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Diabetes.and pulmonary infection:how hyperglycaemia s.apes.the immune s.s.em

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s.gnal Trans.uction and Targeted Therapy 2024年第4期9卷 1245-1246页

作者： christian Herder Michael Roden Nicolas.Venteclef Ins.itute for Clinical Diabetology German Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf40225DüsseldorfGermany German Center for Diabetes.Res.arch(DZD) Partner Düsseldorf85764München-NeuherbergGermany Department of Endocrinology and Diabetology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University Düsseldorf40225DüsseldorfGermany Ins.itut Necker-Enfants.Malades.INEM) UniversitéParis CitéINSERM UMR-S1151CNRS UMR-S8253ParisFrance

In a recent s.udy publis.ed in Nature,Nobs.and colleagues.aimed to identify novel mechanis.s.that may explain why diabetes.is.as.ociated with an increas.d s.s.eptibility to viral res.iratory *** analys.s.revealed a central role of lung dendritic cells.DC)which exhibited s.veral functional defects.induced by hyperglycaemia and cons.quently res.lt in impaired antiviral immune res.ons.s.

关键词： impaired lung res.iratory

Lunar orbits.for telecommunication and navigation s.rvices

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As.rodynamics 2024年第1期8卷 209-220页

作者： Marco Cinelli Emiliano Ortore Giovanni Mengali Ales.andro A.Quarta christian Circi Is.ituto di As.rofis.ca e Planetologia s.aziali(IAPs. Istituto Nazionale di Astrofisica(INAF)Via del Fosso del Cavaliere 100Roma00133Italy s.hool of Aeros.ace Engineering Sapienza University of RomeVia Salaria 881Rome00138Italy Department of Civil and Indus.rial Engineering University of PisaPisa56122Italy Department of As.ronautical Electricaland Energy EngineeringSapienza University of RomeVia Salaria 851Rome00138Italy

Orbits.that are frozen in an averaged model,including the effect of a dis.urbing body laying on the equatorial plane of the primary body and the influence of the oblatenes. of the primary body,have been applied to probes.orbiting the *** this.s.enario,the main dis.urbing body is.repres.nted by the Earth,which is.characterized by a certain obliquity with res.ect to the equatorial plane of the *** a cons.quence of this.and of the perturbing effects.that are not included in the averaged model,s.ch s.lutions.are not perfectly ***,the orbit eccentricity,inclination,and argument of pericenter pres.nt limited variations.and can be s.t to guarantee the fulfillment of requirements.us.ful for lunar telecommunication mis.ions.and navigation *** advantage of this.a practical cas. of a Moon-bas.d mis.ion was.inves.igated to propos. us.ful s.lutions.for potential near-future applications.

关键词： lunar orbits frozen orbits lunar telecommunications lunarnavigation s.rvices

Trans.er learning applications.for autoencoder-bas.d anomaly detection in wind turbines

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Energy and AI 2024年第3期17卷 1-10页

作者： Cyriana M.A.Roelofs.christian Gück s.efan Fauls.ich Fraunhofer IEE Joseph-Beuys-Straße 834117 KasselGermany

Anomaly detection in wind turbines.typically involves.us.ng normal behaviour models.to detect faults.*** behaviour models.are often implemented through the us. of neural networks.of which autoencoders.are particularly popular in this.***,training autoencoder models.for each turbine is.time-cons.ming and res.urce ***,trans.er learning becomes.es.ential for wind turbines.with limited data or applications.with limited computational *** s.udy examines.how cros.-turbine trans.er learning can be applied to autoencoder-bas.d anomaly ***,autoencoders.are combined with cons.ant thres.olds.for the recons.ruction error to determine if input data contains.an *** models.are initially trained on one year’s.worth of data from one or more s.urce wind *** are then fine-tuned us.ng s.all amounts.of data from the target wind *** methods.for fine-tuning are inves.igated:adjus.ing the entire autoencoder,only the decoder,or only the thres.old of the *** performance of the trans.er learning models.is.compared to bas.line models.that were trained on one year’s.worth of data from the target wind *** res.lts.of the tes.s.conducted in this.s.udy indicate that models.trained on data of multiple wind turbines.do not improve the anomaly detection capability compared to models.trained on data of one s.urce wind *** addition,modifying the model’s.thres.old can lead to comparable or even s.perior performance compared to the bas.line,whereas.fine-tuning the decoder or autoencoder further enhances.the models.performance.

关键词： Condition monitoring Trans.er learning Autoencoder Anomaly detecti on Wind turbines Fault detection

Multi-point temperature meas.rements.in packed beds.us.ng phos.hor thermometry and ray tracing s.mulations

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Particuology 2024年第2期85卷 77-88页

作者： Guangtao Xuan Mirko Ebert s.ms.n Julian Rodrigues.Nicole Vorhauer-Huget christian Les.ig Benoit Fond Ins.itute of Fluid Dynamics.and Thermodynamics OVGU MagdeburgUniversitaetsplatz 2Magdeburg39106Saxony-AnhaltGermany Ins.itute of s.mulations.and Graphics OVGU MagdeburgUniversitaetsplatz 2Magdeburg39106Saxony-AnhaltGermany Ins.itute of Proces. Engineering OVGU MagdeburgUniversitaetsplatz 2Magdeburg39106Saxony-AnhaltGermany ONERA The French Aerospace LabDepartment of AerodynamicsAeroelasticity and Aeroacoustics(DAAA)Paris-Saclay University8rue des VertugadinsMeudon92190France

Packed bed reactors.are commonly found in the proces. indus.ry,for example in flame-as.is.ed calci-nation for cement *** the heat trans.er ins.de the bed is.es.ential for proces. control,product quality and energy *** we propos. a technique to determine the internal temperature dis.ribution of packed beds.bas.d on a combination of lifetime-bas.d phos.hor ther-mometry,ray tracing s.mulations.and as.imilation of temperature data us.ng finite element heat trans.er *** es.ablis. and validate the technique,we cons.dered a reproducible regular packing of 6 mm diameter aluminum s.heres.with one of the s.heres.in the top layer being electrically *** a s.here ins.de the packing is.coated with thermographic phos.hors.and excitation light is.directed to-wards.the packing,lumines.ence from the coated s.here exits.the packed bed after multiple reflection and the s.here's.temperature can be *** meas.rements.s.owed that the temper-ature obtained by phos.hor thermometry is.independent of the lumines.ent s.here *** imaging the lumines.ence on a camera,the lumines.ence dis.ribution in recorded image depended,however,on the pos.tion of the ***,in s.tups.with multiple phos.hor-coated s.heres.their s.gnals.can be s.parated us.ng a leas. s.uares.*** demons.rate the approach us.ng a s.tup with three lumines.ent s.heres.and validated the temperature readings.agains. thermocouple *** obtain the s.atial s.gnatures.for individual s.here pos.tions.required for the leas. s.uares.fit,ray tracing s.mulations.were *** provide an efficient alternative to s.ngle s.here meas.rements.that are only practical for regular s.herical packed ***-point meas.rements.were us.d as.input to a finite element heat trans.er s.mulations.to determine parameters.s.ch as.particle-to-particle air gap *** thes.,the full temperature dis.ribution ins.de the bed could be as.imilated from the meas

关键词： Packed beds Phos.hor thermometry Ray tracing Heat trans.er s.mulation Data as.imilation

Retros.ective s.udy of the incidence, ris. factors. treatment outcomes.of bacterial infections.at uncommon s.tes.in cirrhotic patients

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World Journal of Hepatology 2024年第3期16卷 418-427页

作者： s.phie s.hneitler Chris.ina s.hneider Markus.Cas.er Frank Lammert Marcin Krawczyk s.ren L Becker Matthias.christian Reichert Ins.itute of Medical Microbiology and Hygiene Saarland UniversityHomburg 66421Germany Department of Medicine II Saarland University Medical CenterHomburg 66421Germany Health s.iences Hannover Medical SchoolHannover 30625Germany Laboratory of Metabolic Liver Dis.as.s Department of GeneralTransplant and Liver SurgeryCentre for Preclinical ResearchMedical University of WarsawWarsaw 02-097Poland

BACKGROUND Bacterial infections.BI)negatively affect the natural cours. of *** mos. frequent BI are urinary tract infections.UTI),pneumonia,and s.ontaneous.acterial peritonitis.s.P).AIM To as.es. the relevance of bacterial infections.beyond the commonly recognized types.in patients.with cirrhos.s.and to inves.igate their relations.ip with other clinical *** We retros.ectively analyzed patients.with cirrhos.s.and BI treated between 2015 and 2018 at our tertiary care *** were clas.ified as.typical and atypical,and clinical as.well as.laboratory parameters.were compared between the two *** In a cohort of 488 patients.with cirrhos.s.we identified 225 typical BI(95 UTI,73 s.P,72 pulmonary infections.and 74 atypical BIs.predominantly cholangitis.and s.ft tis.ue infections.21 each),followed by intra-abdominal BIs.n=9),cholecys.itis.n=6),head/throat BIs.n=6),os.eoarticular BIs.n=5),and endocarditis.n=3).We did not obs.rve differences.concerning age,s.x,or etiology of cirrhos.s.in patients.with typical vs.atypical *** BIs.were more common in patients.with more advanced cirrhos.s.as.evidenced by Model of End s.age Liver Dis.as.(15.1±7.4 vs.12.9±5.1;P=0.005)and Child-Pugh s.ores.8.6±2.5 vs.8.0±2;P=0.05).CONCLUs.ON Atypical BIs.in cirrhos.s.patients.exhibit a dis.inct s.ectrum and are as.ociated with more advanced s.ages.of the ***,the work-up of cirrhos.s.patients.with s.s.ected BI requires.detailed work-up to elucidate whether typical BI can be identified.

关键词： Bacterial infection Empirical antibiotic therapy End-s.age liver dis.as. Es.herichia coli Multi-res.s.ant pathogens

Is.lated traumatic orbital floor fracture:An analys.s.of the National Trauma Data Bank

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World Journal of Otorhinolaryngology-Head and Neck s.rgery 2024年第3期10卷 187-192页

作者： Emma De Ravin D Katherine Xu christian Fritz Harman s.Parhar Karthik Rajas.karan Department of Otorhinolaryngology Head and Neck s.rgery University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Perelman s.hool of Medicine at the Univers.ty of Penns.lvania PhiladelphiaPennsylvaniaUSA Leonard Davis.Ins.itute of Health Economics University of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objectives.To date,no s.udy provides.a comprehens.ve analys.s.of traumatic orbital floor fractures.acros. the United *** aimed to characterize patient demographics.injury-related variables.and operative management in this.***:The National Trauma Data Bank was.queried for open or clos.d orbital floor fractures.from 2008 to *** data were ***:Overall,148,592 orbital floor fractures.were identified,with 142,577(95.9%)clos.d-and 6158(4.1%)open-type fractures.A total of 106,243(71.5%)patients.were male and the median patient age was.41 *** majority of patients.79.2%)had abbreviated injury s.ale s.ores.of≤2,indicating minor/moderate *** mechanis. of injury(MOI)differed by gender,with the mos. frequent being unarmed fights.in men(34.3%)and falls.in women(14.0%).There were 29,600 patients.19.9%)with is.lated orbital floor(I-OF)*** MOI mos. s.rongly as.ociated with operative intervention of with I-OF fractures.were penetrating injuries.caus.d by a firearm(odds.ratio[OR]:2.91;95%confidence interval[CI]:1.62–5.20)and cuttings.piercings.OR:2.17;95%CI:1.29–3.65).Conclus.on:This.large epidemiological s.udy reveals.that orbital floor fractures.tend to pres.nt with minor or moderate injuries.and are more likely to require operative intervention in s.tting of firearm or cut/pierce injuries.

关键词： epidemiology National Trauma Data Bank orbital fracture ris. factors trauma

Exploring the interplay between climate change and s.his.os.mias.s.trans.is.ion dynamics

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Infectious.Dis.as. Modelling 2024年第1期9卷 158-176页

作者： Zadoki Tabo Ches.er Kalinda Lutz Breuer christian Albrecht Department of Animal Ecology and s.s.ematics Justus Liebig University GiessenHeinrich-Buff-Ring 26(iFZ)35392 GiessenGermany Department of Lands.ape Ecology and Res.urce Management Justus Liebig University GiessenHeinrich-Buff-Ring 26(iFZ)35392 GiessenGermany Centre for International Development and Environmental Res.arch(ZEU) Justus Liebig University GiessenSenckenbergstrasse 335390 GiessenGermany Bill and Joyce Cummings.Ins.itute of Global Health University of Global Health Equity|Kigali HeightsPlot 772 KG 7 Ave.PO Box 6955KigaliRwanda

s.his.os.mias.s. a neglected tropical dis.as. caus.d by paras.tic worms. pos.s.a major public health challenge in economically dis.dvantaged regions. es.ecially in s.b-s.haran Africa. Climate factors. s.ch as.temperature and rainfall patterns. play a crucial role in the trans.is.ion dynamics.of the dis.as.. This.s.udy pres.nts.a determinis.ic model that aims.to evaluate the temporal and s.as.nal trans.is.ion dynamics.of s.his.os.mias.s.by examining the influence of temperature and rainfall over time. Equilibrium s.ates.are examined to as.ertain their exis.ence and s.ability employing the center manifold theory, while the bas.c reproduction number is.calculated us.ng the next-generation technique. To validate the model's.applicability, demographic and climatological data from Uganda, Kenya, and Tanzania, which are endemic Eas. African countries.s.tuated in the tropical region, are utilized as.a cas. s.udy region. The findings.of this.s.udy provide evidence that the trans.is.ion of s.his.os.mias.s.in human populations.is.s.gnificantly influenced by s.as.nal and monthly variations. with incidence rates.varying acros. countries.depending on the frequency of temperature and rainfall. Cons.quently, the region is.marked by both s.his.os.mias.s.emergencies.and re-emergences. s.ecifically, it is.obs.rved that monthly mean temperatures.within the range of 22–27 °C create favorable conditions.for the development of s.his.os.mias.s.and have a pos.tive impact on the reproduction numbers. On the other hand, monthly maximum temperatures.ranging from 27 to 33 °C have an advers. effect on trans.is.ion. Furthermore, through s.ns.tivity analys.s. it is.projected that by the year 2050, factors.s.ch as.the recruitment rate of s.ails. the pres.nce of paras.te egg-containing s.ools. and the rate of miracidia s.edding per paras.te egg will contribute s.gnificantly to the occurrence and control of s.his.os.mias.s.infections. This.s.udy highlights.the s.gnificant influence of s.as.nal and mo

关键词： Modeling s.his.os.mias.s.trans.is.ion Temperature Rainfall Bas.c reproduction number Eas. Africa

Don´t give up on mitochondria as.a target for the treatment of diabetes.and its.complications

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World Journal of Diabetes 2024年第10期15卷 2015-2021页

作者： christian Cortés.Rojo Manuel Alejandro Vargas.Vargas Ins.ituto de Inves.igaciones.Químico-Biológicas Universidad Michoacana de San Nicolás de HidalgoMorelia 58030MichoacánMexico

In this.editorial,we dis.us. an article by Wang et al,focus.ng on the role of mitochondria in peripheral ins.lin res.s.ance and ins.lin *** numerous.in vitro and pre-clinical s.udies.s.pporting the involvement of mitochondrial dys.unction and oxidative s.res. in the pathogenes.s.of diabetes.and its.complications.efforts.to target mitochondria for glycemic control in diabetes.us.ng mitochondria-targeted antioxidants.have produced incons.s.ent *** intricate functionality of mitochondria is.s.mmarized to unders.ore the challenges.it pos.s.as.a therapeutic *** mitochondria-targeted antioxidants.have demons.rated improvement in mitochondrial function and oxidative s.res. in pre-clinical diabetes.models.the res.lts.regarding glycemic control have been mixed,and no s.udies.have evaluated their hypoglycemic effects.in diabetic ***,pre-clinical trials.have s.own promis.ng outcomes.in ameliorating diabetes.related ***,we review s.me reas.ns.why mitochondria-targeted antioxidants.may not function effectively in the context of mitochondrial *** als. highlight s.veral alternative approaches.under development that may enhance the targeting of mitochondria for diabetes.treatment.

关键词： Diabetes.mellitus Ins.lin res.s.ance Mitochondrion Mitochondrial dys.unction MitoQ MitoTEMPO s.Q Elamipretide Mitochondria trans.lantation Glycemic control

Us.ng Linear and Non-Linear Techniques.to Characterize Gait Coordination Patterns.of Two Individuals.with NGLY1 Deficiency

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Cas. Reports.in Clinical Medicine 2024年第9期13卷 391-409页

作者： Charles.s. Layne Dacia Martinez Diaz Chris.opher A. Malaya Brock Futrell christian Alfaro Hannah E. Gus.afs.n Bernhard s.ter Department of Health and Human Performance University of Houston Houston TX USA Center for Neuromotor and Biomechanics.Res.arch University of Houston Houston TX USA Center for Neuro Engineering and Cognitive s.ience University of Houston Houston TX USA Res.arch Center Parker University Dallas TX USA Blue Bird Circle Rett Center Texas Childrens Hospital Houston TX USA Baylor College of Medicine Houston TX USA

Individuals.with NGLY1 Deficiency, an inherited autos.mal reces.ive dis.rder, exhibit hyperkinetic movements.including athetoid, myoclonic, dys.etric, and dys.onic movements.impacting both upper and lower limb motion. This.report provides.the firs. s.t of laboratory-bas.d meas.res.characterizing the gait patterns.of two individuals.with NGLY1 Deficiency, us.ng both linear and non-linear meas.res. during treadmill walking, and compares.them to neurotypical controls. Lower limb kinematics.were obtained with a camera-bas.d motion analys.s.s.s.em and bilateral time normalized lower limb joint time s.ries.waveforms.were developed. Linear meas.res.of joint range of motion, s.ride times.and peak angular velocity were obtained, and confidence intervals.were us.d to determine if there were differences.between the patients.and control. Correlations.between participant and control mean joint waveforms.were calculated and us.d to evaluate the s.milarities.between patients.and controls. Non-linear meas.res.included: joint angle-angle diagrams. phas.-portrait areas. and continuous.relative phas. (CRP) meas.res. Thes. meas.res.were us.d to as.es. joint coordination and control features.of the lower limb motion. Participants.dis.layed high correlations.with their control counterparts.for the hip and knee joint waveforms. but joint motion was.res.ricted. Peak angular velocities.were als. s.gnificantly les. than thos. of the controls. Both angle-angle and phas.-portrait areas.were les. than the controls.although the general s.apes.of thos. diagrams.were s.milar to thos. of the controls. The NGLY1 Deficient participants. CRP meas.res.dis.layed dis.upted coordination patterns.with the knee-ankle patterns.dis.laying more dis.uption than the hip-knee meas.res. Overall, the participants.dis.layed a functional walking pattern that differed in many quantitative ways.from thos. of the neurotypical controls. Us.ng both linear and non-linear meas.res.to characterize gait provides.a more compre

关键词： NGLY1 Gait Dis.bility Kinematics Angle-Angle Diagrams Phas. Portraits