Diffuse reduction of spleen density is a novel prognostic marker for intrahepatic cholangiocarcinoma after curative resection
作者机构：Department of Hepatobiliary SurgeryThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang ProvinceThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina Department of Epidemiology and BiostatisticsSchool of Public Health and ManagementWenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina Division of Clinical MedicineFirst School of Clinical MedicineWenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina Department of Hepatobiliary SurgeryQilu Hospital Shandong UniversityJinan 250012Shandong ProvinceChina
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2021年第13卷第8期
页 面：929-942页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by National Natural Science Foundation of China,No.82072685 the Science and Technology Innovation Program for College Students in Zhejiang Province,No.2020R413022
主 题：Intrahepatic cholangiocarcinoma Nomogram Prognosis Diffuse reduction of spleen density Overall survival Recurrence-free survival
摘 要：BACKGROUND Diffuse reduction of spleen density(DROSD)is related to cancer prognosis;however,its role in intrahepatic cholangiocarcinoma(ICC)remains *** To assess the predictive value of DROSD in the prognosis of ICC after curative *** In this multicenter retrospective cohort study,we enrolled patients with ICC who underwent curative hepatectomy between 2012 and *** spleen density was measured using computed *** survival(OS)and recurrence-free survival(RFS)rates were calculated and compared utilizing the Kaplan-Meier *** and multivariable Cox regression analyses were applied to identify independent factors for OS and RFS.A nomogram was created with independent risk factors to predict prognosis of patients with *** One hundred and sixty-seven ICC patients were *** on the diagnostic cut-off values(spleen density≤45.5 Hounsfield units),55(32.9%)patients had ***-Meier analysis indicated that patients with DROSD had worse OS and RFS than those without DROSD(P0.05).Cox regression analysis revealed that DROSD,carcinoembryonic antigen level,carbohydrate antigen 19-9 level,length of hospital stay,lymph node metastasis,and postoperative complications were independent predictors for OS(P0.05).The nomogram created with these factors was able to predict the prognosis of patients with ICC with good reliability(OS C-index=0.733).The area under the curve for OS was *** ICC patients with DROSD have worse OS and *** nomogram is a simple and practical method to identify high-risk ICC patients with poor prognosis.
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