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Chitin-glucan improves important pathophysiological features of irritable bowel syndrome

World Journal of Gastroenterology 2024年第16期30卷 2258-2271页

作者： Caroline Valibouze Caroline Dubuquoy Philippe Chavatte Michaël Genin Veronique Maquet Salvatore Modica Pierre Desreumaux christel Rousseaux Department of Digestive Surgery and Transplantation Lille UniversityLille 59037France Intestinal Biotech Development Facultéde MédicineLille 59045France U1286-INFINITE-Institute for Translational Research in Inflammation Universitéde LilleLille 59000France ULR 2694-METRICS Évaluation des Technologies de santéet des Pratiques MédicalesUniversity of LilleLille 59000France KitoZyme SA Institution SociétéAnonymeZone 2Parc des Hauts SartsRue de MilmortHerstal 4040Belgium Hepato-Gastroenterology Department Lille University HospitalLille 59037France

BACKGROUND Irritable bowel syndrome(IBS)is one of the most frequent and debilitating conditions leading to gastroenterological ***,recommended treatments remain limited,yielding only limited therapeutic ***-glucan(CG)is a novel dietary prebiotic classically used in humans at a dosage of 1.5-3.0 g/d and is considered a safe food ingredient by the European Food Safety *** provide an alternative approach to managing patients with IBS,we performed preclinical molecular,cellular,and animal studies to evaluate the role of chitin-glucan in the main pathophysiological mechanisms involved in *** To evaluate the roles of CG in visceral analgesia,intestinal inflammation,barrier function,and to develop computational molecular *** Visceral pain was recorded through colorectal distension(CRD)in a model of long-lasting colon hypersensitivity induced by an intra-rectal administration of TNBS[15 milligrams(mg)/kilogram(kg)]in 33 Sprague-Dawley *** pressure was regularly assessed during the 9 wk-experiment(weeks 0,3,5,and 7)in animals receiving CG(n=14)at a human equivalent dose(HED)of 1.5 g/d or 3.0 g/d and compared to negative control(tap water,n=11)and positive control(phloroglucinol at 1.5 g/d HED,n=8)*** anti-inflammatory effect of CG was evaluated using clinical and histological scores in 30 C57bl6 male mice with colitis induced by dextran sodium sulfate(DSS)administered in their drinking water during 14 ***-29 cells under basal conditions and after stimulation with lipopolysaccharide(LPS)were treated with CG to evaluate changes in pathways related to analgesia μ-opioid receptor(MOR),cannabinoid receptor 2(CB2),peroxisome proliferator-activated receptor alpha,inflammation[interleukin(IL)-10,IL-1b,and IL-8]and barrier function[mucin 2-5AC,claudin-2,zonula occludens(ZO)-1,ZO-2]using the real-time PCR *** modelling of CG,LPS,lipoteichoic acid(LTA),and phospholipomannan(PLM)was developed,and the abili

关键词： Chitin-glucan Irritable bowel syndrome Abdominal pain Inflammation Intestinal barrier Molecular modelling Microbial cell walls chelation

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Lafora progressive myoclonus epilepsy: NHLRC1 mutations affect glycogen metabolism

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世界最新医学信息文摘 2015年第5期 6-6页

作者： Philippe Couarch Santiago Vernia Isabelle Gourfinkel-An Ga tan Lesca Svetlana Gataullina Estelle Fedirko Oriane Trouillard christel depienne Olivier Dulac Dominique Steschenko Eric Leguern Pascual Sanz Stéphanie Baulac

Lafora disease is a fatal autosomal recessive formof progressive myoclonus epilepsy. Patients manifest myoclonus and tonic–clonic seizures, visual hallucinations, intellectual, and progressive neurologic deterioration beginning in *** two genes known to be involved in Lafora disease are EPM2 A and NHLRC1(EPM2B). The EPM2 A gene encodes laforin,a dual-specificity protein phosphatase, and the NHLRC1 gene encodes malin, an E3-ubiquitin ligase. The two proteins interact with each other and, as a complex, are thought to regulate glycogen synthesis. Here, we report three Lafora families with two novel pathogenic mutations(C46Y and L261P) and two recurrent mutations(P69A and D146N) in NHLRC1. Investigation of their functional consequences in cultured mammalian cells revealed that malin C46 Y, malin P69 A, malin D146 N, and malin L261 P mutants failed to downregulate the level of R5/PTG, a regulatory subunit of protein phosphatase 1 involved in glycogen synthesis. Abnormal accumulation of intracellular glycogen was observed with all malin mutants, reminiscent of the polyglucosan inclusions(Lafora bodies) present in patients with Lafora disease.

关键词： Epilepsy Mendelian disorder Genetics Autosomal recessive

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Spinal Analgesia with Intrathecal Morphine versus Conventional Analgesia after Laparoscopic Colectomy: A Retrospective Cohort Study

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Open Journal of Anesthesiology 2024年第7期14卷 159-174页

作者： Lionel Diyamona Manon Colin Marc Léone Laurent Zieleskiewicz Joseph Nsiala Wilfrid Mbombo Rachel Mbala Bruno Pastene Chris Nsituavibidila Dan Kankonde Gracia Likinda Jean Claude Mubenga Khazy Anga Noelly Mukuna christel Isengingo Department of Anaesthesia and Intensive Care University Clinics of Kinshasa University of Kinshasa Kinshasa Democratic Republic of the Congo Department of Anaesthesia and Intensive Care Marseilles Nord Hospital Marseille France General Hospital of Kinshasa ex Mama Yemo Kinshasa Democratic Republic of the Congo Department of Anaesthesia and Intensive Care Monkole Hospital Centre Kinshasa Democratic Republic of the Congo

Objective: Postoperative pain (POP) following abdominal surgery can vary from a few hours to several days. This acute, unrelieved pain can become chronic, requiring patients to take analgesics on an almost daily basis for comfort. Analgesia using general opioids has many side effects and intrathecal morphine is a good alternative. This study was conducted to evaluate the efficacy of intrathecal morphine (ITM) versus conventional analgesia in the management of postoperative pain in colectomy performed by laparoscopic surgery. Methods: Cohort study conducted at the Hôpital Nord in Marseille, from 01 January to 31 July 2021 in patients aged at least 18 years undergoing anaesthesia for scheduled colectomy by laparoscopic surgery. The primary endpoint was postoperative pain intensity and the secondary endpoints were morphine consumption, treatment side effects and length of hospital stay. Statistical analysis was performed using XLSTAT software. Results: We included 193 patients: 131 in the control group (conventional analgesia) and 62 in the ITM group. We observed: a significant decrease in pain (assessed by numerical scale) in favour of the ITM group in the post-anaesthetic care room, i.e. 3 (±4) vs 1 (±2), p 0 and H2: 2 (±2) vs. 1 (±2);p Conclusion: These results suggest that intrathecal morphine (ITM) in laparoscopic colectomy provides effective postoperative analgesia with low morphine consumption, and a reduction in morphine side-effects compared with conventional analgesia.

关键词： Intrathecal Morphine Colectomy Laparoscopy Conventional Analgesia

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Efficacy and tolerability of chitin-glucan combined with simethicone(GASTRAP^(■)DIRECT)in irritable bowel syndrome:A prospective,open-label,multicenter study

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第3期15卷 10-22页

作者： Nathalie Talbodec Pauline Le Roy Peggy Fournier Benoit Lesage Elodie Lepoutre François Castex Jean Michel Godchaux Lionel Vandeville Benjamin Bismuth Xavier Lesage Pauline Bayart Michael Genin christel Rousseaux Veronique Maquet Salvatore Modica Pierre Desreumaux Caroline Valibouze Department of Gastroenterology Hôpital privéLe BoisLille 59000France Department of Gastroenterology Hôpital privéde Villeneuve d’AscqVilleneuve d’Ascq 59650France Univ.Lille CHU LilleULR 2694–METRICSÉvaluation des Technologies de Santéet des Pratiques MédicalesLille 59000France Development of Intestinal Biotech 1 Avenue Oscar LambretLille 59045France KitoZyme SA Parc Industriel des hauts Sarts Zone 2Rue de MilmortHerstal 4040Belgium BiOkuris A Parc Industriel des hauts Sarts Zone 2Rue de MilmortHerstal 4040Belgium Department of Hepato-Gastroenterology Lille University HospitalLille 59000France U1286-INFINITE Institute for Translational Research in InflammationUniv.LilleInsermCHU LilleLille 59000France Department of Digestive Surgery and Transplantation Lille University HospitalLille 59037France

BACKGROUND Irritable bowel syndrome(IBS),defined according to the Rome IV diagnostic criteria,is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain related to altered bowel ***-line recommended treatments are limited to combining drugs targeting predominant symptoms,particularly pain(antispasmodics),constipation(laxatives),and diarrhea(loperamide),yielding only a limited therapeutic ***^(■)DIRECT is a class IIa medical formulation composed of a combination of chitin-glucan and simethicone indicated for the symptomatic treatment of gas-related gastrointestinal disorders by combining different mechanisms of *** To evaluate the efficacy,tolerability,and safety of 4-week GASTRAP^(■)DIRECT treatment in patients with *** In this prospective,multicenter,open-label trial,120 patients with IBS received three sticks of GASTRAP^(■)DIRECT(1.5 g/d of chitin-glucan and 0.75 mg/d of simethicone)per day for 4 *** primary endpoint was the responder rate,defined as the number of patients whose abdominal pain score decreased by≥30%from baseline to week(W)*** analysis was performed using the per-protocol *** symptoms,impact of global symptoms on daily life,change in stool consistency,and improvement in defecatory disorders were *** Overall,100 patients were *** W4,67%(95%CI:57-75)showed improvement in abdominal pain(score:5.8±2.4 vs 2.9±2.0,P<0.0001).Similar improvements were observed for bloating[8.0±1.7 vs 4.7±2.9,P<0.0001;60%(95%CI:50-70)responders],abdominal distension[7.2±2.1 vs 4.4±3.1,P<0.0001;53%(95%CI:43-63)responders],and impact of global symptoms on daily life[7.1±2.0 vs 4.6±2.9,P<0.0001;54%(95%CI:44-64)responders].Stool consistency improved in most patients(90%and 57%for patients with liquid and hard stools,respectively).Overall,42%of patients with defecatory disorders reported very much/considerable improvements by *** severe adverse event occurred,and tolerabil

关键词： Chitin-glucan Irritable bowel syndrome Abdominal pain Flatulence Defecatory disorders Stool consistency Natural non-pharmacological treatment

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Can integrated watershed management reduce soil erosion and improve livelihoods? A study from northern Ethiopia

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International Soil and Water Conservation Research 2020年第3期8卷 266-276页

作者： Kassa Teka Mulu Haftu Madelene Ostwald christel Cederberg Department of Land Resources Management and Environmental Protection Mekelle UniversityEthiopia Wukro St.Mary’s Institute WukroTigrayEthiopia Centre for Climate Science and Policy Research Department of Thematic Studies/Environmental ChangeLinköping UniversitySweden Department of Space Earth and EnvironmentPhysical Resource TheoryChalmers University of TechnologySweden

The study aimed at evaluating the impact of integrated watershed management on reducing soil erosion and changes in the livelihoods of rural farming households in *** changes in soil erosion for the years between 2002 and 2015 were estimated using the Revised Universal Soil Loss Equation model,while the impacts on livelihoods were assessed by household *** the study period,the overall average annual soil loss was ***,crop productivity,water availability(irrigation and domestic)and fodder availability increased by 22,33 and 10%,respectively,while an increase in household income(by 56%)was ***,72%of the sampled households were able to cover their 12-month annual expenditure demands in 2015,while only 50%of the households were able to cover these demands in *** can be concluded that the implemented integrated watershed man-agement activities seemingly resulted in reduced soil loss,enhanced vegetation cover,and additional household *** paper also elaborates on the hurdles for integrated watershed management expansion.

关键词： Soil loss Crop productivity Water availability Feed availability Household income

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Existence,uniqueness and comparison results for BSDEs with Levy jumps in an extended monotonic generator setting

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Probability, Uncertainty and Quantitative Risk 2018年第1期3卷 253-285页

作者： christel Geiss Alexander Steinicke University of Jyvaskyla Department of Mathematics and StatisticsP.O.Box 3540014 JyvaskylaFinland Department of Mathematics and Information Technology Montanuniversitaet LeobenLeobenAustria

We show that the comparison results for a backward SDE with jumps established in Royer(*** 116:1358–1376,2006)and Yin and Mao(*** 346:345–358,2008)hold under more simplified ***,we prove existence and uniqueness allowing the coefficients in the linear growth-and monotonicity-condition for the generator to be random and *** the L2-case with linear growth,this also generalizes the results of Kruse and Popier(Stochastics 88:491–539,2016).For the proof of the comparison result,we introduce an approximation technique:Given a BSDE driven by Brownian motion and Poisson random measure,we approximate it by BSDEs where the Poisson random measure admits only jumps of size larger than 1/n.

关键词： Backward stochastic differential equation Levy process´ comparison theorem existence and uniqueness

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In vivo Studies on the Roles of Tic55-Related Proteins in Chloroplast Protein Import in Arabidopsis thaliana

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Molecular Plant 2009年第6期2卷 1397-1409页

作者： Patrik Boij Ramesh Patel christel Garcia Paul Jarvis Henrik Aronsson Department of Plant and Environmental Sciences University of Gothenburg Box 461 SE-405 30 Gothenburg Sweden Department of Biology University of Leicester University Road Leicester LE1 7RH UK

The TicS5 （Translocon at the inner envelope membrane of chloroplasts, 55 kDa） protein was identified in pea as a putative regulator, possibly linking chloroplast protein import to the redox state of the photosynthetic machinery. Two Tic55 homologs have been proposed to exist in Arabidopsis： atTic55-11 and AtPTC52 （Protochlorophyllide-dependent Trans- Iocon Component, 52 kDa; has also been called atTic55-1V）. Our phylogenetic analysis shows that attic55-11 is an ortholog of psTic55 from pea （Pisum sativurn）, and that AtPTC52 is a more distant homolog of the two. AtPTC52 was included in this study to rule out possible functional links between the proteins in Arabidopsis. No detectable mutant phenotypes were found in two independent T-DNA knockout mutant plant lines for each Arabidopsis protein, when compared with wild- type： visible appearance, chlorophyll content, photosynthetic performance, and chloroplast protein import, for example, were all normal. Both wild-type and tic55-11 mutant chloroplasts exhibited deficient protein import when treated with diethylpyrocarbonate, indicating that Tic55 is not the sole target of this reagent in relation to protein import. Furthermore, ptc52 mutant chloroplasts were not defective with respect to pPORA import, which was previously reported to involve PTC52 in barley. Thus, we conclude that atTic55-11 and AtPTC52 are not strictly required for functional protein import in Arabidopsis.

关键词： Arabidopsis chloroplast import protein targeting Tic55.

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Experimental reconstructions of 3D atomic structures from electron microscopy images using a Bayesian genetic algorithm

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npj Computational Materials 2022年第1期8卷 2076-2083页

作者： Annick De Backer Sandra Van Aert christel Faes Ece Arslan Irmak Peter DNellist Lewys Jones EMAT University of AntwerpGroenenborgerlaan 1712020AntwerpBelgium NANOlab Center of Excellence University of AntwerpGroenenborgerlaan 1712020AntwerpBelgium I-BioStat Data Science InstituteHasselt UniversityHasseltBelgium Department of Materials University of OxfordParks RoadOX13PHOxfordUK Advanced Microscopy Laboratory Centre for Research on Adaptive Nanostructures and Nanodevices(CRANN)Dublin 2Ireland School of Physics Trinity College DublinThe University of DublinDublin 2Ireland

We introduce a Bayesian genetic algorithm for reconstructing atomic models of monotype crystalline nanoparticles from a single projection using Z-contrast *** number of atoms in a projected atomic column obtained from annular dark field scanning transmission electron microscopy images serves as an input for the initial three-dimensional *** algorithm minimizes the energy of the structure while utilizing a priori information about the finite precision of the atom-counting results and neighbor-mass *** results show promising prospects for obtaining reliable reconstructions of beam-sensitive nanoparticles during dynamical processes from images acquired with sufficiently low incident electron doses.

关键词： algorithm atomic utilizing

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Unmet supportive care needs in families of children with chronic health conditions: an Australian cross‑sectional study

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World Journal of Pediatrics 2023年第12期19卷 1181-1191页

作者： Sangeetha Thomas Linda K.Byrne Nicholas P.Ryan christel Hendrieckx Victoria White School of Psychology Faculty of HealthDeakin UniversityMelbourneVIC 3125Australia Department of Paediatrics University of MelbourneMelbourneVICAustralia Australian Centre for Behavioural Research in Diabetes MelbourneVICAustralia Institute of Health Transformation Deakin UniversityMelbourneVICAustralia Cancer Council Victoria MelbourneVICAustralia

Background The aim of this study was to identify similarities and diferences in the unmet supportive care needs(USCN)of families of children with major chronic health conditions(CHCs)using a universal need assessment *** A cross-sectional online survey involving parents of children with congenital heart disease(CHD),type 1 diabetes mellitus(T1D),cancer,and asthma diagnosed within the last 5 years recruited via social media and support ***-four items assessing the USCN across six domains(care needs,physical and social needs,informational needs,support needs,fnancial needs,child-related emotional needs)were responded to on a 4-point Likert scale[no need(1)to high need(4)].Descriptive statistics identifed the level of need,and linear regressions identifed factors associated with higher need domain *** to small numbers,the asthma group was excluded from comparisons across *** One hundred and ninety-four parents completed the survey(CHD:n=97,T1D:n=50,cancer:n=39,and asthma:n=8).Parents of children with cancer were most likely to report at least one USCN(92%),followed by parents of children with T1D(62%).The fve most commonly reported USCN across CHCs were drawn from four domains:child-related emotional,support,care,and *** need items were included in the top fve needs for all conditions.A higher USCN was associated with a greater frequency of hospital visits and the absence of parental *** Using a universal need assessment tool,this is one of the frst studies to characterize USCN in families of children diagnosed with common *** proportions endorsing diferent needs varied across conditions,the most endorsed needs were similar across the illness *** suggests that support programs or services could be shared across diferent CHCs.

关键词： Children Chronic illness Need assessment Unmet supportive care needs

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Relationship between early nutrition and deep gray matter and lateral ventricular volumes of preterm infants at term-equivalent age

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World Journal of Pediatrics 2023年第5期19卷 460-468页

作者： Felicia Toppe Tobias Rasche christel Weiss Alexandra Schock Ursula Felderhoff-Müser Hanna Müller Department of Pediatrics I NeonatologyPediatric Intensive Careand Pediatric NeurologyUniversity Hospital EssenUniversity of Duisburg-EssenHufelandstr.5545147EssenGermany Department of Medical Statistics Biomathematicsand Information ProcessingMedical Faculty Mannheim of Heidelberg UniversityTheodor-Kutzer-Ufer 1-368167MannheimGermany Pediatric Surgery University Hospital MarburgUniversity of MarburgBaldingerstraße35043MarburgGermany Department of Pediatrics Neonatology and Pediatric Intensive CareUniversity Hospital MarburgUniversity of MarburgBaldingerstraße35043MarburgGermany

Background The survival of preterm infants has improved over the last decade,but impaired brain development leading to poor neurological outcomes is still a major comorbidity associated with *** aim of this study was to evaluate the effect of nutrition on neurodevelopment in preterm infants and identify markers for improved *** Totally 67 premature infants with a gestational age of 24–34 weeks and a birth weight of 450–2085 g were *** parameters and documented diet were collected from medical *** nutritional analysis comprised the protein,fat,carbohydrate,and energy intake during different time *** development was assessed by determining deep gray matter(DGM;basal ganglia and thalamus)and lateral ventricular(LV)volumes as measured on cerebral magnetic resonance imaging scans obtained at term-equivalent age(TEA),and potential associations between nutrition and brain volumetrics were detected by regression *** We observed a negative correlation between mean daily protein intake in the third postnatal week and MRI-measured DGM volume at TEA(P=0.007).In contrast,head circumference at a corrected age of 35 weeks gestation(P<0.001)and mean daily fat intake in the fourth postnatal week(P=0.004)were positively correlated with DGM ***,mean daily carbohydrate intake in the first postnatal week(P=0.010)and intraventricular hemorrhage(P=0.003)were revealed as independent predictors of LV *** The study emphasizes the importance of nutrition for brain development following preterm birth.

关键词： Deep gray matter Lateral ventricles Magnetic resonance imaging Nutrition Prematurity

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