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Mufangji tang ameliorates pulmonary arterial hypertension through improving vascular remodeling,inhibiting inflammatory response and oxidative stress,and inducing apoptosis

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Traditional Medicine Research 2024年第2期9卷 52-65页

作者： Yu-Ming Wang Hong-Wei Tao Feng-chan Wang Ping Han na Liu Guo-Jing Zhao Hai-Bo Hu Xue-Chao Lu College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Respiratory and Critical Care Medicine Qingdao Hospital of Traditional Chinese Medicine(Qingdao Hiser hospital)Qingdao 266000China.

Background:Mufangji tang(MFJT)is composed of Ramulus Cinnamomi,Radix Ginseng,Cocculus orbiculatus(Linn.)DC.,and *** clinical settings,MFJT has been effectively employed in addressing a range of respiratory disorders,notably including pulmonary arterial hypertension(PAH).However,the mechanism of action of MFJT on PAH remains ***:In this study,a monocrotaline-induced PAH rat model was established and treated with *** therapeutic effects of MFJT on PAH rat model were *** pharmacology was conducted to screen the possible targets for MFJT on PAH,and the molecular docking between the main active components and the core targets was carried *** key targets identified from network pharmacology were ***:Results showed significant therapeutic effects of MFJT on PAH rat *** of network pharmacology revealed several potential targets related to apoptosis,inflammation,oxidative stress,and vascular *** docking showed that the key components were well docked with the core *** experimental validation results that MFJT treatment induced apoptosis(downregulated Bcl-2 levels and upregulated Bax levels in lung tissue),inhibited inflammatory response and oxdative stress(decreased the levels of IL-1β,TNF-α,inducible NOS,and malondialdehyde,and increased the levels of endothelial nitric oxide synthase,nitric oxide,glutathione and superoxide dismutase),reduced the proliferation of pulmonary arterial smooth muscle cells(downregulated ET-1 andβ-catenin levels and ERk1/2 phosphorylation,increased GSk3βlevels).Conclusion:Our study revealed MFJT treatment could alleviate PAH in rats via induction of apoptosis,inhibition of inflammation and oxidative stress,and the prevention of vascular remodeling.

关键词： Mufangji tang pulmonary arterial hypertension apoptosis inflammatory response oxidative stress vascular remodeling

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Eco-friendly synthesis and environmental impact assessment of hierarchical Beta zeolite from kaolinite and recycled mother liquor

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Green Chemical Engineering 2024年第4期5卷 501-510页

作者： Guoxi Xiao Xiaoling Chen Tiesen Li chan Wang Qingyan Cui Yuanyuan Yue national Engineering Research Center of Chemical Fertilizer Catalyst College of Chemical EngineeringFuzhou University Qingyuan Innovation Laboratory

The development of sustainable techniques to produce high-performance zeolite is essential to achieve green production in industry. Herein, we report an eco-friendly route to synthesizing hierarchical Beta zeolite from kaolinite and recycled mother liquor. The results reveal that the unutilized species（such as silicon species and na+） in mother liquor stayed in a stable concentration during eleven recycled experiments. Moreover, the synthesized Beta zeolites still have comparable physicochemical properties and catalytic performance in the esterification of levulinic acid with ethanol over the initial zeolite although eleven recycled experiments. Life cycle assessment exhibits that the synthesis of Beta zeolite with recycled mother liquor can reduce global warming potential by 23% and resource depletion-water use by 36% compared to that without recycled mother liquor. This quantitatively demonstrates that the approach proposed in this work is really a sustainable one, extremely increasing the utilization efficiency of raw materials and decreasing the environmental burden.

关键词： Eco-friendly synthesis Hierarchical Beta zeolite Recycled mother liquor Life cycle assessment

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超声波预处理对贮藏过程中猕猴桃质构、果胶特性及果胶酶活性的影响

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食品科技 2024年第5期49卷 26-34页

作者：盖芸芸何婵李娜于晨烟台职业学院食品与生化工程系山东烟台264670 滨州医学院药学院山东烟台264003

猕猴桃在收获后会经历快速软化及品质变化,这严重影响其经济价值。为延长其贮藏期,将超声波(Ultrasound,US)技术应用于猕猴桃贮藏前处理中,探究不同处理时间(10、20、30 min)对贮藏过程中猕猴桃质构、果胶特性及果胶酶活性的影响,并进... 详细信息

猕猴桃在收获后会经历快速软化及品质变化,这严重影响其经济价值。为延长其贮藏期,将超声波(Ultrasound,US)技术应用于猕猴桃贮藏前处理中,探究不同处理时间(10、20、30 min)对贮藏过程中猕猴桃质构、果胶特性及果胶酶活性的影响,并进行相关性分析。结果表明,US处理20 min猕猴桃在贮藏过程中的硬度、胶着性及咀嚼性明显提高;US处理20 min抑制了猕猴桃贮藏过程果胶降解酶(多聚半乳糖醛酸酶、果胶裂解酶及果胶甲酯酶)的活性,进而抑制了猕猴桃螯合态果胶(Chelate-soluble pectin,CSP)和碳酸钠溶性果胶(na_(2)CO_(3)-soluble pectin,NSP)向水溶性果胶(Water-soluble pectin,WSP)的转化并提高了果胶分子质量。果胶单糖组成表明US处理20 min延缓了猕猴桃果胶线性度及侧链长度的下降。贮藏12 d后,超声波处理20 min的猕猴桃果实硬度提高了61.11%。相关性分析表明猕猴桃硬度与WSP含量、多聚半乳糖醛酸酶、果胶裂解酶及果胶甲酯酶活性呈现负相关关系(r>0.85),与CSP含量及分子质量呈现正相关关系(r>0.90)。US处理可通过调节细胞壁物质代谢来减缓猕猴桃的软化速度。研究结果可为延长猕猴桃货架期提供理论依据。

关键词：猕猴桃超声波预处理质构果胶特性果胶酶活性

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Interdecadal variability of summer precipitation in the Three River Source Region: Influences of SST and zonal shifts of the East Asian subtropical westerly jet

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Atmospheric and Oceanic Science Letters 2024年第5期17卷 47-53页

作者： Yumeng Liu Xianhong Meng Lin Zhao S-Y.Simon Wang Lixia Zhang Zhaoguo Li chan Wang Yingying An key Laboratory of Cryospheric Science and Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouChina Zoige Plateau Wetlands Ecosystem Research Station Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouChina University of Chinese Academy of Sciences BeijingChina Utah Climate Center Utah State UniversityLoganUSA The State key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina

Summer precipitation in the Three Rivers Source Region(TRSR)of China is vital for the headwaters of the Yellow,Yangtze,and Lancang rivers and exhibits significant interdecadal *** study investigates the influence of the East Asian westerly jet(EAWJ)on TRSR rainfall.A strong correlation is found between TRSR summer precipitation and the Jet Zonal Position Index(JZPI)of the EAWJ from 1961 to 2019(R=0.619,pnal function and regression analyses,this research identifies the influence of large-scale circulation anomalies associated with the Atlantic–Eurasian teleconnection(AEA)from the North Atlantic(na).The interdecadal variability between the na and central tropical Pacific(CTP)significantly affects TRSR *** influence is mediated through the AEA via a Rossby wave train extending eastward along the EAWJ,and another south of 45°***,the na–CTP Opposite Phase Index(OPI),which quantifies the difference between the summer mean sea surface temperatures of the na and the CTP,is identified as a critical factor in modulating the strength of this teleconnection and influencing the zonal position of the EAWJ.

关键词： Summer precipitation East Asian subtropical westerly jet Three River Source Region Atlantic-Eurasian teleconnection

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南海地区新局势、新挑战与新思路——2023年度“南海论坛”综述

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亚太安全与海洋研究 2024年第1期 81-90,I0002,I0003页

作者：常娜南京大学中国南海研究协同创新中心、国际关系学院南京210093

2023年南海地区局势复杂多变,危机频发,南海问题依然是全球最为复杂的海洋争端和影响中国-东盟关系的重要因素。如何在中美战略博弈大背景下应对亚太海洋安全新形势,相关问题亟须深入的探讨与总结。在南京大学中国南海研究协同创新中心... 详细信息

2023年南海地区局势复杂多变,危机频发,南海问题依然是全球最为复杂的海洋争端和影响中国-东盟关系的重要因素。如何在中美战略博弈大背景下应对亚太海洋安全新形势,相关问题亟须深入的探讨与总结。在南京大学中国南海研究协同创新中心主办的2023年度“南海论坛”上,与会专家围绕南海维权维稳斗争的新形势与新问题、美国与小多边机制干涉南海的挑战与应对、南海岛礁主权与海洋权益的历史视角和法律斗争新态势与新挑战,以及增进南海合作的新思路新办法等议题进行了深入讨论。面对法律、认知、话语斗争等诸多形势变化,中国需要进一步强化证据链建设和话语权构建,结合具体条件重塑相关实践的规范性,增进南海合作和共同开发。

关键词：南海论坛南海地区南海政策中美战略博弈海洋权益南海合作

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冠心病患者PCI术后健康素养与CSMS评分相关性

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社区医学杂志 2024年第4期22卷 128-132页

作者：刘明贤刘娜赵婵商丘市立医院综合内科河南商丘476000 河南省人民医院心血管综合一病区河南郑州450000

目的分析冠心病患者经皮冠状动脉介入治疗(PCI)术后健康素养与其自我管理量表(CSMS)评分的相关性。方法随机选取2020-03-01-2021-12-30商丘市立医院收治的335例冠心病患者为调查对象,均行PCI术,并统计术后健康素养、CSMS评分,用单因... 详细信息

目的分析冠心病患者经皮冠状动脉介入治疗(PCI)术后健康素养与其自我管理量表(CSMS)评分的相关性。方法随机选取2020-03-01-2021-12-30商丘市立医院收治的335例冠心病患者为调查对象,均行PCI术,并统计术后健康素养、CSMS评分,用单因素、多因素分析冠心病患者PCI术后健康素养的影响因素;Pearson分析冠心病患者PCI术后健康素养与CSMS评分相关性。结果冠心病患者PCI术后健康素养总分为(75.85±10.11)分,其中有114例(34.03%)处于低等水平,162例(48.36%)处于中等水平,59例(17.61%)处于良好水平;CSMS评分总分为(79.50±11.42)分,其35例(10.45%)处于良好水平,51例(15.22%)处于中等水平,239例(71.34%)处于低等水平;单因素分析显示,不同年龄(F=5.346,P=0.005)、婚姻情况(t=4.968,P<0.001)、居住地(t=9.952,P<0.001)、文化程度(F=61.029,P<0.001)、职业(t=3.443,P=0.001)、家庭人均月平均收入(F=23.832,P<0.001)、自我管理行为(t=6.255,P<0.001)比较,差异有统计学意义;多因素分析显示,年龄(t=5.974,P<0.001)、婚姻情况(t=6.659,P<0.001)、文化程度(t=7.588,P<0.001)、家庭人均月平均收入(t=8.591,P<0.001)、自我管理行为(t=11.265,P<0.001)均为冠心病患者PCI术后健康素养的影响因素;Pearson相关性分析显示,冠心病患者PCI术后健康素养与CSMS评分呈正相关,r=0.337,P<0.05。结论冠心病患者PCI术后健康素养处于中低水平,年龄、婚姻情况、文化程度、家庭人均月平均收入、自我管理行为是其影响因素,且与CSMS评分呈正相关。

关键词：冠心病经皮冠状动脉介入治疗健康素养自我管理量表评分相关性

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Evolution of microstructure and tensile properties of cold-drawn hyper-eutectoid steel wires during post-deformation annealing

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Journal of Materials Science & Technology 2020年第6期41卷 1-11页

作者： Majid Jafari chan-Woo Bang Jong-chan Han kyeong-Min kim Seon-Hyeong na chan-Gyung Park Byeong-Joo Lee Department of Materials Science and Engineering POSTECH Pohang 37673 South Korea

Manufacturing temperatures of severely cold-drawn hyper-eutectoid steel wires are sufficiently high to influence the mobility of dislocations and alloy elements,thereby affecting the materials’mechanical ***,we describe the evolution of microstructure and tensile strength of the as-drawn 3.45 GPa steel wire during post-deformation annealing for 30 min at 150-450℃.Annealing at 150℃raised the strength to 3.77 GPa by age-hardening through activation of dislocations pinning by carbon,while further temperature rising up to 450℃caused a severe loss of *** was proved that annealing at 300 and 450℃destabilizes the lamellar microstructure,promoting the formation of carbon-deficient(Fe,Mn,Cr)3 C-type cementite particles with preferentially rounded and partially faceted *** at 450℃yielded the accumulation of Mn and Cr at the ferrite/particle interfaces,and their concentrations at the interfaces were dependent on the interface structure;i.e.,lower concentrations at rounded interfaces(formed through capillarity–driven coarsening of the spheroidized cementite),and higher concentrations at faceted interfaces(that are initially existing in the as-drawn state).Our proof-of-principle observations,supported by thermodynamic calculations and kinetic assessments,provide a pathway for understanding the changes in microstructural and tensile properties during manufacturing of the hyper-eutectoid steel wires.

关键词： Three-dimensional atom probe(3DAP) High resolution transmission electron microscopy(HRTEM) nano-grained low-carbon steel Annealing Tensile behavior

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Unveiling the evolutionary dynamics of microR na-targeted plant laccase genes

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Science China Life Sciences 2024年

作者： Rui-Rui He Meng-Qi Lei Yan-Zhao Feng Jiao Xue Yu-chan Zhang Yue-Qin Chen Yang Yu Guangdong Provincial key Laboratory of Plant Stress Biology State Key Laboratory for Biocontrol School of Life Science Sun Yat-Sen University Guangdong key Laboratory of Crop Germplasm Resources Preservation and Utilization Agro-biological Gene Research Center Guangdong Academy of Agricultural Sciences

Dear Editor,MicroRnas (miRnas) are small noncoding Rna molecules that play crucial roles in the regulation of gene *** have been extensively studied in various organisms, including plants,where they have been found to be involved in diverse biological processes,such as development, growth, and response to environmental stresses. Plant miRnas achieve their regulatory functions by binding to the m Rna of target genes and modulating their expression levels.

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18~24月龄发育性髋关节脱位的治疗研究进展

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临床小儿外科杂志 2024年第5期23卷 489-492页

作者：鲁婵马娜谢睿陈新好杨涵康晓鹏昆明市儿童医院骨科，昆明650000

发育性髋关节脱位(developmental dysplasia of the hip,DDH)是指髋关节结构及功能上的异常,其治疗目的在于恢复髋臼和股骨头的同心圆复位,保证其正常的生长发育。国内外对不同年龄段DDH患儿的治疗方式比较成熟,但对于18~24月龄DDH患儿... 详细信息

发育性髋关节脱位(developmental dysplasia of the hip,DDH)是指髋关节结构及功能上的异常,其治疗目的在于恢复髋臼和股骨头的同心圆复位,保证其正常的生长发育。国内外对不同年龄段DDH患儿的治疗方式比较成熟,但对于18~24月龄DDH患儿的治疗方式选择存在较大争议,由于疾病预后以及手术创伤、费用、时长等因素影响着治疗方式的选择,因此至今尚没有明确的治疗方案。目前采用的手术方法主要包括闭合复位、单纯切开复位及骨盆截骨术,然而每种治疗方式下都有部分患儿存在严重并发症,如残余发育不良(residualacetabular dysplasia,RAD)和股骨头缺血性坏死(avascular necrosis,AVN)。由于DDH患儿术后并发症的影响因素复杂,且18~24月龄这一年龄段髋臼发育的特殊性,如何选择适合不同患儿的手术方法已成为当前临床治疗的难点。本文就18~24月龄DDH患儿的手术治疗研究进展进行综述,旨在为该年龄段患儿选择合适的手术方案提供参考依据。

关键词：发育性髋关节脱位外科手术儿童

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Rna interference and antiviral therapy

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World Journal of Gastroenterology 2007年第39期13卷 5169-5179页

作者： Yan na Chu-Yan chan Ming-Liang He Stanley Ho Centre for Emerging Infectious Diseases and Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong Hong Kong China

Rna interference (Rnai) is an evolutionally conserved gene silencing mechanism present in a variety of eukaryotic species. Rnai uses short double-stranded Rna (dsRna) to trigger degradation or translation repression of homologous Rna targets in a sequence-specific manner. This system can be induced effectively in vitro and in vivo by direct application of small interfering Rnas (siRnas), or by expression of short hairpin Rna (shRna) with non-viral and viral vectors. To date, Rnai has been extensively used as a novel and effective tool for functional genomic studies, and has displayed great potential in treating human diseases, including human genetic and acquired disorders such as cancer and viral infections. In the present review, we focus on the recent development in the use of Rnai in the prevention and treatment of viral infections. The mechanisms, strategies, hurdles and prospects of employing Rnai in the pharmaceutical industry are also discussed.

关键词： Rna interference Short hairpin Rna Micro Rna Antiviral therapy Viral infection Humanimmunodeficiency virus Hepatitis C virus Hepatitis Bvirus SARS-coronavirus

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