检索结果-南通市图书馆

Predicting lifetime risk for developing atherosclerotic cardiovascular disease in Chinese population:the China-PAR project

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2018年第12期63卷 779-787页

作者： Fangchao Liu Jianxin Li Jichun Chen Dongsheng Hu Ying Li Jianfeng Huang Xiaoqing Liu Xueli Yang Jie Cao chong shen Ling Yu Zhendong Liu Xianping Wu Liancheng Zhao Xigui Wu Dongfeng Gu Xiangfeng Lu Department of Epidemiology Fuwai Hospital State Key Laboratory of Cardiovascular DiseaseNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China The 3rd Affiliated Hospital of shenzhen University Shenzhen 518001China Department of Prevention Medicine Shenzhen University School of MedicineShenzhen 518060China Division of Epidemiology Guangdong Provincial People's Hospital and Cardiovascular instituteGuangzhou 510080China Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjing 211166China Department of Cardiology Fujian Provincial People's HospitalFuzhou 350014China Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong Academy of Medical SciencesJinan 250062China Sichuan Center for Disease Control and Prevention Chengdu 610041China

Evidence on the lifetime risk for atherosclerotic cardiovascular disease （ASCVD） is insufficient; yet, estimating an individual＇s lifetime risk allows for a comprehensive assessment of ASCVD burden. We developed and validated lifetime risk prediction equations for ASCVD using four large and ongoing prospective cohorts of Chinese, the China-PAR project （Prediction for ASCVD Risk in China）. Sexspecific equations were developed using two cohorts （as the derivation cohort） of 21,320 participants. Two other independent cohorts with 14,123 and 70,838 participants were used for their external valida- tion, respectively. We evaluated both calibration and discrimination measures for model performance. Furthermore, we estimated ASCVD-ffee years lost or excess absolute risk attributable to high 10-year risk （≥10.0%） and]or high lifetime risk （≥32.8%）. After 12.3 years＇ follow-up of the derivation cohort, 1048 ASCVD events and 1304 non-ASCVD deaths were identified. Our sex-specific equations had good internal validation, with discriminant C statistics of 0.776 （95% confidence interval [CI]： 0.757-0.794） and 0.801 （95% CI： 0.778-0.825）, and calibration Z2 of 9.2 （P = 0.418） and 5.6 （P = 0.777） for men and women, respectively. Good external validation was also demonstrated with predicted rates closely matched to the observed ones. Compared with men having both low 10-year and low lifetime risk, men would develop ASCVD 3.0, 4.6 and 8.6 years earlier if they had high 10-year risk alone, high lifetime risk alone, or both high 10-year and high lifetime risk at the index age of 35 years, respectively. We developed well- performed lifetime risk prediction equations that will help to identify those with the greatest potential to avert ASCVD burden after implementation of innovative clinical and public health interventions in China.

关键词： Atherosclerosis Cardiovascular disease Lifetime risk Risk prediction

Associations of soybean products intake with blood pressure changes and hypertension incidence: the China-PAR project

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2020年第7期17卷 384-392页

作者： Jia-Liu WEI Xin-Yan WANG Fang-Chao LIU Ji-Chun CHEN Jie CAO Jian-Xin LI Dong-sheng HU chong shen Fang-Hong LU Ying-Xin ZHAO Jian-Feng HUANG Xiang-Feng LU Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijingChina Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Prevention Medicine Shenzhen University School of MedicineShenzhenChina Department of Epidemiology and Health Statistics College of Public HealthZhengzhou UniversityZhengzhouChina Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjingChina Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong First Medical UniversityJinanShandongChina

Background The relationships between dietary intake of soybean products and incident hypertension were still *** study aimed to illustrate the associations between intake of soybean products with risks of incident hypertension and longitudinal changes of blood pressure in a prospective cohort *** We included 67,499 general Chinese adults from the Project of Prediction for Atherosclerosis Cardiovascular Disease Risk in China(China-PAR).Information about soybean products consumption was collected by standardized questionnaires,and study participants were categorized into the ideal(≥125 g/day)or non-ideal(<125 g/day)*** ratios(HRs)and corresponding 95%confidence intervals(95%CIs)for incident hypertension were calculated using Cox proportional hazard *** participants with repeated measures of blood pressure,generalized linear models were used to examine the relationships between soybean products consumption and blood pressure *** During a median follow-up of 7.4 years,compared with participants who consumed<125 g of soybean products per day,multivariable adjusted HR for those in the ideal group was 0.73(0.67-0.80).This inverse association remained robust across most subgroups while significant interactions were tested between soybean products intake and age,sex,urbanization and geographic region(P values for interaction<0.05).The mean systolic and diastolic blood pressure levels were 1.05(0.71-1.39)mmHg and 0.44(0.22-0.66)mmHg lower among participants in the ideal group than those in the non-ideal *** Our study showed that intake of soybean products might reduce the long-term blood pressure levels and hypertension incidence among Chinese population,which has important public health implications for primary prevention of hypertension.

关键词： Blood pressure changes Chinese population Cohort study Hypertension Soybean products

Associations of egg consumption with incident cardiovascular disease and all-cause mortality

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2020年第9期63卷 1317-1327页

作者： Xue Xia Fangchao Liu Xueli Yang Jianxin Li Jichun Chen Xiaoqing Liu Jie Cao chong shen Ling Yu Yingxin Zhao Xianping Wu Liancheng Zhao Ying Li Jianfeng Huang Xiangfeng Lu Dongfeng Gu Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Division of Epidemiology Guangdong Provincial People’s Hospital and Cardiovascular InstituteGuangzhou 510080China Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjing 211166China Department of Cardiology Fujian Provincial HospitalFuzhou 350014China Shandong First Medical University Jinan 271016China Sichuan Center for Disease Control and Prevention Chengdu 610041China

Eggs are nutrient-dense while also loaded with abundant cholesterol, thus making the public hesitant about their *** conducted the study to investigate if egg consumption is associated with incident cardiovascular disease(CVD) and all-cause mortality. Using the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China, we included 102,136 adults free of CVD and assessed their egg consumption with food-frequency questionnaires. CVD endpoints and all-cause mortality were confirmed during follow-ups by interviewing participants or their proxies and checking hospital records/death *** HRs(95% CIs) were calculated using the cohort-stratified Cox regression models. During 777,163 person-years of followup, we identified 4,848 incident CVD and 5,511 deaths. U-shaped associations of egg consumption with incident CVD and allcause mortality were observed. Compared with consumption of 3–<6/week, the multivariable-adjusted HRs(95% CIs) of <1/week and ≥10/week for incident CVD were 1.22(1.11 to 1.35) and 1.39(1.28 to 1.52), respectively. The corresponding HRs(95% CIs) for all-cause mortality were 1.29(1.18 to 1.41) and 1.13(1.04 to 1.24). Our findings identified that both low and high consumption were associated with increased risk of incident CVD and all-cause mortality, highlighting that moderate egg consumption of 3–<6/week should be recommended for CVD prevention in China.

关键词： egg consumption cardiovascular disease all-cause mortality cohort study

在线全文

学校读者我要写书评

暂无评论

自噬在骨关节炎中的研究进展

华夏医学 2022年第3期35卷 155-159页

作者：沈翀黄泓钧桂林医学院附属医院脊柱骨病外科广西桂林541001

骨关节炎(OA)是常见的退行性关节疾病,其主要病理变化是软骨细胞凋亡和软骨基质的降解。自噬作为真核细胞中一种重要的细胞内稳态机制,在修复软骨和维持细胞正常功能中起着关键作用,其功能失常与OA的发生发展密切相关。激活自噬可以恢... 详细信息

骨关节炎(OA)是常见的退行性关节疾病,其主要病理变化是软骨细胞凋亡和软骨基质的降解。自噬作为真核细胞中一种重要的细胞内稳态机制,在修复软骨和维持细胞正常功能中起着关键作用,其功能失常与OA的发生发展密切相关。激活自噬可以恢复受损软骨细胞的功能,减缓OA的发展。本文就自噬在OA中调控及治疗作用进行综述。

关键词：自噬骨关节炎软骨细胞凋亡

不同性别FPG正常人群的糖代谢相关因素聚类分析及2型糖尿病发病风险评估

在线全文

学校读者我要写书评

暂无评论

中华疾病控制杂志 2023年第12期27卷 1413-1420,1441页

作者：马睿陈逸超谢涵坤刘宇樊垚唐伟沈冲南京医科大学公共卫生学院流行病学系南京211166 句容市疾病预防控制中心镇江212499 南京医科大学附属老年医院临床流行病学研究室南京210024 南京医科大学附属老年医院内分泌科南京210024

目的基于糖代谢相关因素,对空腹血糖(fasting plasma glucose,FPG)正常的男性和女性分别进行聚类分析,并评价不同聚类组与2型糖尿病(type 2 diabetes mellitus,T2DM)发病风险的关系。方法选取句容市队列研究基线FPG0.05)。相比于女性clu... 详细信息

目的基于糖代谢相关因素,对空腹血糖(fasting plasma glucose,FPG)正常的男性和女性分别进行聚类分析,并评价不同聚类组与2型糖尿病(type 2 diabetes mellitus,T2DM)发病风险的关系。方法选取句容市队列研究基线FPG0.05)。相比于女性cluster 1,cluster 3 T2DM发病风险较低,调整后HR(95%CI)为0.380(0.205~0.704);Cluster 5 T2DM的发病风险较高(P<0.05),调整协变量后差异无统计学意义(HR=1.172,95%CI:0.717~1.916)。结论FPG正常的人群在未诊断为糖尿病时即存在生理代谢异质性,其聚类表型特征呈现出一定的男女性别差异。基于糖代谢相关因素在非糖尿病人群中进行聚类,有助于提高高危亚组的早期筛查和防控干预。

关键词：空腹血糖 2型糖尿病聚类分析糖代谢

13例累及肺部的嗜酸性肉芽肿性多血管炎的临床特征

在线全文

学校读者我要写书评

暂无评论

中南大学学报（医学版） 2022年第10期47卷 1355-1364页

作者：欧彦汝张莲华周莉沈冲欧阳若芸中南大学湘雅二医院呼吸与危重症医学科长沙410011

目的:嗜酸性肉芽肿性多血管炎(eosinophilic granulomatosis with polyangiitis,EGPA)是一种罕见的系统性血管炎,常以哮喘等呼吸系统症状起病,临床早期诊断困难。本研究通过分析累及肺部的EGPA患者的临床特征和诊治经过,以提高临床诊疗... 详细信息

目的:嗜酸性肉芽肿性多血管炎(eosinophilic granulomatosis with polyangiitis,EGPA)是一种罕见的系统性血管炎,常以哮喘等呼吸系统症状起病,临床早期诊断困难。本研究通过分析累及肺部的EGPA患者的临床特征和诊治经过,以提高临床诊疗水平。方法:选取2014年2月1日至2021年7月31日中南大学湘雅二医院收治并确诊为EGPA的患者,对肺部受累患者的临床资料进行分析和总结。结果:13例患者中男女比例为7:6,确诊中位年龄为52(46~68)岁,6例患者曾诊断为“支气管哮喘”。肺部临床表现主要为咳嗽、咳痰、喘息、气促;肺外表现主要有皮疹和皮下包块、发热、肢体麻木、肌肉痛、关节痛、腹痛等。11例患者外周血嗜酸性粒细胞≥10%,10例炎症指标升高,3例抗中性粒细胞胞质抗体(anti-neutrophil cytoplasmic antibody,ANCA)阳性。肺部影像学主要有斑片或条索状密度增高影、双肺多发结节影、支气管扩张、支气管壁增厚、渗出影、纵隔淋巴结增大等表现。8例患者合并鼻窦炎、9例肌电图异常。9例患者病理学检查发现血管外嗜酸粒细胞浸润,其中6例肺活体组织检查可见嗜酸性粒细胞、淋巴细胞和浆细胞浸润,3例嗜酸性粒细胞浸润累及小血管,1例肉芽肿。7例行肺功能检查,5例患者存在不同程度的通气功能障碍,4例弥散功能障碍。激素和免疫抑制药治疗有效。结论:EGPA临床上较为罕见,累及多个系统、危害性大且可合并哮喘样表现,肺部受累较为常见,但临床上对该病的认知不足且肺部影像学表现异质性大,故易发生误诊和漏诊。应尽早行相关实验室、影像学及活体组织检查,并综合考虑肺外的受累情况,早期识别EGPA对提高疾病的诊断率和改善预后有重要意义。

关键词：嗜酸性肉芽肿性多血管炎临床特征肺部影像学诊断治疗

Ideal cardiovascular health and incidence of atherosclerotic cardiovascular disease among Chinese adults:the China-PAR project

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2018年第5期61卷 504-514页

作者： Chao Han Fangchao Liu Xueli Yang Jichun Chen Jianxin Li Jie Cao Ying Li chong shen Ling Yu Zhendong Liu Xianping Wu Liancheng Zhao Dongshen Hu Xiangfeng Lu Xigui Wu Dongfeng Gu Department of Epidemiology Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University Nanjing 211166 China Department of Cardiology Fujian Provincial People's Hospital Fuzhou 350004 China Cardio-Cerebrovascular Control and Research Center Institute of Basic Medicine Shandong Academy of Medical Sciences Jinan 250062 China Sichuan Center for Disease Control and Prevention Chengdu 610041 China Department of Prevention Medicine Shenzhen University School of Medicine Shenzhen 518060 China

Existing evidence on the relationship between cardiovascular health(CVH) metrics and cardiovascular disease(CVD) was primarily derived from western populations. We aimed to evaluate the benefits of ideal CVH metrics on preventing incident atherosclerotic CVD(ASCVD) in Chinese population. This study was conducted among 93,987 adults from the China-PAR project(Prediction for ASCVD Risk in China) who were followed up until 2015. Cox proportional hazard regression models were used to estimate the hazard ratios(HRs) and their corresponding 95% confidence intervals(CIs) of CVH metrics for the risk of ASCVD, including coronary heart disease(CHD), stroke and ASCVD death. We further estimated the population-attributable risk percentage(PAR%) of these metrics in relation to each outcome. We observed gradient inverse associations between the number of ideal CVH metrics and ASCVD incidence. Compared with participants having ≤2 ideal CVH metrics, the multivariable-adjusted HRs(95% CIs) of ASCVD for those with 3, 4, 5, 6 and 7 ideal CVH metrics were 0.83(0.74–0.93), 0.66(0.59–0.74), 0.55(0.48–0.61), 0.44(0.38–0.50) and 0.24(0.18–0.31), respectively(P for trend <0.0001). Approximately 62.1% of total ASCVD, 38.7% of CHD, 66.4% of stroke, and 60.5% of ASCVD death were attributable to not achieving all the seven ideal CVH metrics. After adjusting effects of ideal health factors, having four ideal health behaviors could independently bring adults health benefits in preventing 17.4% of ASCVD, 18.0% of CHD, 16.7% of stroke, and 10.1% of ASCVD death. Among all the seven CVH metrics, to keep with ideal blood pressure(BP) implied the largest public health gains against various ASCVD events(PAR% between 33.0% and 47.2%), while ideal diet was the metric most difficult to be achieved in the long term. Our study indicates that the more ideal CVH metrics adults have, the less ASCVD burden there is in China. Special efforts of health education and behavior modification should be made on keeping

关键词： cardiovascular health ASCVD cohort China

miR-142-3p对膀胱癌细胞增殖和有氧糖酵解的影响及作用机制

在线全文

学校读者我要写书评

暂无评论

浙江医学 2022年第17期44卷 1817-1824页

作者：沈翀阎家骏任煜绍兴市人民医院泌尿外科 312009

目的探究微小RNA(miR)-142-3p对膀胱癌(BC)细胞增殖与有氧糖酵解的影响及作用机制。方法qPCR检测比较人BC细胞系(SW780、UMUC3、T24、BIU87)和人输尿管上皮细胞(SV-HUC-1)中miR-142-3p表达水平,选取低表达的BC细胞进行miR-142-3p过表达... 详细信息

目的探究微小RNA(miR)-142-3p对膀胱癌(BC)细胞增殖与有氧糖酵解的影响及作用机制。方法qPCR检测比较人BC细胞系(SW780、UMUC3、T24、BIU87)和人输尿管上皮细胞(SV-HUC-1)中miR-142-3p表达水平,选取低表达的BC细胞进行miR-142-3p过表达质粒转染;分别采用平板细胞克隆实验、CCK8-法、流式细胞术、2-NBDG葡萄糖摄取实验、糖代谢检测试剂盒检测miR-142-3p表达对BC细胞增殖、活性、周期、有氧糖酵解的影响。双荧光素酶和Western blot法检测miR-142-3p与细胞周期蛋白依赖性激酶(CDK)4、乳酸脱氢酶A(LDHA)的靶向性及作用关系。过表达miR-142-3p的BC细胞分别转染CDK4或LDHA表达质粒,采用CCK8-法、2-NBDG葡萄糖摄取实验、糖代谢检测试剂盒测定转染后的BC细胞活性和有氧糖酵解情况。结果miR-142-3p在T24、UMUC3细胞中显著低表达(均P<0.01)。T24、UMUC3细胞转染过表达miR-142-3p质粒后,克隆能力及活性显著下降(均P<0.05),细胞周期阻滞于G0/G1期(均P<0.01),2-NBDG荧光强度显著减弱(均P<0.01),葡萄糖消耗量和乳酸生成量显著减少(均P<0.01)。miR-142-3p靶向抑制CDK4和LDHA蛋白表达(均P<0.01)。CDK4或LDHA表达显著逆转了miR-142-3p过表达对T24细胞的活性和有氧糖酵解的抑制作用(均P<0.05)。结论miR-142-3p通过靶向CDK4和LDHA抑制BC细胞增殖和有氧糖酵解。

关键词：膀胱癌 miR-142-3p 细胞周期蛋白依赖性激酶4 乳酸脱氢酶A 细胞增殖有氧糖酵解

在线全文

学校读者我要写书评

暂无评论

光化学微反应技术的基础及研究进展

化工进展 2021年第9期40卷 4749-4761页

作者：王昱翰沈冲苏远海上海交通大学化学化工学院上海200240

光化学转化是有效利用光能实现化学反应的重要途径,微反应技术为提高其过程效率提供了一个强有力的平台。本文首先指出微反应器相比于传统釜式光反应器,在光强分布、过程放大、光能利用效率等诸多方面存在明显的优势,能够实现光化学反... 详细信息

光化学转化是有效利用光能实现化学反应的重要途径,微反应技术为提高其过程效率提供了一个强有力的平台。本文首先指出微反应器相比于传统釜式光反应器,在光强分布、过程放大、光能利用效率等诸多方面存在明显的优势,能够实现光化学反应过程的高效强化。简要地介绍了光化学转化及光化学微反应技术的基本特征,然后系统地综述了光化学微反应器的设计构建及其在有机合成、聚合等方面的应用,并详细介绍了自动化控制的光化学微反应系统及应用。重点介绍了微反应技术在紫外光、可见光辐照下的光化学合成进展及其过程放大。最后,对光化学微反应技术的研究进展进行总结,并对其发展趋势进行了展望。

关键词：光化学光辐射场微反应器过程强化有机合成自动化