Functions of human histone deacetylase 5(HDAC5) in the innate immune signaling pathways
作者单位：State Key Laboratory of VirologyWuhan Institute of Virology Chinese Academy of Sciences University of Chinese Academy of Sciences
会议名称：《第十三届全国免疫学学术大会》
会议日期：2018年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
关 键 词：histone deacetylase 5 innate immune anti-inflammatory response
摘 要：As a member of the class IIa family of histone deacetylases, the histone deacetylase 5(HDAC5) is known to be a critical transcriptional regulator and linked to prominent human diseases, including cardiac diseases and *** we find that knockdown of HDAC5 in human cell lines and bone marrow-derived macrophages(BMDMs) from mice results in attenuated phosphorylation of p65 at ***, the levels of inflammation-related cytokines, such as TNF-α and IL-6, obviously reduced in cell culture supernatant after lipopolysaccharide(LPS) stimulation compared to the wild-type *** summary, our findings suggest that HDAC5 acts as a new regulator of anti-inflammatory responses.