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Toxicity and phyto-bioactive constituent of Ficus aurea L. leaf extract: A trado-medicinal herb used in southeastern Nigeria

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Clinical Traditional Medicine and Pharmacology 2024年第4期5卷 54-64页

作者： Sonachi Nnedimma Okeke chinyere godwin chinyere Okezie Emmanuel Department of Biochemistry Abia State UniversityUturuPMB 2000Uturu Abia StateNigeria Department of Animal Sciences College of FoodAgricultural and Environmental Sciencesthe Ohio State UniversityWoosterOH 44691US

Background:The intrinsic adroitness of medicinal plants as a therapy for several maladies is well-documented in African Herbal *** of Ficus aurea L.(Moraceae)are commonly used in folkloric medicine in southeastern Nigeria and other areas of the world to treat malaria,dermatitis,circulatory and intestinal parasitic health ***:The aim of the study was to explore the phytochemical composition and potential toxicity of the ethanolic leaf extract of *** L.(herein afterwards referred to as ELEFA)in albino rats of both ***:Gas chromatography mass spectrometry(GC–MS)was performed to analyze the chemical constituents of *** the acute toxicity study,a single oral dose of up to 5000 mg/kg ELEFA was *** the sub-acute toxicity study,rats were randomly assigned to individual cages to eschew *** groups(A2-A4)and female groups(B2-B4)were administered varying doses of ELEFA(250,500,750 mg/kg)for 28 days,while control groups A1 and B1 received 1 mL/kg of distilled *** analytical procedures were utilized to evaluate the biochemical and haematological profiles,as well as liver and kidney ***:The GC–MS analysis identified 13 phyto-compounds,six of which possess known bioactive and pharmacological *** bioactive compounds include gamma-dodecalactone,n-hexadecanoic acid,methyl stearate,9,12-octadecadienoic acid,oleic acid,octadecanoic *** the acute toxicity,no death was recorded within 24 h following oral administration of ***,haematological and renal biomarkers remained unaltered post-ELEFA ***,elevated levels of serum aspartate and alanine transaminases were detected in ELEFA-treated groups,indicating potential hepatotoxicity.A reduction in atherogenic lipid markers and a dose-dependent elevation in antioxidant concentrations were observed,suggesting a nuanced impact on oxidative ***:The study emphasized caution reg

关键词： Antioxidant Ficus aurea Phytochemical Toxicity Trado-medicine

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Prevalence of HIV, Hepatitis B, and Hepatitis C in Rivers State University, Port Harcourt: Outcome of a Medical Outreach

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Advances in Infectious Diseases 2023年第4期13卷 692-705页

作者： Ibioku Elekima Moore Ikechi Mike-Ogburia chinyere Omereji-David Beatrice Wobiarueri Moore-Igwe Easter godwin Nwokah Ibitoroko Maureen George-Opuda Nkemkanma Vivian Agi Tombari Pius Monsi Ollor Amba Ollor Ozioma Chiagoziem Okoro Ngozi Brisibe Adline Erinma Ben-Chioma Department of Medical Laboratory Science Rivers State University Port Harcourt Nigeria Department of Medical Laboratory Science University of Port Harcourt Teaching Hospital Port Harcourt Nigeria

Background: Infectious diseases associated with Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) continue to pose significant public health challenges that necessitate continuous surveillance and interventions. This study investigates the prevalence of HIV, HBV and HCV infections within the academic community of Rivers State University, Port Harcourt, Nigeria. Given the potential for transmission in university settings and the importance of early detection and intervention, this research explores the extent of these infections and evaluates the outcomes of a medical outreach program aimed at addressing them. Methodology: A cross-sectional study design was employed to recruit 513 participants using a convenience sampling approach between the 20th and 22nd of April 2022. Participants included students and staff members who voluntarily consented to the medical outreach and study. Serological assays were utilized to identify HIV, HBV and HCV infections. The medical outreach program’s design, implementation, and outcomes were evaluated, focusing on testing uptake, counselling utilization, and linkage to care. Statistical analysis employed GraphPad Prism version 9 software. Result: The study revealed low prevalence rates of HIV (0.6%), HBV (1.2%), and HCV (0.6%) infections within the university population. Age-based analysis indicated a slightly higher prevalence in the 15 - 24 age group. Gender-wise, HBV showed a marginal difference, with 1.3% among females and 0.9% among males. The medical outreach program achieved a testing uptake of 80.8%, with 75% utilizing counselling services, and 75% of those identified with infections successfully linked to care. Conclusion: This study provides valuable insights into the prevalence of infections and the effectiveness of a medical outreach program within a university community. While low prevalence rates are encouraging, the findings emphasize the continued importance o

关键词： HIV Hepatitis B Hepatitis C Medical Outreach

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