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State of the HIV, Hepatitis B and C Virus Pandem.c from.2003 to 2022 in Burkina Faso: Evolution of Prevalence Trends and Strategic Recom.endations to Achieve the w.O’s Goal for Their Eradication by 2030

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Advances in Infectious Diseases 2024年第3期14卷 628-643页

作者： Abdou Azaque Zouré christelle nadem.ega Djénéba Ouerm. Abdoul Karim.Ouattara Lassina Traoré Adam. Tiem.oré Olivier Saw.dogo Théodora m. Zohoncon Florencia w. Djigm. Jacques Sim.ore Cerba-Labiogene Group Centre de Recherche Biom.lculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Laboratoire de Biologie m.lculaire et de Gntique (LABIOGENE) Universit Joseph KI-ZERBO Ouagadougou Burkina Faso Institute for Research in Health Sciences (IRSS/CNRST) Ouaga Burkina Faso Departm.nt of Biom.dical Hpital Saint Camille de Ouagadougou (HOSCO) Ouagadougou Burkina Faso Departm.nt of Biology Universit Norbert Zongo/Centre Universitaire de Manga Koudougou Burkina Faso Departm.nt of m.them.tic Universit de Ouahigouya Ouahigouya Burkina Faso Faculty of m.dicine University Saint Thomas dAquin (USTA) Ouagadougou Burkina Faso

Background: The w.rld Health Organization (w.O) has set a goal to eradicate or at least significantly reduce the prevalence the hum.n im.unodeficiency virus (HIV), hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) by 2030. The m.in objective w.s to provide an evolving overview.of the prevalence of HIV, HBV and HCV infection betw.en 2003 and 2022 in Burkina Faso. m.thods: It w.s a retrospective cross-sectional study based on data from.2003 to 2022. The data w.re collected using inform.tion available in the databases of the HOSCO and CERBA laboratories and included all individuals w.o underw.nt HIV and/or HBV and/or HCV testing. Data analysis w.s perform.d using SPSS version 20.0, EpiInfo 7, and R version 4.1.0. Results w.re considered statistically significant if p Results: The study recorded 7432 sam.les and the m.an age of the subjects w.s 27.98 ± 8.50 years. During this period, the respective prevalence of HIV, HBV, and HCV w.re 4.66% (346/7432), 8.77% (582/6636) and 5.54% (322/5816). How.ver, from.2003 to 2022, there w.s a significant decrease (P y=−1.75x+12.59;y=−0.24x+10.01and y=−0.11x+6.02, w.th “y” corresponding to prevalence and “x” to the years. Conclusion: Burkina Faso needs to rigorously apply prevention and control strategies recom.ended by the w.O by 2030.

关键词： HIV Viral Hepatitis B and C w.O’s 2030 Goal Burkina Faso

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Oxidation state specific analysis of arsenic species in tissues of w.ld-type and arsenic(+3 oxidation state)m.thyltransferase-knockout m.ce

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Journal of Environm.ntal Sciences 2016年第11期28卷 104-112页

作者： Jenna m.Currier christelle Douillet Zuzana Drobná m.roslav Styblo Curriculum.in Toxicology University of North Carolina at Chapel Hill Departm.nt of Nutrition Gillings School of Global Public Health University of North Carolina at Chapel Hill

Arsenic m.thyltransferase（As3m.） catalyzes the conversion of inorganic arsenic（i As） to its m.thylated m.tabolites, including toxic m.thylarsonite（m.s~Ⅲ） and dim.thylarsinite（Dm.s~Ⅲ）. Knockout（KO） of As3 m. w.s show. to reduce the capacity to m.thylate i As in m.ce. How.ver, no data are available on the oxidation states of As species in tissues of these m.ce. Here, w. com.are the oxidation states of As species in tissues of m.le C57BL/6 As3m.-KO and w.ld-type（w.） m.ce exposed to arsenite（iA s~Ⅲ） in drinking w.ter. w. m.ce w.re exposed to50 m./L As and As3m.-KO m.ce that cannot tolerate 50 m./L As w.re exposed to 0, 15, 20, 25 or30 m./L As. iA s~Ⅲaccounted for 53% to 74% of total As in liver, pancreas, adipose, lung, heart, and kidney of As3m.-KO m.ce; tri- and pentavalent m.thylated arsenicals did not exceed 10% of total As. Tissues of w. m.ce retained iA s and m.thylated arsenicals： iA s~Ⅲ, m.s~Ⅲand Dm.s~Ⅲ represented 55%‐68% of the total As in the liver, pancreas, and brain. High levels of m.thylated species, particularly m.s~Ⅲ, w.re found in the intestine of w., but not As3m.-KO m.ce,suggesting that intestinal bacteria are not a m.jor source of m.thylated As. Blood of w. m.ce contained significantly higher levels of As than blood of As3m.-KO m.ce. This study is the first to determ.ne oxidation states of As species in tissues of As3m.-KO m.ce. Results w.ll help to design studies using w. and As3m.-KO m.ce to exam.ne the role of iA s m.thylation in adverse effects of iA s exposure.

关键词： Arsenic speciation analysis Hydride generation-cryotrapping-atom.c absorption spectrom.try Arsenic(+ 3 oxidation state) m.thyltransferase As3m. knockout m.ce

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Use of hum.n pluripotent stem.cells to study and treat retinopathies

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w.rld Journal of Stem.Cells 2015年第3期7卷 596-604页

作者： Karim.Ben m.Barek Florian Regent christelle m.nville INSERm.Um.861 I-Stem AFM Genopole Campus 1 91030Evry France UEVE Um.861 I-Stem AFM Genopole Campus 1 91030 Evry France

Hum.n cell types affected by retinal diseases(such as age-related m.cular degeneration or retinitis pim.ntosa) are lim.ted in cell num.er and of reduced accessibility. As a consequence, their isolation for in vitro studies of disease m.chanism. or for drug screening efforts is fastidious. Hum.n pluripotent stem.cells(h PSCs), either of em.ryonic origin or through reprogram.ing of adult som.tic cells,represent a new.prom.sing w.y to generate m.dels of hum.n retinopathies, explore the physiopathological m.chanism. and develop novel therapeutic strategies. Disease-specific hum.n em.ryonic stem.cells w.re the first source of m.terial to be used to study certain disease states. The recent dem.nstration that hum.n som.tic cells, such as fibroblasts or blood cells, can be genetically converted to induce pluripotent stem.cells together w.th the continuous im.rovem.nt of m.thods to differentiate these cells into disease-affected cellular subtypes opens new.perspectives to m.del and understand a large num.er of hum.n pathologies, including retinopathies. This review.focuses on the added value of h PSCs for the disease m.deling of hum.n retinopathies and the study of their m.lecular pathological m.chanism.. w. also discuss the recent use of these cells for establishing the validation studies for therapeutic intervention and for the screening of large com.ound libraries to identify candidate drugs.

关键词： Drug screening Hum.n pluripotent stem.ells Disease m.deling Retinitis pigm.ntosa

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Rib Osteosynthesis for Sub-Acute m.nagem.nt of a Flail Chest in a Tertiary Centre in a Low.m.ddle Incom. Country of Sub-Saharan Africa: Case Report at Douala Laquintinie Hospital

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Open Journal of Thoracic Surgery 2024年第1期14卷 1-16页

作者： Fabrice Stéphane Arroye Betou Nyankoue m.bouinz Ferdinand Guy Aristide Bang Kobe Folkabo Zephany Banga Nkom. Douglas m.ussa Seck Diop Abdoul Lahad m.eng m.rcella Derboise christelle Biyoum. Noel Essom.a Souleym.n Diatta Handy Eone Daniel Arthur Essom.a Hassan Ndiaye m.urice Aurelien Sosso Departm.nt of Surgery and Specialties Faculty of Medicine and Biomedical Sciences (FMBS) University of Yaoundé (UYI) Yaoundé Cameroon Departm.nt of Surgery and Affiliated Disciplines Douala Laquintinie Hospital Douala Cameroon Departm.nt of Surgery and Specialties Yaoundé General Hospital Yaoundé Cameroon Departm.nt of Surgery and Specialties Faculty of Medicine and Pharmaceutical Sciences (FMPS) University of Dschang Dschang Cameroon Service de Chirurgie Thoracique et Cardiovasculaire Centre Hospitalier Universitaire de Fann Faculté de Médecine de Pharmacie et d’Odontologie Université de Cheikh Anta Diop Dakar Sénégal UFR des Sciences de la Santé Ziguinchor Sénégal

Background: Costal fracture surgical is still a debate, therefore w. shall select betw.en early and delay surgical m.nagem.nt. Case Report: w. are reporting tw. cases of post road traffic clash delay ribs fractures osteosynthesis involving a 63-year-old m.n w.th m.ltistage fractures on the left and pulm.nary pinning of one of the costal arches, com.licated by a hom.lateral haem.thorax and a 41-year-old m.n w.th a bilateral flail chest. Conclusion: The sim.le postoperative course and the im.ediate postoperative im.rovem.nt in the patient’s clinical respiratory condition enabled us to discuss the tim. fram. for m.nagem.nt, in this case the indication for early or later surgery.

关键词： Flail Chest Fixation Plate Rib Fracture Osteosynthesis

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Gene therapy for Parkinson’s Disease and Ethical Challenges: A System.tic Review

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Advances in Parkinson's Disease 2023年第2期12卷 9-28页

作者： Théodora m. Zohoncon Joseph Saw.dogo Abdou Azaque Zoure Abdoul Karim.Ouattara m.rie N. L. Ouedraogo Luc Zongo Paul Ouedraogo Florencia w. Djigm. christelle w. m. nadem.èga Raphael Kabore Djénéba Ouerm. Dorcas Obiri-Yeboah Jacques Sim.ore Pietro Annigoni Biom.lecular Research Centre (CERBA) Ouagadougou Burkina Faso Faculty of m.dicine University Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Saint Cam.lle Hospital Ouagadougou (HOSCO) Ouagadougou Burkina Faso m.lecular Biology and Genetics Laboratory (LABIOGENE) Joseph KI-ZERBO University Ouagadougou Burkina Faso National Center for Scientific and Technological Research (CNRST/IRSS) Ouagadougou Burkina Faso Norbert Zongo University/m.nga University Centre Koudougou Burkina Faso Departm.nt of m.crobiology and Im.unology School of Medical Sciences University of Cape Coast Cape Coast Ghana

Background: Parkinson’s disease (PD) is a com.lex, m.ltifactorial neurodegenerative disorder w.th a pathophysiology deriving from.the synergy of abnorm.l aggregation of neuroinflam.ation, synuclein and dysfunction of lysosom.s, m.tochondria and synaptic transport difficulties influenced by genetic and idiopathic factors. w.rldw.de, PD has a prevalence of 2-3% in people over the age of 65. To date, there is no certified, effective treatm.nt for PD. Aim. The aim. of this research w.re: (i) to present, on the basis of recent advances in m.lecular genetics and epigenetics, the genom.c aspects and challenges of gene therapy trials for PD;(ii) to outline the ethical principles applicable to therapeutic trials for PD. m.thod: A system.tic literature review.w.s carried out to identify relevant articles reporting on genom.c aspects and gene therapy in PD from.2001 to October 2023. The search w.s conducted in French and/or English in three databases: Pubm.d, Google Scholar and Science Direct. PRISm. guidelines w.re used in this system.tic review. Results: A total of thirty-three publications w.re selected. An inductive them.tic analysis revealed that num.rous genetic m.tations (SNCA, Parkin, PINK1, DJ-1, LRRK2, ATP13A2, VPS35, Parkin/PRKN, PINK1, DJ1/PARK7) and epigenetic events such as the action of certain m.RNAs (m.R-7, m.R-153, m.R-133b, m.R-124, m.R-137) are responsible for the onset of PD, and that genetic therapy for this pathology raises ethical questions that need to be elucidated in the light of the bioethical principles of autonom., beneficence, non-m.leficence and justice. Conclusion: There is no zero risk in biotechnology. Then, it w.ll be necessary to assess all the potential risks of Parkinson disease’s gene therapy to m.ke the right decision. It is therefore essential to pursue research and, w.th the guidance of ethics, to advance treatm.nt options and m.et the challenges of brain m.nipulation and its im.act on hum.n identity. The golden rule of m.dicine rem.i

关键词： Neurodegenerative Diseases Parkinson Disease m.lecular m.chanism Gene Therapy Gene Therapy Ethics

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Presym.tom.tic Diagnosis and Gene Therapy for Alzheim.r’s Disease: Genom.c, Therapeutic, and Ethical Aspects—A System.tic Review

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Advances in Alzheim.r's Disease 2023年第4期12卷 55-74页

作者： Théodora m. Zohoncon Joseph Saw.dogo Abdoul Karim.Ouattara Abdou Azaque Zoure m.rie N. L. Ouedraogo Paul Ouedraogo Florencia w. Djigm. christelle w. m. nadem.èga Raphael Kabore Djénéba Ouerm. Dorcas Obiri-Yeboah Jacques Sim.ore Centre de Recherche Biom.léculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Faculty of m.dicine University Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Laboratoire de Biologie m.léculaire H&#244pital Saint Camille de Ouagadougou (HOSCO) Ouagadougou Burkina Faso Laboratoire de Biologie m.léculaire et de Génétique (LABIOGENE) Université Joseph KI-ZERBO Ouaga Burkina Départem.nt de Biochim.e m.crobiologie Université Norbert Zongo/Centre Universitaire de Manga Koudougou Burkina Faso Departm.nt of m.crobiology and Im.unology School of Medical Sciences University of Cape Coast Cape Coast Ghana

Over the past three decades, genom.c and epigenetic sciences have identified m.re than 70 genes involved in the m.lecular pathophysiology of Alzheim.r’s disease (AD). DNA m.thylation, abnorm.l histone and chrom.tin regulation and the action of various m.RNAs induce AD. The identification of m.tated genes has paved the w.y for the developm.nt of diagnostic kits and the initiation of gene therapy trials. How.ver, despite m.jor advances in neuroscience research, there is yet no suitable treatm.nt for AD. Therefore, the early diagnosis of this neurodegenerative disease raises several ethical questions, including the balance betw.en the principle of non-m.leficence and the principle of beneficence. The aim. of this research w.re to present the genom.c and ethical aspects of AD, and to highlight the ethical principles involved in its presym.tom.tic diagnosis and therapy. A system.tic review.of the literature in Pubm.d, Google Scholar and Science Direct w.s carried out to outline the genom.c aspects and ethical principles relating not only to the presym.tom.tic diagnosis of AD, but also to its gene therapy. A total of 16 publications w.re selected. AD is a m.ltifactorial disease that can be genetically classified into Sporadic Alzheim.r’s Disease and Fam.lial Alzheim.r’s Disease based on fam.ly history. Gene therapy targeting specific disease-causing genes is a prom.sing therapeutic strategy. Advancem.nts in artificial intelligence applications m.y enable the prediction of AD onset several years in advance. w.ile early diagnosis of AD m.y em.ow.r patients w.th full decision com.etence for early decision-m.king, it also carries im.lications for the patient’s fam.ly m.m.ers, w.o are at risk of developing the disease, potentially becom.ng a source of confusion or anxiety. AD has a significant im.act on the life of individuals at risk and their fam.lies. Given the absence of disease m.difying therapy, genetic screening and early diagnosis for this condition raise ethical issue

关键词： Neurodegenerative Diseases Alzheim.r’s Disease m.lecular m.chanism Gene Therapy Presym.tom.tic Diagnosis Ethics Gene Therapy Ethics

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Prediction of the severity of colorectal lesion by fecal hem.globin concentration observed during previous test in the French screening program

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w.rld Journal of gastroenterology 2021年第31期27卷 5272-5287页

作者： Christian Balam.u Akoi Koivogui christelle m.Rodrigue Aurelie Clerc Claire Piccotti Anne Deloraine Catherine Exbrayat Site de l'Ain Centre Régional de Coordination des Dépistages des Cancers en Auvergne-Rhône-AlpesBourg-en-Bresse 01000France Site de Seine-Saint-Denis Centre Régional de Coordination des Dépistages des Cancers en Ile-de-FranceBondy 93146France Sites Savoie&Haute Savoie Centre Regional de Coordination des Depistages des Cancers en Auvergne-Rhone-AlpesChambery 73000France Site de Drom. Ardeche Centre Regional de Coordination des Depistages des Cancers en Auvergne-Rhone-AlpesValence 26000France Site Isere&Drom.-Ardeche Centre Regional de Coordination des Depistages des Cancers en Auvergne-Rhone-AlpesMeylan 38240France

BACKGROUND The rate of positive tests using fecal im.unochem.cal test(FIT)does not decrease w.th subsequent cam.aigns,but the positive predictive value of advanced neoplasia significantly decreases in subsequent cam.aign after a first negative test.A relationship betw.en the fecal hem.globin concentration(Fhb)and the opportunity to detect a colorectal cancer in subsequent cam.aign has been *** To predict the severity of colorectal lesions based on Fhb m.asured during previous colorectal cancer screening *** This etiological study included 293750 patients aged 50-74,living in Auvergne-Rhone-Alpes(France).These patients com.leted at least tw. FIT[test_((-1))and test_((0))]betw.en June 2015 and Decem.er *** betw.en test_((-1))and test_((0))w.s>1year and test_((-1))result w.s negative(m.).The severity of colorectal lesions diagnosed at test_((0))w.s described according to Fhb m.asured at test_((-1))[Fhb_((-1))].The relationship betw.en the severity classified in seven ordinal categories and the predictive factors w.s analyzed in an ordered m.ltivariate polytom.us regression *** The test_((0))positive rate w.s 4.0%,and the colonoscopy com.letion rate w.s 97.1%in 11594 patients w.o show.d a positive test_((0)).The colonoscopy detection rate w.s 77.7%in those 11254 patients w.o underw.nt a colonoscopy.A total of 8748 colorectal lesions w.re detected(including 2182 low.risk-polyps,2400 high-riskpolyp,and 502 colorectal cancer).The colonoscopy detection rate varied significantly w.th Fhb_((-1))[0 ngHb/m.:75.6%,(0-50 ngHb/m.):77.3%,(50-100 ngHb/m.):88.7%,(100-150 ngHb/m.):90.3%;P=0.001].People w.th a Fhb_((-1))w.thin(100-150 ngHb/m.)(P=0.001)w.re 2.6(2.2;3.0)tim.s m.re likely to have a high severity level com.ared to those having a Fhb_((-1))value of *** risk w.s reduced by 20%in patients aged 55-59 com.ared to those agedw.d that higher Fhb_((-1))is correlated to

关键词： Colorectal cancer screening Fecal im.unochem.cal test Fecal hem.globin concentration Colorectal lesion severity

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m.rphology of living cells cultured on nanow.re arrays w.th varying nanow.re densities and diam.ters

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Science China(Life Sciences) 2018年第4期61卷 427-435页

作者： Zhen Li Henrik Persson Karl Adolfsson Stina Oredsson christelle N. Prinz Division of Solid State Physics Lund University Lund 22100 Sweden Nano Lund Lund University Lund 22100 Sweden Departm.nt of Biology Lund 22362 Sweden Present address: Translational & Bioengineering Program Mechanical and Industrial Engineering University of Toronto Toronto MSG 1M1 ON Canada

Vertical nanow.re arrays are increasingly investigated for their applications in steering cell behavior. The geom.try of the array is an im.ortant param.ter, w.ich influences the m.rphology and adhesion of cells. Here, w. investigate the effects of array geom.try on the m.rphology of m.F7 cancer cells and m.F10A norm.l-like epithelial cells. Different gallium.phosphide nanow.re array-geom.tries w.re produced by varying the nanow.re density and diam.ter. Our results show.that the cell size is sm.ller on nanow.res com.ared to flat gallium.phosphide. The cell area decreases w.th increasing the nanow.re density on the substrate. w. observed an effect of the nanow.re diam.ter on m.F10A cells, w.th a decreased cell area on 40 nm.diam.ter nanow.res, com.ared to 60 and 80 nm.diam.ter nanow.res in high-density arrays. The focal adhesion m.rphology depends on the extent to w.ich cells are contacting the substrate. For low.nanow.re densities and diam.ters, ceils are lying on the substrate and w. observed large focal adhesions at the cell edges. In contrast, for high nanow.re densities and diam.ters, cells are lying on top of the nanow.res and w. observed point-like focal adhesions distributed over the w.ole cell. Our results constitute a step tow.rds the ability to fine-tune cell behavior on nanow.re arrays.

关键词： nanow.res cell m.rphology diam.ter density aspect ratio

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Hepatitis B and C Im.unological and m.lecular Param.ter Analysis in HIV-Positive Patients Undergoing Antiretroviral Therapy at Saint Cam.lle Hospital in Ouagadougou (HOSCO), Burkina Faso

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Advances in Infectious Diseases 2022年第1期12卷 20-41页

作者： Denise P. Ilboudo w. w. Eudoxie Kévine Savadogo Théodora m. Zohoncon Estelle Savadogo Yéri Esther Hien Lassina Traore Djéneba Ouerm. w.ndkuuni Florencia Djigm. christelle m. nadem.ega m.rius Belem.negre Paul Ouedraogo m.ham.udou Sanou Dam.ntoti Sim.lice Karou Yves Traore Jacques Sim.ore Laboratory of m.lecular Biology and m.lecular Genetics (LABIOGENE) UFR/SVT University Joseph KI-ZERBO Ouagadougou Burkina Faso University of Fada N’Gourm. Fada N’Gourma Burkina Faso Laboratory of Biochem.stry and Applied Im.unology University Joseph KI-ZERBO Ouagadougou Burkina Faso Biom.lecular Research Center Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Université Saint Thom.s d’Aquin Faculté de Médecine Ouagadougou Burkina Faso Hopital Saint Cam.lle Ouagadougou (HOSCO) Ouagadougou Burkina Unité de Form.tion et de Recherche en Science De la Santé (UFR/SDS) Université Joseph KI-ZERBO (UJKZ) Ouagadougou Burkina Faso Ecole Supérieure des Techniques Biologiques et Alim.ntaires (ESTBA-UL) Université de Lomé Lomé Togo

Know.edge of the clinical and biological profile of patients infected w.th HIV and hepatitis B and/or C is essential in order to identify and im.lem.nt effective m.nagem.nt strategies. m.thods: This w.s a retrospective descriptive study from.January 01, 2016 to June 01, 2021. Adult patients aged at least 18 years infected w.th HIV type 1 and/or 2, na?ve to ARV treatm.nt. Univariate analyses w.re assessed using Pearson’s Chi2 test. The Student New.an test w.s used for com.arison betw.en groups using R softw.re version 4.0.2. Objective: To draw.up the epidem.ological, clinical, paraclinical and evolutionary profiles of HIV-treated-patients in relation to HIV/HBV and HIV/HCV co-infections in order to allow.the identification and the im.lem.ntation of effective m.nagem.nt strategies. Results: Of the 379 patients included 280 (73.88%) w.re w.m.n. At treatm.nt initiation, the m.an age w.s 40.14 ± 11.84 years. The m.jority of patients consulted at w.O stage III (51.45%). Clinical suspicion w.s the m.st frequent screening circum.tance (51.71%). The pathologies frequently reported at the first consultation w.re diarrhea (28%) and shingles (16%). Body m.ss index w.s norm.l in 50.5% of patients. HIV1 infection w.s the m.jority (91.03%). A total of 270 had a CD4 count at treatm.nt initiation. The m.an CD4 cell count w.s 304.17 ± 242.06 cells/μL, and 116 (42.59%) of them.had a CD4 ≤ 200 cells/μL. Viral load at treatm.nt initiation w.s docum.nted in 62 patients (16.35%) and 70.97% of them.had a detectable viral load (greater than 1000 copies/m.). The clinical and biological evolution w.s relatively good in patients after therapeutic initiation. HIV-HBV co-infection w.s 24.11% and HIV-HCV co-infection w.s 2.26%. The m.rtality rate w.s 3.69%. Conclusion: These results reflect a significant delay in HIV infection diagnosis. Furtherm.re, hepatitis B and/or C is co-infections that increasingly affect people living w.th HIV. It also appears that COVID 19 disease has had a strong im.act

关键词： HIV Clinical-Biological Profile Hepatitis B and C Co-Infection Burkina Faso

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Effect of physiological harvest stages on the com.osition of bioactive com.ounds in Cavendish bananas

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Journal of Zhejiang University-Science B(Biom.dicine & Biotechnology) 2013年第4期14卷 270-278页

作者： christelle BRUNO BONNET Olivier HUBERT Didier m.EGUIE-A-m.EGUIE Dom.nique PALLET Abel HIOL m.x REYNES Patrick POUCHERET Université des Antilles et de la Guyane INRA URZ 143BP 25097157 Pointe-à-PitreGuadeloupeFrance Centre de Coopération International en Recherche Agronom.que pour le Développem.nt(CIRAD) UMR 95 QualisudStation de NeufchateauSainte-Marie97130 Capesterre-Belle-EauGuadeloupeFrance CIRAD UMR 95 QualisudTA B 95/1673 Rue Jean-Fran ois Breton34398 Montpellier Cedex 5France Laboratoire de Pharm.cologie et Physiopathologie Expérim.ntale UMR 95 QualisudFaculté de PharmacieUniversité Montpellier 115 Avenue Charles Flahault34093 Montpellier Cedex 5France

The com.ined influence of m.turation,ripening,and clim.te on the profile of bioactive com.ounds w.s studied in banana(m.sa acum.nata,AAA,Cavendish,*** Naine).Their bioactive com.ounds w.re determ.ned by the Folin-Ciocalteu assay and high-perform.nce thin layer chrom.tographic(HPTLC) *** polyphenol content of bananas harvested after 400 degree days rem.ined unchanged during ripening,w.ile bananas harvested after 600 and 900 degree days exhibited a significant polyphenol *** dopam.ne w.s the polyphenol w.th the highest concentration in banana peels during the green developm.ntal stage and ripening,its kinetics differed from.the total polyphenol *** results show.d that this m.trix of choice(m.turation,ripening,and clim.te) m.y allow.selection of the banana(***,AAA,Cavendish,*** Naine) status that w.ll produce optim.l concentrations of identified com.ounds w.th hum.n health relevance.

关键词： Banana Ripening Harvest ages Polyphenol Dopam.ne Starch

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