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基于异构数据融合的SLAM研究综述

南京信息工程大学学报 2024年第4期16卷 490-503页

作者：周铖君陈炜峰尚光涛王曦杨徐崇辉李振雄南京信息工程大学自动化学院南京210044

激光与视觉SLAM技术经过几十年的发展,目前都已经较为成熟,并被广泛应用于军事和民用领域.单一传感器的SLAM技术都存在局限性,如激光SLAM不适用于周围存在大量动态物体的场景,而视觉SLAM在低纹理环境中鲁棒性差,但两者融合使用具有巨大... 详细信息

激光与视觉SLAM技术经过几十年的发展,目前都已经较为成熟,并被广泛应用于军事和民用领域.单一传感器的SLAM技术都存在局限性,如激光SLAM不适用于周围存在大量动态物体的场景,而视觉SLAM在低纹理环境中鲁棒性差,但两者融合使用具有巨大的取长补短的潜力,激光与视觉甚至是更多传感器融合的SLAM技术将会是未来的主流方向.本文回顾了SLAM技术的发展历程,分析了激光雷达与视觉的硬件信息,给出了一些经典的开源算法与数据集.根据融合传感器所使用的算法,从传统基于不确定度、基于特征以及基于深度学习的角度详细介绍了多传感器融合方案,概述了多传感器融合方案在复杂场景中的优异性能,并对未来发展作出了展望.

关键词：同时定位与地图构建(SLAM) 激光SLAM 视觉SLAM 多传感器融合移动机器人

Development of a novel virus-like particle-based vaccine for preventing tick-borne encephalitis virus infection

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Virologica Sinica 2023年第5期38卷 767-777页

作者： Jielin Tang Muqing Fu chonghui xu Bao xue Anqi Zhou Sijie Chen He Zhao Yuan Zhou Jizheng Chen Qi Yang Xinwen Chen Guangzhou National Laboratory Guangzhou510005China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan430071China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou510530China GMU-GIBH Joint School of Life Sciences Guangzhou Medical UniversityGuangzhou511436China State Key Laboratory of Respiratory Disease Guangzhou Medical UniversityGuangzhou511436China

Tick-borne encephalitis virus(TBEV)is an important tick-borne pathogen that poses as a serious public health *** coverage and immunogenicity of the currently available vaccines against TBEV are relatively low;therefore,it is crucial to develop novel and effective vaccines against *** present study describes a novel strategy for the assembly of virus-like particles(VLPs)by co-expressing the structural(core/prM/E)and non-structural(NS2B/NS3Pro)proteins of *** efficacy of the VLPs was subsequently evaluated in C57BL/6 mice,and the resultant IgG serum could neutralize both Far-Eastern and European subtypes of *** findings indicated that the VLP-based vaccine elicited the production of cross-subtype reactive *** VLPs provided protection to mice lacking the type I interferon receptor(IFNAR^(-/-))against lethal TBEV challenge,with undetectable viral load in brain and intestinal ***,the group that received the VLP vaccine did not exhibit significant pathological changes and the inflammatory factors were significantly suppressed compared to the control *** with the VLP vaccine induced the production of multiple-cytokine-producing antiviral CD4+T cells in vivo,including TNF-α^(+),IL-2^(+),and IFN-γ^(+)T ***,the findings suggest that noninfectious VLPs can serve as a potentially safe and effective vaccine candidate against diverse subtypes of TBEV.

关键词： Tick-borne encephalitis virus(TBEV) Virus-like particle(VLP) Immunogenicity Neutralization Vaccine

Comparison of viral propagation and drug response among SARS-CoV-2 VOCs using replicons capable of recapitulating virion assembly and release

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Virologica Sinica 2022年第5期37卷 695-703页

作者： Lingqian Tian Qiuhong Liu Rongjuan Pei Yingshan Chen chonghui xu Jielin Tang Hao Sun Kunpeng Liu Qi Yang Lei Yang Leshan Li Yongli Zhang Yuan Zhou Chao Shan xue Hu Xinwen Chen Yun Wang State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Department of Gastroenterology Guangzhou Women and Children's Medical CenterGuangzhou510623China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou510530China Innovation Center for Pathogen Research Guangzhou LaboratoryGuangzhou510320China

Several variants of concern(VOCs)have emerged since the WIV04 strain of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was first isolated in January *** to mutations in the spike(S)protein,these VOCs have evolved to enhance viral infectivity and immune ***,whether mutations of the other viral proteins lead to altered viral propagation and drug resistance remains *** replicon is a noninfectious viral surrogate capable of recapitulating certain steps of the viral life *** several SARS-CoV-2 replicons have been developed,none of them were derived from emerging VOCs and could only recapitulate viral genome replication and subgenomic RNA(sgRNA)*** this study,SARS-CoV-2 replicons derived from the WIV04 strain and two VOCs(the Beta and Delta variants)were prepared by removing the S gene from their genomes,while other structural genes remained *** replicons not only recapitulate viral genome replication and sgRNA transcription but also support the assembly and release of viral-like particles,as manifested by electron microscopic ***,the S-deletion replicon could recapitulate virtually all the post-entry steps of the viral life cycle and provides a versatile tool for measuring viral intracellular propagation and screening novel antiviral drugs,including inhibitors of virion assembly and *** the quantification of replicon RNA released into the supernatant,we demonstrate that viral intracellular propagation and drug response to remdesivir have not yet substantially changed during the evolution of SARS-CoV-2 from the WIV04 strain to the Beta and Delta VOCs.

关键词： SARS-CoV-2 Variants of concern(VOC) Viral-like particle(VLP) Replicon Remdesivir

Histone Deacetylase 3 Inhibitor Suppresses Hepatitis C Virus Replication by Regulating Apo-A1 and LEAP-1 Expression

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Virologica Sinica 2018年第5期33卷 418-428页

作者： Yuan Zhou Qian Wang Qi Yang Jielin Tang chonghui xu Dongwei Gai Xinwen Chen Jizheng Chen State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100101China Jiangsu Province Key Laboratory of Human Functional Genomies Department of Biochemistry and Molecular BiologyNanjing Medical UniversityNanjing 210029China

Histone deacetylase (HDAC) inhibitors show clinical promise for the treatment of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the effect of HDAC inhibitor treatment on hepatitis C virus (HCV)replication in Huh7 human liver cells and in a mouse model of HCV infection. Viral replication was markedly suppressed by the HDAC3 inhibitor at concentrations below 1 mmol/L, with no cellular toxicity. This was accompanied by upregulation of liver-expressed antimicrobial peptide 1 (LEAP-1) and downregulation of apolipoprotein-A1 (Apo-A1), as determined by microarray and quantitative RT-PCR analyses. Moreover, HDAC3 was found to modulate the binding of CCAAT-enhancer-binding protein a (C/EBPa), hypoxia-inducible factor 1 a (HIF1 a), and signal transducer and activator of transcription 3 (STAT3) to the LEAP-1 promoter. HDAC3 inhibitor treatment also blocked HCV replication in a mouse model of HCV infection. These results indicate that epigenetic therapy with HDAC3 inhibitor may be a potential treatment for diseases associated with HCV infection such as HCC.

关键词： Hepatitis C virus (HCV) HDAC3 Apolipoprotein-A1 (Apo-A1) LEAP-1 Hepatocellular carcinoma Viral replication

Histone deacetylase 4 inhibits NF-κB activation by facilitating IκBα sumoylation

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Journal of Molecular Cell Biology 2020年第12期12卷 933-945页

作者： Qi Yang Jielin Tang chonghui xu He Zhao Yuan Zhou Yanyi Wang Min Yang Xinwen Chen Jizheng Chen Department of Gastroenterology Guangzhou Women and Children's Medical CenterGuangzhou 510623China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China

Protein modification by small ubiquitin-like modifier(SUMO)is an important regulatory mechanism for multiple cellular *** the canonical pathway involving the ubiquitylation or phosphorylation of IκBα has been well characterized,little is known about the sumoylation of IkBa in the control of NF-κB ***,we find that histone deacetylase 4(HDAC4)negatively regulates tumor necrosis factor-alpha-or lipopolysaccharide-triggered NF-κB ***4 belongs to the SUMO E3 ligase family and can directly sumoylate IκBα.The cytoplasm location of HDAC4 is essential for IκBα*** Cys292 of HDAC4 is a key site for its SUMO E3 ligase *** sumoylation of IkBc prevents its polyubiquitination and degradation be-cause these two modifications occur both at the *** findings reveal a previously undiscovered role for HDAC4 in the inflammatory response as a SUMO E3 ligase for IκBα*** work provides insight into mechanisms ensuring optimal mediation of the NF-κB pathway.

关键词： histone deacetylase 4 sumoylation IκBα NF-κB SUMO E3 ligase

Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3

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Journal of Molecular Cell Biology 2019年第2期11卷 158-169页

作者： Qi Yang Jielin Tang Rongjuan Pei XiaoXiao Gao Jing Guo chonghui xu Yun Wang QianWang Chunchen Wu Yuan Zhou xue Hu He Zhao Yanyi Wang Xinwen Chen Jizheng Chen State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China University of Chinese Academy of Sciences Beijing 100049 China Key Laboratory of Human Functional Genomics of Jiangsu Province School of Basic Medical Science Nanjing Medical University Nanjing 210093 China

Class II HDACs, such as HDAC4, are critical regulators of the immune response in various immune cells;however, its role in innate immunity remains largely ***, we report that the overexpression of HDAC4 suppresses the production of type I interferons triggered by pattern-recognition receptors (PRRs). HDAC4 repressed the translocation of transcription factor IRF3 to the nucleus, thereby decreasing IRF3-mediated IFN-β expression. In particular, we also determined that HDAC4 can be phosphorylated and simultaneously block the phosphorylation of IRF3 at Ser386 and Ser396 by TBK1 and IKKε, respectively, by interacting with the kinase domain of TBK1 and IKKε. Furthermore, IFN-β may stimulate the expression of HDAC4. Our findings suggest that HDAC4 acts as a regulator of PRR signaling and is a novel mechanism of negative feedback regulation for preventing an overreactive innate immune response.

关键词： HDAC4 antiviral response IRF3 TBK1 IKKε

Functions of human histone deacetylase 5(HDAC5) in the innate immune signaling pathways

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Functions of human histone deacetylase 5(HDAC5) in the innat...

产前超声心动图诊断胎儿复杂先天性心脏病1例

第十三届全国免疫学学术大会

作者： chonghui xu Jielin Tang Qi Yang Jizheng Chen Xinwen Chen State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences University of Chinese Academy of Sciences

As a member of the class IIa family of histone deacetylases, the histone deacetylase 5(HDAC5) is known to be a critical transcriptional regulator and linked to prominent human diseases, including cardiac diseases and *** we find that knockdown of HDAC5 in human cell lines and bone marrow-derived macrophages(BMDMs) from mice results in attenuated phosphorylation of p65 at ***, the levels of inflammation-related cytokines, such as TNF-α and IL-6, obviously reduced in cell culture supernatant after lipopolysaccharide(LPS) stimulation compared to the wild-type *** summary, our findings suggest that HDAC5 acts as a new regulator of anti-inflammatory responses.

关键词： histone deacetylase 5 innate immune anti-inflammatory response

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中国医学影像技术 2022年第7期38卷 1107-1108页

作者：徐星胡雪飞袁红霞周启昌许崇惠郭黎漓田蕾琪长沙市妇幼保健院超声科湖南长沙410007 浏阳市妇幼保健院超声科湖南长沙410300 湘雅二医院超声科湖南长沙410000

孕妇20岁,孕1产0,孕22+6周,未经规律产检,外院超声提示胎儿肺动脉狭窄;既往体健,无家族遗传病史。产前超声心动图:胎儿心脏位置、心胸比未见明显异常,左心房内见飘动的高回声带,左侧房室瓣似呈三叶;右心室长径较短,心尖部见调节束样声像... 详细信息

孕妇20岁,孕1产0,孕22+6周,未经规律产检,外院超声提示胎儿肺动脉狭窄;既往体健,无家族遗传病史。产前超声心动图:胎儿心脏位置、心胸比未见明显异常,左心房内见飘动的高回声带,左侧房室瓣似呈三叶;右心室长径较短,心尖部见调节束样声像,右侧房室瓣较左侧更靠近心尖、开放受限;主动脉粗大,肺动脉窄小,起始部交叉;右侧房室瓣口舒张期仅见小股流入道血流,收缩期见反流;肺动脉连于右心室,血流来自动脉导管逆向灌注,肺动脉瓣未见明显启闭运动,瓣下见反流(图1A、1B);诊断:胎儿复杂先天性心脏病,考虑肺动脉狭窄、动脉导管逆向灌注,右心室发育不良?

关键词：胎儿心脏先天性畸形超声检查,产前

Functional characterization of the human histone deacetylase 3(HDAC3) in the innate immune signaling pathways

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Functional characterization of the human histone deacetylase...