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航空制造技术 2015年第14期58卷 63-64页

作者： Erilk Kappel Nico Liebers Manuel Buggisch Philipp hilmer Markus Kleineberg christian hühne 李进松德国宇航中心复合材料结构与自适应系统研究所

装备周期越来越短,成本利用率越来越高的工艺方法使得高质量可循环利用的碳纤维复合材料产品在成本水平上具有竞争力。这种优势产品能够满足不断增长的产品要求。

关键词：碳纤维复合材料质量浸渍压注产品要求可循环利用工艺方法竞争力

Cellular models of stress resistance may pave ways to fight neurodegenerative diseases

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Neural Regeneration Research 2025年第9期20卷 2579-2580页

作者： Thu Nguyen Minh Pham christian Behl Institute of Pathobiochemistry University Medical Center of the Johannes Gutenberg UniversityMainzGermany

Alzheimer's disease(AD),the most common form of neurodegeneration,is characterized by selective neuronal vulnerability and brain regionselective neuron *** entorhinal cortex and hippoc,ampal CA1 projection neurons are at greater risk in AD whereas other regions display resistance to ***,the cerebellum,a phylogenetically very old region,is affected only very late in the disease progression.

关键词： cortex resistance Alzheimer

Many faces of neuronal activity manipulation in Drosophila

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Neural Regeneration Research 2025年第9期20卷 2574-2576页

作者： Amber Krebs Steffen Kautzmann christian Klämbt Institut für Neuro-und Verhaltensbiologie MünsterGermany

Animals exhibit complex responses to external and internal *** information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane *** can neuronal activity orchestrate complex motor patterns or allow learning from previous experience?To answer such questions,we need the ability not only to record,but also to modulate neuronal activity in both space(e.g.,neuronal subsets)and time.

关键词： manipulation potential. neuronal

New drug treatments show neuroprotective effects in Alzheimer's and Parkinson's diseases

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Neural Regeneration Research 2014年第21期9卷 1870-1873页

作者： christian h?lscher Neuroscience research group Faculty of Health and MedicineLancaster UniversityLancaster LA1 4YQUK

Type 2 diabetes is a risk factor for Alzheimer’s disease and Parkinson’s disease. Insulin signaling in the brains of people with Alzheimer’s disease or Parkinson’s disease is impaired. Preclinical studies of growth factors showed impressive neuroprotective effects. In animal models of Alz-heimer’s disease and Parkinson’s disease, insulin, glia-derived neurotrophic factor, or analogues of the incretin glucagon-like peptide-1 prevented neurodegenerative processes and improved neuronal and synaptic functionality in Alzheimer’s disease and Parkinson’s disease. On the basis of these promising ifndings, several clinical trials are ongoing with the ifrst encouraging clinical results published. This gives hope for developing effective treatments for Alzheimer’s disease and Parkinson’s disease that are currently unavailable.

关键词： neurodegeneration neurotrophic factors neuroprotection growth factor memory amyloid

Park size and prey density limit occurrence of Eurasian Sparrowhawks in urban parks during winter

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Avian Research 2018年第3期9卷 206-213页

作者： Claudia Schütz christian h.Schulze Department of Botany and Biodiversity Research University of ViennaRennweg 141030 ViennaAustria

Background: Eurasian Sparrowhawks(Accipiter nisus) increasingly represent successful city-dwellers. Thereby, a rich food supply indicated by high numbers of small birds is believed to be the key driver for this bird-eating raptor species to settle in urban environments. however, as small passerine birds show particularly strong antipredator responses, sparrowhawks may not simply focus on patches of highest prey densities, but rather respond strategically to prey behavior, raising the importance of other parameters in determining the occurrence within urban ***: To deepen our knowledge on habitat requirements of urban sparrowhawks, bird surveys were carried out during winter between December 2005 and January 2017 in 36 city parks in Vienna, Austria. Besides food supply also park size, canopy heterogeneity and the connectivity with other green spaces were ***: Occurrence of sparrowhawks was positively affected by increasing park size, prey density and the interaction between both. Bird feeder density and park connectivity with other green spaces were of minor importance in explaining the presence of this species. Canopy heterogeneity didn't affect city park occupancy by Eurasian ***: Our results suggest that large city parks, particularly when characterized by high prey densities, substantially contribute to protect and preserve ecologically important bird species such as raptors within the urban environment—a landscape already struggling with biodiversity losses and functional homogenization.

关键词： Birds of prey Bird feeders Prey abundance habitat connectivity Tree cover Urban ecology

A cost driven predictive maintenance policy for structural airframe maintenance

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Chinese Journal of Aeronautics 2017年第3期30卷 1242-1257页

作者： Yiwei WANG christian GOGU Nicolas BINAUD christian BES Raphael T.hAFTKA Nam h.KIM Universite de Toulouse INSA/UPS/ISAE/Mines Albi ICA UMR CNRS 5312 Toulouse 31400 Frallce Department of Mechanical & Aerospace Engineering University of Florida Gainesville 32611 USA

Airframe maintenance is traditionally performed at scheduled maintenance *** decision to repair a fuselage panel is based on a fixed crack size threshold,which allows to ensure the aircraft safety until the next scheduled maintenance *** progress in sensor technology and data processing techniques,structural health monitoring（ShM） systems are increasingly being considered in the aviation *** systems track the aircraft health state continuously,leading to the possibility of planning maintenance based on an actual state of aircraft rather than on a fixed *** paper builds upon a model-based prognostics framework that the authors developed in their previous work,which couples the Extended Kalman filter（EKF） with a firstorder perturbation（FOP） *** using the information given by this prognostics method,a novel cost driven predictive maintenance（CDPM） policy is proposed,which ensures the aircraft safety while minimizing the maintenance *** proposed policy is formally derived based on the trade-off between probabilities of occurrence of scheduled and unscheduled maintenance.A numerical case study simulating the maintenance process of an entire fleet of aircrafts is *** the condition of assuring the same safety level,the CDPM is compared in terms of cost with two other maintenance policies：scheduled maintenance and threshold based ShM *** comparison results show CDPM could lead to significant cost savings.

关键词： Extended Kalman filter First-order perturbation method Model-based prognostic Predictive maintenance Structural airframe maintenance

Low-complexity online correction and calibration of pedestrian dead reckoning using map matching and GPS

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Geo-Spatial Information Science 2019年第2期22卷 114-127,I0004页

作者： Fabian hölzke Johann-P.Wolff Frank Golatowski christian haubelt Institute of Applied Microelectronics and CE University of RostockRostockGermany

Dead Reckoning is a relative positioning scheme that is used to infer the change of position relative to a point of origin by measuring the traveled distance and orientation *** Dead Reckoning(PDR)applies this concept to walking *** method can be used to track someone's movement in a building after a known landmark like the building's entrance is ***,the movement of a foot and the corresponding direction change is measured and summed up,to infer the current *** and integrating the corresponding physical parameters,*** inertial sensors,introduces small errors that accumulate quickly into large distance *** of a buildings geography may reduce these errors as it can be used to keep the estimated position from moving through walls and onto likely *** this paper,we use building maps to improve localization based on a single foot-mounted inertial *** describe our localization method using zero velocity updates to accurately compute the length of individual steps and a Madgwick filter to determine the step *** though the computation of individual steps is quite accurate,small errors still accumulate in the long *** show how correction algorithms using likely and unlikely paths can rectify errors intrinsic to pedestrian dead reckoning tasks,such as orientation and displacement drift,and discuss restrictions and disadvantages of these *** also present a method of deriving the initial position and orientation from GPS *** verify our PDR correction methods analyzing the corrected and raw trajectories of six participants walking four routes of varying length and complexity through an office building,walking each route three *** quantitative results show an endpoint accuracy improvement of up to 60%when using likely paths and 23%when using unlikely ***,both approaches can also decrease accuracy in certain *** identify those scenarios and

关键词： Indoor localization Pedestrian Dead Reckoning(PDR) Inertial Navigation System(INS) map matching Zero Velocity Update(ZUPT)

Schrodinger and Klein-Gordon theories of black holes from the quantization of the Oppenheimer and Snyder gravitational collapse

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Communications in Theoretical Physics 2023年第9期75卷 122-135页

作者： christian Corda SUNY Polytechnic Institute 13502 UticaNew YorkUSAIstituto Livi59100 PratoTuscanyItaly and International Institute for Applicable Mathematics and Information SciencesB M Birla Science CentreAdarshnagarHyderabad 500063India

The Schrodinger equation of the Schwarzschild black hole(Bh) has been recently derived by the author and collaborators. The Bh is composed of a particle, the 'electron', interacting with a central field, the 'nucleus'. Via de Broglie's hypothesis, one interprets the 'electron' in terms of Bh horizon's modes. Quantum gravity effects modify the Bh semi-classical structure at the Schwarzschild scale rather than at the Planck scale. The analogy between this Bh Schrodinger equation and the Schrodinger equation of the s states of the hydrogen atom permits us to solve the same equation. The quantum gravitational quantities analogous of the fine structure constant and of the Rydberg constant are not constants, but the dynamical quantities have well-defined discrete spectra. The spectrum of the 'gravitational fine structure constant' is the set of non-zero natural numbers. Therefore, Bhs are well-defined quantum gravitational systems obeying Schrodinger's theory: the 'gravitational hydrogen atoms'. By identifying the potential energy in the Bh Schrodinger equation as being the gravitational energy of a spherically symmetric shell, a different nature of the quantum Bh seems to surface. Bhs are self-interacting, highly excited,spherically symmetric, massive quantum shells generated by matter condensing on the apparent horizon, concretely realizing the membrane paradigm. The quantum Bh described as a'gravitational hydrogen atom' is a fictitious mathematical representation of the real, quantum Bh, a quantum massive shell having a radius equal to the oscillating gravitational *** consequences emerge from this result:(i) Bhs have neither horizons nor singularities;(ii) there is neither information loss in Bh evaporation, nor Bh complementarity, nor firewall paradox. These results are consistent with previous ones by hawking, Vaz, Mitra and ***, the special relativistic corrections to the Bh Schrodinger equation give the Bh Klein–Gordon equation and the cor

关键词： quantum black holes information paradox quantum shells quantum levels Schrodinger and Klein-Gordon theories

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide dual receptor agonist DA-Ch5 is superior to exendin-4 in protecting neurons in the 6-hydroxydopamine rat Parkinson model

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Neural Regeneration Research 2021年第8期16卷 1660-1670页

作者： Ling-Yu Zhang Qian-Qian Jin christian hölscher Lin Li Gerontology Institute Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Forensic Pathology Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Second HospitalShanxi Medical UniversityTaiyuanShanxi ProvinceChina Research and Experimental Center Henan University of Chinese MedicineZhengzhouHenan ProvinceChina

Patients with Parkinson's disease(PD) have impaired insulin signaling in the brain. Incretin hormones, including glucagon-like peptide-1(GLP-1) and glucose-dependent insulinotropic polypeptide(GIP), can re-sensitize insulin signaling. In a recent phase II clinical trial, the first GLP-1 mimic, exendin-4, has shown reliable curative effect in patients with PD. DA-Ch5 is a novel GLP-1/GIP receptor unimolecular coagonist with a novel peptide sequence added to cross the blood-brain barrier. here we showed that both exendin-4 and DA-Ch5 protected against 6-hydroxydopamine(6-OhDA) cytotoxicity, inhibited apoptosis, improved mitogenesis and induced autophagy flux in Sh-SY5Y cells via activation of the insulin receptor substrate-1(IRS-1)/alpha serine/threonine-protein kinase(Akt)/c AMP response element-binding protein(CREB) pathway. We also found that DA-Ch5(10 nmol/kg) daily intraperitoneal administration for 30 days post-lesion alleviated motor dysfunction in rats and prevented stereotactic unilateral administration of 6-OhDA induced dopaminergic neurons loss in the substantia nigra pars compacta. however, DA-Ch5 showed curative effects in reducing the levels of α-synuclein and the levels of pro-inflammatory cytokines(tumor necrosis factor-α, interleukin-1β). It was also more effective than exendin-4 in inhibiting apoptotic process and protecting mitochondrial functions. In addition, insulin resistance was largely alleviated and the expression of autophagy-related proteins was upregulated in PD model rats after DA-Ch5 treatment. These results in this study indicate DA-Ch5 plays a therapeutic role in the 6-OhDAunilaterally lesioned PD rat model and is superior to GLP-1 analogue exendin-4. The study was approved by the Animal Ethics Committee of Shanxi Medical University of China.

关键词： neurodegenerative disease Parkinson's disease insulin resistance inflammation GLP-1/GIP receptor unimolecular co-agonist