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A demonstration project of Global Alliance against Chronic Respiratory Diseases:Prediction of interactions between air pollution and allergen exposure—the Mobile Airways Sentinel NetworK-Impact of air POLLution on Asthma and Rhinitis approach

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Chinese Medical Journal 2020年第13期133卷 1561-1567页

作者： Mikhail Sofiev Yuliia Palamarchuk Annabelle Bedard Xavier Basagana Josep M.Anto Rostislav Kouznetsov Rodrigo Delgado Urzua Karl christian bergmann Joao A.Fonseca Govert De Vries Michiel Van Erd Isabella Annesi-Maesano Daniel Laune Jean Louis Pepin Ingrid Jullian-Desayes Stephane Zeng Wienczyslawa Czarlewski Jean Bousquet Finnish Meteorological Institute(FMI) Helsinki 00560Finland Barcelona Institute for Global Health Centre for Research in Environmental Epidemiology(CREAL)Barcelona 08003Spain Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica(CIBER)Epidemiologia y Salud Publica(CIBERESP) Barcelona 08003Spain Universitat Pompeu Fabra(UPF) Barcelona 08003Spain Institut Hospital del Mar d'lnvestigacions Mediques(IMIM) Barcelona 08003Spain Charite-Universitatsmedizin Berlin Corporate Member of Freie Universitat BerlinHumboldt-Uniersitat zu Berlin and Berlin Institute of HealthComprehensive Allergy-CentreDepartment of Dermatology and AllergyBerlin 10117Germany Center for Health Technology and Services Research(CINTESIS) Center for Research in Health Technology and Information SystemsFaculdade de Medicina da Universidade do Portoand MedidaLda Porto s/n 4200-450Portugal Peercode BV Geldermalsen 4191 NWThe Netherlands Epidemiology of Allergic and Respiratory Diseases Department Institute Pierre Louis of Epidemiology and Public HealthINSERM and Sorbonne UniversiteMedical School Saint AntoineParis 75571France KYomed Innovation Montpellier 34184France Universite Grenoble Alpes Laboratoire HP2GrenobleINSERMU1042 and CHU de GrenobleGrenoble 38000France Bull DSAS Echirolles 38130France Medical Consulting Czarlewski Levalloisand MASK-airMontpellier 92300France University Hospital Montpellier Montpellier 34000France Contre les Maladies Chroniques pour un Vieillissement Actif en Languedoc Roussillon-France MontpellierFrance Charite Universitatsmedizin BerlinHumboldt-Universitat zu Berlinand Berlin Institute of HealthComprehensive Allergy CenterDepartment of Dermatology and AllergyBerlin 10117Germany

This review analyzes the state and recent progress in the field of information support for pollen allergy *** decades,information available for the patients and allergologists consisted of pollen counts,which are vital but *** technology paves the way to substantial increase in amount and diversity of the *** paper reviews old and newly suggested methods to predict pollen and air pollutant concentrations in the air and proposes an allergy risk concept,which combines the pollen and pollution information and transforms it into a qualitative risk *** new index is available in an app(Mobile Airways Sentinel NetworK-air)that was developed in the frame of the European Union grant Impact of Air POLLution on sleep,Asthma and Rhinitis(a project of European Institute of Innovation and Technology-Health).On-going transformation of the pollen allergy information support is based on new technological solutions for pollen and air quality monitoring and *** new information-technology and artificial-intelligence-based solutions help to convert this information into easy-to-use services for both medical practitioners and allergy sufferers.

关键词： Pollen allergy Pollen season Google trends Pollen dispersion modeling System for Integrated modeLling of Atmospheric coMposition model Pollen index Air quality index

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我的椅子

城市环境设计 2010年第1期 70-71页

作者： Ben van Berkel Martijn Prins christian bergmann Arne Nielsen UNStudio

MYchair是Benvan Berkel/UNStudio设计的第一把椅子。建筑师对于家具的设计理念不同于家具行业的设计师:建筑师会先从空间和环境着手。并且,所有的建筑师都会对空间有自己的理解

关键词：椅子建筑师美术家家具行业

扭转的住宅—Haus am Weinberg

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中国建筑装饰装修 2013年第1期 78-85页

作者： Ben van Berkel Caroline Bos Astrid Piber René Wysk Kirsten Hollmann-Schrter Cynthia Markhoff christian bergmann Jan Schellhoff Iris Pastor Rodrigo Caizares Albert Gnodde Beatriz Zorzo Talavera Shany Barath Esteve Umbert Morits Hannes Pfau Iwan Baan christian Richters UNStudio工作室

“扭转”是该房屋设计的核心元素，它支撑着房屋的主楼梯结构．并通过扭转的每一次变化．使得阳光照射的轨迹和房屋的内部视角达到完美契合．为主人提供了奇妙的居住体验。

关键词：扭转住宅房屋设计阳光照射楼梯结构居住支撑

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Association between heart failure severity and mobility in geriatric patients: an in-clinic study with wearable sensors

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Journal of Geriatric Cardiology 2022年第9期19卷 660-674页

作者： Tobias Braun Anna Wiegard Johanna Geritz Clint Hansen Kim Eng Tan Hanna Hildesheim Jennifer Kudelka Corina Maetzler Julius Welzel Robbin Romijnders Walter Maetzler Philipp bergmann Department of Neurology Kiel UniversityArnold-Heller-Straße 324105 KielGermany Department of Internal Medicine I Christian-Albrechts-University of KielArnold-Heller-Straße 324105 KielGermany Department of Applied Health Sciences Division of PhysiotherapyHochschule für Gesundheit(University of Applied Sciences)Gesundheits-campus 6-844801 BochumGermany HSD Hochschule Döpfer(University of Applied Sciences) Waidmarkt 3 und 950676 CologneGermany

BACKGROUND Individuals with heart failure(HF) frequently experience limitations in mobility, but specific aspects of these limitations are not well understood. This study investigated the association of HF severity, based on the New York Heart Association(NYHA) classes, with digital mobility outcomes(DMOs) and handgrip strength in older inpatients with *** For this explorative analysis, hospital admission and discharge data from an ongoing, prospective cohort study were used. The sample included older participants with HF and a sub-sample of heart-healthy individuals. Participants were equipped with a wearable inertial measurement unit(IMU) system during mobility performance(balancing, sit-to-stand transfer,walking). We analyzed the association between 17 DMOs and HF severity with multiple linear regression *** The total sample included 61 older participants(65–97 years of age, 55.7% female). Of all DMOs, only sway path in a semi-tandem stance position(m/s^(2)) showed a relevant association with NYHA classes(admission: β =-0.28, P = 0.09;discharge:β =-0.39, P = 0.02). Handgrip strength showed a trend towards a significant association(admission: β =-0.15, P = 0.10;discharge:β =-0.15, P = 0.19).CONCLUSIONS This is to our best knowledge the first analysis on the association of HF severity and IMU-based DMOs. Sway path and handgrip strength may be the most promising parameters for monitoring mobility aspects in treatment of HF.

关键词： severity wear limitations

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DNA methylation profile of a hepatosplenic gamma/delta T-cell lymphoma patient associated with response to interferon-α therapy

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Cellular & Molecular Immunology 2021年第5期18卷 1332-1335页

作者： Jaydeep Bhat Anke Kbergmann Silvio Waschina Christoph Nerl Christoph Kaleta Reiner Siebert Ole Ammerpohl Dieter Kabelitz Institute of Immunology Christian-Albrechts-University Kiel&University Hospital Schleswig-HolsteinCampus KielKielGermany Metabolic Programming School of Life Sciences WeihenstephanTechnical University Munich(TUM)85354FreisingGermany Institute of Human Genetics Christian-Albrechts-University Kiel&University Hospital Schleswig-HolsteinCampus KielKielGermany Institute of Human Genetics Medical School HannoverHannoverGermany Institute of Experimental Medicine Christian-Albrechts-University Kiel&University Hospital Schleswig-HolsteinCampus KielKielGermany Institute of Human Nutrition and Food Science Christian-Albrechts-University KielKielGermany Städtisches Krankenhaus München-Schwabing MunichGermany Institute of Human Genetics Ulm University&Ulm University Medical Center89081UlmGermany

The 2–5%γδT cells in healthy human peripheral blood recognize nonpeptide antigens,in contrast toαβT cells.1 DistinctγδT-cell malignancies have been identified,with hepatosplenic T-cell lymphoma(γδ-HSTL)being a rare but aggressive(median survival 13 months)subset.2γδ-HSTL usually presents with hepatosplenomegaly without lymphadenopathy,anemia,and *** is histologically characterized by the involvement of the hepatic sinusoids,splenic red pulp and bone marrow interstitium,with or without leukemic presentation in peripheral blood.3 A standard treatment regimen is not well established,but therapy mostly includes various chemotherapeutic ***,interferon-α(IFN-α)has been proven to be effective in some patients withγδ-HSTL,but other patients require allogeneic or autologous stem cell transplantation.

关键词： hepato splenic interferon

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单细胞技术揭示肝癌免疫图谱与动态特征

科学新闻 2020年第2期 41-41页

作者：彭吉润任仙文张泽民刘康 Qiming Zhang Yao He Nan Luo Shashank J.Patel Yanjie Han Ranran Gao Madhura Modak Sebastian Carotta christian Haslinger David Kind Gregory W.Peet Guojie Zhong Shuangjia Lu Weihua Zhu Yilei Mao Mengmeng Xiao Michael bergmann Xueda Hu Sid P.Kerkar Anne B.Vogt Stefan Pflanz 首都医科大学附属北京世纪坛医院胃肠及肝胆肿瘤外科北京大学生物医学前沿创新中心(BIOPIC) 北京未来基因诊断高精尖创新中心(ICG) 勃林格殷格翰公司

文章简介肝细胞癌是世界范围内死亡率排名第三的癌症,其中中国的肝癌发病率居世界之先。肿瘤存在多种免疫逃逸机制,提出了研究肿瘤微环境中不同免疫细胞状态的重要性。而不同类型的单细胞测序技术则是研究不同类型免疫细胞的状态和动态... 详细信息

文章简介肝细胞癌是世界范围内死亡率排名第三的癌症,其中中国的肝癌发病率居世界之先。肿瘤存在多种免疫逃逸机制,提出了研究肿瘤微环境中不同免疫细胞状态的重要性。而不同类型的单细胞测序技术则是研究不同类型免疫细胞的状态和动态的有力手段。本研究结合了两种单细胞测序技术,充分发挥不同数据类型的优势,获得高分辨率的肝癌免疫图谱。肿瘤中的树突状细胞是重要的抗原呈递细胞,除传统的树突状细胞外,本研究鉴定出一群高表达LAMP3,CCR7等与细胞

关键词：肝癌患者免疫细胞癌旁组织单细胞动态特征