ranging from 50 to 90mol%)using a sol-gel-based *** influence of CaO content in B_(2)O_(3)-CaO borate BG on morphology,structure and ion release behavior was investigated in *** dissolution(ion release)and crystallization could be observed in borate BGs when CaO content increased,while the morphology was not significantly altered by increasing CaO *** results evidenced that the ion release behavior of borate BGs could be tailored by tuning the B_(2)O_(3)/CaO molar *** also evaluated the in vitro cytotoxicity,hemostatic,antibacterial and angiogenic activities of borate *** was validated for all borate ***,borate BGs exhibited composition-dependent hemostatic,antibacterial and angiogenic ***,higher contents of Ca in borate BGs facilitated hemostatic activity,while higher contents of B_(2)O_(3) were beneficial for pro-angiogenic *** synthesized sol-gel-derived borate BGs are promising materials for developing advanced wound healing dressings,given their fast ion release behavior and favorable hemostatic,antibacterial and angiogenic activities.

关键词： borate glasses sol-gel processing glass composition wound healing

Expedition to the blockchain application potential for higher education institutions

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BLOCKCHAIn-RESEARCH AnD APPLICATIOnS 2024年第3期5卷 53-66页

作者： Gottlieb, Matthias Deutsch, christina Hoops, Felix Pongratz, Hans Krcmar, Helmut Bavarian Minist Digital Affairs D-80333 Munich Germany Tech Univ Munich D-85478 Garching Germany TU Dortmund Univ D-44139 Dortmund Germany

In the education sector, blockchain is currently at the end of the peak of inflated expectations in Gartner's Hype Cycle. Thus, it is crucial to understand whether this technology meets the expectations of Higher Education Institutions (HEIs). We go on an expedition to identify blockchain application scenarios and its potential for HEI administration-the universities are digitalized to just 23.3%. Current information systems research addresses classifications of blockchain-based projects (application level) rather than their technical realization (protocol level). Thus, when evaluating blockchain application scenarios in HEI administration, we intensively consider the technical side of blockchain-based projects. We perform a three- step approach: (1) systematic literature review, (2) qualitative exploratory semi-structured interviews to supplement information on market-ready solutions, and (3) an evaluation of the potential of the blockchain-based projects identified, based on HEI administration requirements. We find that the leading blockchain application scenarios are credential verification and record-sharing. At the protocol level, we obtain equivocal results regarding the technical realization of projects, e.g., their underlying blockchain types and storage models. At the application level, when discussing the potential of different projects, we find that most of them address adaptability, complexity decomposition, and cost reduction requirements between HEIs; interest diversity and stakeholder collaboration between HEIs and business actors; privacy and trust between HEIs and students.

关键词： Blockchain Higher education institution (HEI) Administration Protocol level Application level Application

Exploring impacts of COVID-19 on spatial and temporal patterns of visitors to Canadian Rocky Mountain national Parks from social media big data

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Journal of Forestry Research 2024年第4期35卷 13-33页

作者： Dehui christina Geng Amy Li Jieyu Zhang Howie W.Harshaw Christopher Gaston Wanli Wu Guangyu Wang national Park Research Centre Faculty of ForestryUniversity of British ColumbiaVancouver V6T 1Z4Canada Faculty of Applied Science University of British ColumbiaVancouver V6T 1Z3Canada Paul G.Allen School of Computer Science&Engineering University of WashingtonSeattleWA 98195USA Faculty of Kinesiology Sportand RecreationUniversity of AlbertaEdmonton T6G 2J9Canada Department of Wood Science Faculty of ForestryUniversity of British ColumbiaVancouver V6T 1Z4Canada

COVID-19 posed challenges for global tourism *** in visitor temporal and spatial patterns and their associated determinants pre-and peri-pandemic in Canadian Rocky Mountain national Parks are *** was collected through social media programming and analyzed using spatiotemporal analysis and a geographically weighted regression(GWR)*** highlight that COVID-19 significantly changed park visitation *** tended to explore more remote areas *** GWR model also indicated distance to nearby trails was a significant influence on visitor *** results indicate that the pandemic influenced tourism temporal and spatial *** research presents a novel approach using combined social media big data which can be extended to the field of tourism management,and has important implications to manage visitor patterns and to allocate resources efficiently to satisfy multiple objectives of park management.

关键词： Tourism management Social media big data national parks COVID-19 Geographical weighted regression

Effects of early postnatal gastric and colonic microbiota transplantation on piglet gut health

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Journal of Animal Science and Biotechnology 2024年第2期15卷 645-658页

作者： christina Larsen Simone Margaard Offersen Anders Brunse Mattia Pirolo Soumya Kanti Kar Luca Guadabassi Thomas Thymann Department of Veterinary and Animal Science University of CopenhagenDyrlagevej 681870 Frederiksberg CDenmark Animal nutrition Wageningen Livestock ResearchWageningen University&Research1 De Elst6708 WageningenThe Netherlands

Background Diarrhea is a major cause of reduced growth and mortality in piglets during the suckling and weaning periods and poses a major threat to the global pig *** and gut dysbiosis may in part be prevented via improved early postnatal microbial colonization of the *** secure better postnatal gut colonization,we hypothesized that transplantation of colonic or gastric content from healthy donors to newborn recipients would prevent diarrhea in the recipients in the post-weaning *** objective was to examine the impact of transplanting colonic or gastric content on health and growth parameters and paraclinical parameters in recipient single-housed piglets exposed to a weaning transition and challenged with enterotoxigenic Escherichia coli(ETEC).Methods Seventy-two 1-day-old piglets were randomized to four groups:colonic microbiota transplantation(CMT,n=18),colonic content filtrate transplantation(CcFT,n=18),gastric microbiota transplantation(GMT,n=18),or saline(COn,n=18).Inoculations were given on d 2 and 3 of life,and all piglets were milk-fed until weaning(d 20)and shortly after challenged with ETEC(d 24).We assessed growth,diarrhea prevalence,ETEC concentration,organ weight,blood parameters,small intestinal morphology and histology,gut mucosal function,and microbiota composition and *** Episodes of diarrhea were seen in all groups during both the milk-and the solid-feeding phase,possibly due to stress associated with single ***,CcFT showed lower diarrhea prevalence on d 27,28,and 29 compared to COn(all Pnce on d 27(Pnd a difference in beta diversity compared to COn(Pnd other paraclinical endpoints were similar across *** In conclusion,only CcFT reduced ETEC-related post-weaning ***,the protective effect was marginal,suggesting that higher doses,more effective modalities of administration

关键词： Colonic content filtrate transplantation Colonic microbiota transplantation Gastric microbiota transplantation Gut microbiota Mucosa neonatal Post-weaning diarrhea

Giant panda(Ailuropoda melanoleuca)neonates use broadband calls to communicate with their mothers

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Integrative Zoology 2024年第2期19卷 277-287页

作者： Lin ZHAO Jianbin CHEnG Wen ZEnG Bo YAnG Guiquan ZHAnG Desheng LI Hemin ZHAnG christina DBUESCHInG Dingzhen LIU Ministry of Education Key Laboratory of Biodiversity Science and Ecological EngineeringCollege of Life SciencesBeijing Normal UniversityBeijingChina Key Laboratory of State Forestry and Grassland Administration on Conservation Biology of Rare Animals in The Giant Panda national Park China Conservation and Research Center for the Giant PandaDujiangyanSichuan611830China Department of Biology Irving K.Barber Faculty of ScienceUniversity of British ColumbiaOkanaganKelownaBritish ColumbiaCanada

Infant call structure should have evolved to elicit maximum maternal attention and *** of giant pandas produce three types of vocalizations reported to be vitally important in the context of mother–infant ***,how cubs,0–15 days old,communicate with their mothers to elicit maternal care remains *** analyzed 12 different call parameters of 3475 squawks,1355 squalls,and 491 croaks from 11 captive giant panda(Ailuropoda melanoleuca)neonates from age 0 to 15 *** playback experiments,we also tested whether mothers could detect *** results show that neonates use broadband calls with ultrasonic frequencies up to 65 kHz to convey information about their physiological needs and to attract maternal *** playback experiments,we tested if mothers reacted differently to broadband calls(BBC)than to artificially altered calls that included only frequenciesncluded only frequencies>20 kHz(USC).Playback confirmed that,although adult females responded significantly less often to USC,BBC than to or AUDC,they could detect USC,BBC and generally made appropriate behavioral responses,indicating a potential benefit for neonates to utilize ultrasonic and broadband *** findings provide a new insight into mother–infant communication in giant pandas and will be helpful for reducing the mortality of cubs,younger than 1 month old,in captivity.

关键词： acoustic communication broadband calls maternal care neonates ultrasonic frequencies

Males armed with big weapons win fights at limited cost in ant-mimickingjumping spiders

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Current Zoology 2024年第1期70卷 98-108页

作者： Guocheng Yu Boon Hui Wong christina J.Painting Hongze Li Long Yu Zengtao Zhang Shichang Zhang Daiqin Li State Key Laboratory of Biocatalysis and Enzyme Engineering and Centre for Behavioral Ecology and Evolution School of Life SciencesHubei UniversityWuhan430062China Departmentof Biological Sciences National University of Singapore14 Science Drive 4Singapore 117543Singapore Te Aka Matuatua School of Science University of WaikatoPrivate Bag 3105Hamilton 3240New Zealand

A core assumption of sexual selection theory is that sexually selected weapons,specialized morphological structures used directly in male con-tests,can improve an individual's reproductive success but only if the bearer can overcome associated costs,the negative effects on the bear-er's fitness ***,recent studies have shown that producing and wielding exaggerated weapons may not necessarily be ***,some traits can be selected for supporting,or compensating for,the expense of producing and wielding such exaggerated weapons.n the ant-mimicking jumping spider Myrmarachne gisti,exaggerated chelicerae are borne only by adult males and not females,showing sexual dimorphism and steep positive allometry with body ***,we determine the potential benefits of bearing exaggerated chelicerae during male contests and explore the potential for costs in terms of prey-capture efficiency and compensation between chelicera size and neighboring trait *** males with longer chelicerae won most of their male-male contests,we found no significant differences in prey-capture effi-ciency between males and females regardless of whether prey was winged or ***'elongated chelicerae thus do not impede their efficiency at capturing ***,we found that the sizes of all neighboring traits are positively correlated with chelicera size,suggesting that these traits may be under correlational *** together,our findings suggest that *** males armed with the exaggerated chelicerae that function as weapons win more fights at limited cost for performance in prey capture and compensate for neighboring structures.

关键词： allometry ant-mimic costs elongated chelicerae threat devices trait compensations