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Adjuvant-attenuated symptom severity of influenza infections in vaccinated children

Infectious Medicine 2022年第3期1卷 163-170页

作者： Charlotte Switzer chris p.verschoor Eleanor pullenayegum pardeep Singh Mark Loeb Department of Health Methods Evaluation and ImpactMcMaster UniversityHamiltonONCanada Health Sciences North Research Institute SudburyONCanada Dalla Lana School of public Health University of TorontoTorontoONCanada Sick Kids Research Institute TorontoONCanada Department of pathology and Molecular Medicine McMaster UniversityHamiltonONCanada

Background:Young children are at high risk for developing complications of influenza,as well as severe clinical presentation of *** provides direct protection and reduces symptom severity in breakthrough *** assessed whether adjuvanted trivalent seasonal influenza vaccine is associated with symptom severity in children who developed laboratory-confirmed influenza,as compared to children who received quadrivalent inactivated ***:A cluster randomized controlled trial of influenza vaccines in Canadian Hutterite colonies was conducted from the 2016-2017 to the 2018-2019 influenza *** were vaccinated with either quadrivalent inactivated influenza vaccine(QIV),or the MF59 adjuvanted trivalent influenza vaccine(aTIV).We assessed children who developed pCR-confirmed influenza infection for symptom severity outcomes using multivariable generalized negative binomial ***:Among vaccinated children,49 infections were observed across 1779 *** formulation(aTIV vs QIV)was not significantly associated with composite symptom outcomes,including total number of symptoms or total duration of symptom presentation(p>0.05 for all outcomes).Receipt of aTIV vaccination was significantly associated with attenuation of fever,with an estimated 74%reduction in fever *** influenza A type infections,adjuvanted vaccination was significantly associated with reduced systemic symptoms(incidence rate ratios:0.16,95%confidence intervals:0.03,0.64,p=0.01).No associations were observed between vaccine formulation and symptom severity in influenza B ***:In vaccinated children who develop an influenza infection,vaccine formulation was associated with attenuated fever severity,leading to reduced systemic *** influenza A infections,adjuvanted vaccination was significantly associated with reduced systemic symptoms.

关键词： Influenza Adjuvanted influenza vaccine Vaccination Symptoms

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Likelihood of hospitalization for a chronic respiratory condition following pediatric infection with enterovirus and rhinovirus strains

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Infectious Medicine 2022年第4期1卷 245-252页

作者： Charlotte Switzer chris pverschoor Kenneth Gavina Dominik Mertz Kathy Luinstra Jeffrey Mpernica Marek Smieja Dept.of Health Methods Evaluation and ImpactMcMaster UniversityHamiltonON CANADA Dept.of Medicine McMaster UniversityHamiltonON CANADA Dept.of pediatrics McMaster UniversityHamiltonON CANADA Dept.of pathology and Molecular Medicine McMaster UniversityHamiltonON CANADA Research Institute of St Joseph’s Healthcare Hamilton HamiltonON CANADA Health Sciences North Research Institute SudburyON CANADA

Background:Rhino-enteroviruses,particularly enterovirus strain D68(EV-D68),have been associated with severe respiratory distress in *** goal of this study was to compare the long-term outcomes of children with EV-D68 infection to that of children with other enterovirus/***:Nasopharyngeal swabs from 174 children presenting with respiratory distress were tested by pCR for respiratory *** primary outcome was diagnosis of a chronic respiratory condition within the followup *** to intensive care,and length of stay were *** ratios were determined using multinomial logistic ***:During 5 years of follow-up,the crude odds of diagnosis with a chronic respiratory condition were significantly more likely in EV-D68 cases(OR:1.95,95%CI:1.02,3.82),but failed to remain significant after adjusting for a past history of *** admission for a primary concern of asthma,length of stay both in hospital and intensive care were significantly longer in EV-D68 cases(OR:2.10[95%CI:1.56,2.82,pppital,admitted for 1.94 days for each day that controls were admitted(95%CI:1.40,2.68).In admissions to intensive care,EV-D68 cases spent 2.74 days for each day of admission in controls(95%CI:1.62,4.97,pprognostic respiratory outcomes of patients infected with EV-D68 in *** study finds that EV-D68 cases were significantly more likely be hospitalized for longer than other enterovirus/rhinovirus controls in subsequent admissions for respiratory *** for intensive care was significantly longer in EV-D68 *** next steps will be validation in a larger sample size.

关键词： Enterovirus-D68 pediatric infectious disease Respiratory infection Asthma

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Universal insertion of molecules in ionic compounds under pressure

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National Science Review 2024年第1期11卷 120-128页

作者： Feng peng Yanming Ma chris J.pickard Hanyu Liu Maosheng Miao College of physics and Electronic Information Luoyang Normal University Department of Chemistry and Biochemistry California State University Northridge State Key Laboratory of Superhard Materials & Key Laboratory of Material Simulation Methods and Software of Ministry of Education College of Physics Jilin University International Center of Future Science Jilin University Department of Materials Science & Metallurgy University of Cambridge Advanced Institute for Materials Research Tohoku University Department of Earth Science University of California Santa Barbara

Using first-principles calculations and crystal structure search methods, we found that many covalently bonded molecules such as H2, N2, CO2, NH3, H2O and CH4may react with NaC l, a prototype ionic solid,and form stable compounds under pressure while retaining their molecular structure. These molecules,despite whether they are homonuclear or heteronuclear, polar or non-polar, small or large, do not show strong chemical interactions with surrounding Na and Cl ions. In contrast, the most stable molecule among all examples, N2, is found to transform into cyclo-N5-anions while reacting with NaC l under high pressures. It provides a new route to synthesize pentazolates, which are promising green energy materials with high energy density. Our work demonstrates a unique and universal hybridization propensity of covalently bonded molecules and solid compounds under pressure. This surprising miscibility suggests possible mixing regions between the molecular and rock layers in the interiors of large planets.

关键词： molecule-solid hybrid materials high-pressure crystal structure prediction density functional theory planet interior

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Gastroesophageal signet ring cell carcinoma morbidity and mortality: A retrospective review

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1629-1636页

作者： Megan Grinlinton chris Furkert Andrew Maurice Neville Angelo Michael Booth Department of General Surgery North Shore HospitalAuckland 0620New Zealand Department of pathology North Shore HospitalAuckland 0620New Zealand

BACKGROUND Upper gastrointestinal(GI)signet ring cell carcinomas(SRCC)confer a poor *** benefit of operative intervention for this patient group is contro-versial in terms of overall *** To investigate factors relating to survival in patients with upper GI *** A retrospective,tertiary,single-centre review of patients who were diagnosed with oesophageal,gastroesophageal junction and gastric SRCC was *** primary outcome was to compare mortality of patients who underwent operative management with those who had nonoperative ***-dary outcomes included assessing the relationship between demographic and histopathological factors,and *** One hundred and thirty-one patients were *** one-year survival for the operative group was 81%and for the nonoperative group was 19.1%.The five-year survival in the operative group was 28.6%vs 1.5%in the nonoperative *** difference in overall survival between groups was statistically significant(HR 0.19,95%CI(0.13-0.30),ppatients who underwent surgical management,those with a lower stage of disease,and those with a lower Charlson Comorbidity Index(CCI)had significantly improved *** Well-selected patients with upper GI SRCC appear to have reasonable medium-term survival following *** surgery to a carefully selected patient group may improve the outcome for this disease.

关键词： Signet ring cell carcinoma Gastric cancer Oesophageal cancer poorly cohesive gastric cancer Diffuse gastric cancer

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A remarkable class of elliptic surfaces of amplitude 1 in weighted projective spaces

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Science China Mathematics 2024年

作者： Gregory pearlstein chris peters Wim Nijgh Department of Mathematics University of Pisa Department of Mathematics & Computer Science Technical University of Eindhoven Department of Mathematics University of Leiden

Surfaces of amplitude 1 in the ordinary projective space are of the general type, but this need not be the case in weighted projective spaces. Indeed, there are 4 classes of quasi-smooth weighted hypersurfaces in p（1, 2, a, b） of amplitude 1 with an elliptic pencil cut out by hyperplanes. Their moduli spaces are constructed,and the monodromy of their universal families is determined as well as their period maps which turn out to be generally immersive. For those that are not, a mixed Torelli theorem holds. We added an application to certain compactifications of moduli spaces of surfaces of the general type with K2= 1, pg= 2 and q = 0 as a follow up of Gallardo et al.（2022）, as well as detailed SageMath-calculations. The appendix written by Wim Nijgh shows that the general member of the types 1 and 2 elliptic family has a “trivial” picard lattice, i.e., is spanned by fiber components and a multisection.

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Hepatic vein reconstruction during hepatectomy:A feasible and underused technique

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Hepatobiliary & pancreatic Diseases International 2024年第4期23卷 421-427页

作者： Manish Ahuja Kunal Joshi chris Coldham paulo Muiesan Bobby Dasari Manuel Abradelo Ravi Marudanayagam Darius Mirza John Isaac David Bartlett Nikolaos A Chatzizacharias Robert p Sutcliffe Keith J Roberts Department of HpB and Liver Transplant Surgery University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Immunology and Immunotherapy University of BirminghamBirminghamUK

Complete surgical resection(R0)of liver tumors,primary or metastatic,remains the main objective in management of primary and metastatic liver tumors[1].Tumors invading to the proximity of the hepatic venous outflow pose a peculiar challenge to achieve R0 resections,because this location may render a tumor *** median survival of patients with liver tumor without surgery is less than 12 months[2].Even with surgery,post-hepatectomy liver failure and subsequently increased mortality are the main problems associated with complex resection[3].Moreover,when the vein is affected,vein resection and subsequent reconstruction are *** resection is a standard practice in liver resection and transplantation[4],for example,hepatic vein reconstruction during a living-donor liver transplant,porto-mesenteric axis reconstruction during resection of advanced pancreatic cancer and caval reconstruction during resection of retroperitoneal ***,novel techniques like total hepatic vascular exclusion(HVE)[5],veno-venous bypass[6]and ex vivo hepatic resection[7,8]have facilitated curative resections of tumors close to one or more major hepatic veins.

关键词： hepatectomy surgery mortality

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Efficiency of a Modular Cleanroom for Space Applications

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Fluid Dynamics & Materials processing 2024年第3期20卷 547-562页

作者： Matthew R.Coburn Charlie Young chris Smith Graham Schultz Miguel Robayo Zheng-Tong Xie Faculty of Engineering and physical Sciences University of SouthamptonSouthamptonSO171BJUK plastron UK Ltd. Westcott Venture ParkWestcottHP180XBUK Renewable Energy Group University of ExeterExeterTR109FEUK

A prototype cleanroom for hazardous testing and handling of satellites prior to launcher encapsulation,satisfying the ISO8 standard has been designed and analyzed in terms of *** Reynolds Averaged Navier-Stokes(URANS)models have been used to study the related flow field and particulate matter(pM)*** outcomes of the URANS models have been validated through comparison with equivalent large-eddy *** attention has been paid to the location and shape of the air intakes and their orientation in space,in order to balance the pM convection and diffusion inside the *** a cyclone-type flow pattern inside the cleanroom is a key to maintaining a high ventilation efficiency.

关键词： Diffuser LES pM RANS unsteady flow exponential decay

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A Machine Learning Classification Model for Detecting prediabetes

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Journal of Data Analysis and Information processing 2024年第3期12卷 462-478页

作者： A. K. M. Raquibul Bashar Mahdi Goudarzi chris p. Tsokos Department of Mathematics & Computer Science Augustana College Rock Island Illinois USA Independent Researcher San Francisco California USA Department of Mathematics & Statistics University of South Florida Tampa Florida USA

The incidence of prediabetes is in a dangerous condition in the USA. The likelihood of increasing chronic and complex health issues is very high if this stage of prediabetes is ignored. So, early detection of prediabetes conditions is critical to decrease or avoid type 2 diabetes and other health issues that come as a result of untreated and undiagnosed prediabetes condition. This study is done in order to detect the prediabetes condition with an artificial intelligence method. Data used for this study is collected from the Centers for Disease Control and prevention’s (CDC) survey conducted by the Division of Health and Nutrition Examination Surveys (DHANES). In this study, several machine learning algorithms are exploited and compared to determine the best algorithm based on Average Squared Error (ASE), Kolmogorov-Smirnov (Youden) scores, areas under the ROC and some other measures of the machine learning algorithm. Based on these scores, the champion model is selected, and Random Forest is the champion model with approximately 89% accuracy.

关键词： prediabetes Machine Learning SVM Forest Cumulative Lift

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Chronic effects of stretching on range of motion with consideration of potential moderating variables:A systematic review with meta-analysis

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Journal of Sport and Health Science 2024年第2期13卷 186-194页

作者： Andreas Konrad Shahab Alizadeh Abdolhamid Daneshjoo Saman Hadjizadeh Anvar Andrew Graham Ali Zahiri Reza Goudini chris Edwards Carina Scharf David George Behm Institute of Human Movement Science Sport and HealthGraz UniversityGraz A-8010Austria School of Human Kinetics and Recreation Memorial University of NewfoundlandSt.John’sNL A1C 5S7Canada Department of Sport Injuries and Corrective Exercises Faculty of Sport SciencesShahid Bahonar University of KermanKerman 76169-13439Iran

Background:It is well known that stretch training can induce prolonged increases in joint range of motion(ROM).However,to date more information is needed regarding which training variables might have greater influence on improvements in ***,the purpose of this metaanalysis was to investigate the effects of stretch training on ROM in healthy participants by considering potential moderating variables,such as stretching technique,intensity,duration,frequency,and muscles stretched,as well as sex-specific,age-specific,and/or trained state-specific adaptations to stretch ***:We searched through pubMed,Scopus,Web of Science,and SportDiscus to find eligible studies and,finally,assessed the results from 77 studies and 186 effect sizes by applying a random-effect ***,by applying a mixed-effect model,we performed the respective subgroup *** find potential relationships between stretch duration or age and effect sizes,we performed a ***:We found a significant overall effect,indicating that stretch training can increase ROM with a moderate effect compared to the controls(effect size=-1.002;Z=-12.074;95%confidence interval:-1.165 to-0.840;pp analysis showed a significant difference between the stretching techniques(p=0.01)indicating that proprioceptive neuromuscular facilitation and static stretching produced greater ROM than did ballistic/dynamic ***,there was a significant effect between the sexes(p=0.04),indicating that females showed higher gains in ROM compared to ***,further moderating analysis showed no significant relation or ***:When the goal is to maximize ROM in the long term,proprioceptive neuromuscular facilitation or static stretching,rather than ballistic/dynamic stretching,should be *** to consider in future research as well as sports practice is that neither volume,intensity,nor frequency of stretching were

关键词： Flexibility Long-term stretching Stretch training

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Nitrate reduction capacity of the oral microbiota is impaired in periodontitis:potential implications for systemic nitric oxide availability

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International Journal of Oral Science 2024年第1期16卷 52-61页

作者： Bob T.Rosier William Johnston Miguel Carda-Diéguez Annabel Simpson Elena Cabello-Yeves Krystyna piela Robert Reilly Alejandro Artacho chris Easton Mia Burleigh Shauna Culshaw Alex Mira Department of Genomics and Health FISABIO FoundationCenter for Advanced Research in Public HealthValenciaSpain Department of Biological and Biomedical Sciences Glasgow Caledonian UniversityGlasgowUK Oral Sciences University of Glasgow Dental SchoolSchool of MedicineDentistry and NursingCollege of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowUK Sport and physical Activity Research Institute University of the West of ScotlandBlantyreScotland Instituto de Biomedicina de Valencia Consejo Superior de Investigaciones Científicas(IBV-CSIC)ValenciaSpain CIBER Center for Epidemiology and public Health MadridSpain

The reduction of nitrate to nitrite by the oral microbiota has been proposed to be important for oral health and results in nitric oxide formation that can improve cardiometabolic conditions. Studies of bacterial composition in subgingival plaque suggest that nitrate-reducing bacteria are associated with periodontal health, but the impact of periodontitis on nitrate-reducing capacity(NRC)and, therefore, nitric oxide availability has not been evaluated. The current study aimed to evaluate how periodontitis affects the NRC of the oral microbiota. First, 16S rRNA sequencing data from five different countries were analyzed, revealing that nitratereducing bacteria were significantly lower in subgingival plaque of periodontitis patients compared with healthy individuals(p ples per dataset). Secondly, subgingival plaque, saliva, and plasma samples were obtained from 42 periodontitis patients before and after periodontal treatment. The oral NRC was determined in vitro by incubating saliva with 8 mmol/L nitrate(a concentration found in saliva after nitrate-rich vegetable intake) and compared with the NRC of 15healthy individuals. Salivary NRC was found to be diminished in periodontal patients before treatment(p post-treatment. Additionally, the subgingival levels of nitrate-reducing bacteria increased after treatment and correlated negatively with periodontitis-associated bacteria(p periodontal treatment on the baseline saliva and plasma nitrate and nitrite levels was found, indicating that differences in the NRC may only be revealed after nitrate intake. Our results suggest that an impaired NRC in periodontitis could limit dietary nitrate-derived nitric oxide levels, and the effect on systemic health should be explored in future studies.

关键词： impaired intake nitrate

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