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Implementation of cancer screening in rural primary care practices after joining an accountable care organisation:a multiple case study

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Family Medicine and Community Health 2021年第4期9卷 42-49,I0013,I0014,I0015页

作者： Heather Nelson-Brantley Edward F Ellerbeck Stacy McCrea-Robertson Jennifer Brull Jennifer Bacani McKenney K Allen Greiner christie befort School of Nursing University of Kansas Medical CenterKansas CityKansasUSA University of Kansas Cancer Center University of Kansas Medical CenterKansas CityKansasUSA Population Health University of Kansas Medical CenterKansas CityKansasUSA Family Medicine University of Kansas Medical CenterKansas CityKansasUSA

Objective To describe common strategies and practice-specific barriers,adaptations and determinants of cancer screening implementation in eight rural primary care practices in the Midwestern United States after joining an accountable care organisation(ACO).Design This study used a multiple case study *** sampling was used to identify a diverse group of practices within the *** were collected from focus group interviews and workflow *** Consolidated Framework for Implementation Research(CFIR)was used to guide data collection and *** were cross-analysed by clinic and CFIR domains to identify common themes and practice-specific determinants of cancer screening *** The study included eight rural primary care practices,defined as Rural-Urban Continuum Codes 5-9,in one ACO in the Midwestern United *** Providers,staff and administrators who worked in the primary care practices participated in focus groups.28 individuals participated including 10 physicians;one doctor of osteopathic medicine;three advanced practice registered nurses;eight registered nurses,quality assurance and licensed practical nurses;one medical assistant;one care coordination manager;and four *** With integration into the ACO,practices adopted four new strategies to support cancer screening:care gap lists,huddle sheets,screening via annual wellness visits and information ***-case analysis revealed that all practices used both visit-based and population-based cancer screening strategies,although workflows varied widely across *** of the four strategies was adapted for fit to the local context of the *** shared that joining the ACO provided a strong external incentive for increasing cancer screening *** predominant determinants of cancer screening success at the clinic level were use of the electronic health record(EHR)and fully engaging nurses in the screening ***

关键词： nurse joining screening

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Methyl-β-cyclodextrin enhanced biodegradation of polycyclic aromatic hydrocarbons and associated microbial activity in contaminated soil

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Journal of Environmental Sciences 2012年第5期24卷 926-933页

作者： Peter christie Agri-Environment Branch Agri-Food and Biosciences Institute Newforge Lane Belfast BT9 5PX United Kingdom

The contamination of soils by polycyclic aromatic hydrocarbons （PAHs） is a widespread environmental problem and the remediation of PAHs from these areas has been a major concern. The effectiveness of many in situ bioremediation systems may be constrained by low contaminant bioavailability due to limited aqueous solubility or a large magnitude of sorption. The objective of this research was to evaluate the effect of methyl-β-cyclodextrin （MCD） on bioaugmentation by Paracoccus sp. strain HPD-2 of an aged PAH-contaminated soil. When 10% （W/W） MCD amendment was combined with bioaugmentation by the PAH-degrading bacterium Paracoccus sp. strain HPD-2, the percentage degradation of total PAHs was significantly enhanced up to 34.8%. Higher counts of culturable PAH- degrading bacteria and higher soil dehydrogenase and soil polyphenol oxidase activities were observed in 10% （W/W） MCD-assisted bioaugmentation soil. This MCD-assisted bioaugmentation strategy showed significant increases （p 〈 0.05） in the average well color development （AWCD） obtained by the BIOLOG Eco plate assay, Shannon-Weaver index （H） and Simpson index （λ） compared with the controls, implying that this strategy at least partially restored the microbiological functioning of the PAH-contaminated soil. The results suggest that MCD-aided bioaugmentation by Paracoccus sp. strain HPD-2 may be a promising practical bioremediation strategy for aged PAH-contaminated soils.

关键词： polycyclic aromatic hydrocarbons methyl-β-cyclodextrin biodegradation Paracoccus sp. strain HPD-2 microbial activity

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Metal concentrations and mycorrhizal status of plants colonizing copper mine tailings: potential for revegetation

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Science China(Life Sciences) 2005年第z1期48卷 156-164页

作者： christie Peter Department of Agricultural and Environmental Science The Queen's University of Belfast Newforge Lane Belfast BT9 5PX Northern Ireland UK

A field survey of metal concentrations and mycorrhizal status of plants growing on copper mine tailings was conducted in Anhui Province, China. Available phosphorus and organic matter in the tailings were very low. High concentrations of Pb, Zn, As and Cd as well as Cu were observed on some sites. The dominant plants growing on mine tailings belonged to the families Gramineae and Compositae, and the most widely distributed plant species were Imperata cylin-drica, Cynodon dactylon and Paspalum distichum. Coreopsis drummondii also grew well on the arid sites but not on wet sites. Very low or zero arbuscular mycorrhizal (AM) fungal colonization was observed in most of the plants, but extensive mycorrhizal colonization was recorded in the roots of C. drummondii and C. dactylon. Metal concentrations in plant tissues indicated that /. cylindrica and P. distichum utilized avoidance mechanisms to survive at high metal concentrations. The investigation suggests that remediation and revegetation of heavy metal contaminated sites might be facilitated by selection of tolerant plant species. Isolation of tolerant AM fungi may also be warranted.

关键词： phytoremediation, revegetation, heavy metals, copper mine tailings, arbuscular mycorrhiza.

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Estimating total nitrogen deposition in agroecosystems in northern China during the wheat cropping season

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Journal of Arid Land 2010年第1期2卷 2-8页

作者： christie PETER Fangmeier ANDREAS College of Resources and Environmental Sciences China Agricultural University Agri-Environment Branch Agri-Food and Biosciences Institute Institute of Plant Ecology and Landscape University of Hohenheim

Atmospheric nitrogen (N) deposition has been poorly documented in northern China, an intensive agricultural and industrial region with large emissions of NHx and NOy. To quantify N deposition, total airborne N deposition was determined at three agricultural sites using a manual integrated total nitrogen input (ITNI) system during growth of winter wheat (Triticum aestivum L.) and Italian ryegrass (Lolium multiflorum Lam.) from September 2005 to May 2006. Total estimated N deposition averaged 54.9 and 43.2 kg N/hm2 across the three sites when wheat was grown to flowering and maturing, respectively. The average value was 50.2 kg N/hm2 when ryegrass was the indicator plant. Both indicator species gave similar total airborne N input results. The intermediate level of N supplied resulted in the highest N deposition, and the ratio of N acquired from deposition to total N content of the whole system decreased with increasing N supply to the roots. The contribution of atmospheric N to the total N content of the wheat and ryegrass sand culture systems ranged from 10% to 24%.

关键词： airborne nitrogen inputs 15N pool dilution method sand culture system biological indicators

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Responses of Greenhouse Tomato and Pepper Yields and Nitrogen Dynamics to Applied Compound Fertilizers

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Pedosphere 2004年第2期14卷 213-222页

作者： ZHUJian-Hua LIXiao-Lin ZHANGFu-Suo LIJun-Liang P,christie P．christie KeyLaboratoryofPlant-SoilInteractions MinistryofEducation.ChinaAgriculturalUniversityBeijing100094（China）／E-mail：zhucool@*** DepartmentofAgronomy LaiyangAgriculturalCollegeShandong265200（china） AgriculturalandEnuironmentalSciencsDepartment Queen＇sUniversityBelfastNewforgeLaneBelfastBT95PX（UX）

Yield and N uptake of tomato (Lycopersicum esculentum Mill.) and pepper(Capsicum annuum L.) crops in five successive rotations receiving two compound fertilizers (12-12-17and 21-8-11 N-P_2O_5-K_2O) were studied to determine 1) crop responses, 2) dynamics of NO_3-N andNH_4-N in different soil layers, 3) N balance and 4) system-level N efficiencies. Five treatments (2fertilizers, 2 fertilizer rates and a control), each with three replicates, were arranged in thestudy. The higher N fertilizer rate,300 kg N ha^(-1) (versus 150 kg N ha^(-1)), returned highervegetable fruit yields and total aboveground N uptake with the largest crop responses occurring forthe low-N fertilizer (12-12-17) applied at 300 kg N ha^(-1) rather than with the high-N fertilizer(21-8-11). Ammonium-N in the top 90 cm of the soil profile declined during the experiment, whilenitrate-N remained at a similar level throughout the experiment with the lower rate of fertilizer *** the higher rate of N fertilizer there was a continuous NO_3-N accumulation of over 800 kg Nha^(-1). About 200 kg N ha^(-1) was applied with irrigation to each crop using NO_3-contaminatedgroundwater. In general, about 50% of the total N input was recovered from all treatments. Pepper,relative to tomato, used N more efficiently with smaller N losses, but the crops utilized less than29% of the fertilizer N over the two and a half-year period. Local agricultural practices maintainedhigh residual soil nutrient status. Thus, optimization of irrigation is required to minimizenitrate leaching and maximize crop N recovery.

关键词： greenhouse vegetables N dynamics N efficiency N uptake N utilization

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Proteomic response of wheat embryos to fosthiazate stress in a protected vegetable soil

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Journal of Environmental Sciences 2012年第10期24卷 1843-1853页

作者： Chunyan Yin Ying Teng Yongming Luo Peter christie Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Graduate University of Chinese Academy of Sciences Beijing 100049China Yantai Institute of Coastal Zone Research Chinese Academy of SciencesYantai 264003China Agri-Environment Branch Agri-Food and Biosciences InstituteNewforge LaneBelfast BT95PXUnited Kingdom

A proteomic analysis of wheat defense response induced by the widely used organophosphorus nematicide fosthiazate is reported. Seed germination and two-dimensional gel electrophoresis （2-DE） experiments were performed using a Chinese wheat cultivar, Zhenmai No. 5. Root and shoot elongation decreased but thiobarbituric acid reactive substances （TBARS） content in embryos increased with increasing pesticide concentration. More than 1000 protein spots were reprodueibly detected in each silver-stained gel. Thirty-seven protein spots with at least 2-fold changes were identified using MALDI-TOF MS/MS analysis. Of these, 24 spots were up-regulated and 13 were down-regulated. Proteins identified included some well-known classical stress responsive proteins under abiotic or biotic stresses as well as some unusual responsive proteins. Ten responsive proteins were reported for the first time at the proteomic level, including fatty acyl CoA reductase, dihydrodipicolinate synthase, DEAD-box ATPase-RNA-helicase, fimbriata-like protein, waxy B 1, rust resistance kinase Lrl0, putative In2.1 protein, retinoblastoma-related protein 1, pollen allergen-like protein and S-adenosyl-L- methionine：phosphoethanolamine N-methyltransferase. The proteins identified were involved in several processes such as metabolism, defense/detoxification, cell structure/ceU growth, signal transduction]transcription, photosynthesis and energy. Seven candidate proteins were further analyzed at the mRNA level by RT-PCR to compare transcript and protein accumulation patterns, revealing that not all the genes were correlated well with the protein level. Identification of these responsive proteins may provide new insight into the molecular basis of the fosthiazate-stress response in the early developmental stages of plants and may be useful in stress monitoring or stress-tolerant crop breeding for environmentally friendly agricultural production.

关键词： fosthiazate proteomic wheat embryo stress response biological indicator

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Reductive dechlorination of polychlorinated biphenyls is coupled to nitrogen fixation by a legume-rhizobium symbiosis

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Science China Earth Sciences 2018年第3期61卷 285-291页

作者： Chen TU Yongming LUO Ying TENG Peter christie Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of Sciences Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of Sciences

Chlorinated persistent organic pollutants, including polychlorinated biphenyls （PCBs）, represent a particularly serious environmental problem and human health risk worldwide. Leguminous plants and their symbiotic bacteria （rhizobia） are important components of the biogeochemical cycling of nitrogen in both agricultural and natural ecosystems. However, there have been relatively few detailed studies of the remediation of PCB-contaminated soils by legume-rhizobia symbionts. Here we report for the first time evidence of the reductive dechlorination of 2,4,4＇-trichlorobiphenyl （PCB 28） by an alfalfa-rhizobium nitrogen fixing symbiont. Alfalfa （Medicago sativa L.） inoculated with wild-type Sinorhizobiurn meliloti had significantly larger biomass and PCB 28 accumulation than alfalfa inoculated with the nitrogenase negative mutant rhizobium SmY. Dechlorination products of PCB 28, 2,4＇-dichlorobiphenyl （PCB 8）, and the emission of chloride ion （C1-） were also found to decrease significantly in the ineffective nodules infected by the mutant strain SmY. We therefore hypothesize that N2-fixation by the legume-rhizobium symbiont is coupled with the reductive dechlorination of PCBs within the nodules. The combination of these two processes is of great importance to the biogeochemical cycling and bioremediation of organochlorine pollutants in terrestrial ecosystems.

关键词： Biogeochemical cycling Legume-rhizobia symbiosis Microbe-assisted phytoremediation Nitrogen fixation,Polychlorinated biphenyls Soil pollution and remediation Reductive dechlorination

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Effect of Alkaline-Stabilised Sewage Sludge on Extractable Organic Carbon and Copper in Soils

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Pedosphere 2002年第2期12卷 97-102页

作者： LUOYONGMING P.christie InstituteofSoilScience theChineseAcademyofSciencesNanjing210008（China） DepartmentofAgriculturalandEnvironmentalScience TheQueen′sUniversityofBelfastNewforgeLaneBelfastBT95PX（U

An incubation experiment was conducted to evaluate the potential for water contamination with sludge-derived organic substances and copper following land application of alkaline-stabilised sewage sludge. Twocontrasting sludge-amended soils were studied. Both soils were previously treated with urban and ruralalkaline biosolids separately at sludge application rates of 0, 30 and 120 t ha-1 fresh product. The air-driedsoil/sludge mixtures were wetted with distilled water, maintained at 40 % of water-holding capacity andequilibrated for three weeks at 4 ℃ before extraction. Subsamples were extracted with either distilled wateror 0.5 mol L-1 K2SO4 solution. The concentrations of organic C in the aqueous and chemical extractswere determined directly with a total organic carbon (TOC) analyser. The concentrations of Cu in the twoextracts were also determined by atomic absorption spectrophotometry The relationship between the twoextractable organic C fractions was examined, together with that between extractable organic C concentrationand extractable Cu concentration. Application of alkaline biosolids increased the concentrations of soil mobileorganic substances and Cu. The results are discussed in terms of a possible increase in the potential forleaching of sludge-derived organics and Cu in the sludge-amended soils.

关键词： clay extracts,leaching organic matter trace metals

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Phytotoxicity in seven higher plant species exposed to di-n-butyl phthalate or bis （2-ethylhexyl） phthalate

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Frontiers of Environmental Science & Engineering 2015年第2期9卷 259-268页

作者： Tingting MA Ying TENG Peter christie Yongming LUO Key Laboratory of Soil Environment and Pollution Remediation of Chinese Academy of Sciences Institute of Soil Science Nanjing 210008 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Agri-Environment Branch Agri-Food and Biosciences Institute Newforge Lane Belfast BT9 5PX United Kingdom Yantai Institute of Costal Zone Research Chinese Academy of Sciences Yantai 264003 China

We investigated phytotoxicity in seven plant species exposed to a range of concentrations （0- 500 mg· kg^-1 soil） of di-n-butyl phthalate （DnBP） or his （2- ethylhexyl） phthalate （DEHP）, two representative phthalate esters （PAEs） nominated by USEPA as priority pollutants and known environmental estrogens. We studied seed germination, root elongation, seedling growth, biomass （fresh weight, FW） and malondialdehyde （MDA） content of shoots and roots of wheat （Triticum aestivum L.）, alfalfa （Medicago sativa L.）, perennial ryegrass （Lolium perenne）, radish （Raphanus sativus L.）, cucumber （Cucumis sativus L.）, oat （Avena sativa） and onion （Allium cepa L.）, together with monitoring of plant pigment content （chlorophyll a, b and earotinoids） in alfalfa, radish and onion shoots. Root elongation, seedling growth and biomass of the test species were generally inhibited by DnBP but not by DEHP, indicating a lower level of phytotoxicity of DEHP than of DnBP. MDA contents of four species were promoted by PAE exposure, but not in alfalfa, ryegrass or onion shoots, indicating lower sensitivity of these three species to PAE pollutants. Plant pigment contents were clearly affected under the stress of both pollutants, implying the potential damage to the photosynthetic system of test plants, mainly by decreasing the content of chlorophyll a and b. Results of DnBP and DEHP phytotoxicity to the primary growth of test plants has provided information for the assessment of their environmental risk in the soil and also forms a basis for the further analysis of their toxic effects over the whole growth period of different plant species.

关键词： phytotoxicity di-n-butyl phthalate bis(2- ethylhexyl) phthalate malondialdehyde plant pigments(chlorophyll a b and carotinoids)

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Alleviation of Soil Acidity and Aluminium Phytotoxicityin Acid Soils by Using Alkaline-Stabilized Biosolids

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Pedosphere 2002年第2期12卷 185-188页

A pot experiment was catried out to study alleviation of soil acidity and Al toxicity by applying analkaline-stabilised sewage sludge product (biosolids) to an acid clay sandy loam (pH 5.7) and a strongly acidsandy loam (pH 4.5). Barley (Hondeum vulgare L. cv. Forrester) was used as a test crop and was grownin the sewage sludge-amended (33.5 t sludge DM ha-1) and unamended soils. The results showed that thealka1ine biosloids increased soil pH from 5.7 to 6.9 for the clay sandy loam and from 4.5 to 6.0 for the sandyloam. The sludge product decreased KCl-extractable Al from 0.1 to 0.0 cmol kg-1 for the former soil andfrom 4.0 to 0.1 cmol kg-1 for the latter soil. As a result, barley plants grew much better and grain yieldincreased greatly in the amended treatments compared with the unamended controls. These observationsindicate that alkaline-stabilised biosolids can be used as a liming material for remedying Al phytotoxicity instrongly acid soils by increasing soil pH and lowering Al bioavailability.

关键词： alkaline biosolids phytotoxicity,soil acidity soil remediation

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