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Vitamin D deficiency and hepatitis viruses-associated liver diseases:a literature review

World Journal of gastroenterology 2018年第4期24卷 445-460页

作者： Nghiem Xuan Hoan Hoang Van Tong Le Huu Song christian g meyer Thirumalaisamy P Velavan Institute of Clinical Infectious Diseases 108 Military Central HospitalHanoi 10004Vietnam Molecular genetics of Infectious Diseases Institute of Tropical MedicineUniversity of TübingenTübingen 72074Germany Vietnamese-german Center of Medical Research(Vg-CARE) Hanoi 10004Vietnam Institute of Biomedicine and Pharmacy Vietnam Military Medical UniversityHanoi 10004Vietnam Medical Faculty Duy Tan UniversityDa NangVietnam

The secosteroid hormone vitamin D has, in addition to its effects in bone metabolism also functions in the modulation of immune responses against infectious agents and in inhibiting tumorigenesis. Thus, deficiency of vitamin D is associated with several malignancies, but also with a plethora of infectious diseases. Among other communicable diseases, vitamin D deficiency is involved in the pathogenesis of chronic liver diseases caused by hepatitis B and C viruses(HBV, HCV) and high prevalence of vitamin D deficiency with serum levels below 20 mg/mL in patients with HBV and HCV infection are found worldwide. Several studies have assessed the effects of vitamin D supplementation on the sustained virological response(SVR) to interferon(IFN) plus ribavirin(RBV) therapy in HBV and HCV infection. In these studies, inconsistent results were reported. This review addresses general aspects of vitamin D deficiency and, in particular, the significance of vitamin D hypovitaminosis in the outcome of HBVand HCV-related chronic liver diseases. Furthermore,current literature was reviewed in order to understand the effects of vitamin D supplementation in combination with IFN-based therapy on the virological response in HBV and HCV infected patients.

关键词： Vitamin D vitamin D deficiency chronic liver disease hepatitis B virus infection hepatitis C virus infection liver cirrhosis hepatocellular carcinoma sustained virological response vitamin D supplementation

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genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection

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World Journal of gastroenterology 2018年第2期24卷 248-256页

作者： Bui Tien Sy Nghiem Xuan Hoan Hoang Van Tong christian g meyer Nguyen Linh Toan Le Huu Song Claus-Thomas Bock Thirumalaisamy P Velavan Vietnamese-german Center of Excellence in Medical Research HanoiVietnam Institute of Clinical Infectious Diseases 108 Military Central HospitalHanoiVietnam Institute of Tropical Medicine University of TübingenTübingen 72074Germany Department of Infectious Diseases Robert Koch InstituteBerlin 13302Germany Department of Pathophysiology Vietnam Military Medical UniversityHanoiVietnam

AIM To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibilityto hepatitis B virus(HBV) infection and progression of liver diseases among clinically classified Vietnamese *** Four IFR5 SNPs(rs13242262 A/T, rs77416878 C/T, rs10488630 A/g, and rs2280714 T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B(CHB). n = 99; liver cirrhosis(LC), n = 131; hepatocellular carcinoma(HCC), n = 149] and in 242 healthy controls by direct sequencing and Taq Man realtime PCR assays. RESULTS Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262 T and rs10488630 g contributed to an increased risk of liver cirrhosis(LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCgT constructed from 4 SNPs was observed frequently in LC compared to CHB patients(OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups(LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. CONCLUSION Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections.

关键词： hepatitis B virus infection Liver diseases IRF5 IFR5 polymorphisms IFR5 haplotypes

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Dual-Targeting of Arabidopsis 6-Phosphogluconolactonase 3 （PgL3）to Chloroplasts and Peroxisomes Involves Interaction with Trx m2 in the Cytosol

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Molecular Plant 2014年第1期7卷 252-255页

作者： christian Holscher Tanja meyer Antje von Schaewen Institut for Biologie und Biotechnologie der Pflanzen Westfalische Wilhelms-Universitat Munster Schlossgarten 3 48149 Munster Germany

The oxidative pentose-phosphate pathway （OPPP） represents a central branch of cellular metabolism emanating from glucose-6-phosphate （g6P） to provide reductive power （NADPH） and sugar phosphates for anabolic biosyntheses. In plant cells, the oxidative OPPP branch is found in the cytosol and in plastids, consisting of glucose-6-phosphate dehydrogenase （g6PD）, 6-phosphogluconolactonase （PgL）, and 6-phosphogluconate dehydrogenase （6PgD）. These enzymes are encoded by small gene families in the nuclear genome, which, in Arabidopsis, comprise six g6PD, five 6-PgL, and three 6-PgD isoforms （Kruger and von Schaewen, 2003）. Specific targeting motifs at the C-terminus of 6-PgL and 6-PgD isoforms suggested that the OPPP may also occur in peroxisomes （Reumann et al., 2004）.

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硬化水泥浆体弹性模量细观力学模型

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复合材料学报 2007年第2期24卷 184-189页

作者：林枫 meyer christian 美国哥伦比亚大学土木工程与工程力学系

应用复合材料力学理论和有孔介质力学(Poromechanics)理论建立了一个描述硬化硅酸盐水泥浆体弹性模量的细观力学模型,将硬化水泥浆体从不同尺度上划分为4个层次,即C-S-H凝胶、水泥水化产物、水泥浆体骨架和水泥浆体,分别应用不同的细观... 详细信息

应用复合材料力学理论和有孔介质力学(Poromechanics)理论建立了一个描述硬化硅酸盐水泥浆体弹性模量的细观力学模型,将硬化水泥浆体从不同尺度上划分为4个层次,即C-S-H凝胶、水泥水化产物、水泥浆体骨架和水泥浆体,分别应用不同的细观力学模型予以描述:将C-S-H视为饱和的有孔介质;应用Mori-Tanaka模型描述水泥水化产物的弹性性质;应用三相模型(Three-phase model)模拟水泥浆体骨架的有效弹性模量;最后,再次应用Mori-Tanaka模型和有孔介质理论,计算水泥浆体的排水和不排水弹性模量(Drained and undrainedelastic moduli)。该模型所需要的参数为水泥浆体各个组成部分的自身弹性性质,使用方便。通过预测文献中的实测结果,证明了该模型的有效性。

关键词：硅酸盐水泥浆体有效弹性模量复合材料力学有孔介质力学细观力学模型

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Simulation of Random Crack generation in Concrete Members with Uniform Stress Fields

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Journal of China University of Mining and Technology 2006年第4期16卷 518-522页

作者： LIU Xing LU Wei DENg Xi christian meyer School of Civil Engineering Wuhan University Wuhan Hubei 430072 China Department of Civil Engineering and Engineering Mechanics Columbia University New York 10027 U.S.A

The randomness of strength and deformation of concrete material is serious and should be considered both in theoretical analyses such as Finite Element Methods and engineering practice, specially for those structural members with a uniform stress field, where stresses or strains are approximately the same under loading. A mathematical ap- proach of producing a series of random variables of the ultimate tensile strain in concrete is proposed to describe the randomness ofconcrete deformation. With reinforced concrete finite elements a real model calculation method is found for the randomness of initial cracks determined by a minimum tension strain within the uniform stress fields of concrete members. The proposed methods in our paper have as aim to improve the existing method used by FEM and other rela- tive approaches, which normally pay less attention to randomness with consequences that may possibly differ from testing or practice. The method and sample computation as indicated is meaningful and comply with testing and engi- neering practice.

关键词： concrete member uniform stress fields crack randomness real model

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Lateral lymph node dissection for low rectal cancer: Is it necessary?

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World Journal of gastroenterology 2019年第31期25卷 4294-4299页

作者： Niki Christou Jeremy meyer christian Toso Frédéric Ris Nicolas christian Buchs Service de Chirurgie Digestive Endocrinienne et GénéraleCHU de LimogesLimoges Cedex 87042France Division of Digestive Surgery University Hospitals of GenevaGenève 1211Switzerland Unit of Surgical Research University of GenevaGenève 1206Switzerland

Rectal cancer constitutes a major public health *** mesorectal excision has remained the gold standard treatment for mid and low rectal tumors since its introduction in the late *** of all lymph nodes located in the mesorectum has indeed improved pathological and oncological ***,when cancer spreads to the lateral lymph nodes(located along the iliac and obturator arteries)Western and Japanese practices *** the Western guidelines consider this condition as an advanced form of the disease and use neoadjuvant radiochemotherapy liberally,the Japanese guidelines define it as a local disease and proceed to lateral lymph node dissection with or without neoadjuvant ***,we review the current literature regarding both therapeutic strategies,with the aim of contributing to potential improvements in treatment and outcome for patients with low and mid rectal cancer.

关键词： Total mesorectum excision Mesorectal resection Lateral node metastasis Extended lymphadenectomy

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Simulator Coupled with Distributed Co-Simulation Protocol for Automated Driving Tests

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Automotive Innovation 2021年第4期4卷 373-389页

作者： Max-Arno meyer Lina Sauter christian granrath Hassen Hadj-Amor Jakob Andert Teaching and Research Area Mechatronics in Mobile Propulsion RWTH Aachen UniversityAachenGermany FEV Software and Testing Solutions SAS TrappesFrance

To meet the challenges in software testing for automated vehicles,such as increasing system complexity and an infinite number of operating scenarios,new simulation methods must be ***-loop simulations for automated driving(AD)require highly complex simulation models for multiple controlled vehicles with their perception systems as well as their surrounding *** the realization of such models,different simulation domains must be coupled with ***,widely supported model integration standards such as functional mock-up interface(FMI)lack native support for distributed platforms,which is a key feature for AD due to the computational intensity and platform exclusivity of certain *** newer FMI companion standard distributed co-simulation protocol(DCP)introduces platform coupling but must still be used in conjunction with AD *** part of an assessment framework for AD,this paper presents a DCP compliant implementation of an interoperable interface between a 3D environment and vehicle simulator and a co-simulation platform.A universal Python wrapper is implemented and connected to the simulator to allow its control as a DCP slave.A C-code-based interface enables the co-simulation platform to act as a DCP master and to realize cross-platform data exchange and time synchronization of the environment simulation with other integrated models.A model-in-the-loop use case is performed with the traffic simulator CARLA running on a Linux machine connected to the co-simulation master xMOD on a Windows computer via *** virtual vehicles are successfully controlled by cooperative adaptive cruise controllers executed outside of *** standard compliance of the implementation is verified by exemplary connection to prototypic DCP solutions from 3rd party *** exemplary application demonstrates the benefits of DCP compliant tool coupling for AD simulation with increased tool interoperability,reuse potential,and per

关键词： Distributed co-simulation protocol Co-simulation Automated driving Traffic simulation Tool coupling

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Role of near-infrared fluorescence in colorectal surgery

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World Journal of gastroenterology 2021年第31期27卷 5189-5200页

作者： Elodie Zocola Jeremy meyer Niki Christou Emilie Liot christian Toso Nicolas christian Buchs Frederic Ris Medical School University of GenevaGenève 1205Switzerland Division of Digestive Surgery University Hospitals of GenevaGenève 1205Switzerland Service de Chirurgie Digestive Endocrinienne et GénéraleCHU de LimogesLimoges Cedex 87025France

Near-infrared fluorescence(NIRF)is a technique of augmented reality that,when applied in the operating theatre,allows the colorectal surgeon to visualize and assess bowel vascularization,to identify lymph nodes draini... 详细信息

关键词： Fluorescence Enhanced reality Anastomotic leak Ureter Anastomosis

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Targeting new ways for large-scale,high-speed surface functionalization using direct laser interference patterning in a roll-to-roll process

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International Journal of Extreme Manufacturing 2023年第3期5卷 569-583页

作者： Christoph Zwahr Nicolas Serey Lukas Nitschke christian Bischoff Ulrich Radel Alexandra meyer Penghui Zhu Wilhelm Pfleging Laser Precision Manufacturing Fraunhofer Institute for Material and Beam Technology(IWS)DresdenGermany Topag Lasertechnik gmbH DarmstadtGermany Institute of Manufacturing Science and Engineering Technical University DresdenDresdenGermany Institute for Applied Materials—Applied Materials Physics(IAM-AWP) Karlsruhe Institute of Technology(KIT)Eggenstein-LeopoldshafenGermany

Direct Laser Interference Patterning(DLIP)is used to texture current collector foils in a roll-to-roll process using a high-power picosecond pulsed laser system operating at either fundamental wavelength of 1064 nm or 2nd harmonic of 532 *** raw beam having a diameter of 3 mm@1/e^(2) is shaped into an elongated top-hat intensity profile using a diffractive so-called FBS■-L element and cylindrical *** shaped beam is split into its diffraction orders,where the two first orders are parallelized and guided into a galvanometer *** deflected beams inside the scan head are recombined with an F-theta objective on the working position generating the interference *** DLIP spot has a line-like interference pattern with about 15μm spatial *** fluences of up to 8 J cm^(-2) were achieved using a maximum pulse energy of 0.6 ***,an in-house built roll-to-roll machine was *** this setup,aluminum and copper foil of 20μm and 9μm thickness,respectively,could be *** to current collector structuring coating of composite electrode material took *** case of lithium nickel manganese cobalt oxide(NMC 622)cathode deposited onto textured aluminum current collector,an increased specific discharge capacity could be achieved at a C-rate of 1℃.For the silicon/graphite anode material deposited onto textured copper current collector,an improved rate capability at all C-rates between C/10 and 5℃ was *** rate capability was increased up to 100%compared to reference *** C-rates between C/2 and 2℃,the specific discharge capacity was increased to 200 mAh g^(-1),while the reference electrodes with untextured current collector foils provided a specific discharge capacity of 100 m Ah g^(-1),showing the potential of the DLIP technology for cost-effective production of battery cells with increased cycle lifetime.

关键词： DLIP lithium-ion battery surface texturing copper aluminum

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Reducing anastomotic leak in colorectal surgery: The old dogmas and the new challenges

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World Journal of gastroenterology 2019年第34期25卷 5017-5025页

作者： Jeremy meyer Surennaidoo Naiken Niki Christou Emilie Liot christian Toso Nicolas christian Buchs Frédéric Ris Division of Digestive Surgery University Hospitals of Geneva

Anastomotic leak(AL)constitutes a significant issue in colorectal surgery,and its incidence has remained stable over the last *** use of intra-abdominal drain or the use of mechanical bowel preparation alone have been proven to be useless in preventing AL and should be *** role or oral antibiotics preparation regimens should be clarified and compared to other routes of administration,such as the intravenous route or *** parallel,preoperative antibiotherapy should aim at targeting collagenase-inducing pathogens,as identified by the microbiome *** can be further reduced by fluorescence angiography,which leads to significant intraoperative changes in surgical *** of fluorescence angiography should be *** made in AL comprehension and prevention might probably allow reducing the rate of diverting stoma and conduct to a revision of its indications.

关键词： Anastomotic leakage Rectal surgery Colic surgery Prevention Surgical site infection Anastomosis Complication

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