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Neural Regeneration Research 2022年第9期17卷 1881-1884页

作者： christian Humpel Laboratory of Psychiatry and Experimental Alzheimer’s Research Medical University of InnsbruckInnsbruckAustria

Neurodegenerative brain disorders are a major burden in our society,such as Alzheimer´s *** order to repair or prevent such diseases,drugs are designed which enter the brain,but the blood-brain barrier limits their entry and the search for alternative pathways is ***,we reported that intranasal delivery of the amyloid-beta degrading enzyme neprilysin eliminated amyloid-beta plaques in transgenic Alzheimer´s disease *** review describes the anatomical structure of the intranasal pathway,explains the intranasal delivery of pure neprilysin,cell-loaded neprilysin(platelets)and collagen-embedded neprilysin to destruct amyloid-beta plaques in Alzheimer´s disease in transgenic APP_SweDI mice and hypothesizes why this may cause compensation and why the amyloid-beta cascade hypothesis may fail.

关键词： amyloid-beta amyloid-beta degrading enzyme clear plaque collagen biomaterial intranasal neprilysin nose-to-brain

Integrating geometallurgical ball mill throughput predictions into short-term stochastic production scheduling in mining complexes

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International Journal of Mining Science and Technology 2023年第2期33卷 185-199页

作者： christian Both Roussos Dimitrakopoulos COSMO–Stochastic Mine Planning Laboratory Department of Mining and Materials EngineeringMcGill UniversityMontreal H3A 0E8Canada

This article presents a novel approach to integrate a throughput prediction model for the ball mill into short-term stochastic production scheduling in mining *** datasets for the throughput prediction model include penetration rates from blast hole drilling(measurement while drilling),geological domains,material types,rock density,and throughput rates of the operating mill,offering an accessible and cost-effective method compared to other geometallurgical ***,the comminution behavior of the orebody was geostatistically simulated by building additive hardness proportions from penetration rates.A regression model was constructed to predict throughput rates as a function of blended rock properties,which are informed by a material tracking approach in the mining ***,the throughput prediction model was integrated into a stochastic optimization model for short-term production *** way,common shortfalls of existing geometallurgical throughput prediction models,that typically ignore the non-additive nature of hardness and are not designed to interact with mine production scheduling,are overcome.A case study at the Tropicana Mining Complex shows that throughput can be predicted with an error less than 30 t/h and a correlation coefficient of up to *** integrating the prediction model and new stochastic components into optimization,the production schedule achieves weekly planned production reliably because scheduled materials match with the predicted performance of the *** to optimization using conventional mill tonnage constraints reveal that expected production shortfalls of up to 7%per period can be mitigated this way.

关键词： Geometallurgy Stochastic optimization Short-term open pit mine production scheduling Measurement while drilling Non-additivity Hardness

Cross-Talk between ROS and Calcium in Regulation of Nuclear Activities

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Molecular Plant 2010年第4期3卷 706-718页

作者： christian Mazars Universite de Toulouse UPS UMR 5546 Surfaces Cellulaires et Signalisation chez les Vegetaux BP 42617 F-31326 Castanet-Tolosan France CNRS UMR 5546 BP 42617 F-31326 Castanet-Tolosan France Universite de Bourgogne UMR Plante-Microbe-Environnement BP 86510 21065 Dijon cedex France UMR INRA 1088 CNRS 5184 Universite de Bourgogne Plante-Microbe-Environnement BP 86510 21065 Dijon cedex France

Calcium and Reactive Oxygen Species （ROS） are acknowledged as crucial second messengers involved in the response to various biotic and abiotic stresses. However, it is still not clear how these two compounds can play a role in different signaling pathways leading the plant to a variety of processes such as root development or defense against pathogens. Recently, it has been shown that the concept of calcium and ROS signatures, initially discovered in the cytoplasm, can also be extended to the nucleus of plant cells. In addition, it has been clearly proved that both ROS and calcium signals are intimately interconnected. How this cross-talk can finally modulate the translocation and/or the activity of nuclear proteins leading to the control of specific genes expression is the main focus of this review. We will especially focus on how calcium and ROS interact at the molecular level to modify their targets.

关键词： Nucleus Calcium ROS Crosstalk Signalling.

Spatio-temporal modelling of the effect of selected environmental and land-use factors on acid grassland vegetation

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Journal of Plant Ecology 2022年第2期15卷 253-264页

作者： christian Damgaard Department of Bioscience Aarhus UniversityVejlsøvej 258600 SilkeborgDenmark

Acid grasslands are threatened both by agricultural intensification with nutrient addition and increased livestock densities as well as by land *** order to understand and quantify the effect of selected environmental and land-use factors on the observed variation and changes in the vegetation of acid grasslands,large-scale spatial and temporal pin-point plant cover monitoring data are fitted in a structural equation *** important sources of measurement and sampling uncertainties have been included using a hierarchical model ***,uncertainties associated with the measurement and sampling are separated from the process uncertainty,which is important when generating ecological predictions that may feed into local conservation management ***,increasing atmospheric nitrogen deposition led to more grass-dominated acid grassland habitats at the expense of the cover of *** soils were relatively more acidic,and the effects of soil type on the vegetation include both direct effects of soil type and indirect effects mediated by the effect of soil type on soil *** soil type and soil pH affected the vegetation of acid *** though only a relatively small proportion of the temporal variation in cover was explained by the model,it would still be useful to quantify the uncertainties when using the model for generating local ecological predictions and adaptive management plans.

关键词： joint distribution of plant abundance spatial and temporal variation of cover hierarchical Bayesian models pin-point cover data structural equation modelling acid grassland vegetation

A model-based prognostics method for fatigue crack growth in fuselage panels

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Chinese Journal of Aeronautics 2019年第2期32卷 396-408页

作者： Yiwei WANG christian GOGU Nicolas BINAUD christian BES Jian FU School of Mechanical Engineering and Automation Beihang University Institut Clément Ader (UMR CNRS 5312) INSA/UPS/ISAE/Mines Albi Université de Toulouse

This paper proposes a model-based prognostics method that couples the Extended Kalman Filter(EKF) and a new developed linearization method. The proposed prognostics method is developed in the context of fatigue crack propagation in fuselage panels where the model parameters are unknown and the crack propagation is affected by different types of uncertainties. The coupled method is composed of two steps. The first step employs EKF to estimate the unknown model parameters and the current damage state. In the second step, the proposed efficient linearization method is applied to compute analytically the statistical distribution of the damage evolution path in some future time. A numerical case study is implemented to evaluate the performance of the proposed method. The results show that the coupled EKF-linearization method provides satisfactory results: the EKF algorithm well identifies the model parameters, and the linearization method gives comparable prediction results to Monte Carlo(MC) method while leading to very significant computational cost saving. The proposed prognostics method for fatigue crack growth can be used for developing predictive maintenance strategy for an aircraft fleet, in which case, the computational cost saving is significantly meaningful.

关键词： Aircraft fuselage panels Extended Kalman filter Fatigue crack propagation Linearization method Model-based prognostics

Phosphorus recovery from municipal and fertilizer wastewater:China's potential and perspective

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Journal of Environmental Sciences 2017年第2期29卷 151-159页

作者： Kuangxin Zhou Matthias Barjenbruch christian Kabbe Goulven Inial christian Remy Berlin Centre of Competence for Water Berlin 10709Germany Department of Urban Water Management Technical University of BerlinBerlin 13355Germany Research&Innovation Asia Veolia EnvironmentBeijing 10004China

Phosphorus（P） is a limited resource, which can neither be synthesized nor substituted in its essential functions as nutrient. Currently explored and economically feasible global reserves may be depleted within generations. China is the largest phosphate fertilizer producing and consuming country in the world. China’s municipal wastewater contains up to 293,163 Mg year of phosphorus, which equals approximately 5.5% of the chemical fertilizer phosphorus consumed in China. Phosphorus in wastewater can be seen not only as a source of pollution to be reduced, but also as a limited resource to be recovered. Based upon existing phosphorus-recovery technologies and the current wastewater infrastructure in China, three options for phosphorus recovery from sewage sludge, sludge ash and the fertilizer industry were analyzed according to the specific conditions in China.

关键词： Phosphorus recovery Municipal Wastewater Fertilizer Industry Sewage sludge China

Recent Advances in Plant Cell Nuclear Signaling

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Molecular Plant 2012年第5期5卷 968-970页

作者： Patrice Thuleau christian Briere christian Mazars Universite de Toulouse UPS UMR 5546 Laboratoire de Recherche en Sciences Vegetales BP 42617 F-31326 Castanet-Tolosan France CNRS UMR 5546 BP 42617 F-31326 Castanet-Tolosan France

In plants, a growing amount of evidence suggests an impor- tant role for the nucleus in the establishment of developmen- tal and adaptive processes. Recent years have contributed to an increase in the knowledge about the nuclear compart- ment that has been considered for a long time as an orga- nelle in which only mechanisms such as transcription and DNA replication occurred. The scenario appears now largely more complicated, in that the nucleus has been shown to harbor a number of partially autonomous regulatory mecha- nisms, to such an extent that some authors claimed that the nucleus is ＇a cell within a cell＇（Rodrigues et al., 2009）. In 2010, Molecular Plant published a special issue bringing together a series of articles on the plant nucleus organization and func- tions （Volume 3, Number 4, 2010）. Here, we give a short high- light of these different reviews that we complement with the most recent advances in this fast-moving field. The readers are also invited to refer to the Focus Issue recently published in Plant Physiology （Cheung and Reddy, 2012）.

关键词： Advances Signaling Cell

Robot Off-Line Programming for Thermal Spraying

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稀有金属材料与工程 2012年第S1期41卷 13-17页

作者： christian Coddet Laboratoire d'Etudes et de Recherches sur les Matériaux les Procédés et les Surfaces(LERMPS)Université de Technologie de Belfort-Montbéliard(UTBM)Belfort Cedex 90010French

The purpose of this study is to introduce the current applications of off-line programming technology in thermal spraying,including some popular methods of path generation,procedure simulation,robot kinematics optimization,*** this technology reduces the difficulty of robot programming and enormously improves its facility for thermal *** the last part of this paper,presented two examples of off-line programming in thermal spraying which refer to trajectory optimization on a work piece with a great angle and path generation on the complex work *** simulations and experiments have proved that off-line programming can effectively improve the production efficiency and the quality of coating.

关键词： off-line programming toolkit thermal spraying trajectory optimization

Probabilistic approach for open pit bench slope stability analysis——A mine case study

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International Journal of Mining Science and Technology 2019年第4期29卷 629-640页

作者： christian Obregon Hani Mitri Department of Mining and Materials Engineering McGill University

The geotechnical slope design of an open pit wall starts at the bench scale *** this scale,the rock slope stability is governed primarily by the geological discontinuities within the rock mass and as a result,structurally-controlled failures(***,wedge or toppling)are most likely to *** probabilistic approach offers a major advantage over the traditional deterministic method in that it accounts for the different degrees of variability and uncertainty often encountered in rock *** paper presents a bench slope stability assessment for an open pit mine in Peru using a probabilistic-based approach by coupling a kinematic analysis based on stereographic projection techniques followed by a kinetic analysis by means of the limit equilibrium ***,these two probabilities are combined to provide an overall measure of the probability of failure(PoF)of the bench slope *** case study is characterized by significant scatter in the geometrical and mechanical properties of the *** surface mapping was conducted at 36 different sites following the ISRM suggested *** direct shear tests were carried *** is shown that by combining field and laboratory measurements and engineering judgment,the probability density functions(PDF)of the discontinuity parameters can be *** are then used in a Monte Carlo simulation process to compute both kinematic and kinetic probabilities of *** overall probability of failure aims to provide the design engineer with a tool to critically evaluate the bench performance from a geotechnical risk perspective and to provide a basis for future bench design optimization.

关键词： Mine safety Rock slope stability Kinematic analysis Probability of failure Limit equilibrium analysis Case study

Experimental investigations of a full model with adaptive elasto-flexible membrane wings

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Chinese Journal of Aeronautics 2021年第7期34卷 211-218页

作者： Jonathan PFLU GER christian BREITSAMTER Chair of Aerodynamics and Fluid Mechanics Technical University of MunichGarching 85748Germany

The morphing wing concept aims to constantly adapt the aerodynamics to different flight *** wing is able to adapt to different flight conditions by an adjustable Aspect Ratio(AR)and sweep.A high AR configuration provides high aerodynamic efficiency,while a low AR configuration,with highly swept wings offers a good ***,the flexible membrane allows the wing surface to stretch and contract in-plane as well as the airfoil to adapt to different aerodynamic *** the context of this work,the aerodynamic characteristics of a full model with form-adaptive elasto-flexible membrane wings are investigated *** focus is on the high-lift regime and on the analysis of the aerodynamic coefficients as well as their ***,the lateral aerodynamic derivatives at asymmetric wing positions are of interest.

关键词： Experimental aerodynamics Flexible wing surface Force and moment measurements Morphing wing Particle image velocimetry