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Current Medical Science 2023年第1期43卷 35-47页

作者： Ning JI chong-guang wu Xiao-die WANG Zhi-xue SONG Pei-yuan wu Xin LIU Xu FENG Xiang-mei ZHANG Xiu-fang WANG Zhan-jun LV Department of Genetics Hebei Medical UniversityHebei Key Lab of Laboratory AnimalShijiazhuang 050017China Research Center Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011China

Objective:To investigate whether human short interspersed nuclear element antisense RNA(Alu antisense RNA;Alu asRNA)could delay human fibroblast senescence and explore the underlying ***:We transfected Alu asRNA into senescent human fibroblasts and used cell counting kit-8(CCK-8),reactive oxygen species(ROS),and senescence-associated beta-galactosidase(SA-β-gal)staining methods to analyze the anti-aging effects of Alu asRNA on the *** also used an RNA-sequencing(RNA-seq)method to investigate the Alu asRNA-specific mechanisms of *** examined the effects of KIF15 on the anti-aging role induced by Alu *** also investigated the mechanisms underlying a KIF15-induced proliferation of senescent human ***:The CCK-8,ROS and SA-β-gal results showed that Alu asRNA could delay fibroblast ***-seq showed 183 differentially expressed genes(DEGs)in Alu asRNA transfected fibroblasts compared with fibroblasts transfected with the calcium phosphate transfection(CPT)*** KEGG analysis showed that the cell cycle pathway was significantly enriched in the DEGs in fibroblasts transfected with Alu asRNA compared with fibroblasts transfected with the CPT ***,Alu asRNA promoted the KIF15 expression and activated the MEK-ERK signaling ***:Our results suggest that Alu asRNA could promote senescent fibroblast proliferation via activation of the KIF15-mediated MEK-ERK signaling pathway.

关键词： senescent fibroblast cell proliferation Alu antisense RNA KIF15 gene expression MEK-ERK signaling pathway cell cycle

Alu antisense RNA ameliorates methylglyoxal-induced human lens epithelial cell apoptosis by enhancing antioxidant defense

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International Journal of Ophthalmology(English edition) 2023年第2期16卷 178-190页

作者： Pei-Yuan wu Ning Ji chong-guang wu Xiao-Die Wang Xin Liu Zhi-Xue Song Murad Khan Suleman Shah Ying-Hua Du Xiu-Fang Wang Li-Fang Yan Department of Genetics Hebei Medical UniversityHebei Key Lab of Laboratory AnimalShijiazhuang 050017Hebei ProvinceChina Department of Ophthalmology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

AIM:To determine whether an antisense RNA corresponding to the human Alu transposable element(Aluas RNA)can protect human lens epithelial cells(HLECs)from methylglyoxal-induced ***:Cell counting kit-8(CCK-8)and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assays were used to assess HLEC *** viability/death was detected using a Calcein-AM/PI double staining kit;the annexin V-FITC method was used to detect HLEC *** cytosolic reactive oxygen species(ROS)levels in HLECs were determined using a reactive species assay *** levels of malondialdehyde(MDA)and the antioxidant activities of total-superoxide dismutase(T-SOD)and glutathione peroxidase(GSH-Px)were assessed in HLECs using their respective ***-q PCR and Western blotting were used to measure m RNA and protein expression levels of the ***:Aluas RNA rescued methylglyoxal-induced apoptosis in HLECs and ameliorated both the methylglyoxalinduced decrease in Bcl-2 m RNA and the methylglyoxalinduced increase in Bax m *** addition,Aluas RNA inhibited the methylglyoxal-induced increase in Alu sense RNA *** RNA inhibited the production of ROS induced by methylglyoxal,restored T-SOD and GSHPx activity,and moderated the increase in MDA content after treatment with *** RNA significantly restored the methylglyoxal-induced down-regulation of Nrf2 gene and antioxidant defense genes,including glutathione peroxidase,heme oxygenase 1,γ-glutamylcysteine synthetase and quinone oxidoreductase *** RNA ameliorated methylglyoxal-induced increases of the m RNA and protein expression of Keap1 that is the negative regulator of ***:Aluas RNA reduces apoptosis induced by methylglyoxal by enhancing antioxidant defense.

关键词： human Alu antisense RNA human lens epithelial cells methylglyoxal toxicity antioxidant defense apoptosis

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu Jing wu guang Yin Fan‑Zhen Jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

Efficient and Stable Perovskite Solar Cells and Modules Enabled by Tailoring Additive Distribution According to the Film Growth Dynamics

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Nano-Micro Letters 2025年第2期17卷 387-400页

作者： Mengen Ma Cuiling Zhang Yujiao Ma Weile Li Yao Wang Shaohang wu chong Liu Yaohua Mai Institute of New Energy Technology College of Physics&Optoelectronic EngineeringJinan UniversityGuangzhou 510632People’s Republic of China Key Laboratory of New Semiconductors and Devices of guangdong Higher Education Institutes Jinan UniversityGuangzhou 510632People’s Republic of China guangdong Mellow Energy Co. LimitedYuanming RoadZhuhai 519075GuangdongPeople’s Republic of China

Gas quenching and vacuum quenching process are widely applied to accelerate solvent volatilization to induce nucleation of perovskites in blade-coating *** this work,we found these two pre-crystallization processes lead to different order of crystallization dynamics within the perovskite thin film,resulting in the differences of additive *** then tailor-designed an additive molecule named 1,3-bis(4-methoxyphenyl)thiourea to obtain films with fewer defects and holes at the buried interface,and prepared perovskite solar cells with a certified efficiency of 23.75%.Furthermore,this work also demonstrates an efficiency of 20.18%for the large-area perovskite solar module(PSM)with an aperture area of 60.84 cm^(2).The PSM possesses remarkable continuous operation stability for maximum power point tracking of T_(90)>1000 h in ambient air.

关键词： Gas quenching Additive distribution Buried passivation Blade coating Crystallization dynamics

智慧医疗情境下四方主体隐私行为的交互机理及演化趋势研究

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现代情报 2025年第1期45卷 135-149页

作者：朱光吴晗逸刘雯南京信息工程大学风险治理与应急决策研究院江苏南京210044 南京信息工程大学管理工程学院江苏南京210044

[目的/意义]本文针对智慧医疗情境下隐私行为研究在博弈主体、模型参数等方面的不足,探寻患者、医疗机构、智慧医疗平台和政府四方主体之间的隐私行为交互机理与演化趋势。[方法/过程]基于演化博弈理论,构建患者、医疗机构、智慧医疗平... 详细信息

[目的/意义]本文针对智慧医疗情境下隐私行为研究在博弈主体、模型参数等方面的不足,探寻患者、医疗机构、智慧医疗平台和政府四方主体之间的隐私行为交互机理与演化趋势。[方法/过程]基于演化博弈理论,构建患者、医疗机构、智慧医疗平台和政府四方博弈模型。根据不同参数调节下各方行为策略的收益、成本、损失等计算收益矩阵,求解主体的演化稳定策略,并考虑不同因素对主体行为策略及系统稳定状态的影响。[结果/结论]患者的隐私披露行为与披露隐私后获得的服务收益密切相关,医疗机构的隐私保护投入成本和隐私泄露概率对其隐私保护行为有显著影响,智慧医疗平台的政府奖惩、罚款收益和投入成本是影响其严格管理行为的关键因素,政府的监管行为与奖惩机制等因素密切相关。通过应用本文模型和方法,可以动态调整隐私保护机制,明确各方职责,推动智慧医疗可持续健康发展。

关键词：智慧医疗演化博弈隐私行为患者医疗机构智慧医疗平台政府

FIXED POINTS OF INCREASING OPERATORS IN ORDERED SPACE WITH APPLICATIONS

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Applied Mathematics and Mechanics(English Edition) 2002年第3期23卷 341-349页

作者： YANG guang-chong(杨光崇) Department of Basic Computation Science Chengdu University of Information Technology Chengdu 610041 P R China

The minimal-maximal fixed points theorems of increasing operators are proved in ordered space and some well-known results of increasing operators and monotone operators are improved and generalized. The obtained results are then applied to singular nonlinear boundary problem in ordinary differential equation without any assumption of continuity, compactness, convexity and concavity.

关键词： ordered space supremum and infimum increasing operator and fixed point singular boundary problem

Advanced Functional Electromagnetic Shielding Materials:A Review Based on Micro‑Nano Structure Interface Control of Biomass Cell Walls

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Nano-Micro Letters 2025年第1期17卷 98-134页

作者： Yang Shi Mingjun wu Shengbo Ge Jianzhang Li Anoud Saud Alshammari Jing Luo Mohammed A.Amin Hua Qiu Jinxuan Jiang Yazeed M.Asiri Runzhou Huang Hua Hou Zeinhom M.El‑Bahy Zhanhu Guo chong Jia Kaimeng Xu Xiangmeng Chen Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037People’s Republic of China State Key Laboratory of Efficient Production of Forest Resourced Beijing Forestry UniversityQinghua East Road 35Haidian DistrictBeijing 100083People’s Republic of China Department of Physics Faculty of Sciences‑ArarNorthern Border UniversityArar 91431Saudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 1109921944 TaifSaudi Arabia Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Integrated Composites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024People’s Republic of China Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr CityCairo 11884Egypt Yunnan Provincial Key Laboratory of Wood Adhesives and Glued Products International Joint Research Center for Biomass MaterialsSouthwest Forestry UniversityKunming 650224People’s Republic of China School of Science Henan Agricultural UniversityZhengzhou 450002People’s Republic of China

Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass *** materials offer numerous advantages such as being lightweight,porous,and *** to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding *** concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding *** particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be *** preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and *** composite methods and fillers of various biomass materials were *** paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.

关键词： Biomass materials Electromagnetic interference shielding Micro-nano structure interface control Conductivity

Recent advances in catalytica symmetric Buchner reaction

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Chinese Chemical Letters 2023年第12期34卷 87-92页

作者： chong-Yang Shi guang-Yu Zhu Yin Xu Ming-Yu Teng Long-wu Ye College of Chemistry and Chemical Engineering Yunnan Normal UniversityKunming 650500China Key Laboratory of Chemical Biology of Fujian Province State Key Laboratory of Physical Chemistry of Solid Surfacesand College of Chemistry and Chemical EngineeringXiamenUniversity.Xiamen361005China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Bichner reaction,as a unique type of expansive dearomatization,has become a practical strategy for the straightforward assembly of valuable functionalized cycloheptatrienes from ubiquitous aromatic *** the asymmetric version has been investigated since the early 1990s,enantioselective Bichner reaction is still limited by the catalyst type and substrate *** review aims to propose the limitation and possible development direction of this field by summarizing the evolution of catalytic asymmetric Bichner reaction,which is organized on the basis of intra-and intermolecular *** the different metal carbene precursors,the reactions are further classified by carbene sources.

关键词： Bichner reaction Diazo compounds Metal carbenes Cycloheptatrienes Dearomatization reactions

The cross-ratio distortion of integrably asymptotic affine homeomorphism of unit circle

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Science China Mathematics 2012年第3期55卷 625-632页

作者： wu chong Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China

Let QS* (S 1) be the space of quasisymmetric homeomorphisms of the unit circle such that the corresponding subspace of the universal Teichmu¨ller space has Weil-Petersson *** this paper we give a necessary condition ... 详细信息

关键词： universal Teichm/iller space quasisymmetric homeomorphism Weil-Petersson metric cross-ratio

Disagreement and Antagonism in Signed Networks: A Survey

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IEEE/CAA Journal of Automatica Sinica 2022年第7期9卷 1166-1187页

作者： Yuxin wu Deyuan Meng Zheng-guang wu Seventh Research Division Beihang University(BUAA)and also with the School of Automation Science and Electrical EngineeringBeihang University(BUAA)Beijing 100191China National Laboratory of Industrial Control Techno-logy Institute of Cyber-Systems and ControlZhejiang UniversityHangzhou 310027China IEEE

Signed networks refer to a class of network systems including not only cooperative but also antagonistic interactions among *** to the existence of antagonistic interactions in signed networks,the agreement of nodes may not be established,instead of which disagreement behaviors generally *** paper reviews several different disagreement behaviors in signed networks under the single-integrator linear dynamics,where two classes of topologies,namely,the static topology and the dynamic topology,are *** the static signed networks with the adjacency weights as(time-varying)scalars,we investigate the convergence behaviors and the fluctuation behaviors with respect to fixed topologies and switching topologies,respectively,and give some brief introductions on the disagreement behaviors of general time-varying signed ***,several classes of behavior analysis approaches are also *** the dynamic signed networks with the adjacency weights as transfer functions or linear time-invariant systems,we show the specific descriptions and characteristics of them such that the disagreement behaviors can be obtained by resorting to the derived static signed ***,we give their applications to the behavior analysis of static signed networks in the presence of high-order dynamics or communication delays.

关键词： Antagonistic interaction disagreement behavior dynamic topology signed network static topology