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Cellular models of stress resistance may pave ways to fight neurodegenerative diseases

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Neural Regeneration Research 2025年第9期20卷 2579-2580页

作者： Thu Nguyen Minh Pham christian Behl Institute of Pathobiochemistry University Medical Center of the Johannes Gutenberg UniversityMainzGermany

Alzheimer's disease(AD),the most common form of neurodegeneration,is characterized by selective neuronal vulnerability and brain regionselective neuron *** entorhinal cortex and hippoc,ampal CA1 projection neurons are at greater risk in AD whereas other regions display resistance to ***,the cerebellum,a phylogenetically very old region,is affected only very late in the disease progression.

关键词： cortex resistance Alzheimer

Many faces of neuronal activity manipulation in Drosophila

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Neural Regeneration Research 2025年第9期20卷 2574-2576页

作者： Amber Krebs Steffen Kautzmann christian Klämbt Institut für Neuro-und Verhaltensbiologie MünsterGermany

Animals exhibit complex responses to external and internal *** information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane *** can neuronal activity orchestrate complex motor patterns or allow learning from previous experience?To answer such questions,we need the ability not only to record,but also to modulate neuronal activity in both space(e.g.,neuronal subsets)and time.

关键词： manipulation potential. neuronal

Single-mode and tunable VCSELs in the near-to mid-infrared Invited Paper

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Chinese Optics Letters 2008年第10期6卷 743-747页

作者： Markus-christian Amann werner Hofmann Walter Schottky Institut Technische Universitt MnchenD-85748 GarchingGermany

Single-mode, long-wavelength vertical-cavity surface-emitting lasers （VCSELs） in the near- to mid-infrared covering the wavelength range from 1.3 to 2.3 μm are presented. This wide spectral emission range opens applications in gas sensing and optical interconnects. All these lasers are monolithically grown in the InGaAlAs-InP material system utilizing a buried tunnel junction （BTJ） as current aperture. Fabricated with a novel high-speed design with reduced parasitics, bandwidths in excess of 10 GHz at 1.3 and 1.55 μm have been achieved. Therefore, the coarse wavelength division multiplexing （CWDM） wavelength range of 1.3 to 1.6 μm at 10 Gb/s can be accomplished with one technology. Error-free data-transmission at 10 Gb/s over a fiber link of 20 km is demonstrated. One-dimensional arrays have been fabricated with emission wavelengths addressable by current tuning. Micro-electro-mechanical system （MEMS） tunable devices provide an extended tuning range in excess of 50 nm with high spectral purity. All these devices feature continuous-wave （CW） operation with typical single-mode output powers exceeding 1 mW. The operation voltage is around 1 - 1.5 V and power consumption is as low as 10 - 20 mW. Furthermore, we have also developed VCSELs based on GaSb, targeting functionality of tunable diode laser spectroscopy （TDLS） applying a 1.84-μm VCSEL. at the wavelength range from 2.3 to 3.0 μm. The systems is shown by presenting a laser hygrometer

关键词： mode VCSEL Single-mode and tunable VCSELs in the near-to mid-infrared Invited Paper

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

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Natural Products and Bioprospecting 2020年第6期10卷 377-410页

作者： md.Josim Uddin christian Zidorn Pharmazeutisches Institut Abteilung Pharmazeutische BiologieChristian-Albrechts-Universität zu KielGutenbergstraße 7624118 KielGermany Department of Pharmacy Faculty of Science and EngineeringInternational Islamic University ChittagongChittagong 4318Bangladesh

The majority of the population in Bangladesh uses traditional plant-based medicines to manage various ailments,including central nervous system(CNS)*** review presents ethnobotanical information and relevant scientific studies on plants used in traditional healthcare for the management of various CNS disorders in *** information on the medicinal plants of Bangladesh effective against CNS disorders published in scientific journals,books,and reports was com-piled from different electronic databases using specific key *** present article provides comprehensive information on a total of 224 medicinal plant species belonging to 81 families used for the treatment of CNS disorders by the various peoples of *** total,we reviewed more than 290 relevant *** this study,leaves were found as the most often used plant organ,followed by roots,fruits,whole plants,barks,seeds,stems,rhizomes,and *** Fabaceae family contributes the highest number of used species,followed by Rubiaceae,Lamiaceae,Cucurbitaceae,Vitaceae,Euphorbiaceae,Malvaceae,and *** most frequently used species(in decreasing order)are Asparagus racemosus,Centella asiatica,Stephania japonica,Aegle marmelos,Coccinia grandis,Tabernaemontana divaricata,Bacopa monnieri,Abroma augusta,and Scoparia *** review may serve as a starting point for a rational search for neuroactive natural products against CNS disorders within the Flora of Bangladesh.

关键词： CNS disorder Medicinal plants Traditional plants Ethnopharmacology Review

Scanning gate imaging of quantum point contacts and the origin of the 0.7 anomaly

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Nano Research 2015年第3期8卷 948-956页

作者： Andrea lagallo Nicola Paradiso Stefano Roddaro christian Reichl werner Wegscheider Giorgio Biasiol Lucia Sorba Fabio Beltram Stefan Heun National Enterprise for Nanoscience and Nanotechnology (NEST) Istituto Nanoscienze-CNR and Scuola Normale Superiore Piazza San Silvestro 12 56127 Pisa Italy Istituto Offcina dei Materiali CNR Laboratorio TASC 34149 Trieste Italy Solid State Physics Laboratory ETH Zurich Schafmattstrasse 16 8093 Zurich Switzerland

The origin of the anomalous transport feature appearing at a conductance G 0.7× （2e2/h） in quasi-lD ballistic devices-the so-called 0.7 anomaly-represents a long standing puzzle. Several mechanisms have been proposed to explain it, but a general consensus has not been achieved. Proposed explanations have been based on quantum interference, the Kondo effect, Wigner crystallization, and other phenomena. A key open issue is whether the point defects that can occur in these low-dimensional devices are the physical cause behind this conductance anomaly. Here we adopt a scanning gate microscopy technique to map individual impurity positions in several quasi-lD constrictions and correlate these with conductance characteristics. Our data demonstrate that the 0.7 anomaly can be observed irrespective of the presence of localized defects, and we conclude that the 0.7 anomaly is a fundamental property of low-dimensional systems.

关键词： two-dimensional electrongas (2-DEG) scanning gate microscopy 0.7 anomaly

N-Propionylmannosamine:using biochemical glycoengineering to promote peripheral nerve regeneration

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Neural Regeneration Research 2015年第12期10卷 1947-1948页

作者： Georgios Koulaxouzidis werner Reutter christian Witzel Department of Plastic and Hand Surgery University of Freiburg Medical Center Institut für Laboratoriumsmedizin Klinische Chemie und Pathobiochemie Charité-Universit?tsmedizin (Freie Universit?t Berlin) Plastic and Reconstructive Surgery Charité-Universit?tsmedizin Berlin

The peripheral nervous system,in contrast to the central nervous system,is capable of spontaneous ***,nerve reconstruction in the peripheral nervous system remains a major challenge,as the functional outcomes followin... 详细信息

关键词： N-Propionylmannosamine Figure Man ST UDP acid

Schrodinger and Klein-Gordon theories of black holes from the quantization of the Oppenheimer and Snyder gravitational collapse

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Communications in Theoretical Physics 2023年第9期75卷 122-135页

作者： christian Corda SUNY Polytechnic Institute 13502 UticaNew YorkUSAIstituto Livi59100 PratoTuscanyItaly and International Institute for Applicable Mathematics and Information SciencesB M Birla Science CentreAdarshnagarHyderabad 500063India

The Schrodinger equation of the Schwarzschild black hole(BH) has been recently derived by the author and collaborators. The BH is composed of a particle, the 'electron', interacting with a central field, the 'nucleus'. Via de Broglie's hypothesis, one interprets the 'electron' in terms of BH horizon's modes. Quantum gravity effects modify the BH semi-classical structure at the Schwarzschild scale rather than at the Planck scale. The analogy between this BH Schrodinger equation and the Schrodinger equation of the s states of the hydrogen atom permits us to solve the same equation. The quantum gravitational quantities analogous of the fine structure constant and of the Rydberg constant are not constants, but the dynamical quantities have well-defined discrete spectra. The spectrum of the 'gravitational fine structure constant' is the set of non-zero natural numbers. Therefore, BHs are well-defined quantum gravitational systems obeying Schrodinger's theory: the 'gravitational hydrogen atoms'. By identifying the potential energy in the BH Schrodinger equation as being the gravitational energy of a spherically symmetric shell, a different nature of the quantum BH seems to surface. BHs are self-interacting, highly excited,spherically symmetric, massive quantum shells generated by matter condensing on the apparent horizon, concretely realizing the membrane paradigm. The quantum BH described as a'gravitational hydrogen atom' is a fictitious mathematical representation of the real, quantum BH, a quantum massive shell having a radius equal to the oscillating gravitational *** consequences emerge from this result:(i) BHs have neither horizons nor singularities;(ii) there is neither information loss in BH evaporation, nor BH complementarity, nor firewall paradox. These results are consistent with previous ones by Hawking, Vaz, Mitra and ***, the special relativistic corrections to the BH Schrodinger equation give the BH Klein–Gordon equation and the cor

关键词： quantum black holes information paradox quantum shells quantum levels Schrodinger and Klein-Gordon theories

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

光学纯(4S,5R)-4-甲基-5-羟基-3-羰基己酸特丁酯的化学酶促合成

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有机化学 2002年第12期22卷 1009-1012页

作者：吉爱国 Michael Mueller Michael Wolberg werner Hummel christian Wandreyb 山东大学药学院济南250012 德国于利希研究中心生物技术研究所于利希52425 德国于利希研究中心杜塞尔多夫大学酶技术研究所于利希52426

采用化学方法合成了 4 甲基 3,5 二羰基己酸特丁酯 .以Lactobacillusbrevis醇脱氢酶为生物催化剂 ,选择性地将 4 甲基 3,5 二羰基己酸特丁酯还原为 (4S ,5R) 4 甲基 5 羟基 3 羰基己酸特丁酯 (99.2 %ee,syn∶anti=97∶3) .

关键词：光学纯 (4S,5R)-4-甲基-5-羟基-3-羰基己酸特丁酯化学酶促合成 Lactobacillus brevis醇脱氢酶药物中间体