Microglia-Mediated Aβ Propagation in Alzheimer’s Disease

作     者：Luoman Yang Shu Feng Chongyun Wu Luodan Yang Luoman Yang;Shu Feng;Chongyun Wu;Luodan Yang

作者机构：Department of AnesthesiologyPeking University Third HospitalBeijing100083China Department of NeurologyLouisiana State University Health Sciences CenterShreveportLA71103USA Laboratory of Regenerative Medicine in Sports ScienceSchool of Physical Education and Sports ScienceSouth China Normal UniversityGuangzhou510006China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2022年第38卷第10期

页      面：1274-1276页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：This highlight was supported by the National Natural Science Foundation of China(32100918) the Sigma Xi Grants in Aid of Research program(G03152021115804390) 

主　　题：Aβ Alzheimer homeostasis 

摘      要：The accumulation of extracellular amyloid-βpeptide(Aβ)in thebrain is oneof theprimary pathological hallmarks of Alzheimer s disease(AD)[1].Several factors contribute to theformation and spread of Aβ,includingmicroglia[1,2].Microglia,the primary resident macrophages in the central nervous system,play a vital role in brain development,homeostasis,and neurodegeneration[3,4].