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A single-cell morpho-transcriptomic map of brassinosteroid action in the Arabidopsis root

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Molecular Plant 2021年第12期14卷 1985-1999页

作者： Moritz Graeff surbhi Rana Jos R.Wendrich Julien Dorier Thomas Eekhout Ana Cecilia Aliaga Fandino Nicolas Guex George W.Bassel Bert De Rybel chris.ian s.hardtke Department of Plant Molecular Biology University of LausanneBiophore Building1015 LausanneSwitzerland Ghent University Department of Plant Biotechnology and BioinformaticsTechnologiepark 719000 GhentBelgium VIB Center for Plant systems Biology Technologiepark 719000 GhentBelgium Bioinformatics Competence Center University of LausanneGenopode Building1015 LausanneSwitzerland school of Life sciences The University of WarwickCoventryCV47ALUK Lead contact

The effects of brassinosteroid signaling on shoot and root development have been characterized in great detail but a simple consistent positive or negative impact on a basic cellular parameter was not *** this study,we combined digital 3D single-cell shape analysis and single-cell mRNA sequencing to charac-terize root meristems and mature root segments of brassinosteroid-blind mutants and wild *** resul-tant datasets demonstrate that brassinosteroid signaling affects neither cell volume nor cell proliferation ***,brassinosteroid signaling is essential for the precise orientation of cell division planes and the extent and timing of anisotropic cell ***,we found that the cell-aligning effects of brassinosteroid signaling can propagate to normalize the anatomy of both adjacent and distant brassinosteroid-blind cells through non-cell-autonomous functions,which are sufficient to restore growth ***,single-cell transcriptome data discern directly brassinosteroid-responsive genes from genes that can react non-cell-autonomously and highlight arabinogalactans as sentinels of brassinosteroid-dependent anisotropic cell expansion.

关键词： Arabidopsis root meristem brassinosteroid single-cell mRNA sequencing segmentation morphology BRI1 digital single-cell analysis

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

sucrose-responsive osmoregulation of plant cell size by a long non-coding RNA

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Molecular Plant 2024年第11期17卷 1719-1732页

作者： Jakub Hajný Tereza Trávnícková Martina pundová Michelle Roenspies R.M.Imtiaz Karim Rony sebastian sacharowski Michal Krzyszton David Zalabák chris.ian s.hardtke Ales Pecinka Holger Puchta szymon swiezewski Jaimie M.van Norman Ondrej Novák Laboratory of Growth Regulators Czech Academy of SciencesInstitute of Experimental Botany and Palacky UniversitySlechtitelu 2777900 OlomoucCzech Republic Department of Biophysics Faculty of SciencePalacky UniversitySlechtitelu 2777900 OlomoucCzech Republic Joseph Gottlieb Kölreuter Institute for Plant sciences(JKIP)–Molecular Biology Karlsruhe Institute of Technology76131 KarlsruheGermany Department of Molecular Celland Systems BiologyUniversity of CaliforniaRiversideCA 92521USA Laboratory of seeds Molecular Biology Institute of Biochemistry and Biophysics Polish Academy of SciencesPawinskiego 5a02-106 WarsawPoland Department of Plant Molecular Biology University of Lausanne1015 LausanneSwitzerland Center of Plant structural and Functional Genomics Institute of Experimental BotanyCzech Academy of SciencesSlechtitelu 3177900 OlomoucCzech Republic Department of Molecular Celland Developmental BiologyUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA

In plants,sugars are the key source of energy and metabolic building *** systemic transport of sugars is essential for plant growth and *** evolved intricate molecular networks to effectively distribute *** dynamic distribution of these osmotically active compounds is a handy tool for regulating cell turgor pressure,an instructive force in developmental *** this study,we have investigated the molecular mechanism behind the dual role of the receptor-like kinase *** functionally characterized a long non-coding RNA,CARMA,as a negative regulator of *** CARMA specifically fine-tunes CANAR expression in the phloem,the route of sugar *** genetic,molecular,microscopy,and biophysical data suggest that the CARMA–CANAR module controls the shoot-to-root phloem transport of sugars,allows cells to flexibly adapt to the external osmolality by appropriate water uptake,and thus adjust the size of vascular cell types during organ growth and *** study identifies a nexus of plant vascular tissue formation with cell internal pressure monitoring,revealing a novel functional aspect of long non-coding RNAs in developmental biology.

关键词： lncRNA auxin turgor sugar transport cell size

Finding effective combinations of compounds to prevent Alzheimer's disease

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Neural Regeneration Research 2022年第11期17卷 2450-2451页

作者： sudip Dhakal ian Macreadie school of science Bundoora CampusRMIT University

Alzheimer's disease AD remains one of the significant causes of death and morbidity in the older population (2021).The cause of AD remains unclear despite there being numerous *** the most widely accepted hypothesis is the amyloid cascade hypothesis which is based on the accumulation of amyloid beta (Aβ) in neurons (Dhakal et al., 2019).

关键词： Alzheimer Aβ death

Influence of reference states on Jupiter’s dynamo simulations

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Earth and Planetary Physics 2021年第4期5卷 305-313页

作者： LongHui Yuan YuFeng Lin chris AJones Department of Earth and space sciences Southern University of Science and TechnologyShenzhen 518055China Department of Earth sciences The University of Hong KongPokfulam RoadHong KongChina school of Mathematics University of LeedsLeedsLS29JTUnited Kingdom

Jupiter’s magnetic field is thought to be generated in its deep metallic hydrogen region through dynamo action,yet the detailed dynamic process remains poorly *** simulations have produced Jupiter-like magnetic fields,albeit using different control parameters and reference state *** this study,we investigate the influence of different reference state models,based on ab initio calculations and based on the polytropic equation of *** doing so,we perform five anelastic convection dynamo simulations that can be divided into two *** each group,different reference states are used while other control parameters and conditions are set to be *** find the reference state model can be very influential for the simulations in which buoyancy force is dominant over the Lorentz *** this regime,different dynamical outcomes can be attributed to the effective buoyancy force resulting from different reference *** simulations in which the Lorentz force is dominant over the buoyancy force,however,dynamo actions tend to be insensitive to different reference state *** Jupiter’s dynamo is in a strong field regime,i.e.,the Lorentz force plays a dominant role,our numerical results suggest that Jupiter’s internal reference state,which remains poorly constrained,may play a minor role in the dynamo process of the planet.

关键词： giant planets planetary dynamo Jupiter’s magnetic field internal structure

sCENIC HUDsON's LONG DOCK PARK CULTIVATING REsILIENCE:TRANsFORMING A POsT-INDUsTRIAL BROWNFIELD INTO A FUNCTIONAL ECOsYsTEM

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Journal of Green Building 2016年第3期11卷 55-77页

作者： chris Moyles Timothy Craul Reed Hilderbrand LLC Craul Land scientists Inc

scenic Hudson’s Long Dock Park is a resilient living work of art and a vibrant community asset for the Hudson River Valley.A 23-acre peninsula on the east side of the Hudson at Beacon,New York,the site includes the Peter *** Park and the Klara sauer Hudson River *** decades in the making,beginning in 1997,it took a decade to plan and remediate,and,by its completion in early 2017,it will have taken just as long to build and *** 1997,nonprofit scenic Hudson,the largest environmental and land preservation group focused on the Hudson River Valley,started assembling the different ownership parcels of the Long Dock *** 1999 to 2003,they engaged the Beacon community through a series of community meetings and workshops to articulate its vision for its waterfront and cleanup of the site *** 2003 to 2007,the design team developed the architectural and site program for the project,restoration measures,and its physical expression with the *** with the City and the New York state Department of Environmental Conservation(NYsDEC),the project completed the state Environmental Quality Review Act(sEQR)process,filing a Draft Environmental Impact statement(DEIs)and received approval of the final EIs ensuring that there was significant environmental,social,or economic *** NYsDEC and the *** Corps of Engineers(UsACE)were also directly involved in oversight of the brownfield remediation and work within the Hudson River and site *** the sEQR process complete and approval of a mitigation plan from the UsACE,the team worked with the City of Beacon to complete the site plan application process for *** mandate was clear from the start-build resilience,but realize it *** project’s first phase,opened in 2009,included additional remediation and removal of contaminated soils,removal of invasive species,stabilization of the south shoreline,a test plot for different materials,a wetland boardwalk and interior pat

关键词： waterfront park brownfield remediation sustainable sITEs designing soil for the urban environment stormwater treatment invasive plant species

Potential contributions of trace amines in Alzheimer's disease and therapeutic prospects

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Neural Regeneration Research 2021年第7期16卷 1394-1396页

作者： sudip Dhakal ian Macreadie school of science Bundoora CampusRMIT UniversityVictoriaAustralia

Trace amines and their biochemistry: Trace amines represent endogenous monoamines present in very low concentration(usually nM) in the brain in comparison to classical monoamine *** trace amines can regulate the amoun... 详细信息

关键词： amines Trace usual