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Diffuse reduction of spleen density is a novel prognostic marker for intrahepatic cholangiocarcinoma after curative resection

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World Journal of Gastrointestinal Oncology 2021年第8期13卷 929-942页

作者： Li-ming Deng Yi Wang Jin-Huan Yang Jia-Liang Li Zi-Yan Chen Wen-ming Bao Kai-Yu Chen Xin-Fei Yao chong-ming zheng Jiu-Yi zheng zheng-Ping Yu Bin Jin Gang Chen Department of Hepatobiliary Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina Department of Epidemiology and Biostatistics School of Public Health and ManagementWenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina Division of Clinical Medicine First School of Clinical MedicineWenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina Department of Hepatobiliary Surgery Qilu Hospital Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Diffuse reduction of spleen density(DROSD)is related to cancer prognosis;however,its role in intrahepatic cholangiocarcinoma(ICC)remains *** To assess the predictive value of DROSD in the prognosis of ICC after curative *** In this multicenter retrospective cohort study,we enrolled patients with ICC who underwent curative hepatectomy between 2012 and *** spleen density was measured using computed *** survival(OS)and recurrence-free survival(RFS)rates were calculated and compared utilizing the Kaplan-Meier *** and multivariable Cox regression analyses were applied to identify independent factors for OS and RFS.A nomogram was created with independent risk factors to predict prognosis of patients with *** One hundred and sixty-seven ICC patients were *** on the diagnostic cut-off values(spleen density≤45.5 Hounsfield units),55(32.9%)patients had ***-Meier analysis indicated that patients with DROSD had worse OS and RFS than those without DROSD(P<0.05).Cox regression analysis revealed that DROSD,carcinoembryonic antigen level,carbohydrate antigen 19-9 level,length of hospital stay,lymph node metastasis,and postoperative complications were independent predictors for OS(P<0.05).The nomogram created with these factors was able to predict the prognosis of patients with ICC with good reliability(OS C-index=0.733).The area under the curve for OS was *** ICC patients with DROSD have worse OS and *** nomogram is a simple and practical method to identify high-risk ICC patients with poor prognosis.

关键词： Intrahepatic cholangiocarcinoma Nomogram Prognosis Diffuse reduction of spleen density Overall survival Recurrence-free survival

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From ancient wisdom to modern science:Gut microbiota sheds light on property theory of traditional Chinese medicine

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Journal of Integrative Medicine 2024年第4期22卷 413-444页

作者： Ya-nan Yang Jia-guo Zhan Ying Cao chong-ming Wu School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine Tianjin 301617China

The property theory of traditional Chinese medicine(TCM) has been practiced for thousands of years,playing a pivotal role in the clinical application of TCM. While advancements in energy metabolism,chemical composition analysis, machine learning, ion current modeling, and supercritical fluid technology have provided valuable insight into how aspects of TCM property theory may be measured, these studies only capture specific aspects of TCM property theory in isolation, overlooking the holistic perspective inherent in TCM. To systematically investigate the modern interpretation of the TCM property theory from multidimensional perspectives, we consulted the Chinese Pharmacopoeia(2020 edition) to compile a list of Chinese materia medica(CMM). Then, using the Latin names of each CMM and gut microbiota as keywords, we searched the PubMed database for relevant research on gut microbiota and CMM. The regulatory patterns of different herbs on gut microbiota were then summarized from the perspectives of the four natures, the five flavors and the meridian tropism. In terms of the four natures, we found that warm-natured medicines promoted the colonization of specific beneficial bacteria,while cold-natured medicines boosted populations of some beneficial bacteria while suppressing pathogenic bacteria. Analysis of the five flavors revealed that sweet-flavored and bitter-flavored CMMs positively influenced beneficial bacteria while inhibiting harmful bacteria. CMMs with different meridian tropism exhibited complex modulative patterns on gut microbiota, with Jueyin(Liver) and Taiyin(Lung) meridian CMMs generally exerting a stronger effect. The gut microbiota may be a biological indicator for characterizing the TCM property theory, which not only enhances our understanding of classic TCM theory but also contributes to its scientific advancement and application in healthcare.

关键词： Traditional Chinese medicine Property theory Gut microbiota Four natures Five flavors Meridian tropism

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A Self-Healing Elastomer with Extremely High Toughness Achieved by Acylsemicarbazide Hydrogen Bonding and Cu^(2+)-Neocuproine Coordination Interactions

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Chinese Journal of Polymer Science 2024年第10期42卷 1425-1434,I0007页

作者： Xiao-ming An Yi-Ping Wang Tang-Song Zhu chong Xing Xu-Dong Jia Qiu-Hong Zhang Key Laboratory of High Performance Polymer Material and Technology of MOE Department of Polymer Science and EngineeringSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing210093China State Key Laboratory of Coordination Chemistry Nanjing UniversityNanjing210093China

Elastomers with high mechanical toughness can guarantee their durability during service ***-healing ability,as well as recyclability,can also extend the life of materials and save the consuming cost of the *** efforts have been dedicated to promoting the mechanical toughness as well as the self-healing capability of elastomers at the same time,while it remains a challenge to balance the trade-off between the above properties in one *** we proposed a molecular design driven by dual interactions of acylsemicarbazide hydrogen bonding and Cu^(2+)-neocuproine coordination *** introducing the reversible multiple hydrogen bonds and strong coordination bonds,we successfully fabricated an extremely tough and self-healing *** elastomer can achieve an impressive top-notch toughness of 491 MJ/m^(3).Furthermore,it boasted rapid elastic restorability within 10 min and outstanding crack tolerance with high fracture energy(152.6kJ/m^(2)).Benefiting from the combination of dynamic interactions,the material was able to self-repair under 80℃conveniently and could be reprocessed to restore the exceptional mechanical properties.

关键词： Metal-ligand coordination Hydrogen bond Ultra-tough elastomer Self-healing

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Highly Stretchable and Tunable Thermo-fluorochromic Polymer Elastomer through Eu^(3+)Dynamic Coordination Cross-linking

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Chinese Journal of Polymer Science 2024年第10期42卷 1449-1458,I0008页

作者： Qiu-Li Tan Kai Gou Jing-Zhi Tang ming-Hui Wei chong Wang Yi-Jing Nie Geng-Sheng Weng School of Materials Science and Chemical Engineering State Key Laboratory Base of Novel Functional Materials and Preparation ScienceNingbo UniversityNingbo315211China Institute of Polymer Materials School of Materials Science and EngineeringJiangsu UniversityZhenjiang212013China

Thermochromic polymers with tunable thermochromism,high stretchability and mechanical strength are of interests for optical information storage and *** this work,we demonstrate a new design of thermo-fluorochromic carboxylated nitrile butadiene rubber(XNBR)elastomer cross-linked by Eu^(3+)-COOH dynamic coordination with deprotonated imidazole(DPIm)as the ancillary *** presence of DPIm not only improves the mechanical strength and stretchability,but also dramatically intensifies the fluorescence emission and lifetime of the Eu-containing *** elastomer behaves reversible thermo-fluorochromism with easily tunable transition temperature and emission intensity by the simple change of the deprotonation degree of *** facile tunable thermo-fluorochromism,exceptional mechanical strength,and high stretchability(up to about 5000%)enable the Eu-containing XNBR elastomer with potential applications in soft electronics where optical information storage and encryption are required.

关键词： Dynamic coordination Thermochromism Highly stretchable Elastomer Europium

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Mice with type I interferon signaling deficiency are prone to epilepsy upon HSV-1 infection

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Virologica Sinica 2024年第2期39卷 251-263页

作者： Wei Yang chong-Yang Tang Dong-Ying Fan Yi-Song Wang Pei-Gang Wang Jing An Guo-ming Luan Beijing Key Laboratory of Epilepsy Sanbo Brain HospitalCapital Medical UniversityBeijing100093China Beijing Institute for Brain Disorders Capital Medical UniversityBeijing100093China Department of Neurosurgery Epilepsy CenterSanbo Brain HospitalCapital Medical UniversityBeijing100093China Department of Microbiology School of Basic Medical SciencesCapital Medical UniversityBeijing100069China Chinese Institute for Brain Research Beijing102206China

Viral encephalitis continues to be a significant public health *** our previous study,we discovered a lower expression of antiviral factors,such as IFN-β,STING and IFI16,in the brain tissues of patients with Rasmussen's encephalitis(RE),a rare chronic neurological disorder often occurred in children,characterized by unihemispheric brain ***,a higher cumulative viral score of human herpes viruses(HHVs)was also found to have a significant positive correlation with the unihemispheric atrophy in *** I IFNs(IFN-I)signaling is essential for innate anti-infection response by binding to IFN-α/βreceptor(IFNAR).In this study,we infected WT mice and IFNAR-deficient A6 mice with herpes simplex virus 1(HSV-1)via periocular injection to investigate the relationship between IFN-I signaling and HHVs-induced brain *** all mice exhibited typical viral encephalitis lesions in their brains,HSV-induced epilepsy was only observed in A6 *** gene expression matrix,functional enrichment analysis and protein-protein interaction network revealed four gene models that were positively related with HSV-induced ***,ten key genes with the highest scores were *** together,these findings indicate that intact IFN-I signaling can effectively limit HHVs induced neural symptoms and brain lesions,thereby confirming the positive correlation between IFN-I signaling repression and brain atrophy in RE and other HHVs encephalitis.

关键词： IFN-I signaling Human herpes viruses(HHVs) Rasmussen's encephalitis(RE)

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Generation of polarization-multiplexed terahertz orbital angular momentum combs via all-silicon metasurfaces

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Light(Advanced Manufacturing) 2024年第3期5卷 120-129页

作者： ming-Zhe chong Yiwen Zhou Zong-Kun Zhang Jin Zhao Yue-Yi Zhang chong-Qi Zhang Xiaofei Zang Chao-Hai Du Pu-Kun Liu ming-Yao Xia School of Electronics Peking UniversityBeijing 100871China Terahertz Technology Innovation Research Institute and Shanghai Key Lab of Modern Optical SystemUniversity of Shanghai for Science and TechnologyNo.516 Jun Gong RoadShanghai 200093China State Key Laboratory of Advanced Optical Communication Systems and Networks School of ElectronicsPeking UniversityBeijing 100871China

Electromagnetic waves carrying orbital angular momentum(OAM),namely OAM beams,are important in various fields including optics,communications,and quantum ***,most current schemes can only generate single or several simple OAM ***-mode OAM beams are rarely *** paper proposes a scheme to design metasurfaces that can generate multiple polarization-multiplexed OAM modes with equal intervals and intensities(i.e.,OAM combs)working in the terahertz(THz)*** a proof of concept,we first design a metasurface to generate a pair of polarization-multiplexed OAM combs with arbitrary mode ***,another metasurface is proposed to realize a pair of polarization-multiplexed OAM combs with arbitrary locations and intervals in the OAM *** results agree well with full-wave simulations,verifying a great performance of OAM combs *** method may provide a new solution to designing high-capacity THz devices used in multi-mode communication systems.

关键词： Metasurfaces Terahertz Orbital angular momentum comb Polarization multiplexing

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Interaction mechanism between BaZrO_(3)/Y_(2)O_(3) refractory and Ti_(2)Ni alloy melts

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Journal of Iron and Steel Research International 2024年第6期31卷 1376-1388页

作者： Xiao Hou Guang-yao Chen Jian Liu ming-rui Lv Fei-hai Yu Qi-sheng Feng Rong-bin Li Xiong-gang Lu chong-he Li State Key Laboratory of Advanced Special Steel and Shanghai Key Laboratory of Advanced Ferromeallurgy and School of Materials Science and Engineering Shanghai UniversityShanghai 200072China Shanghai Special Casting Engineering Technology Research Center Shanghai 201605China Zhejiang Institute of Advanced Materials Shanghai UniversityJiashan 314100ZhejiangChina School of Materials Science and Engineering Shanghai DianJi UniversityShanghai 201306China

The titanium alloys with highly chemical activity require stable crucible refractories that can withstand the erosion of alloy *** phase composition and microstructure are crucial factors that affect the stability of the refractory *** effect of Y_(2)O_(3) on the composition and microstructure of BaZrO_(3) crucible was systematically investigated,and the improved mechanism of the stability of BaZrO_(3)/Y_(2)O_(3) crucible was clarified in comparison with the BaZrO_(3) *** results showed that the erosion layer thickness of the BaZrO_(3)/Y_(2)O_(3) crucible was only 63μm,which was far less than that in the BaZrO_(3) crucible(485μm),and the erosion layer in the BaZrO_(3)/Y_(2)O_(3) crucible also exhibited a higher density than that in the BaZrO_(3) *** the sintering,Y_(2)O_(3) could improve the densification of the BaZrO_(3) crucible due to the solid solution effect between Y_(2)O_(3) and ZrO_(2),which also caused the evaporation of BaO,resulting in the generation of a Y_(2)O_(3)(ZrO_(2))film on the surface of the ***,the Y_(2)O_(3)(ZrO_(2))had higher thermodynamic stability than Y_(2)O_(3),confirming that the BaZrO_(3)/Y_(2)O_(3) crucible with high density exhibited a superior erosion resistance to titanium *** dual-phase structure provides a strategy to design a long-life and stable refractory for melting titanium alloys.

关键词： Barium zirconate Yttrium oxide Dual-phase refractory Titanium alloy Interaction

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Construction and evaluation of a liver cancer risk prediction model based on machine learning

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3839-3850页

作者： Ying-Ying Wang Wan-Xia Yang Qia-Jun Du Zhen-Hua Liu ming-Hua Lu chong-Ge You Laboratory Medicine Center The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina

BACKGROUND Liver cancer is one of the most prevalent malignant tumors worldwide,and its early detection and treatment are crucial for enhancing patient survival rates and quality of ***,the early symptoms of liver cancer are often not obvious,resulting in a late-stage diagnosis in many patients,which significantly reduces the effectiveness of *** a highly targeted,widely applicable,and practical risk prediction model for liver cancer is crucial for enhancing the early diagnosis and long-term survival rates among affected *** To develop a liver cancer risk prediction model by employing machine learning techniques,and subsequently assess its *** In this study,a total of 550 patients were enrolled,with 190 hepatocellular carcinoma(HCC)and 195 cirrhosis patients serving as the training cohort,and 83 HCC and 82 cirrhosis patients forming the validation *** regression(LR),support vector machine(SVM),random forest(RF),and least absolute shrinkage and selection operator(LASSO)regression models were developed in the training *** performance was assessed in the validation ***,this study conducted a comparative evaluation of the diagnostic efficacy between the ASAP model and the model developed in this study using receiver operating characteristic curve,calibration curve,and decision curve analysis(DCA)to determine the optimal predictive model for assessing liver cancer *** Six variables including age,white blood cell,red blood cell,platelet counts,alpha-fetoprotein and protein induced by vitamin K absence or antagonist II levels were used to develop LR,SVM,RF,and LASSO regression *** RF model exhibited superior discrimination,and the area under curve of the training and validation sets was 0.969 and 0.858,*** values significantly surpassed those of the LR(0.850 and 0.827),SVM(0.860 and 0.803),LASSO regression(0.845 and 0.831),and ASAP(0.866 and 0.813)model

关键词： Hepatocellular carcinoma Cirrhosis Prediction model Machine learning Random forest

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Effect of inflammatory response on joint function after hip fracture in elderly patients:A clinical study

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World Journal of Orthopedics 2024年第4期15卷 337-345页

作者： Jia-ming Wang Yu-Tao Pan Chen-Song Yang ming-chong Liu Sheng-Chao Ji Ning Han Fang Liu Gui-Xin Sun Department of Traumatic Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200092China

BACKGROUND Excellent hip joint function facilitates limb recovery and improves the quality of *** study aimed to investigate the potential risk factors affecting postoperative joint functional activity and outcomes in elderly hip fractures patients and to provide evidence for patient rehabilitation and clinical *** To explore the relationship between inflammatory factors and hip function and the interaction between inflammation and health after hip fracture in elderly *** The elderly patients who had hip fracture surgery at our hospital between January 1,2021,and December 31,2022 were chosen for this retrospective clinical *** with excellent and fair postoperative hip function had their clinical information and characteristics gathered and ***,gender,fracture site,surgical technique,laboratory indices,and other variables that could have an impact on postoperative joint function were all included in a univariate *** further identify independent risk factors affecting postoperative joint function in hip fractures,risk factors that showed statistical significance in the univariate analysis were then included in a multiple logistic regression *** addition to this,we also compared other outcome variables such as visual analogue scale and length of hospital stay between the two *** A total of 119 elderly patients with hip fractures were included in this study,of whom 37 were male and 82 were *** results of univariate logistic regression analysis after excluding the interaction of various factors showed that there was a statistically significant difference in interleukin(IL)-6,IL-8,IL-10,C-reactive protein(CRP),and complement C1q(C1q)between the fair and excellent joint function groups(P20 pg/mL[Odds ratio(OR)3.070,95%CI:1.243-7.579],IL-8>21.4 pg/mL(OR 3.827,95%CI:1.498-9.773),CRP>10 mg/L(OR 2.142,95%CI:1.

关键词： Hip function Fracture Inflammatory factors Risk factors Prevention

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Flagellate erythema in transcription intermediary factor 1 gamma dermatomyositis

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Rheumatology & Autoimmunity 2024年第3期4卷 194-195页

作者： Wei ming chong Chuanhui Xu Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore Department of Rheumatology Allergy and Immunology Tan Tock Seng HospitalSingaporeSingapore

A 52-year-old Chinese woman was diagnosed with transcription intermediary factor 1(TIF1)gamma dermatomyositis in November 2022,with manifestations of myositis,polyarthralgia,and low-grade *** had cutaneous manifestations of Gottron's sign,V-neck sign,shawl sign,and flagellate erythema(Figure 1A).No interstitial lung disease was detected by high-resolution computed *** malignancy screenings,encompassing pap smear and mammogram,endoscopic examination,and computed tomography scans of the thorax,abdomen,and pelvis,were *** returned negative,apart from a lobulated nodule with biopsy confirmed as sclerosing pneumocytoma at the left lower lobe(Figure 1C).The therapeutic regimen,consisting of high-dose steroids and mycophenolate mofetil,effectively ameliorated the patient's myositis and rash(Figure 1B).

关键词： dermatomyositis erythema flagellate erythema skin manifestations

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