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A Novel Method to Improve the Physical Property and Biocompatibility of Decellularized Heart Valve Scaffold with Sericin and Polydopamine

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Journal of Bionic Engineering 2022年第4期19卷 1109-1123页

作者： Peng Bai Gangcheng Kong Weihua Qiao Yu Song Yixuan Wang Jiawei Shi Nan Zhang chungeng Liu chong chu Tixiusi Xiong Ying Zhou Cuifen Lu Lin Wang Nianguo Dong Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430032China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Research Center for Tissue Engineering and Regenerative Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Endocrinology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430032China Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry Hubei UniversityWuhan 430062China Department of Clinical Laboratory Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Cardiac valve replacement is an effective method to treat valvular heart *** valves used routinely in clinic still have *** our study,we explored a novel method to modify the performance of Decellularized Heart Valve(DHV)*** decellularized porcine aortic valve was prepared using sequential hydrophile and lipophile solubilization *** sericin was extracted from silk fibroin-deficient silkworm cocoon by lithium bromide ***,DHV was immersed in sericin solution to produce the sericin–DHV composite ***,we modified the DHV by making a Polydopamine(PDA)coating on the DHV first and then binding the *** physical properties and biological compatibility of our composite scaffold were assessed in vitro and in *** were successfully prepared,combined to DHV and improved its *** coating further promoted the combination of sericin on DHV and improved the physical properties of *** decay rate of our modified valve scaffold was decreased in vivo and it showed good compatibility with *** conclusion,our modification improved the physical properties and biocompatibility of the valve *** combination of PDA and sericin promoted the recellularization of decellularized valves,showing great potential to be a novel artificial valve.

关键词： Decellularized heart valve Sericin Polydopamine Biocompatibility

Therapeutic efficacy and stent patency of transhepatic portal vein stenting after surgery

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World Journal of Gastroenterology 2016年第44期22卷 9822-9828页

作者： Ung Bae Jeon Chang Won Kim Tae Un Kim Ki Seok Choo Joo Yeon Jang Kyung Jin Nam chong Woo chu Je Ho Ryu Department of Radiology Pusan National University Yangsan Hospital Department of Radiology Medical Research Institute Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology Pusan National University Hospital Department of Surgery Pusan National University Yangsan Hospital

AIM To evaluate portal vein(PV) stenosis and stent patency after hepatobiliary and pancreatic surgery, using abdominal computed tomography(CT).METHODS Percutaneous portal venous stenting was attempted in 22 patients with significant PV stenosis(> 50%)-after hepatobiliary or pancreatic surgery- diagnosed by abdominal CT. Stents were placed in various stenotic lesions after percutaneous transhepatic portography. Pressure gradient across the stenotic segment was measured in 14 patients. Stents were placed when the pressure gradient across the stenotic segment was > 5 mm Hg or PV stenosis was > 50%, as observed on transhepatic portography. Patients underwent followup abdominal CT and technical and clinical success, complications, and stent patency were *** Stent placement was successful in 21 patients(technical success rate: 95.5%). Stents were positioned through the main PV and superior mesenteric vein(n = 13), main PV(n = 2), right and main PV(n = 1), left and main PV(n = 4), or main PV and splenic vein(n = 1). Patients showed no complications after stent placement. The time between procedure and final follow-up CT was 41-761 d(mean: 374.5 d). Twenty stents remained patent during the entire follow-up. Stent obstruction-caused by invasion of the PV stent by a recurrent tumor- was observed in 1 patient in a follow-up CT performed after 155 d after the procedure. The cumulative stent patency rate was 95.7%. Small in-stent low-density areas were found in 11(55%) patients; however, during successive follow-up CT, the extent of these areas had *** Percutaneous transhepatic stent placement can be safe and effective in cases of PV stenosis after hepatobiliary and pancreatic surgery. Stents show excellent patency in follow-up abdominal CT, despite development of small in-stent low-density areas.

关键词： Liver Vein Stent Computed tomography Surveillance Efficace

Deciphering transcriptome alterations in bone marrow hematopoiesis at single-cell resolution in immune thrombocytopenia

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Signal Transduction and Targeted Therapy 2022年第11期7卷 4190-4207页

作者： Yan Liu Xinyi Zuo Peng Chen Xiang Hu Zi Sheng Anli Liu Qiang Liu Shaoqiu Leng Xiaoyu Zhang Xin Li Limei Wang Qi Feng Chaoyang Li Ming Hou chong chu Shihui Ma Shuwen Wang Jun Peng Department of Hematology Qilu HospitalCheeloo College of MedicineShandong UniversityJinan250012China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin300020China Department of Hematology the Affiliated Hospital of Qingdao UniversityQingdao266000China Advanced Medical Research Institute Shandong UniversityJinan250012China Shangdong Key Laboratory of Immunochematology Qilu HospitalCheeloo College of MedicineShandong UniversityJinan250012China Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of HealthQilu HospitalCheeloo College of MedicineShandong UniversityJinan250012China Department of Biomedical Informatics Harvard Medical SchoolBoston02115MAUSA

Immune thrombocytopenia(ITP)is an autoimmune disorder,in which megakaryocyte dysfunction caused by an autoimmune reaction can lead to thrombocytopenia,although the underlying mechanisms remain ***,we performed single-cell transcriptome profiling of bone marrow CD34+hematopoietic stem and progenitor cells(HSPCs)to determine defects in megakaryopoiesis in *** expression,cell-cell interactions,and transcriptional regulatory networks varied in HSPCs of ITP,particularly in immune cell *** expressed gene(DEG)analysis indicated that there was an impaired megakaryopoiesis of *** cytometry confirmed that the number of CD9+and HES1+cells from Lin−CD34+CD45RA−HSPCs decreased in *** culture assays demonstrated that CD9+Lin−CD34+CD45RA−HSPCs tended to differentiate into megakaryocytes;however,this tendency was not observed in ITP patients and more erythrocytes were *** percentage of megakaryocytes differentiated from CD9+Lin−CD34+CD45RA−HSPCs was 3-fold higher than that of the CD9−counterparts from healthy controls(HCs),whereas,in ITP patients,the percentage decreased to only 1/4th of that in the HCs and was comparable to that from the CD9−***,when co-cultured with pre-B cells from ITP patients,the differentiation of CD9+Lin−CD34+CD45RA−HSPCs toward the megakaryopoietic lineage was *** analysis revealed that megakaryocytic progenitors(MkP)can be divided into seven subclusters with different gene expression patterns and *** ITP-associated DEGs were MkP subtype-specific,with most DEGs concentrated in the subcluster possessing dual functions of immunomodulation and platelet *** study comprehensively dissects defective hematopoiesis and provides novel insights regarding the pathogenesis of ITP.

关键词： impaired alterations progenitor

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国力牌液压爬架在蓝旗营住宅小区工程的应用

施工技术 2000年第3期29卷 55-56页

作者：褚崇英中国建筑一局集团四公司北京100102

中国建筑一局集团四公司承建北大清华蓝旗营高校教师住宅小区工程中的2栋高层塔楼及2栋多层院士楼,总建筑面积约为50400m2.2栋高层住宅(8号、9号)为全现浇钢筋混凝土剪力墙结构.其中,8号住宅地下2层,地上20层;9号住宅地下2层,地上18层;... 详细信息

中国建筑一局集团四公司承建北大清华蓝旗营高校教师住宅小区工程中的2栋高层塔楼及2栋多层院士楼,总建筑面积约为50400m2.2栋高层住宅(8号、9号)为全现浇钢筋混凝土剪力墙结构.其中,8号住宅地下2层,地上20层;9号住宅地下2层,地上18层;檐口高度分别为54.0m、48.6m.为保证施工质量,8、9号楼的外脚手架体系选择了国力牌框架式液压爬架.

关键词：液压爬架体系设计住宅小区工程

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激光冷却器高精度表面的超精密加工工艺研究

组合机床与自动化加工技术 2015年第5期 121-122,126页

作者：韩长庆楚翀中国工程物理研究院机械制造工艺研究所四川绵阳621900

冷却器是重要的换热、冷却设备,在激光行业常用的是循环水冷却器,是激光系统中必不可少的部件之一。工件表面质量决定了产品的冷却性能、温度控制精确度、发热元件的寿命等。文章在无应力装夹、刀具选择、加工参数选择、冷却润滑条件、... 详细信息

冷却器是重要的换热、冷却设备,在激光行业常用的是循环水冷却器,是激光系统中必不可少的部件之一。工件表面质量决定了产品的冷却性能、温度控制精确度、发热元件的寿命等。文章在无应力装夹、刀具选择、加工参数选择、冷却润滑条件、进刀方式等方面优化了切削工艺参数,实现了超精密冷却器高精度表面质量的加工。

关键词：冷却器工艺参数表面质量

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直驱气浮平台工作模态的分析方法及实验验证

工程科学与技术 2020年第5期52卷 230-235页

作者：陈东生楚翀余德平刘佳鑫中国工程物理研究院机械制造工艺研究所四川绵阳621900 四川大学机械工程学院四川成都610065

直驱气浮平台是集气浮支承、伺服驱动及机械结构为一体的精密运动系统,具有较复杂的振动性能,一般通过模态分析得到机械结构的振动性能,但在工程应用中,更需要获得驱动作用下平台工作时的振动性能。因此,为简单、快捷、准确地分析平台... 详细信息

直驱气浮平台是集气浮支承、伺服驱动及机械结构为一体的精密运动系统,具有较复杂的振动性能,一般通过模态分析得到机械结构的振动性能,但在工程应用中,更需要获得驱动作用下平台工作时的振动性能。因此,为简单、快捷、准确地分析平台工作状态的振动性能,本文提出一种机电耦合的振动分析方法,即将驱动系统的伺服特性和气浮支承的气膜特性均等效成弹簧阻尼单元,建立机电耦合仿真模型,基于该模型分析得到平台工作状态下的振动模态。为验证该方法,采用LMS模态测试仪对平台进行模态测试,试验结果同仿真结果较一致,基于此方法分析计算得到的振动模态最大偏差为8.16%。模态实验表明所提出的机电耦合模态分析方法可以准确地分析平台工作状态的振动特性。

关键词：气浮平台机电耦合工作模态模态测试

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建筑结构防连续倒塌分析与设计方法研究进展

工程抗震与加固改造 2014年第1期36卷 52-56,66页

作者：潘毅王初翀卢立恒秦楠西南交通大学土木工程学院四川成都610031

建筑结构防连续倒塌日益受到工程界的关注,已成为结构工程领域的一个研究热点。本文介绍了连续倒塌的破坏机理及其分类,对连续倒塌的评价准则及其适用情况进行了总结,将防连续倒塌的研究分为分析方法和设计方法两个方面,对其研究特点与... 详细信息

建筑结构防连续倒塌日益受到工程界的关注,已成为结构工程领域的一个研究热点。本文介绍了连续倒塌的破坏机理及其分类,对连续倒塌的评价准则及其适用情况进行了总结,将防连续倒塌的研究分为分析方法和设计方法两个方面,对其研究特点与研究现状进行了阐述,并对不同的设计方法进行了对比。最后,提出了建筑结构防连续倒塌需要进一步研究的问题。

关键词：连续性倒塌分析方法设计方法

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微圆弧金刚石刀具修磨技术研究

金刚石与磨料磨具工程 2017年第3期37卷 69-73页

作者：夏志辉贾鲁张晓峰楚翀中国工程物理研究院机械制造工艺研究所四川绵阳621900

微圆弧金刚石刀具是超精密加工中的重要应用工具,基于机械研磨法开展微圆弧金刚石刀具修磨技术研究。通过分析微圆弧金刚石刀具制备技术现状和制备难点,设计一种微圆弧金刚石刀具的修磨技术路线。通过修磨实验解决难磨、易磨方向定位,... 详细信息

微圆弧金刚石刀具是超精密加工中的重要应用工具,基于机械研磨法开展微圆弧金刚石刀具修磨技术研究。通过分析微圆弧金刚石刀具制备技术现状和制备难点,设计一种微圆弧金刚石刀具的修磨技术路线。通过修磨实验解决难磨、易磨方向定位,刀尖容易崩刃及精修刀尖圆弧等技术难点,制备刀尖半径R8.2μm的微圆弧金刚石刀具。利用原子力显微镜和高倍光学显微镜进行观测,结果表明:前刀面粗糙度R_a=1.50nm,刀尖轮廓波纹度优于0.1μm,与进口高精度刀具指标相当。将其应用在微结构的超精密切削中,取得良好效果。

关键词：超精密加工微圆弧金刚石刀具修磨

KDP晶体切入角度对切削力和表面粗糙度影响试验

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机床与液压 2017年第20期45卷 21-24,74页

作者：夏志辉张晓峰孔金星楚翀中国工程物理研究院机械制造工艺研究所四川绵阳621900

KDP晶体具有各向异性,使得沿不同晶向切入时切削力的大小和作用效果发生改变,进而可能影响表面质量。利用高精度三向测力仪搭建了KDP切削力测试平台,对其沿不同晶向的切削力进行了测试。结果表明:切削力沿特定的角度呈一定的规律分布,... 详细信息

KDP晶体具有各向异性,使得沿不同晶向切入时切削力的大小和作用效果发生改变,进而可能影响表面质量。利用高精度三向测力仪搭建了KDP切削力测试平台,对其沿不同晶向的切削力进行了测试。结果表明:切削力沿特定的角度呈一定的规律分布,与理论计算有一定的吻合,同时表面粗糙度值在不同的晶向也呈典型的周期分布。在切削力测试基础上,开展了表面粗糙度优化试验,在50 mm×50 mm工件上实现了S_q<1.8 nm的超光滑表面加工。

关键词： KDP晶体各向异性切削力表面粗糙度