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Microglia-Mediated Aβ Propagation in Alzheimer’s Disease

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Neuroscience Bulletin 2022年第10期38卷 1274-1276页

作者： Luoman Yang Shu Feng chongyun wu Luodan Yang Department of Anesthesiology Peking University Third HospitalBeijing100083China Department of Neurology Louisiana State University Health Sciences CenterShreveportLA71103USA Laboratory of Regenerative Medicine in Sports Science School of Physical Education and Sports ScienceSouth China Normal UniversityGuangzhou510006China

The accumulation of extracellular amyloid-βpeptide(Aβ)in thebrain is oneof theprimary pathological hallmarks of Alzheimer's disease(AD)[1].Several factors contribute to theformation and spread of Aβ,includingmicroglia[1,2].Microglia,the primary resident macrophages in the central nervous system,play a vital role in brain development,homeostasis,and neurodegeneration[3,4].

关键词： Aβ Alzheimer homeostasis

Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation

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Translational Neurodegeneration 2020年第2期9卷 248-269页

作者： Luodan Yang Hannah Youngblood chongyun wu Quanguang Zhang Department of Neuroscience and Regenerative Medicine Medical College of GeorgiaAugusta University112015th StreetAugustaGA30912USA Department of Cellular Biology and Anatomy Medical College of GeorgiaAugusta University112015th StreetAugustaGA30912USA

Mitochondrial dysfunction plays a central role in the formation of neuroinflammation and oxidative stress,which are important factors contributing to the development of brain *** evidence suggests mitochondria are a promising target for ***,methods targeting mitochondria have been considered as potential approaches for treatment of brain disease through the inhibition of inflammation and oxidative *** review will discuss two widely studied approaches for the improvement of brain mitochondrial respiration,methylene blue(MB)and photobiomodulation(PBM).MB is a widely studied drug with potential beneficial effects in animal models of brain disease,as well as limited human ***,PBM is a non-invasive treatment that promotes energy production and reduces both oxidative stress and inflammation,and has garnered increasing attention in recent *** and PBM have similar beneficial effects on mitochondrial function,oxidative damage,inflammation,and subsequent behavioral ***,the mechanisms underlying the energy enhancing,antioxidant,and anti-inflammatory effects of MB and PBM *** review will focus on mitochondrial dysfunction in several different brain diseases and the pathological improvements following MB and PBM treatment.

关键词： Mitochondrial dysfunction Neuroprotection Methylene blue Photobiomodulation

Oligodendrocyte progenitor cells in Alzheimer’s disease:from physiology to pathology

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Translational Neurodegeneration 2023年第1期12卷 134-153页

作者： Peibin Zou chongyun wu Timon Cheng-Yi Liu Rui Duan Luodan Yang Laboratory of Exercise and Neurobiology School of Physical Education and Sports ScienceSouth China Normal UniversityGuangzhou 510006China Department of Neurology Louisiana State University Health Sciences Center1501 Kings HighwayShreveportLA 71103USA

Oligodendrocyte progenitor cells(OPCs)play pivotal roles in myelin formation and phagocytosis,communicating with neighboring cells and contributing to the integrity of the blood-brain barrier(BBB).However,under the pathological circumstances of Alzheimer’s disease(AD),the brain’s microenvironment undergoes detrimental changes that significantly impact OPCs and their *** with OPC functions,we delve into the transformation of OPCs to myelin-producing oligodendrocytes,the intricate signaling interactions with other cells in the central nervous system(CNS),and the fascinating process of phagocytosis,which influences the function of OPCs and affects CNS ***,we discuss the essential role of OPCs in BBB formation and highlight the critical contribution of OPCs in forming CNS-protective *** the context of AD,the deterioration of the local microenvironment in the brain is discussed,mainly focusing on neuroinflammation,oxidative stress,and the accumulation of toxic *** detrimental changes disturb the delicate balance in the brain,impacting the regenerative capacity of OPCs and compromising myelin *** pathological conditions,OPCs experience significant alterations in migration and proliferation,leading to impaired differentiation and a reduced ability to produce mature ***,myelin degeneration and formation become increasingly active in AD,contributing to progressive ***,we summarize the current therapeutic approaches targeting OPCs in *** to revitalize OPC senescence,modulate signaling pathways to enhance OPC differentiation,and explore other potential therapeutic avenues are promising in alleviating the impact of AD on OPCs and CNS *** conclusion,this review highlights the indispensable role of OPCs in CNS function and their involvement in the pathogenesis of *** intricate interplay between OPCs and the AD brain microenvironment underscores the complex

关键词： Oligodendrocyte progenitor cells Alzheimer’s disease Senescence Microenvironment

Microglial SIRPα Deletion Facilitates Synapse Loss in Preclinical Models of Neurodegeneration

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Neuroscience Bulletin 2022年第2期38卷 232-234页

作者： chongyun wu Luodan Yang Hannah Youngblood Timon Cheng-Yi Liu Rui Duan Laboratory of Regenerative Medicine in Sports Science School of Physical Education and Sports ScienceSouth China Normal UniversityGuangzhou 510006China Department of Neuroscience and Regenerative Medicine Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA Department of Cellular Biology and Anatomy Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA

Microglia,the principal immune cells in the brain,play a vital role in the development and homeostasis of the central nervous system[1,2].During early brain development,microglia-mediated synapse pruning contributes to eliminating excess synapses that are unnecessary in adulthood[3].Excessive microglia-mediated pruning in the adult brain is implicated in neurodegeneration-associated behav・ioral deficits[4,5].

关键词： degeneration homeostasis clinical

Photobiomodulation:A Potential Non-invasive Method to Alleviate Neurological Events Following COVID-19 Infection

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Neuroscience Bulletin 2023年第10期39卷 1595-1597页

作者： chongyun wu Timon Cheng-Yi Liu Rui Duan Luodan Yang College of Physical Education and Sport Science South China Normal UniversityGuangzhou 510006China

In the past several months,confirmed cases have surged as many countries have loosened their bans on Coronavirus disease 2019(COVID-19)epidemic prevention and *** a respiratory infectious disease caused by a novel coronavirus called SARS-CoV-2,COVID-19 emerged in late December 2019 and lasted for more than three years worldwide[1].

关键词： prevention respiratory cases

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运动改善药物依赖者免疫功能障碍的研究进展

中国体育科技 2021年第6期57卷 38-45页

作者：石海旺李婕吴冲云张福龙张秀丽段锐华南师范大学广东广州510006 华南师范大学-广东省戒毒管理局运动戒毒与康复训练科研合作基地广东广州510006

药物滥用会导致药物依赖者机体免疫系统损坏,抵抗病原体入侵的能力显著下降。而通过药物或心理行为对药物滥用的治疗效果甚微,并由于治疗成本的增加与周期的延长,导致药物依赖者对治疗的依从性下降。随着"体医融合"的开展日益深入,运动... 详细信息

药物滥用会导致药物依赖者机体免疫系统损坏,抵抗病原体入侵的能力显著下降。而通过药物或心理行为对药物滥用的治疗效果甚微,并由于治疗成本的增加与周期的延长,导致药物依赖者对治疗的依从性下降。随着"体医融合"的开展日益深入,运动或体力活动作为戒毒过程中人体机能恢复的一个有效手段逐渐被人们所认识和接受。通过结合阿片类药物对机体免疫系统的损害和运动改善免疫系统功能的相关研究,分析运动提高药物依赖者免疫功能的可行性。

关键词：运动药物依赖成瘾免疫功能戒毒

人类白细胞抗原-抗原肽复合物特异性细胞毒性T细胞的诱生及克隆

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同济医科大学学报 2001年第5期30卷 407-409页

作者：房崇芸吴雄文龚非力华中科技大学同济医学院基础医学院免疫学教研室武汉430030

为建立一种有效诱导及克隆人类白细胞抗原 ( HL A) -抗原肽复合物特异性细胞毒性 T细胞 ( CTL)的方法。用 EB病毒转化的 B淋巴母样细胞系细胞作为刺激细胞 ,采用长期混合淋巴细胞培养法诱导自身外周血 T细胞库中抗原肽 - HL A复合物特异... 详细信息

为建立一种有效诱导及克隆人类白细胞抗原 ( HL A) -抗原肽复合物特异性细胞毒性 T细胞 ( CTL)的方法。用 EB病毒转化的 B淋巴母样细胞系细胞作为刺激细胞 ,采用长期混合淋巴细胞培养法诱导自身外周血 T细胞库中抗原肽 - HL A复合物特异性 CTL 增殖、分化 ,并用有限稀释法对之进行克隆。通过细胞毒实验证实获得的 CD3 +、CD8+ T细胞克隆具有高度抗原特异性并受某些 HL A型别的限制。

关键词：细胞毒性诱生克隆细胞人白细胞抗原抗原肽复合物

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碎屑岩沉积相模式

石油学报 1981年第4期 1-10页

作者：吴崇筠刘宝珺王德发信荃麟项立嵩

本文系根据1980年全国碎屑岩沉积相模式和相标志讨论会的分组总结并参考国内、外研究现状写成的。文中首先谈到沉积相模式的研究在科研和生产上的重要意义,沉积环境、沉积相和沉积相模式的含义,以及鉴别沉积相的主要相标志类型。然后针... 详细信息

本文系根据1980年全国碎屑岩沉积相模式和相标志讨论会的分组总结并参考国内、外研究现状写成的。文中首先谈到沉积相模式的研究在科研和生产上的重要意义,沉积环境、沉积相和沉积相模式的含义,以及鉴别沉积相的主要相标志类型。然后针对我国地层中经常见到的河流相、湖泊相、浊流相、三角洲相、海滩相和潮坪相,以及相标志中的层理进行较详细的阐述。

关键词：沉积相模式沉积模式地质环境碎屑沉积岩碎屑岩前三角洲沉积构造层理地质构造盆地浊流沉积

Dual strategy of modulating growth temperature and inserting ultrathin barrier to enhance the wave function overlap in type-Ⅱ superlattices

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Nano Research 2022年第6期15卷 5626-5632页

作者： Yuyang wu Yahui Zhang Yi Zhang Yunhao Zhao Yu Zhang Yingqiang Xu chongyun Liang Zhichuan Niu Yi Shi Renchao Che Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsDepartment of Materials ScienceFudan UniversityShanghai 200438China State Key Laboratory for Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China National Laboratory of Solid-State Microstructures School of Electronic Science and Engineering and CollaborativeInnovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China Joint-Research Center for Computational Materials Zhejiang LaboratoryHangzhou 311100China

Maximizing wave function overlap(WFO)within type-II superlattices(T2SL)is demonstrated to be important for improving their photoelectric properties,such as optical transition strength and quantum efficiency,which,however,remains a great challenge for ***,the dual strategy of modulating growth temperature and inserting ultrathin AlAs barrier into the AlSb layers is presented to enhance the WFO in InAs/AlSb *** charge distributions and strain states indicate that moderate growth temperature of 470°C promotes the As-Sb exchange at AlSb-on-InAs(AOI)interfaces,which would introduce skew of energy band structure towards InAs-on-AlSb(IOA)*** band structure could drive electrons and holes to the IOA interfaces simultaneously,thus resulting in the enhanced *** this basis,insertion of relatively thick(0.3 nm)AlAs layers is found to squeeze more holes towards adjacent interfaces,boosting the WFO *** InAs/AlSb superlattices with optimized WFO reveal better optical performance,where the peak intensity shows 50%improvement in the PL spectra than the original ***,a dual-miniband radiative transition mechanism appears in the InAs/AlSb superlattice with relatively thick AlAs intercalation,which helps broaden the wavelength range of the superlattice.

关键词： wave function overlap type-II superlattices photoelectric properties charge distribution energy band alignment