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Current Zoology 2021年第3期67卷 337-340页

作者： Giulia Perroud David Nusbaumer christian de guttry Claus Wedekind department of Ecology and Evolution University of Lausanne1015 LausanneSwitzerland

Salmonids like whitefish(Coregonus spp.)are often propagated in supportive *** are caught from their spawning locations,their gametes mixed,and the resulting offspring reared in a protected environment before being released into the *** procedure can affect sexual selection,for example,by enhancing the importance of sperm competition or by reducing the relevance of sexual *** it is often unclear how sperm competitiveness is affected by a male's overall genetic quality,there is accumulating evidence that sexual signals reveal good genes and that mate choice based on such signals can increase offspring viability(Auld et al.2019).Therefore,supportive breeding may affect the genetic variance and the mean genetic quality of next generations.

关键词： sexual signaling sperm competition whitefish

Cellular models of stress resistance may pave ways to fight neurodegenerative diseases

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Neural Regeneration Research 2025年第9期20卷 2579-2580页

作者： Thu Nguyen Minh Pham christian Behl Institute of Pathobiochemistry University Medical Center of the Johannes Gutenberg UniversityMainzGermany

Alzheimer's disease(AD),the most common form of neurodegeneration,is characterized by selective neuronal vulnerability and brain regionselective neuron *** entorhinal cortex and hippoc,ampal CA1 projection neurons are at greater risk in AD whereas other regions display resistance to ***,the cerebellum,a phylogenetically very old region,is affected only very late in the disease progression.

关键词： cortex resistance Alzheimer

Many faces of neuronal activity manipulation in Drosophila

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Neural Regeneration Research 2025年第9期20卷 2574-2576页

作者： Amber Krebs Steffen Kautzmann christian Klämbt Institut für Neuro-und Verhaltensbiologie MünsterGermany

Animals exhibit complex responses to external and internal *** information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane *** can neuronal activity orchestrate complex motor patterns or allow learning from previous experience?To answer such questions,we need the ability not only to record,but also to modulate neuronal activity in both space(e.g.,neuronal subsets)and time.

关键词： manipulation potential. neuronal

Alzheimer’s in a dish-induced pluripotent stem cell-based disease modeling

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Translational Neurodegeneration 2019年第1期8卷 257-269页

作者： Sherida de Leeuw christian Tackenberg Institute for Regenerative Medicine University of ZurichSchlierenSwitzerland Neuroscience Center Zurich University of Zurich and ETH ZurichZurichSwitzerland

Background:Since the discovery of the induced pluripotent stem cell(iPSC)technique more than a decade ago,extensive progress has been made to develop clinically relevant cell culture ***’s disease(AD)is the most common neurodegenerative disease,accounting for approximately two thirds of all cases of *** massively increasing number of affected individuals explains the major interest of research in this disease as well as the strong need for better understanding of disease *** body:IPSC-derived neural cells have been widely used to recapitulating key aspects of *** this Review we highlight the progress made in studying AD pathophysiology and address the currently available techniques,such as specific differentiation techniques for AD-relevant cell types as well as 2D and 3D ***,we critically discuss the key challenges and future directions of this field and how some of the major limitations of the iPSC technique may be ***:Stem cell-based disease models have the potential to induce a paradigm shift in biomedical *** particular,the combination of the iPSC technology with recent advances in gene editing or 3D cell cultures represents a breakthrough for in vitro disease modeling and provides a platform for a better understanding of disease mechanisms in human cells and the discovery of novel therapeutics.

关键词： Alzheimer’s disease Induced pluripotent stem cells iPSC-derived neurons iPSC-derived astrocytes iPSCderived microglia Disease modeling

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh department of Neurosurgery Emory University School of MedicineAtlantaGAUSA department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Laser-Welded Steel Foils with Sapphire Substrates

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Acta Metallurgica Sinica(English Letters) 2016年第7期29卷 683-688页

作者： Araceli de Pablos-Martin christian Grosse Andreas Cismak Thomas Hoche Fraunhofer Institute for Microstructure of Materials and Systems IMWS Walter-Htilse-Strage 1 06120 HalleGermany

A nanosecond pulsed laser was used to weld stainless steel foils of 10 ~tm thickness to the sapphire substrates. The microstructure of the bonded interface was studied. Both materials were partially ablated under the influence of the laser beam. An inhomogeneous distribution of the steel and sapphire along the bonded interface is observed. The electrical resistance of the steel foil was measured before and after laser welding, showing that the weld slightly increases the electrical resistance but still keeps the values acceptable for electrical contacts.

关键词： Laser welding Stainless steel Sapphire Electrical resistance

Trajectory optimization for the Horyu-VI international lunar mission

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Astrodynamics 2021年第3期5卷 263-278页

作者： Federico de Grossi Paolo Marzioli Mengu Cho Fabio Santoni christian Circi Sapienza University of Rome 00138 RomeItaly Kyushu Institute of Technology Kitakyushu 804-8550Japan

The Horyu-VI nano-satellite is an international lunar mission with the purpose of studying the lunar horizon glow(LHG)—a still unclear phenomenon caused by electrostatically charged lunar dust *** study analyzes the mission trajectory with the hypothesis that it is launched as a secondary payload of the NASA ARTEMIS-II *** particular,the effect of the solar gravity gradient is studied;in fact,depending on the starting relative position of the Moon,the Earth,and the Sun,the solar gradient acts differently on the trajectory—changing it ***,the transfer and lunar capture problem is solved in several cases with the initial Sun–Earth–Moon angle as the key ***,the inclination with respect to the Moon at capture is constrained to be ***,the problem of stabilization and circularization of the lunar orbit is addressed in a specific case,providing an estimate of the total propellant cost to reach the final orbit around the Moon.

关键词： trajectory optimization Artemis mission lunar mission lunar horizon glow(LHG) weak stability boundary

Schrodinger and Klein-Gordon theories of black holes from the quantization of the Oppenheimer and Snyder gravitational collapse

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Communications in Theoretical Physics 2023年第9期75卷 122-135页

作者： christian Corda SUNY Polytechnic Institute 13502 UticaNew YorkUSAIstituto Livi59100 PratoTuscanyItaly and International Institute for Applicable Mathematics and Information SciencesB M Birla Science CentreAdarshnagarHyderabad 500063India

The Schrodinger equation of the Schwarzschild black hole(BH) has been recently derived by the author and collaborators. The BH is composed of a particle, the 'electron', interacting with a central field, the 'nucleus'. Via de Broglie's hypothesis, one interprets the 'electron' in terms of BH horizon's modes. Quantum gravity effects modify the BH semi-classical structure at the Schwarzschild scale rather than at the Planck scale. The analogy between this BH Schrodinger equation and the Schrodinger equation of the s states of the hydrogen atom permits us to solve the same equation. The quantum gravitational quantities analogous of the fine structure constant and of the Rydberg constant are not constants, but the dynamical quantities have well-defined discrete spectra. The spectrum of the 'gravitational fine structure constant' is the set of non-zero natural numbers. Therefore, BHs are well-defined quantum gravitational systems obeying Schrodinger's theory: the 'gravitational hydrogen atoms'. By identifying the potential energy in the BH Schrodinger equation as being the gravitational energy of a spherically symmetric shell, a different nature of the quantum BH seems to surface. BHs are self-interacting, highly excited,spherically symmetric, massive quantum shells generated by matter condensing on the apparent horizon, concretely realizing the membrane paradigm. The quantum BH described as a'gravitational hydrogen atom' is a fictitious mathematical representation of the real, quantum BH, a quantum massive shell having a radius equal to the oscillating gravitational *** consequences emerge from this result:(i) BHs have neither horizons nor singularities;(ii) there is neither information loss in BH evaporation, nor BH complementarity, nor firewall paradox. These results are consistent with previous ones by Hawking, Vaz, Mitra and ***, the special relativistic corrections to the BH Schrodinger equation give the BH Klein–Gordon equation and the cor

关键词： quantum black holes information paradox quantum shells quantum levels Schrodinger and Klein-Gordon theories

Large-area flexible nanostripe electrodes featuring plasmon hybridization engineering

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Nano Research 2021年第3期14卷 858-867页

作者： Carlo Mennucci debasree Chowdhury Giacomo Manzato Matteo Barelli Roberto Chittofrati christian Martella Francesco Buatier de Mongeot Dipartimento di Fisica Universitàdegli Studi di Genovavia Dodecaneso 33I-16146GenovaItaly

Multifunctional flexible Au electrodes based on one-dimensional(1D)arrays of plasmonic gratings are nanofabricated over large areas with an engineered variant of laser interference lithography optimized for low-cost transparent *** nanostripe(NS)arrays achieve sheet resistance in the order of 20 Ohm/square on large areas(∼cm^(2))and are characterized by a strong and dichroic plasmonic response which can be easily tuned across the visible(VIS)to near-infrared(NIR)spectral range by tailoring their cross-sectional *** vertically a second nanostripe,separated by a nanometer scale dielectric gap,we form near-field coupled Au/SiO_(2)/Au dimers which feature hybridization of their localized plasmon resonances,strong local field-enhancements and a redshift of the resonance towards the NIR *** possibility to combine excellent transport properties and optical transparency on the same plasmonic metasurface template is appealing in applications where low-energy photon management is mandatory like e.g.,in plasmon enhanced spectroscopies or in photon harvesting for ultrathin photovoltaic *** remarkable lateral order of the plasmonic NS gratings provides an additional degree of freedom for tailoring the optical response of the multifunctional electrodes via the excitation of surface lattice resonances,a Fano-like coupling between the broad localised plasmonic resonances and the collective sharp Rayleigh modes.

关键词： nanofabrication nanostripes transparent electrodes plasmonic dimers interference lithography surface lattice resonances

Low-k integration: Gas screening for cryogenic etching and plasma damage mitigation

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Frontiers of Chemical Science and Engineering 2019年第3期13卷 511-516页

作者： Romain Chanson Remi Dussart Thomas Tillocher P. Lefaucheux christian Dussarrat Jean Francois de M arneffe IMEC v.z.w. 3001 LeuvenBelgium GREMI/University of Orleans OrleansFrance Air Liquide Laboratories TsukubaJapan

The integration of porous organo-silicate low-k materials has met a lot of technical *** of the main issues is plasma-induced damage,occurring for all plasma steps involved during interconnects *** the present paper,we focus on porous SiOCH low-k damage mitigation using cryogenic temperature so as to enable micro-capillary *** aim is to protect the porous low-k from plasma-induced damage and keep the k-value of the material unchanged,in order to limit the RC delay of interconnexion levels while shrinking the microchip *** cryogenic temperature is used to condense a gas inside the porous low-k ***,the etching process is performed at the temperature of condensation in order to keep the condensate trapped inside the material during the *** the first part of this work,the condensation properties of several gases are screened,leading to a down selection of five ***,their stability into the porous structure is evaluated at different *** of them are used for plasma damage mitigation *** mitigation is effective and shows negligible damage for one of the gases at-50℃.

关键词： low-A nanotechnology micro-electronics cryo-etching plasma processing