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Effect of Mono- and Di-ethanolammonium Formate Ionic Liquids on the Volatility of Water, Ethanol, and Methanol

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Chinese Journal of Chemical Engineering 2013年第10期21卷 1162-1171页

作者：李雪梅沈冲李春喜 State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 China College of Chemical Engineering Beijing University of Chemical Technology Beijing 100029 China Liming Research Institute of Chemical Industry Luoyang 471000 China

Vapor pressures were measured for six binary systems containing water, ethanol, or methanol with one of the two ionic liquids(ils) at different component concentrations and temperatures using a quasi-static ebulliometer,with the ils mono-ethanolammonium formate([HMEA][HCOO]) and di-ethanolammonium formate([HDEA][HCOO]).The vapor pressures of the il-containing binary systems are well correlated using the NRTL model with an overall average absolute relative deviation(AARD) of 0.0062. The effect of ils on the vapor pressure depression of solvents at 0.050 mole fraction of il is that [HDEA][HCOO]>[HMEA][HCOO], and the vapor pressure lowering degree follows the order of water>methanol>ethanol. Further, the activity coefficients of three solvents(viz. water,ethanol, and methanol) for the binary systems {solvent(1) + il(2)} predicted based on the fitted NRTL parameters at T 333.15 K indicate that the two ils generate a negative deviation from Raoult's law for water and methanol and a positive deviation for ethanol to a varying degree, change the relative volatility of a solvent. [HMEA][HCOO]may be a promising entrainer to efficiently separate ethanol aqueous solutions by special rectification.

关键词：乙醇水溶液离子液体甲酸盐甲醇白细胞介素波动铵 NRTL模型

Characterization of an ionic liquid electrospray thruster with a porous ceramic emitter

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Plasma Science and Technology 2020年第9期22卷 66-74页

作者：陈冲陈茂林周浩浩 Combustion Internal Flow and Thermal-Structure LaboratoryNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China

An ionic liquid(il)electrospray thruster was developed for application in micro-nano satellites or gravitational wave *** thruster employed a porous ceramic emitter with seven emitter strips located on its emission *** any liquid-supply device,il was delivered through porous media to emitter strips via capillary *** emission sites then formed at the tip of each strip.A charged beam of up to 350μA(with a current density of 540μA cm^(-2))was stably produced in the negative ***,in the positive mode,a corona was observed which could prevent the thruster from emitting larger current.A time-of-flight mass spectrometer with significantly improved signal-to-noise ratio was built,which was used to obtain the mass distribution of the beam of the thruster.A retarding potential analysis was also *** test results showed that the thruster worked in the pure-ion regime,and delivered a maximum thrust of 67.1μN with specific impulses of 3952 s and 3117 s in the positive and negative modes,respectively.

关键词： electrospray thruster time-of-flight(TOF) retarding potential analysis(RPA)

基于JAK1/STAT3信号通路研究高车前素对肝纤维化小鼠的影响

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中草药 2022年第19期53卷 6093-6100页

作者：徐冲秦小东任丽罗先钦重庆市中医院药剂科重庆400021 重庆医科大学中医药学院重庆400016

目的基于Janus激酶1(Janus kinase 1,JAK1)和转录激活因子3(signal transducer and activator of transcription3,STAT3)信号通路研究高车前素对四氯化碳(carbon tetrachloride,CCl_(4))诱导肝纤维化(hepatic fibrosis,HF)小鼠的影响。方法小鼠连续6周背部sc CCl_(4)溶液制备HF模型,将HF小鼠随机分为模型组、秋水仙碱(2 mg/kg)组和高车前素高、低剂量(30、10 mg/kg)组,各给药组连续4周ip相应药物,末次给药后24 h制备血清,计算肝脏指数;采用全自动生化分析仪测定血清中丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天冬氨酸氨基转移酶(aspartate aminotransferase,AST)活性及总胆红素(total bilirubin,TBil)水平;测定血清和肝组织中羟脯氨酸(hydroxyproline,Hyp)水平;测定肝组织中丙二醛(malondialdehyde,MDA)、还原型谷胱甘肽(glutathione,GSH)水平及超氧化物歧化酶(superoxide dismutase,SOD)活性;检测血清中透明质酸(hyaluronic acid,HA)、层黏连蛋白(laminin,LN)、Ⅲ型前胶原(type Ⅲ procollagen,PⅢNP)、Ⅳ型胶原(type Ⅳ collagen,Col-Ⅳ)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-1β(interleukin-1β,il-1β)和il-6水平;采用苏木素-伊红(HE)染色观察肝组织病理改变;采用q RT-PCR法检测肝组织中尿激酶型纤溶酶原激活物(urokinase type plasminogen activator,uPA)和纤溶酶原激活物抑制因子-1(plasminogen activator inhibitor-1,PAI-1)m RNA表达;采用Western blotting检测肝组织中JAK1/STAT3信号通路中相关蛋白表达。结果与模型组比较,高车前素组小鼠体质量显著增加(Pil水平显著降低(Pil-1β和il-6水平均显著降低(P<0.05、0.01);光镜下可见肝组织细胞水肿、空泡样改变、炎细胞浸润明显减轻;肝组织中uPA m RNA表达水平显著升高(P<0.01),PAI-1 m RNA表达水平显著降低(P<0.01);肝组织中p-JAK1和p-STAT3蛋白表达水平显著降低(P<0.001)。结论高车前素可减轻HF小鼠的肝损伤和炎症程度,其抗HF的作用机制可能与激活uPA纤溶酶系统和干预JAK1/STAT3信号转导通路有关。

关键词：高车前素肝纤维化 Janus激酶1/转录激活因子3信号通路尿激酶型纤溶酶原激活物纤溶酶原激活物抑制因子-1

白茶多酚对D-半乳糖致小鼠肾损伤模型的改善作用

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食品与发酵工业 2022年第4期48卷 226-234页

作者：李冲杨悦骞宇赵欣重庆第二师范学院重庆市功能性食品协同创新中心重庆400067 重庆第二师范学院重庆市功能性食品工程技术研究中心重庆400067 重庆第二师范学院功能性食品研发重庆市工程实验室重庆400067 重庆第二师范学院生物与化学工程学院重庆400067

该研究建立D-半乳糖诱导小鼠肾损伤模型,用不同剂量[250、500 mg/(kg·d)]白茶多酚灌胃小鼠42 d,于第6周末测量小鼠肾组织中谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)、过氧化氢酶(catalase,CAT)、总抗氧化能力(total antioxi... 详细信息

该研究建立D-半乳糖诱导小鼠肾损伤模型,用不同剂量[250、500 mg/(kg·d)]白茶多酚灌胃小鼠42 d,于第6周末测量小鼠肾组织中谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)、过氧化氢酶(catalase,CAT)、总抗氧化能力(total antioxidant capacity,T-AOC)、一氧化氮(nitric oxide,NO)、丙二醛(malondialdehyde,MDA)和细胞因子il-6、il-10、TNF-α、IFN-β、IFN-γ的含量。组织学分析肾脏切片病理变化,体外抗氧化试验考察白茶多酚对DPPH自由基、ABTS阳离子自由基清除能力以及肾脏器官系数的分析。此外,通过HPLC分析白茶多酚的生物活性成分。结果表明,白茶多酚显著(Pil-10、IFN-β含量,降低MDA、NO、il-6、TNF-α、IFN-γ含量,使肾脏细胞排列顺序更为规则,且对DPPH自由基以及ABTS阳离子自由基具有明显的清除效果,也能有效抵抗由D-半乳糖导致的小鼠肾脏萎缩。同时,HPLC分析发现白茶多酚里面含有隐绿原酸、没食子儿茶素没食子酸酯、表儿茶素、芦丁、山柰苷、对香豆酸6种活性物质。总之,白茶多酚具有较好的抗氧化活性,能有效改善由D-半乳糖诱导的小鼠肾损伤,其药理价值可进一步深入研究。

关键词：白茶多酚体外抗氧化活性 D-半乳糖肾损伤高效液相色谱

Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase

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International Journal of Oral Science 2021年第3期13卷 311-322页

作者： Xida Zhao Jingbo Liu chong Zhang Ning Yu Ze Lu Shuwei Zhang Yuchao Li Qian Li Junchao Liu Dongjuan Liu Yaping Pan Department of Periodontology School and Hospital of StomatologyChina Medical UniversityLiaoning Provincial Key Laboratory of Oral DiseasesShenyangChina Center for Implant Dentistry School and Hospital of StomatologyChina Medical UniversityLiaoning Provincial Key Laboratory of Oral DiseaseShenyangChina The Forsyth Institute CambridgeMAUSA Department of Emergency and Oral Medicine School and Hospital of StomatologyChina Medical UniversityLiaoning Provincial Key Laboratory of Oral DiseasesShenyangChina

Abstract:Ulcerative Colitis(UC)has been reported to be related to Porphyromonas gingivalis(***).Porphyromonas gingivalis peptidylarginine deiminase(PPAD),a virulence factor released by ***,is known to induce inflammatory *** explore the pathological relationships between PPAD and UC,we used homologous recombination technology to construct a *** strain in which the PPAD gene was deleted(Δppad)and aΔppad strain in which the PPAD gene was restored(comΔppad).C57 BL/6 mice were orally gavaged with saline,***,Δppad,or comΔppad twice a week for the entire 40 days(days 0-40),and then,UC was induced by dextran sodium sulfate(DSS)solution for 10 days(days 31-40).*** and comΔppad exacerbated DDS-induced colitis,which was determined by assessing the parameters of colon length,disease activity index,and histological activity index,butΔppad failed to exacerbate DDS-induced *** cytometry and ELISA revealed that compared withΔppad,***,and comΔppad increased T helper 17(Th17)cell numbers and interleukin(il)-17 production but decreased regulatory T cells(Tregs)numbers and il-10 production in the spleens of mice with *** also cocultured ***,Δppad,or comΔppad with T lymphocytes in vitro and found that *** and comΔppad significantly increased Th17 cell numbers and decreased Treg cell *** staining of colon tissue paraffin sections also confirmed these *** results suggested that *** exacerbated the severity of UC in part via PPAD.

关键词： gingivalis colitis colon

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调节性B细胞在呼吸系统疾病中的研究进展

医学研究生学报 2022年第8期35卷 877-882页

作者：叶磊张贤(综述) 李翀(审校) 常州市第一人民医院呼吸与危重症学科常州213000

B细胞通过抗体产生、抗原呈递和细胞因子分泌在体液免疫中起重要作用。调节性B细胞(Bregs)作为B细胞的一类亚群,通过分泌il-10、il-35和肿瘤生长因子-β以及直接与细胞接触来调节免疫反应。呼吸系统疾病的发生与发展和Bregs数量和功能... 详细信息

B细胞通过抗体产生、抗原呈递和细胞因子分泌在体液免疫中起重要作用。调节性B细胞(Bregs)作为B细胞的一类亚群,通过分泌il-10、il-35和肿瘤生长因子-β以及直接与细胞接触来调节免疫反应。呼吸系统疾病的发生与发展和Bregs数量和功能异常相关,说明了Bregs在呼吸系统免疫反应中的重要性。文章主要就Bregs在肺部感染、肺部肿瘤、支气管哮喘/气道炎症性疾病和间质性肺疾病中的作用及其在维持呼吸道免疫环境稳态方面的重要性进行综述。

关键词：呼吸系统疾病调节性B细胞免疫调节

Predictors of sperm recovery after cryopreservation n testicular cancer

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Asian Journal of Andrology 2016年第1期18卷 35-38页

作者： James M Hotaling Darshan P Patel Christopher Vendryes Natalya A Lopushnyan Angela P Presson chong Zhang charles H Muller Thomas J Walsh Division of Urology Department of Surgery University of Utah Salt Lake City UT 84132 USA Department of Urology University of Illinois-Chicago Chicago IL 60612 USA Department of Urology University of Washington Seattle WA 98195 USA Division of Epidemiology Department of Internal Medicine University of Utah Salt Lake City UT 84132 USA

Our objective was to identify predictors of improved postthaw semen quality in men with testicular cancer banking sperm for fertility preservation. We reviewed 173 individual semen samples provided by 67 men with testicular germ cell tumor （TGCT） who cryopreserved sperm before gonadotoxic treatment between 1994 and 2010 at our tertiary university medical center. Our main outcomes measures were independent predictors for the greater postthaw total motile count （TMC） in men with TGCT. Men with NSGCT were more likely to be younger （P 〈 0.01） and had high cancer stage （Ⅱ or Ⅲ, P 〈 0.01） compared with men with seminoma. In our multiple regression model, NSGCT histology, use of density gradient purification, and fresh TMC 〉 median fresh TMC each had increased odds of a postthaw TMC greater than median postthaw TMC. Interestingly, age, advanced cancer stage （11 or III）, rapid freezing protocol, and motility enhancer did not show increased odds of improved postthaw TMC in our models. In conclusion, men with TGCT or poor fresh TMC should consider preserving additional vials （at least 15 vials） before oncologic treatment. Density gradient purification should be routinely used to optimize postthaw TMC in men with TGCT. Larger, randomized studies evaluating cancer stage and various cryopreservation techniques are needed to assist in counseling men with TGCT regarding fertility preservation and optimizing cryosurvival.

关键词： cryopreservation fertility preservation seminoma testicular neoplasms

复方甘草酸苷片联合盐酸西替利嗪治疗慢性荨麻疹患者的临床研究

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中国临床药理学杂志 2022年第24期38卷 2954-2958页

作者：种树彬刘春林华南理工大学附属六院皮肤科广东佛山528200 华南理工大学附属六院检验科广东佛山528200

目的探讨复方甘草酸苷片联合盐酸西替利嗪治疗慢性荨麻疹患者的疗效及作用机制。方法将110例慢性荨麻疹患者采用随机数字表法分为对照组(55例)和试验组(55例)。对照组给予盐酸西替利嗪片,每次10 mg,每天1次,口服。试验组在对照组的基... 详细信息

目的探讨复方甘草酸苷片联合盐酸西替利嗪治疗慢性荨麻疹患者的疗效及作用机制。方法将110例慢性荨麻疹患者采用随机数字表法分为对照组(55例)和试验组(55例)。对照组给予盐酸西替利嗪片,每次10 mg,每天1次,口服。试验组在对照组的基础上给予复方甘草酸苷片,以甘草酸苷计每次150 mg,每天3次,口服。2组均治疗12周,随访2个月。比较2组临床疗效、炎性因子、趋化因子水平、慢性荨麻疹评分、免疫功能、药物不良反应发生情况及复发情况。结果治疗后,试验组总有效率(94.55%)高于对照组(80.00%,Pil-4)水平分别为(4.22±1.24)和(7.35±1.73)ng·L^(-1);血清白细胞介素-10(il-10)水平分别为(22.03±3.04)和(35.04±3.82)ng·L^(-1);血清白细胞介素-25(il-25)水平分别为(120.78±14.31)和(162.08±17.48)ng·L^(-1);血清白细胞介素-33(il-33)水平分别为(89.73±9.62)和(103.92±11.59)ng·L^(-1);血清干扰素-γ(IFN-γ)水平分别为(19.52±3.82)和(13.28±3.29)pg·mL^(-1);血清单核细胞趋化蛋白-1(MCP-1)水平分别为(284.30±37.59)和(331.82±41.95)pg·mL^(-1);血清正常T细胞表达和分泌因子(RANTES)水平分别为(29.94±3.52)和(48.78±6.41)μg·L^(-1);血清嗜酸性粒细胞趋化因子(Eotaxin)水平分别为(55.74±5.39)和(73.29±6.94)μg·L^(-1);慢性荨麻疹评分分别为(2.04±0.89)和(5.73±1.92)分;血清补体3(C3)水平分别为(0.98±0.24)和(0.89±0.21)g·L^(-1);血清补体4(C4)水平分别为(0.42±0.06)和(0.28±0.05)g·L^(-1);血清补体5a(C5a)水平分别为(38.58±3.28)和(49.72±5.28)ng·mL^(-1);血清免疫球蛋白E(IgE)水平分别为(106.84±11.27)和(184.37±28.47)U·mL^(-1),差异均有统计学意义(均P0.05)。随访2个月,试验组和对照组复发率分别为12.73%和27.27%,差异有统计学意义(P<0.05)。结论复方甘草酸苷片辅助治疗慢性荨麻疹患者,可有效改善患者临床症状,降低患者机体炎症反应、趋化因子水平,调节患者机体免疫功能,安全性较好,同时可有效降低患者复发率,具有较好的治疗效果。

关键词：复方甘草酸苷片盐酸西替利嗪片慢性荨麻疹细胞因子免疫功能

Anti-inflammatory Activity and Mechanism of Total Flavonoids from the Phloem of Paulownia elongate S.Y. Hu in LPS-stimulated RAW264.7 Macrophages

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Agricultural Biotechnology 2021年第3期10卷 117-120,124页

作者： Liyan LI Tao HUANG chong LAN Medical School Huanghe Science&Technology UniversityZhengzhou 450063China Zhengzhou Key Laboratory of Drug Screening and Activity Evaluation Huanghe Science&Technology UniversityZhengzhou 450063China

The juice leaked from broken phloem of Paulownia elongate *** has been used to cure acute inflammation resulted from stung injury by poisonous insects for a long time in China,but its potential mechanism remains *** present study was designed to evaluate anti-inflammatory activity and mechanism of total flavonoids from the phloem of *** *** in RAW264.7 ***(LPS)-induced nitric oxide(NO)was measured by Griess and mRNA of pro-inflammatory mediators was analyzed by *** viability was measured using cell counting kit(CCK)-8 *** protein level was analyzed by Western *** results showed that the total flavonoids of *** significantly inhibited the production of the pro-inflammatory mediators such as NO,interleukin(il)-1β and interleukin(il)-6 in LPS-stimulated RAW264.7 *** flavonoids of *** exerted potential anti-inflammatory activity through the regulation of several signaling *** flavonoids of *** inhibited JAK/STAT by blocking JAK2 and STAT3 phosphorylation *** is the first report on anti-inflammatory activity of total flavonoids from the phloem of ***,which suggests that the total flavonoids of *** may have great potential for the development of anti-inflammatory drug to treat inflammatory disorders.

关键词： Paulownia elongate Total flavonoids Anti-inflammatory activity Mechanisms