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Recurrent chromosomal rearrangements at bands 8q24 and 11q13 in gastric cancer as detected by multicolor spectral karyotyping

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World Journal of Gastroenterology 2005年第33期11卷 5129-5135页

作者： Yasuhide Yamashita Kazuhiro Nishida Takashi Okuda Kenichi Nomura Yosuke Matsumoto Shoji Mitsufuji Shigeo Horiike Hiroyuki Hata chohei sakakura Akio Hagiwara Hisakazu Yamagishi Masafumi Taniwaki Department of Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Department of Hematology and Oncology Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Second Department of Internal Medicine Kumamoto University School of Medicine Kumamoto 860-8555 Japan Department of Digestive Surgery Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Department of Clinical Molecular Genetics and Laboratory Medicine Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan

AIM: To identify chromosomal translocations specific to gastric cancer (GC), spectral karyotyping (SKY) analysis was performed on established cell lines and cancerous ascitic ***: SKY analysis of 10 established cell lines and seven cancerous ascitic fluid samples identified recurrent chromosomal breakpoints and translocations in GC,several of which involved chromosomal loci of oncogenes or tumor suppressor ***: A total of 630 chromosomal breaks were identified. Chromosome no.8 was the most frequently involved in rearrangements (65 breaks), followed by chromosomes no. 11 (53), no. 1 (49), no. 7 (46), no. 13 (37), no. 3 (36), no. 17 (33), and no. 20 (29). Frequent breakpoints were detected in 8q24.1 (30 breaks), 11q13 (29), 13q14 (16), 20q11.2 (14), 7q32 (13), 17q11.2 (13),18q21 (12), 17q23 (9), 18q11.2 (9). SKY analysis identified a total of 242 chromosomal rearrangements including 190 reciprocal and non-reciprocal translocations. The recurrent combinations of chromosomal bands involved in translocations were 8q24.1 and 13q14 (3 cases), 8q24.1 and 11q13 (3), 11q13 and 17q11.2 (2), and 18q11.2 and 20q11.2 (2). Our study validated the ability of SKY to characterize in detail the chromosomal rearrangements in solid tumors and derived cell lines. Moreover,fluorescence in situ hybridization helped to identify the insertions, translocations, and homogeneously staining regions of MYCand CCND1 gene ***: The non-random co-localization of certain cytogenetic bands suggests the importance of chromosomal translocations in gastric carcinogenesis, by serving as landmarks for the cloning of GC causing genes.

关键词： Gastric cancer SKY FISH Chromosomaltranslocation

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Surgical treatment of hepatocellular carcinoma with severe intratumoral arterioportal shunt

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World Journal of Gastroenterology 2010年第25期16卷 3211-3214页

作者： Hiromichi Ishii Teruhisa Sonoyama Shingo Nakashima Hiroyuki Nagata Atsushi Shiozaki Yoshiaki Kuriu Hisashi Ikoma Masayoshi Nakanishi Daisuke Ichikawa Hitoshi Fujiwara Kazuma Okamoto Toshiya Ochiai Yukihito Kokuba chohei sakakura Eigo Otsuji Division of Digestive Surgery Department of Surgery Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan

We report a case of hepatocellular carcinoma (HCC) that caused a severe arterioportal shunt (APS). A 49-year-old man was admitted to hospital due to esophagogastric variceal hemorrhage and HCC, and underwent endoscopic variceal ligation (EVL) and endoscopic injection sclerotherapy (EIS). He was then referred to our hospital. Abdominal computed tomography revealed a lowdensity lesion in the posterior segment of the liver and an intratumoral APS, which caused portal hypertension. Although the patient underwent EVL, EIS, Hassab’s operation, and transcatheter arterial embolization for APS, he vomited blood due to rupture of esophagogastric varices. Right hepatectomy was performed for the treatment of HCC and APS, although the indocyanine green retention value at 15 min after intravenous injection was poor (30%). The patient’s postoperative course was uneventful. Eventually, APS disappeared and the esophagogastric varices improved.

关键词： Arterioportal shunt Hepatocellular carcinoma Esophagogastric varices

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Ultralow-loss geometric phase and polarization shaping by ultrafast laser writing in silica glass

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Light(Science & Applications) 2020年第1期9卷 1860-1869页

作者： Masaaki sakakura Yuhao Lei Lei Wang Yan-Hao Yu Peter G.Kazansky Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK

Polarization and geometric phase shaping via a space-variant anisotropy has attracted considerable interest for fabrication of flat optical elements and generation of vector beams with applications in various areas of science and *** the methods for anisotropy patterning,imprinting of self-assembled nanograting structures in silica glass by femtosecond laser writing is promising for the fabrication of space-variant birefringent optics with high thermal and chemical durability and high optical damage ***,a drawback is the optical loss due to the light scattering by nanograting structures,which has limited the ***,we report a new type of ultrafast laser-induced modification in silica glass,which consists of randomly distributed nanopores elongated in the direction perpendicular to the polarization,providing controllable birefringent structures with transmittance as high as 99% in the visible and near-infrared ranges and >90% in the UV range down to 330 *** observed anisotropic nanoporous silica structures are fundamentally different from the femtosecond laser-induced nanogratings and conventional nanoporous silica.A mechanism of nanocavitation via interstitial oxygen generation mediated by multiphoton and avanlanche defect ionization is *** demonstrate ultralow-loss geometrical phase optical elements,including geometrical phase prism and lens,and a vector beam convertor in silica glass.

关键词： polarization silica phase

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Efficient ultrafast laser writing with elliptical polarization

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Light(Science & Applications) 2023年第4期12卷 605-612页

作者： Yuhao Lei Gholamreza Shayeganrad Huijun Wang Masaaki sakakura Yanhao Yu Lei Wang Dmitrii Kliukin Linards Skuja Yuri Svirko Peter G.Kazansky Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK Institute of Solid State Physics University of Latvia8 Kengaraga StrasseRiga LV-1063Latvia Institute of Photonics Department of Physics and MathematicsUniversity of Eastern FinlandFI-80101 JoensuuFinland

Photosensitivity in nature is commonly associated with stronger light *** is also believed that artificial optical anisotropy to be the strongest when created by light with linear *** to intuition,ultrafast laser direct writing with elliptical polarization in silica glass,while nonlinear absorption is about 2.5 times weaker,results in form birefringence about twice that of linearly polarized ***,a larger concentration of anisotropic nanopores created by elliptically polarized light pulses is *** phenomenon is interpreted in terms of enhanced interaction of circularly polarized light with a network of randomly oriented bonds and hole polarons in silica glass,as well as efficient tunneling ionization produced by circular *** to multiplexed optical data storage and birefringence patterning in silica glass are demonstrated.

关键词： polarization laser polarized

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Long-term survival of a case with multiple liver metastases from duodenal gastrointestinal stromal tumor drastically reduced by the treatment with imatinib and hepatectomy

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World Journal of Gastroenterology 2006年第17期12卷 2793-2797页

作者： Chouhei sakakura Akeo Hagiwara Koji Soga Koji Miyagawa Susumu Nakashima Tetsuji Yoshikawa Shuichi Kin Yuenn Nakase Nobuki Yamaoka Yoshihiko Sagara Hisakazu Yamagishi Department of Digestive Surgery Kyoto Prefectural University of Medicine Kawaramachi-doriKamigyokuKyoto 602-0841Japan

Constitutive activation of KIT receptor tyrosine kinase is a critical factor in the pathogenesis of gastrointestinal stromal tumors （GISTs）. But there is little information on whether combination of imatinib mesylate （IM） and surgical treatment can prolong survival in the cases with unresectable multiple liver metastases. We report a case of postoperative recurrence of GIST treated by the tyrosine kinase inhibitor IN and surgical treatment. The initial complete response （CR） to treatment continued for 18 mo, but single liver metastasis showed regrowth in the left hepatic lobe during IN treatment. After partial resection of the recurrent tumor, postoperative course was uneventful and the patient has survived without recurrence for 24 too. Currently, imatinib is the first- line therapy for non-resectable GISTs, but a single agent therapy often leads to tumor resistance. Even if tolerance to imatinib occurs, a combination of imatinib and surgical treatment can prolong survival in some cases as reported here. However, further studies on a large number of cases of recurrent GIST are necessary to evaluate the effectiveness of IN treatment combined with surgery.

关键词： GIST Imatinib mesylate Liver metastases

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Picosecond burst pulse machining with temporal energy modulation

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Chinese Optics Letters 2020年第12期18卷 87-91页

作者： Akinao Nakamura Tomoki Mizuta Yasuhiko Shimotsuma Masaaki sakakura Tomohito Otobe Masahiro Shimizu Kiyotaka Miura Department of Material Chemistry Graduate School of Engineering Kyoto University National Institutes for Quantum and Radiological Science and Technology Kansai Photon Science Institute

Suppression of stress and crack generation during picosecond laser processing in transparent brittle materials such as glass was successfully demonstrated by a picosecond laser pulse with temporal energy modulation. The origin of deterioration in processing accuracy could be interpreted in terms of the discontinuous movement of plasma in the vicinity of the focus. To reveal the effectiveness of the temporal energy modulation for smooth machining, such plasma motion was simulated by the finite-difference time-domain method. Furthermore, photoinduced birefringence was observed using a high-speed polarization camera.

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Picosecond burst pulse machining with temporal energy modulation [Invited]

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Chinese Optics Letters 2020年第12期18卷 83-87页

作者： Akinao Nakamura Tomoki Mizuta Yasuhiko Shimotsuma Masaaki sakakura Tomohito Otobe Masahiro Shimizu Kiyotaka Miura Department of Material Chemistry Graduate School of EngineeringKyoto UniversityKyoto 615-8510Japan National Institutes for Quantum and Radiological Science and Technology Kansai Photon Science InstituteKyoto 619-0215Japan

Suppression of stress and crack generation during picosecond laser processing in transparent brittle materials such as glass was successfully demonstrated by a picosecond laser pulse with temporal energy *** origin of deterioration in processing accuracy could be interpreted in terms of the discontinuous movement of plasma in the vicinity of the *** reveal the effectiveness of the temporal energy modulation for smootli machining,such plasma motion was simulated by the fiidtc-d ifference time-domain method.F urt her more,photoinduced birefringence was observed using a high-speed polarization camera.

关键词： picosecond laser energy modulation burst pulse material processing stress distribution

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Complete withdrawal of glucocorticoids after dupilumab therapy in allergic bronchopulmonary aspergillosis:A case report

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World Journal of Clinical Cases 2021年第23期9卷 6922-6928页

作者： Tadashi Nishimura Tomohito Okano Masahiro Naito Chikashi Tsuji Soichi Iwanaka Yasumasa sakakura Taro Yasuma Hajime Fujimoto Corina N D'Alessandro-Gabazza Yasuhiro Oomoto Tetsu Kobayashi Esteban C Gabazza Hidenori Ibata Department of Pulmonary Medicine Mie Chuo Medical CenterTsu 514-1101MieJapan Department of Pulmonary and Critical Care Medicine Mie UniversityTsu 514-8507MieJapan Department of Immunology Mie University School of MedicineMie UniversityTsu 514-8507MieJapan Department of Pulmonary and Critical Care Medicine Graduate School of Medicine MieMie UniversityTsu 514-8507MieJapan

BACKGROUND Allergic bronchopulmonary aspergillosis(ABPA)is an allergic reaction to Aspergillus species that aggravates bronchial *** studies demonstrated the glucocorticoid-sparing effect of dupilumab in patients with *** is no report of complete withdrawal of glucocorticoids after *** SUMMARY The patient was a 54-year-old woman with bronchial asthma treated with inhaled corticosteroids and a long-acting beta-2 *** consulted our institution for productive cough and fever in March *** computed tomography scan revealed mucoid impaction,and the bronchial lavage fluid culture was positive for Aspergillus *** diagnosis was *** patient was treated with oral glucocorticoids from April 2017 to November *** January 2019,she had bronchial asthma exacerbation,and a chest computed tomography scan showed recurrent mucoid *** was treated with oral glucocorticoids and *** February 2020,during tapering of oral glucocorticoid,she had the third episode of bronchial asthma exacerbation and a mucoid *** patient was treated with dupilumab in addition to oral glucocorticoid and *** clinical response improved,and oral glucocorticoid was discontinued in June *** This is the first case of ABPA in which complete withdrawal of glucocorticoid was possible after treatment with dupilumab.

关键词： Allergic bronchopulmonary aspergillosis Dupilumab Asthma Interleukin-13 Interleukin-4 Case report

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Neurological Changes after Surgical Intervention for Intrinsic Cavernous Anigoma

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Open Journal of Modern Neurosurgery 2012年第4期2卷 63-65页

作者： Takafumi Nishizaki Norio Ikeda Shigeki Nakano Tomomi Okamura Takanori sakakura Department of Neurosurgery Ube Industries Central Hospital Nishikiwa Ube Yamaguchi Japan

We report neurological changes and circulatory and pulmonary symptoms after surgical intervention in cases of brainstem cavernous angioma. Eight patients who underwent surgical intervention for brainstem cavernous angiomas were retrospectively reviewed. Two of 4 patients who underwent total removal of the mass showed marked resolution of the preoperative signs including IX nerve palsy, MLF syndrome, cerebellar sign and homonymous hemianopsia, and two patients who underwent partial removal of the lesions had permanent neurological deficits. Inadequate excision results in not only recurrence of hemorrhage, but also postoperative neurological deterioration. Bradycardia can occur during the surgical intervention, and careful monitoring is mandatory for a couple of days after operation to detect circulatory and pulmonary failure such as atrial flutter.

关键词： Surgical Intervention Brainstem Cavernous Angioma Postoperative Neurological Changes Circulatory Pulmonary Symptoms

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Laparoscopic transhiatal approach for resection of an adenocarcinoma in long-segment Barrett's esophagus

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World Journal of Gastroenterology 2015年第29期21卷 8974-8980页

作者： Atsushi Shiozaki Hitoshi Fujiwara Hirotaka Konishi Osamu Kinoshita Toshiyuki Kosuga Ryo Morimura Yasutoshi Murayama Shuhei Komatsu Yoshiaki Kuriu Hisashi Ikoma Masayoshi Nakanishi Daisuke Ichikawa Kazuma Okamoto Chouhei sakakura Eigo Otsuji Division of Digestive Surgery Department of Surgery Kyoto Prefectural University of Medicine

Barrett's esophagus(BE) is a precursor of esophageal adenocarcinoma and is associated with gastroesophageal reflux disease, which is often preceded by a hiatal hernia. We describe a case of esophageal adenocarcinoma arising in long-segment BE(LSBE) associated with a hiatal hernia that was successfully treated with a laparoscopic transhiatal approach(LTHA) without thoracotomy. The patient was a 42-year-old male who had previously undergone laryngectomy and tracheal separation to avoid repeated aspiration pneumonitis. An ulcerative lesion was found in a hiatal hernia by endoscopy and superficial esophageal cancer was also detected in the lower thoracic esophagus. The histopathological diagnosis of biopsy samples from both lesions was adenocarcinoma. There were difficulties with the thoracic approach because the patient had severe kyphosis and muscular contractures from cerebral palsy. Therefore, we performed subtotal esophagectomy by LTHA without thoracotomy. Using hand-assisted laparoscopic surgery, the esophageal hiatus was divided and carbon dioxide was introduced into the mediastinum. A hernial sac was identified on the cranial side of the right crus of the diaphragm and carefully separated from the surrounding tissues. Abruption of the thoracic esophagus was performed up to the level of thearch of the azygos vein via LTHA. A cervical incision was made in the left side of the permanent tracheal stoma, the cervical esophagus was divided, and gastric tube reconstruction was performed via a posterior mediastinal route. The operative time was 175 min, and there was 61 m L of intra-operative bleeding. A histopathological examination revealed superficial adenocarcinoma in LSBE. Our surgical procedure provided a good surgical view and can be safely applied to patients with a hiatal hernia and kyphosis.

关键词： Laparoscopic transhiatal approach Barrett'sesophageal carcinoma Hiatal hernia

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